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公开(公告)号：US11022785B2
公开(公告)日：2021-06-01
申请号：US16745256
申请日：2020-01-16
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Denis Pristinski , David P. Stumbo
Abstract: Detection system comprising an examination region, a one-piece optical element including a focusing portion to concentrate light received from the examination region and a guiding portion to homogenize light received from the focusing portion, and a detector configured to detect homogenized light received from the guiding portion.
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公开(公告)号：US20170322401A1
公开(公告)日：2017-11-09
申请号：US15656877
申请日：2017-07-21
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Denis Pristinski , David P. Stumbo
CPC classification number: G02B19/0028 , G01N15/1434 , G01N15/1459 , G01N21/645 , G01N35/08 , G01N2015/1006 , G01N2021/6478 , G01N2201/0806 , G02B6/0008 , G02B6/262 , G02B19/0076
Abstract: Detection system comprising an examination region, a one-piece optical element including a focusing portion to concentrate light received from the examination region and a guiding portion to homogenize light received from the focusing portion, and a detector configured to detect homogenized light received from the guiding portion.
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公开(公告)号：US20140221239A1
公开(公告)日：2014-08-07
申请号：US14171766
申请日：2014-02-03
Applicant: Bio-Rad Laboratories, Inc.
Inventor： George Carman , Thomas H. Cauley, III , David P. Stumbo
Abstract: System, including methods and apparatus, for spacing droplets from each other and for detection of spaced droplets.
Abstract translation: 系统，包括用于将液滴彼此间隔开并用于检测间隔液滴的方法和装置。
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公开(公告)号：US12239987B2
公开(公告)日：2025-03-04
申请号：US17986873
申请日：2022-11-14
Applicant: Bio-Rad Laboratories, Inc.
Inventor： David P. Stumbo , George Carman , Steve Hobbs , Anthony J. Makarewicz, Jr. , Dmitri Simonian , David Glade , Joshua Oen , Denis Pristinski , John Dzenitis
IPC: B01L3/00 , B01F23/41 , C12Q1/6844 , C12Q1/6848 , C12Q1/6851 , C12Q1/686 , G01N15/14 , G01N15/1429 , G01N15/1434
Abstract: Systems and methods for detection of a signal from droplets of an emulsion. An exemplary system may comprise a fluid transporter having a tube with an open end for aspirating droplets, a singulator to arrange the droplets in single file and to space the single-file droplets from one another, and a detection channel in optical communication with a detector configured to detect a signal from droplets. In some embodiments, the singulator may have a channel junction at which a stream of droplets in single file is combined with a stream of spacing fluid, and a tapered spacing channel extending downstream from the channel junction toward the detection channel. In some embodiments, the fluid transporter may suck droplet-containing fluid and spacing fluid through the detection channel from respective sources. In some embodiments, droplets may be subjected to a disaggregation routine before they are passed through the detection channel.
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公开(公告)号：US11499183B2
公开(公告)日：2022-11-15
申请号：US16022500
申请日：2018-06-28
Applicant: Bio-Rad Laboratories, Inc.
Inventor： David P. Stumbo , George Carman , Steve Hobbs , Anthony J. Makarewicz, Jr. , Dmitri Simonian , David Glade , Joshua Oen , Denis Pristinski , John Dzenitis
IPC: G01N15/14 , B01F3/08 , C12Q1/6848 , C12Q1/6844 , C12Q1/686 , B01L3/00 , C12Q1/6851 , B01F23/41
Abstract: Systems and methods for detection of a signal from droplets of an emulsion. An exemplary system may comprise a fluid transporter having a tube with an open end for aspirating droplets, a singulator to arrange the droplets in single file and to space the single-file droplets from one another, and a detection channel in optical communication with a detector configured to detect a signal from droplets. In some embodiments, the singulator may have a channel junction at which a stream of droplets in single file is combined with a stream of spacing fluid, and a tapered spacing channel extending downstream from the channel junction toward the detection channel. In some embodiments, the fluid transporter may suck droplet-containing fluid and spacing fluid through the detection channel from respective sources. In some embodiments, droplets may be subjected to a disaggregation routine before they are passed through the detection channel.
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Patent Agency Ranking
公开(公告)号：US09726871B2
公开(公告)日：2017-08-08
申请号：US14170394
申请日：2014-01-31
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Denis Pristinski , David P. Stumbo
CPC classification number: G02B19/0028 , G01N15/1434 , G01N15/1459 , G01N21/645 , G01N35/08 , G01N2015/1006 , G01N2021/6478 , G01N2201/0806 , G02B6/0008 , G02B6/262 , G02B19/0076
Abstract: Detection system comprising an examination region, a one-piece optical element including a focusing portion to concentrate light received from the examination region and a guiding portion to homogenize light received from the focusing portion, and a detector configured to detect homogenized light received from the guiding portion.
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公开(公告)号：US20170191923A1
公开(公告)日：2017-07-06
申请号：US15394624
申请日：2016-12-29
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Yunfeng Ling , David P. Stumbo , George Carman , Denis Pristinski
IPC: G01N15/14
CPC classification number: G01N15/1429 , G01N15/1404 , G01N15/1434 , G01N15/1459 , G01N2015/1488
Abstract: Systems and methods for detecting and processing signals from particles. In an exemplary method, particles may be passed through a zone of a channel, while the zone is irradiated with light. Interaction of the light with the particles may deflect light and induce photoluminescence. A deflection signal and a photoluminescence signal may be detected from the zone. Particle waveforms may be identified in the deflection signal. At least a subset of the particle waveforms may be double-peak waveforms including a pair of peaks corresponding to a particle entering and exiting the zone. Amplitudes may be obtained from the photoluminescence signal. The amplitudes may correspond to respective particles and their particle waveforms, and at least a subset of the amplitudes may correspond to the double-peak waveforms. Individual particles may be assigned as positive or as negative for an analyte based on the corresponding amplitudes.
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8.发明申请DETECTION SYSTEM WITH ONE-PIECE OPTICAL ELEMENT TO CONCENTRATE AND HOMOGENIZE LIGHT 有权具有单色光学元件的检测系统，用于浓缩和均质光公开(公告)号：US20140218719A1
公开(公告)日：2014-08-07
申请号：US14170394
申请日：2014-01-31
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Denis Pristinski , David P. Stumbo
IPC: G01N21/01
CPC classification number: G02B19/0028 , G01N15/1434 , G01N15/1459 , G01N21/645 , G01N35/08 , G01N2015/1006 , G01N2021/6478 , G01N2201/0806 , G02B6/0008 , G02B6/262 , G02B19/0076
Abstract: Detection system comprising an examination region, a one-piece optical element including a focusing portion to concentrate light received from the examination region and a guiding portion to homogenize light received from the focusing portion, and a detector configured to detect homogenized light received from the guiding portion.
Abstract translation: 检测系统，包括检查区域，一体式光学元件，其包括聚焦部分，用于集中从检查区域接收的光;以及引导部分，用于使从聚焦部分接收的光均匀;以及检测器，被配置为检测从引导 一部分。
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公开(公告)号：US11878302B2
公开(公告)日：2024-01-23
申请号：US17465763
申请日：2021-09-02
Applicant: Bio-Rad Laboratories, Inc.
Inventor： George Carman , Thomas H. Cauley, III , David P. Stumbo
IPC: B01L3/00
CPC classification number: B01L3/502784 , B01L2200/0647 , B01L2200/0673 , B01L2300/0816 , B01L2300/0867 , B01L2400/0487
Abstract: System, including methods and apparatus, for spacing droplets from each other and for detection of spaced droplets.
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公开(公告)号：US20210394189A1
公开(公告)日：2021-12-23
申请号：US17465763
申请日：2021-09-02
Applicant: Bio-Rad Laboratories, Inc.
Inventor： George Carman , Thomas H. Cauley, III , David P. Stumbo
IPC: B01L3/00
Abstract: System, including methods and apparatus, for spacing droplets from each other and for detection of spaced droplets.
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