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公开(公告)号：US20180250292A1
公开(公告)日：2018-09-06
申请号：US15756793
申请日：2016-08-23
Inventor： Ghaeth H. Yassen , Jeffrey A. Platt , Richard L. Gregory
IPC: A61K31/496 , A61K47/38 , A61K47/02 , A61K9/06 , A61P31/02
CPC classification number: A61K31/496 , A61K9/06 , A61K31/4164 , A61K47/02 , A61K47/38 , A61K2300/00 , A61P31/02
Abstract: Antibiotic gel formulations for use in dental applications are disclosed. More particularly, the present disclosure is directed to antibiotic gel formulations including low concentrations of antibiotics that are capable of killing root canal pathogens without harming the stem cells inside the root canal. Additionally, the present disclosure is directed to delivery systems and methods for applying the antibiotic gel formulations into a subject's intracanal region.
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公开(公告)号：US10052628B2
公开(公告)日：2018-08-21
申请号：US15198359
申请日：2016-06-30
Inventor： James A. Glazier , Stephen C. Jacobson , Dragos Amarie
CPC classification number: B01L3/502715 , B01F3/0865 , B01F5/06 , B01F5/0601 , B01F13/0059 , B01F13/0062 , B01F15/0404 , B01F2003/0896 , B01F2215/0037 , B01L3/502776 , B01L2200/0694 , B01L2200/12 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/0896 , B01L2400/0415
Abstract: Disclosed is a method and apparatus for manipulating fluids. The apparatus may include a microfluidic structure including inlet channels (1 and 2) and outlet channels (306, 307, 308, 309, 310, 311, 312, 313, and 314) oriented among bifurcated (5), trifurcated (6) and merging junctions (7 and 8). The apparatus splits and merges fluids flowing in the channels to produce successive dilutions of the fluids within the outlet channels. Multiple apparatus may be combined in serial, parallel, combined serial and parallel and/or stacked configurations. One or more apparatus may be used alone or to provide various devices or chambers with the diluted fluids.
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公开(公告)号：US20180214169A1
公开(公告)日：2018-08-02
申请号：US15745955
申请日：2016-08-10
Applicant: Indiana University Research and Technology Corporation , Rose-Hulman Institute of Technology, Inc.
Inventor： Luke G. Gutwein , Rajiv Sood , Barry Davignon
IPC: A61B17/3201
CPC classification number: A61B17/3201 , A61B17/285 , A61B2017/00353 , A61B2017/00761 , A61B2017/00792 , A61B2017/00969 , A61B2017/320044
Abstract: A scar subcision devices comprising a first elongated element comprising a pivotal connection to a second elongated element, the first elongated element having a blunt distal end, the second elongated element having a proximal-facing cutting edge at a distal end thereof, the device having a first state wherein the cutting edge is retracted to a location within an outer perimeter of the first elongated element, and a second state wherein the cutting edge is exposed outside of the outer perimeter of the first elongated element and the device transitioning between the first state and the second state by the first elongated element and the second elongated element rotating relative to each other about the pivotal connection are disclosed. Methods are also disclosed.
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公开(公告)号：US20180153146A1
公开(公告)日：2018-06-07
申请号：US15848870
申请日：2017-12-20
Inventor： A. Joseph Tector
IPC: A01K67/027 , C12N15/90 , C12N15/877 , C12N15/85 , C12N9/40 , C12N9/22 , C12N9/10 , C12N9/02 , A61K35/407
CPC classification number: A01K67/0276 , A01K2217/00 , A01K2217/075 , A01K2217/15 , A01K2227/108 , A01K2267/025 , A61K35/407 , C07K2319/80 , C12N9/0071 , C12N9/1048 , C12N9/22 , C12N9/2465 , C12N15/8509 , C12N15/8778 , C12N15/907
Abstract: The invention provides double knockout transgenic pigs (GT/CMAH-KO pigs) lacking expression of any functional αGAL and CMAH. Double knockout GT/CMAH-KO transgenic organs, tissues and cells are also provided. Methods of making and using the GT/CMAH-KO pigs and tissue are also provided.
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65.发明授权公开(公告)号：US09956189B2
公开(公告)日：2018-05-01
申请号：US15192535
申请日：2016-06-24
Inventor： Craig A. Erickson
IPC: A61K31/16 , A61K31/185 , A61K31/4035
CPC classification number: A61K31/16 , A61K31/185 , A61K31/4035
Abstract: The present invention is directed to a method of treating a subject with autism spectrum disorder by administering an acetylaminopropane sulfonate. The acetylaminopropane sulfonate may have the following formula
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Patent Agency Ranking
公开(公告)号：US20180079998A1
公开(公告)日：2018-03-22
申请号：US15564139
申请日：2016-03-31
Inventor： Lisa M. Jones , Aimee Rinas
IPC: C12M3/06 , C12M1/34 , G01N33/487
CPC classification number: C12M23/16 , C01B15/00 , C12M1/34 , C12M29/00 , C12M33/00 , C12M41/46 , G01N33/487
Abstract: In one embodiment, a flow assembly for cells comprises a first flow path configured to receive a plurality of cells, a second flow path configured to receive a buffer, and a third flow path configured to receive the plurality of cells and the buffer. The plurality of cells are in a single-file orientation and the buffer generally surrounds the single-file orientation of the plurality of cells when in the third flow path.
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公开(公告)号：US09885059B2
公开(公告)日：2018-02-06
申请号：US14379486
申请日：2013-02-21
Applicant: Indiana University Research and Technology Corporation , The Regents of the University of California
Inventor： Chris Ballas , Masa Rao , Yanyan Zhang
CPC classification number: C12N15/89 , B01J19/0046 , B01J2219/00452 , B01J2219/00502 , B01J2219/00587 , B01J2219/00743 , C12M23/12
Abstract: Many applications in cell biology, genetic engineering, cell-based therapeutics, and drug discovery require precise and safe methods for introducing membrane-impermeable molecules into cells. This can be implemented satisfactorily by microinjection. However, disadvantages of traditional manual microinjection include high degree of operator skill, low throughput and labor-intensiveness. Many studies have focused on developing automated and high-throughput systems for microinjection to address these limitations. However, none have provided sufficient throughput for applications such as ex vivo cell therapy, where manipulation of many cells is helpful.
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68.发明申请公开(公告)号：US20180002728A1
公开(公告)日：2018-01-04
申请号：US15540326
申请日：2015-12-21
Inventor： James McKinlay , Amanda Posto , Timothy Kremer , Breah LaSarre
CPC classification number: C12P7/065 , C12N1/20 , C12N1/38 , C12P7/04 , C12P7/10 , C12P7/16 , Y02E50/16 , Y02E50/17
Abstract: Chemically defined culture medium and culture conditions that allow bacteria to assimilate dinitrogen gas (N2) as a nitrogen source during bio-ethanol production are disclosed herein. Methods of bioethanol production using the chemically defined culture medium and culture conditions are also disclosed.
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公开(公告)号：US09846106B2
公开(公告)日：2017-12-19
申请号：US14729663
申请日：2015-06-03
Applicant: Toyota Motor Engineering & Manufacturing North America, Inc. , Toyota Jidosha Kabushiki Kaisha , The Ohio State University , Indiana University Research and Technology Corporation
Inventor： Stanley Yung-Ping Chien , Chi-chih Chen , Rini Sherony , Hiroyuki Takahashi , Jason Brink , Qiang Yi , Domenic Belgiovane
CPC classification number: G01M17/007 , B62H3/06 , G01S13/931 , G01S2007/4086 , H01Q15/14
Abstract: An apparatus and device for repetitive use in automotive testing is provided. The apparatus includes a frame dimensioned in the same shape as a bicycle frame. The frame includes a first support beam and a plurality of second support beams. The apparatus further includes an elastic member elastically coupling each of the plurality of second support beams to the first support beam so as to allow the frame to separate when impacted and be easily reassembled for further testing. The device includes a disk having a first radar transparent layer opposite a second radar transparent layer and a reflective film disposed between the first radar transparent layer and the second radar transparent layer. The reflective film has a radar cross section pattern similar to that of an actual bicycle wheel when seen by automotive radar.
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公开(公告)号：US20170313755A1
公开(公告)日：2017-11-02
申请号：US15487768
申请日：2017-04-14
Inventor： Richard D. DiMARCHI , Sarah J. BRANDT , Alexander ZAYKOV , Yan ZHAO
Abstract: Disclosed herein are insulin analog conjugates comprising an insulin agonist covalently linked to an insulin antagonist peptide. The conjugates are high potency insulin agonists but with decreased maximal activity relative to the maximal activity of native insulin.
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