中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

141 records (took 0.063 seconds)

    AKT ligands and polynucleotides encoding AKT ligands
    64.
    发明授权
    AKT ligands and polynucleotides encoding AKT ligands 有权
    AKT配体和编码AKT配体的多核苷酸

    公开(公告)号：US09493525B2

    公开(公告)日：2016-11-15

    申请号：US14335550

    申请日：2014-07-18

    Applicant: Intrexon Corporation

    Inventor： Thomas D. Reed

    IPC: C12Q1/48 ,  C12N15/00 ,  C12N1/20 ,  C12P21/06 ,  C07H21/04 ,  C07K14/47 ,  C07K14/00 ,  C12N15/62 ,  C07K14/435

    CPC classification number: C07K14/47 ,  C07K14/00 ,  C07K14/435 ,  C07K2319/01 ,  C07K2319/41 ,  C07K2319/43 ,  C07K2319/60 ,  C12N15/62

    Abstract: The invention relates to kinase ligands and polyligands. In particular, the invention relates to ligands, homopolyligands, and heteropolyligands that modulate AKT activity. The ligands, homopolyligands, and heteropolyligands are utilized as research tools or as therapeutics. The invention includes linkage of the ligands, homopolyligands, and heteropolyligands to a cellular localization signal, epitope tag and/or a reporter. The invention also includes polynucleotides encoding the ligands, homopolyligands, and heteropolyligands.

    Abstract translation: 本发明涉及激酶配体和聚合配体。 特别地，本发明涉及调节AKT活性的配体，均聚配体和杂多糖配体。 配体，均聚配体和杂多糖被用作研究工具或作为治疗剂。 本发明包括配体，均聚配体和杂多糖配体与细胞定位信号，表位标签和/或报告子的连接。 本发明还包括编码配体的多核苷酸，均聚配体和杂多糖配体。

    Modified forms of pseudomonas exotoxin A
    65.
    发明授权
    Modified forms of pseudomonas exotoxin A 有权
    假单胞菌外毒素A的修​​饰形式

    公开(公告)号：US09447387B2

    公开(公告)日：2016-09-20

    申请号：US14984006

    申请日：2015-12-30

    Applicant: Intrexon Corporation

    Inventor： Timothy David Jones ,  Francis Joseph Carr

    IPC: C12N9/10 ,  C07K16/28 ,  C07K14/21 ,  A61K39/00 ,  A61K39/02 ,  A61K38/00

    CPC classification number: C12N9/1077 ,  A61K38/00 ,  A61K39/00 ,  A61K39/02 ,  C07K14/21 ,  C07K16/2803 ,  C07K2317/622 ,  C12Y204/02036

    Abstract: Pseudomonas exotoxin A or “PE” is a 66kD, highly potent, cytotoxic protein secreted by the bacterium Pseudomonas aeruginosa. Various forms of PE have been coupled to other proteins, such as antibodies, to generate therapeutically useful cytotoxin conjugates that selectively target cells of a desired phenotype (such as tumor cells). In the present invention, peptides spanning the sequence of an approximately 38kD form of Pseudomonas exotoxin A protein were analyzed for the presence of immunogenic CD4+ T cell epitopes. Six immunogenic T cell epitopes were identified. Residues were identified within each epitope for introduction of targeted amino acid substitutions to reduce or prevent immunogenic T-cell responses in PE molecules which may be administered to a heterologous host.

    Abstract translation: 假单胞菌外毒素A或“PE”是由细菌绿脓假单胞菌分泌的66kD，高效的细胞毒性蛋白质。 已经将各种形式的PE偶联到其它蛋白质，例如抗体，以产生选择性靶向所需表型细胞（例如肿瘤细胞）的治疗上有用的细胞毒素缀合物。 在本发明中，分析跨越约38kD形式的假单胞菌外毒素A蛋白的序列的免疫原性CD4 + T细胞表位的存在。 鉴定了6种免疫原性T细胞表位。 在每个表位内鉴定出残基，用于引入靶向氨基酸取代，以减少或预防可能施用于异源宿主的PE分子中的免疫原性T细胞应答。

Patent Agency Ranking