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公开(公告)号：US20230014092A1
公开(公告)日：2023-01-19
申请号：US17757199
申请日：2020-12-11
Applicant: Janssen Biotech, Inc.
Inventor： Ernesto MUNOZ , Julianty ANGSANA , Carl MANTHEY , Xuejun LIU
IPC: G01N33/50
Abstract: A method of identifying a subject who is likely to be responsive to a treatment comprising an inhibitor of IL1α, or predicting the responsiveness of a subject to a treatment comprising an inhibitor of IL1α, comprising providing a sample from a subject; administering the inhibitor of IL1α to the sample; measuring levels of one or more biomarkers in the sample; and determining the pharmacodynamic or the pharmacokinetic effect of the inhibitor of IL1α based on the levels of the one or more biomarkers.
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62.发明授权公开(公告)号：US11538167B2
公开(公告)日：2022-12-27
申请号：US17115036
申请日：2020-12-08
Applicant: Janssen Biotech, Inc.
Inventor： Yanqing Chen , Charles Tang , Ernesto J. Munoz-Elias
IPC: G06T7/11
Abstract: An image processing method is provided that automatically calculates Body Surface Area (BSA) score using machine learning techniques. A Felzenszwalb image segmentation algorithm is used to define proposed regions in each of a plurality of training set images. The training set images are oversegmented, and then each of the proposed regions in each of the plurality of oversegmented training set images are manually classified as being a lesion or a non-lesion. A Convolutional Neural Network (CNN) is then trained using the manually classified proposed regions in each of the plurality of training set images. The trained CNN is then used on test images to calculate BSA scores.
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公开(公告)号：US20220401657A1
公开(公告)日：2022-12-22
申请号：US17776832
申请日：2020-11-13
Applicant: JANSSEN BIOTECH, INC.
Inventor： Peter KRULEVITCH , Anthony R. DIUBALDI , Francesco N. ALBERTINI , Sanjay JAIN , Bradley SARGENT , Jared NATHANSON , Kevin CHRISTOPHER
Abstract: Various exemplary drug delivery device sensing modules and methods of using drug delivery device sensing modules are provided. In general, a sensing module can be configured to be attached to a drug delivery device configured to deliver a drug. The drug delivery device can be any of a variety of types of drug delivery devices, such as a syringe, an injection device (e.g., an autoinjector, a jet injector, and an infusion pump), a nasal delivery device, and an inhaler. The sensing module can be configured to gather data for one or more parameters related to drug delivery and to transmit data indicative of the gathered data to an external source configured to analyze the data received from the sensing module.
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公开(公告)号：US11492367B2
公开(公告)日：2022-11-08
申请号：US16478866
申请日：2018-01-26
Applicant: Janssen Biotech, Inc.
Inventor： Stuart Emanuel , Mark Richter , Peter J. Connolly , James Patrick Edwards , Guangyi Wang , Santhosh Kumar Thatikonda , Leonid Beigelman , Minghong Zhong , Gilles Bignan , Wim Schepens , Marcel Viellevoye , Johannes Wilhelmus John Fitzgerald Thuring
Abstract: Disclosed are compounds, compositions and methods for treating of diseases, syndromes, or disorders that are affected by the modulation of STING. Such compounds are represented by Formula (I) as follows: wherein R, R1B, R1C, R2B, R2C, B1, W, X, Y, Z are defined herein.
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公开(公告)号：US20220306738A1
公开(公告)日：2022-09-29
申请号：US17702042
申请日：2022-03-23
Applicant: Janssen Biotech, Inc.
Inventor： Kyle J. Bednar , Naresh Kumar , Sanjaya Singh , Danlin Yang , Rajkumar Ganesan
Abstract: Provided herein are multispecific antibodies, that bind to CD79b and CD22, polynucleotides encoding them, vectors, host cells, methods of making and using them.
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Patent Agency Ranking
公开(公告)号：US20220282206A1
公开(公告)日：2022-09-08
申请号：US17633991
申请日：2020-07-21
Applicant: Janssen Biotech, Inc.
Inventor： John Bodek , Kristina Demjanick , Laura Grussendorf , John Jerbasi , Claus Lang , Dominik Lüthy , Peter Hebbeln
IPC: C12N1/20
Abstract: The present invention relates to media compositions for culturing bacteria. In particular, the present invention relates to media for culture and/or fermentation of Clostridia bacteria.
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公开(公告)号：US20220275101A1
公开(公告)日：2022-09-01
申请号：US17667656
申请日：2022-02-09
Applicant: Janssen Biotech, Inc.
Inventor： Jordan Schecter
IPC: C07K16/28 , A61K31/573 , A61K9/00 , A61K45/06 , A61K38/47
Abstract: The present invention relates to methods of achieving a complete hematologic response in light chain amyloidosis patients and methods of treating light chain amyloidosis using an approved drug product comprising daratumumab and hyaluronidase in combination with bortezomib, cyclophosphamide and dexamethasone. Also described are drug products containing daratumumab and hyaluronidase, and methods of selling or offering for sale a drug product comprising daratumumab and hyaluronidase.
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公开(公告)号：US20220259289A1
公开(公告)日：2022-08-18
申请号：US17732420
申请日：2022-04-28
Applicant: JANSSEN BIOTECH, INC
Inventor： Michael Diem , Rebecca Hawkins , Steven Jacobs , Manuel Sepulveda
IPC: C07K14/78 , A61P35/00 , C12N15/85 , C07K14/705 , G01N33/68 , G01N33/574 , G01N33/53
Abstract: FN3 domains that specifically bind to CD137, their conjugates, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making and using them are useful in therapeutic and diagnostic applications.
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公开(公告)号：US11414484B2
公开(公告)日：2022-08-16
申请号：US17060362
申请日：2020-10-01
Applicant: Janssen Biotech, Inc.
Inventor： Ken Boakye , Alfred Del Vecchio , John Kehoe , Eilyn Lacy , Lynne Murray , Mary Ryan , Sandra Santulli-Marotto , John Wheeler , Brian Whitaker , Alexey Teplyakov
Abstract: The present invention relates to antibodies specifically binding CCL17, polynucleotides encoding the antibodies or fragments, and methods of making and using the foregoing.
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公开(公告)号：US11369642B2
公开(公告)日：2022-06-28
申请号：US16539401
申请日：2019-08-13
Applicant: Janssen Biotech, Inc.
Inventor： Jean Xu
IPC: A61K35/39
Abstract: The present invention provides a method for lowering blood glucose levels in an animal by transplanting a population of pancreatic endocrine precursor cells into an animal.
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