公开(公告)号：US07776267B2

公开(公告)日：2010-08-17

申请号：US11850129

申请日：2007-09-05

Applicant: Beom-seok Lee ,  Yoon-kyoung Cho ,  Jeong-gun Lee ,  Jong-myeon Park

Inventor： Beom-seok Lee ,  Yoon-kyoung Cho ,  Jeong-gun Lee ,  Jong-myeon Park

IPC: G01N9/30

CPC classification number: G01N33/54326 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0806 ,  B01L2300/0867 ,  B01L2300/1861 ,  B01L2400/0409 ,  B01L2400/0633 ,  B01L2400/0677 ,  B01L2400/0688 ,  G01N33/54366 ,  Y10T436/25375

Abstract: A centrifugal force-based microfluidic device for the detection of a target biomolecule and a microfluidic system including the same are provided. The device includes a body of revolution; a microfluidic structure disposed in the body of revolution including chambers, channels connecting the chambers, and valves disposed in the channels to control fluid flow, the microfluidic structures transmitting fluid using centrifugal force due to rotation of the body of revolution; and beads disposed in the microfluidic structures, the beads having capture probes on the surfaces thereof which are selectively bonded with target protein; and a detection probe disposed in the microfluidic structures and selectively bonded to the target protein, and which includes a material required to express an optical signal, wherein the microfluidic structure mixes the beads, biological samples, and the detection probe to react and washes and separates the beads after the reaction.

Abstract translation: 提供了用于检测靶生物分子的离心力微流体装置和包括其的微流体系统。 该装置包括一个革命体; 设置在旋转体中的微流体结构，包括腔室，连接腔室的通道，以及设置在通道中的阀，以控制流体流动，微流体结构由于旋转体旋转而使用离心力传送流体; 和珠子，其设置在微流体结构中，珠粒在其表面上具有与靶蛋白质选择性结合的捕获探针; 以及设置在微流体结构中并选择性地结合到靶蛋白上并且包括表达光信号所需的材料的检测探针，其中微流体结构混合珠，生物样品和检测探针以反应和洗涤和分离 反应后的珠子。

公开(公告)号：US07767069B2

公开(公告)日：2010-08-03

申请号：US11536319

申请日：2006-09-28

Applicant: Jeong Gun Lee ,  Hye Jung Cho ,  Nam Huh ,  Sung Jae Kim

Inventor： Jeong Gun Lee ,  Hye Jung Cho ,  Nam Huh ,  Sung Jae Kim

IPC: G01N27/447

CPC classification number: B01L3/502792 ,  B01L2300/089 ,  B01L2300/161 ,  B01L2400/0427 ,  F04B19/006

Abstract: A method for controlling the hydrophilic droplet using the electrowetting principle is disclosed. More specifically, the present invention provides a method for increasing the change of the contact angle in the interface that is formed between the hydrophilic droplet and the nonpolar fluid by adding a constant concentration of two-element electrolyte or three-element electrolyte to the hydrophilic droplet; and an apparatus for controlling the droplet having the change of the contact angle and velocity scope increased by the method.

Abstract translation: 公开了一种使用电润湿原理控制亲水性液滴的方法。 更具体地说，本发明提供了一种通过向亲水液滴中加入恒定浓度的双元素电解质或三元素电解质来增加形成在亲水性液滴和非极性流体之间的界面中的接触角变化的方法 ; 并且通过该方法增加了具有接触角和速度范围的变化的液滴的控制装置。

公开(公告)号：US20100092985A1

公开(公告)日：2010-04-15

申请号：US12578628

申请日：2009-10-14

Applicant: Beom Seok LEE ,  Jeong Gun LEE ,  Jeong Woo CHOI ,  Byung Keun OH

Inventor： Beom Seok LEE ,  Jeong Gun LEE ,  Jeong Woo CHOI ,  Byung Keun OH

IPC: C12Q1/68 ,  G01N33/544 ,  G01N33/553 ,  G01N33/545

CPC classification number: G01N33/54306 ,  B82Y15/00

Abstract: A solid support on which a labeled nucleic acid including a high density of signal materials, a kit containing the same, and a method of detecting a target material are provided.

Abstract translation: 提供了包含高密度信号材料的标记核酸的固体支持物，含有其的试剂盒和检测靶材料的方法。

公开(公告)号：US20090189932A1

公开(公告)日：2009-07-30

申请号：US12141988

申请日：2008-06-19

Applicant: Beom-seok Lee ,  Dustin Moon ,  Jeong-gun Lee ,  Hye-jung Cho ,  In-seok Kang ,  Jin-seok Hong

Inventor： Beom-seok Lee ,  Dustin Moon ,  Jeong-gun Lee ,  Hye-jung Cho ,  In-seok Kang ,  Jin-seok Hong

IPC: B41J25/308 ,  B41J29/38

CPC classification number: B41J2/175 ,  B01L3/0268 ,  B01L2400/0415 ,  B41J2/04 ,  Y10T436/2575

Abstract: Provided are a droplet emitting apparatus and a method of emitting droplets using the same. The apparatus includes a solution tank for containing a solution; a nozzle including an opening through which at least a droplet of the solution is emitted; and a voltage generator including a piezoelectric material for generating a voltage by instantaneous pressure application, wherein the voltage generated by the pressure to the piezoelectric material is applied to the solution in order for the at least a droplet of the solution to be emitted through the nozzle

Abstract translation: 提供了一种液滴喷射装置和使用其发射液滴的方法。 该装置包括用于容纳溶液的溶液罐; 喷嘴，其包括开口，所述溶液的至少一个液滴通过所述开口发射; 以及电压发生器，其包括用于通过瞬时压力施加产生电压的压电材料，其中由压电材料的压力产生的电压被施加到溶液，以便溶液的至少一个液滴通过喷嘴发射

公开(公告)号：US20090099782A1

公开(公告)日：2009-04-16

申请号：US12128680

申请日：2008-05-29

Applicant: Su-hyeon KIM ,  Yoon-kyoung CHO ,  Jeong-gun LEE

Inventor： Su-hyeon KIM ,  Yoon-kyoung CHO ,  Jeong-gun LEE

IPC: G01N33/50

CPC classification number: G01N35/00732 ,  G01N35/00069 ,  G01N35/08 ,  G01N2035/00752 ,  Y10T436/11

Abstract: Provided are an automatic analyzing method and apparatus for a microfludic system. The apparatus includes means for recognizing a disc or chip in the microfludic system, performs an operation and detection by automatically loading a DB according to a recognized type, and perform quantitation of a test.

Abstract translation: 本发明提供一种微流体系统的自动分析方法和装置。 该装置包括用于识别微流体系统中的盘或芯片的装置，通过根据识别的类型自动加载数据库进行操作和检测，并执行测试的定量。

公开(公告)号：US20080300148A1

公开(公告)日：2008-12-04

申请号：US12128981

申请日：2008-05-29

Applicant: Beom-seok Lee ,  Yoon-kyoung Cho ,  Jong-myeon Park ,  Jeong-gun Lee

Inventor： Beom-seok Lee ,  Yoon-kyoung Cho ,  Jong-myeon Park ,  Jeong-gun Lee

IPC: C40B60/12

CPC classification number: B01L3/502738 ,  B01L3/502723 ,  B01L3/502746 ,  B01L3/502753 ,  B01L2200/0684 ,  B01L2200/10 ,  B01L2300/0636 ,  B01L2300/0803 ,  B01L2300/0806 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2400/0409 ,  B01L2400/0677 ,  B01L2400/084 ,  B01L2400/086 ,  F16K99/0001 ,  F16K99/0019 ,  F16K99/0032 ,  F16K99/004 ,  F16K99/0061 ,  F16K2099/0084 ,  G01N35/00069

Abstract: Provided is a rotatable microfluidic device for conducting simultaneously two or more assays. The device includes a platform which can be rotated, a first unit which is disposed at one portion of the platform and detects a target material from a sample using surface on which a capture probe selectively binds to the target material is attached, and a second unit which is disposed at another portion of the platform and detects a target material included in the sample by a different reaction from the reaction conducted in the first unit.

Abstract translation: 提供了用于同时进行两种或更多种测定的可旋转的微流体装置。 该装置包括能够旋转的平台，第一单元，其设置在平台的一部分处，并且从附着有目标材料的捕获探针的样品使用表面检测目标材料;以及第二单元 其设置在平台的另一部分并且通过与在第一单元中进行的反应的不同反应来检测包含在样品中的目标材料。

公开(公告)号：US20080274015A1

公开(公告)日：2008-11-06

申请号：US12114214

申请日：2008-05-02

Applicant: Jong-myeon PARK ,  Jeong-gun LEE ,  Jung-suk YOO

Inventor： Jong-myeon PARK ,  Jeong-gun LEE ,  Jung-suk YOO

IPC: B01L3/00 ,  G01N1/10

CPC classification number: G01N35/00069 ,  B01L3/502738 ,  B01L2300/0654 ,  B01L2300/0806 ,  B01L2400/0409 ,  B01L2400/0677 ,  F16K99/0001 ,  F16K99/0032 ,  F16K99/004 ,  F16K2099/0078 ,  F16K2099/008

Abstract: Provided is a microfluidic device and microfluidic system with the device. The microfluidic device includes a substrate; a channel formed in the substrate and in which a fluid can move; a valve controlling flow of a fluid flowing along the channel and including a phase transition material which can be melted by energy such as electromagnetic wave energy; and a lens disposed on the substrate and adjusting an irradiating region of the valve, onto which the energy is applied.

Abstract translation: 提供了一种具有该装置的微流体装置和微流体系统。 微流体装置包括基板; 在基板中形成的流体可以移动的通道; 控制沿着通道流动的流体的流动的阀，并且包括能够通过诸如电磁波能量的能量熔化的相变材料; 以及透镜，其设置在所述基板上并且调节施加有所述能量的所述阀的照射区域。

公开(公告)号：US20080171366A1

公开(公告)日：2008-07-17

申请号：US11838550

申请日：2007-08-14

Applicant: Kwang Ho CHEONG ,  Dong-kee YI ,  Jeong-gun LEE ,  Jong-myeon PARK

Inventor： Kwang Ho CHEONG ,  Dong-kee YI ,  Jeong-gun LEE ,  Jong-myeon PARK

IPC: C12N13/00 ,  C12P19/34 ,  C12M1/00

CPC classification number: C12N1/066 ,  C12M47/06 ,  C12N13/00 ,  C12P19/34

Abstract: Provided is a method of disrupting cells comprising adding gold nanorods to a solution containing cells and irradiating the gold nanorods with a laser to disrupt the cells. A method and an apparatus for continuously disrupting cells and amplifying nucleic acids in a single microchamber are also provided, wherein the method comprises introducing a solution containing cells and gold nanorods into a microchamber, irradiating a laser onto the gold nanorods to disrupt the cells, and amplifying a nucleic acid from the disrupted cells in the microchamber.

Abstract translation: 提供一种破坏细胞的方法，包括向含有细胞的溶液中加入金纳米棒并用激光照射金纳米棒以破坏细胞。 还提供了用于在单个微室中连续破坏细胞和扩增核酸的方法和装置，其中所述方法包括将含有细胞和金纳米棒的溶液引入微室中，将激光照射到金纳米棒上以破坏细胞，以及 在微室中从破碎的细胞中扩增核酸。

公开(公告)号：US20080058192A1

公开(公告)日：2008-03-06

申请号：US11847623

申请日：2007-08-30

Applicant: Yoon-kyoung CHO ,  Jeong-gun LEE ,  Beom-seok LEE ,  Jong-myeon PARK

Inventor： Yoon-kyoung CHO ,  Jeong-gun LEE ,  Beom-seok LEE ,  Jong-myeon PARK

IPC: B04B15/02 ,  B01D21/26 ,  B04B13/00

CPC classification number: F16K99/003 ,  B01L3/502738 ,  B01L2300/0806 ,  B01L2300/0867 ,  B01L2300/0887 ,  B01L2400/0409 ,  B01L2400/0677 ,  F16K99/0001 ,  F16K99/0032 ,  F16K99/004 ,  F16K2099/0084

Abstract: A centrifugal force based microfluidic device including a thermal activation unit, a microfluidic system including the same, and a method of operating the microfluidic system are provided. The thermal activation unit accompanies a temperature change in order to carry out its functions and having heat generation particles that absorb electromagnetic waves and generate heat in the activation unit therein.

Abstract translation: 提供了一种基于离心力的微流体装置，其包括热激活单元，包括该激活单元的微流体系统以及操作微流体系统的方法。 热激活单元伴随着温度变化，以便执行其功能并具有吸收电磁波并在其中的激活单元中产生热量的发热颗粒。

公开(公告)号：US20080056063A1

公开(公告)日：2008-03-06

申请号：US11751677

申请日：2007-05-22

Applicant: Yoon-kyoung Cho ,  Jeong-gun Lee ,  Beom-seok Lee ,  Jong-myeon Park

Inventor： Yoon-kyoung Cho ,  Jeong-gun Lee ,  Beom-seok Lee ,  Jong-myeon Park

IPC: B01F9/00

CPC classification number: B01F13/0059 ,  B01F11/0002 ,  B01F11/0014 ,  B01F15/0201 ,  B01F15/0233

Abstract: Provided is a method of mixing fluids including introducing at least two kinds of fluids to a chamber of a substrate including a microchannel structure; and alternately rotating the substrate clockwise and counter-clockwise until the at least two kinds of fluids are mixed, wherein the rotation is changed from one direction to the opposite direction before a vortex created in the mixing chamber by the one direction rotation disappears.

Abstract translation: 提供了一种混合流体的方法，包括将至少两种流体引入到包括微通道结构的基板的室中; 并且顺时针和逆时针地交替地旋转衬底，直到混合至少两种流体，其中在通过单向旋转在混合室中产生的涡流消失之前，旋转从一个方向改变到相反的方向。