公开(公告)号：US20120322132A1

公开(公告)日：2012-12-20

申请号：US13594293

申请日：2012-08-24

申请人： Yoon-kyoung CHO ,  Jeong-gun LEE ,  Beom-seok LEE ,  Jong-myeon PARK

发明人： Yoon-kyoung CHO ,  Jeong-gun LEE ,  Beom-seok LEE ,  Jong-myeon PARK

IPC分类号： C12M1/10 ,  G01N1/34 ,  C12N13/00

CPC分类号： B01L3/502738 ,  B01F13/0059 ,  B01F15/0201 ,  B01F15/0233 ,  B01L3/502753 ,  B01L3/502761 ,  B01L2300/0806 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2400/0409 ,  B01L2400/0677 ,  F16K99/0001 ,  F16K99/0017 ,  F16K99/0019 ,  F16K99/0032 ,  F16K99/004 ,  F16K2099/0076 ,  F16K2099/0084

摘要： A centrifugal force-based microfluidic device for nucleic acid extraction and a microfluidic system are provided. The microfluidic device includes a body of revolution; a microfluidic structure disposed in the body of revolution, the microfluidic structure including a plurality of chambers, channels connecting the chambers, and valves disposed in the channels to control fluid flow, the microfluidic structure transmitting the fluid using centrifugal force due to rotation of the body of revolution; and magnetic beads contained in one of the chambers which collect a target material from a biomaterial sample flowing into the chamber, wherein the microfluidic structure washes the magnetic beads which collect the target material, and separates nucleic acid by electromagnetic wave irradiation from an external energy source to the magnetic beads. The microfluidic system includes the microfluidic device; a rotation operating unit which rotates the body of revolution; and an external energy source which irradiates electromagnetic waves.

摘要翻译： 提供了用于核酸提取的离心力微流体装置和微流体系统。 微流体装置包括一个革命体; 设置在旋转体内的微流体结构，所述微流体结构包括多个室，连接所述室的通道和设置在通道中的阀以控制流体流动，所述微流体结构由于所述体的旋转而使用离心力传递流体 的革命 以及包含在其中一个室中的磁珠，其从流入腔室的生物材料样品收集目标材料，其中微流体结构洗涤收集目标材料的磁珠，并通过来自外部能量源的电磁波照射分离核酸 到磁珠。 微流体系统包括微流体装置; 使旋转体旋转的旋转操作单元; 以及照射电磁波的外部能量源。

公开(公告)号：US08281815B2

公开(公告)日：2012-10-09

申请号：US12027290

申请日：2008-02-07

申请人： Jong-myeon Park ,  Beom-seok Lee

发明人： Jong-myeon Park ,  Beom-seok Lee

IPC分类号： F15C1/04

CPC分类号： F16K99/0019 ,  B01L3/502738 ,  B01L2300/1861 ,  B01L2400/0677 ,  F16K99/0001 ,  F16K99/0032 ,  F16K99/004 ,  F16K2099/0069 ,  F16K2099/0084 ,  Y10T137/2196

摘要： Provided are a valve filler and a valve unit including the valve filler. The valve filler includes: a phase transition material; and a heating fluid comprising a carrier oil and a plurality of micro heating particles suspended in the carrier oil, the heating fluid being mixed with the phase transition material, wherein, when external energy is supplied, the micro heating particles receive the external energy and generate heat to melt the phase transition material into a fluid state, and when no external energy is supplied, the phase transition material hardens into a solid state.

摘要翻译： 提供了一种阀填料和包括阀填料的阀单元。 阀填料包括：相变材料; 以及加热流体，其包含载体油和悬浮在载体油中的多个微加热颗粒，所述加热流体与所述相变材料混合，其中，当供应外部能量时，所述微加热颗粒接收外部能量并产生 将相变材料熔化成流体状态的热量，当没有外部能量供给时，相变材料变硬。

公开(公告)号：US20120028850A1

公开(公告)日：2012-02-02

申请号：US13269249

申请日：2011-10-07

申请人： Beom-seok LEE ,  Yoon-kyoung CHO ,  Jong-myeon PARK ,  Jeong-gun LEE

发明人： Beom-seok LEE ,  Yoon-kyoung CHO ,  Jong-myeon PARK ,  Jeong-gun LEE

IPC分类号： C40B60/12 ,  G01N33/48

CPC分类号： B01L3/502738 ,  B01L3/502723 ,  B01L3/502746 ,  B01L3/502753 ,  B01L2200/0684 ,  B01L2200/10 ,  B01L2300/0636 ,  B01L2300/0803 ,  B01L2300/0806 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2400/0409 ,  B01L2400/0677 ,  B01L2400/084 ,  B01L2400/086 ,  F16K99/0001 ,  F16K99/0019 ,  F16K99/0032 ,  F16K99/004 ,  F16K99/0061 ,  F16K2099/0084 ,  G01N35/00069

摘要： Provided is a rotatable microfluidic device for conducting simultaneously two or more assays. The device includes a platform which can be rotated, a first unit which is disposed at one portion of the platform and detects a target material from a sample using surface on which a capture probe selectively binds to the target material is attached, and a second unit which is disposed at another portion of the platform and detects a target material included in the sample by a different reaction from the reaction conducted in the first unit.

公开(公告)号：US08057759B2

公开(公告)日：2011-11-15

申请号：US11835461

申请日：2007-08-08

申请人： Jeong-gun Lee ,  Yoon-kyoung Cho ,  Beom-seok Lee ,  Jong-myeon Park

发明人： Jeong-gun Lee ,  Yoon-kyoung Cho ,  Beom-seok Lee ,  Jong-myeon Park

IPC分类号： B01L3/02 ,  B01L3/00 ,  G01N15/06 ,  G01N33/00

CPC分类号： B01L3/502715 ,  B01L3/5027 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/14 ,  B01L2300/0806 ,  B01L2300/1861 ,  B01L2400/0409 ,  B01L2400/0677 ,  F16K99/0001 ,  F16K99/0032 ,  F16K2099/0084 ,  F16K2099/0086 ,  G01N35/00069 ,  Y10T436/11 ,  Y10T436/25375 ,  Y10T436/2575

摘要： Provided are an apparatus and a method of controlling a microfluidic system, and the microfluidic system. The apparatus of controlling the microfluidic system includes a central control block controlling an operation of the microfluidic system, a rotator control block controlling a rotator, a position control block controlling the position of a moving unit, the moving unit moving to a position of the microfluidic structure, and a radiation energy source control block controlling energy of a radiation energy source, the radiation energy source using an electromagnetic wave to scan over a position of the microfluidic structure. Such a configuration allows effective control of a miniaturized portable microfluidic system.

摘要翻译： 提供了一种控制微流体系统和微流体系统的装置和方法。 控制微流体系统的装置包括控制微流体系统的操作的中央控制块，控制旋转器的旋转体控制块，控制移动单元的位置的位置控制块，移动到微流体位置的移动单元 结构以及辐射能量源控制块，其控制辐射能源的能量，所述辐射能源使用电磁波扫描微流体结构的位置。 这种配置允许有效地控制微型便携式微流体系统。

公开(公告)号：US20110126918A1

公开(公告)日：2011-06-02

申请号：US12979049

申请日：2010-12-27

申请人： Jong-myeon PARK ,  Yoon-kyuong CHO ,  Jeong-gun LEE ,  Beom-seok LEE ,  Sung-woo HONG

发明人： Jong-myeon PARK ,  Yoon-kyuong CHO ,  Jeong-gun LEE ,  Beom-seok LEE ,  Sung-woo HONG

IPC分类号： F16K49/00

CPC分类号： F16K99/0019 ,  B01L3/502738 ,  B01L2300/0803 ,  B01L2300/1861 ,  B01L2400/0409 ,  B01L2400/0677 ,  F16K99/0001 ,  F16K99/0032 ,  F16K99/0034 ,  F16K99/004 ,  F16K2099/0084 ,  Y10T137/1827 ,  Y10T137/2196 ,  Y10T137/6606 ,  Y10T137/7755

摘要： Provided are a valve unit and a reaction apparatus having the valve unit. The valve unit includes a phase transition material, which melts and expands upon an application of the electromagnetic waves to the valve filler, and the valve filler is directed into the channel through the connection passage and closes the channel. The valve unit also includes heat generation particles, which are dispersed in the phase transition material and generate heat upon an application of electromagnetic wave energy.

摘要翻译： 提供具有阀单元的阀单元和反应装置。 阀单元包括相变材料，其在将电磁波施加到阀填充器时熔化和膨胀，并且阀填料通过连接通道引导到通道中并关闭通道。 阀单元还包括发散颗粒，其分散在相变材料中并且在施加电磁波能量时产生热量。

公开(公告)号：US07951333B2

公开(公告)日：2011-05-31

申请号：US12851819

申请日：2010-08-06

申请人： Beom Seok Lee ,  Yoon Kyoung Cho ,  Jeong Gun Lee ,  Jong-myeon Park

发明人： Beom Seok Lee ,  Yoon Kyoung Cho ,  Jeong Gun Lee ,  Jong-myeon Park

IPC分类号： G01N9/30

CPC分类号： B01L3/502738 ,  B01L3/50273 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0806 ,  B01L2300/0867 ,  B01L2300/1861 ,  B01L2400/0409 ,  B01L2400/0442 ,  B01L2400/0633 ,  B01L2400/0677 ,  B01L2400/0688 ,  G01N33/54326 ,  G01N33/54366 ,  Y10T436/25375

摘要： A centrifugal force-based microfluidic device for the detection of a target biomolecule and a microfluidic system including the same are provided. The device includes a body of revolution; a microfluidic structure disposed in the body of revolution including chambers, channels connecting the chambers, and valves disposed in the channels to control fluid flow, the microfluidic structures transmitting fluid using centrifugal force due to rotation of the body of revolution; and beads disposed in the microfluidic structures, the beads having capture probes on the surfaces thereof which are selectively bonded with target protein; and a detection probe disposed in the microfluidic structures and selectively bonded to the target protein, and which includes a material required to express an optical signal, wherein the microfluidic structure mixes the beads, biological samples, and the detection probe to react and washes and separates the beads after the reaction.

摘要翻译： 提供了用于检测靶生物分子的离心力微流体装置和包括其的微流体系统。 该装置包括一个革命体; 设置在旋转体中的微流体结构，包括腔室，连接腔室的通道，以及设置在通道中的阀，以控制流体流动，微流体结构由于旋转体旋转而使用离心力传送流体; 和珠子，其设置在微流体结构中，珠粒在其表面上具有与靶蛋白质选择性结合的捕获探针; 以及设置在微流体结构中并选择性地结合到靶蛋白上并且包括表达光信号所需的材料的检测探针，其中微流体结构混合珠，生物样品和检测探针以反应和洗涤和分离 反应后的珠子。

公开(公告)号：US20100081207A1

公开(公告)日：2010-04-01

申请号：US12563291

申请日：2009-09-21

申请人： Jeong Gun Lee ,  In Duk Hwang ,  Jongmyeon Park ,  Beom Seok Lee

发明人： Jeong Gun Lee ,  In Duk Hwang ,  Jongmyeon Park ,  Beom Seok Lee

IPC分类号： B05D3/12 ,  G01N21/75 ,  B05D3/06 ,  G01N31/22

CPC分类号： G06K19/06028 ,  G01N31/22 ,  G01N2021/7783 ,  G01N2021/7786

摘要： One or more exemplary embodiments providing an assay material including an assay material that includes a substrate, a compound linked to the substrate wherein the compound is linkable specifically to a target, and a patterned region disposed on the substrate wherein the patterned region provides an optical output signal when an incident optical signal is irradiated thereto and wherein the optical output signal corresponds to a code on the substrate.

摘要翻译： 提供包括测定材料的测定材料的一个或多个示例性实施方案，所述测定材料包括基底，连接到所述基底的化合物，其中所述化合物可特异性地与靶标连接，以及设置在所述基底上的图案化区域，其中所述图案化区域提供光学输出 当入射光信号被照射到其上并且其中光输出信号对应于衬底上的代码时的信号。

公开(公告)号：US20100068735A1

公开(公告)日：2010-03-18

申请号：US12556912

申请日：2009-09-10

申请人： Kui-hyun KIM ,  Beom-seok LEE

发明人： Kui-hyun KIM ,  Beom-seok LEE

IPC分类号： G01N33/566 ,  C12M1/34

CPC分类号： G01N33/54366 ,  B01L3/5027 ,  B01L2200/10 ,  B01L2300/0645 ,  B01L2300/0806 ,  B01L2300/0867 ,  B01L2400/0409 ,  B01L2400/0487 ,  B01L2400/0677

摘要： Provided are a microfluidic device including a unit for evaluating a capture material and a method of evaluating a capture material.

摘要翻译： 提供了包括用于评估捕获材料的单元的微流体装置和评估捕获材料的方法。

公开(公告)号：US07677482B2

公开(公告)日：2010-03-16

申请号：US11781714

申请日：2007-07-23

申请人： Beom-seok Lee ,  Jeong-gun Lee ,  Hye-jung Cho

发明人： Beom-seok Lee ,  Jeong-gun Lee ,  Hye-jung Cho

IPC分类号： B05B5/00

CPC分类号： B05B5/0255 ,  B01J2219/00367 ,  B01J2219/00369 ,  B01J2219/00371 ,  B01L3/0268 ,  B01L2300/0838 ,  B01L2300/161 ,  B01L2400/027 ,  B01L2400/0406 ,  B01L2400/0487 ,  B05B1/14 ,  B05B5/0533 ,  B41J2/06

摘要： Provided is a droplet dispensing device having a nonconductive capillary nozzle. The droplet dispensing device comprises: a nonconductive capillary nozzle disposed in a downward position; a pump connected with the nonconductive capillary nozzle through a hermetically sealed fluid tube and generating a negative pressure to decrease the influence of gravity on a solution within the nonconductive capillary nozzle and the fluid tube; and an open circuit voltage supplier applying a voltage to the solution. The droplet dispensing device supplies the solution by capillary force to regularly maintain the shape of a droplet surface in the tip of the nonconductive capillary nozzle without using a separate driving device.

摘要翻译： 提供了具有非导电毛细管喷嘴的液滴分配装置。 液滴分配装置包括：设置在向下位置的非导电毛细管喷嘴; 泵，其通过气密密封的流体管与非导电毛细管喷嘴连接并产生负压，以减少重力对非导电毛细管喷嘴和流体管内的溶液的影响; 以及向该溶液施加电压的开路电压供给器。 液滴分配装置通过毛细管力提供溶液以在不使用单独的驱动装置的情况下规定地保持非导电毛细管喷嘴的尖端中的液滴表面的形状。

公开(公告)号：US20080193336A1

公开(公告)日：2008-08-14

申请号：US12029480

申请日：2008-02-12

申请人： Yoon-kyoung CHO ,  Jeong-gun Lee ,  Beom-seok Lee ,  Jong-myeon Park ,  Young-sun Lee

发明人： Yoon-kyoung CHO ,  Jeong-gun Lee ,  Beom-seok Lee ,  Jong-myeon Park ,  Young-sun Lee

IPC分类号： B01L11/00

CPC分类号： B01L3/502738 ,  B01L3/50273 ,  B01L3/502792 ,  B01L2200/0605 ,  B01L2200/0647 ,  B01L2200/16 ,  B01L2300/0806 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/0887 ,  B01L2300/1861 ,  B01L2400/0409 ,  B01L2400/0677

摘要： Provided are a centrifugal force based microfluidic device which can automatically perform a dilution operation and a microfluidic system including the same. The centrifugal force based microfluidic device for dilution includes a rotatable disk type platform, a mixing chamber disposed on the platform; a buffer solution storage disposed on a portion of the platform which is closer to a center of the platform than the mixing chamber, connected to the mixing chamber through a channel to supply a predetermined amount of buffer solution to the mixing chamber at least one time, and a plurality of diluted solution chambers which are disposed on a portion of the platform which is farther from the center of the platform than the mixing chamber, are each connected to the mixing chamber through flow paths extended from a middle exit corresponding to a predetermined water level, and sequentially receiving a solution which is serially diluted in the mixing chamber at least one time.

摘要翻译： 提供了一种能够自动执行稀释操作的离心力微流体装置和包括其的微流体系统。 用于稀释的基于离心力的微流体装置包括可旋转盘式平台，设置在平台上的混合室; 缓冲溶液储存器，其设置在所述平台的比混合室更靠近所述平台的中心的部分上，所述缓冲溶液存储器经由通道至少一次向所述混合室提供预定量的缓冲溶液，所述通道连接到所述混合室， 并且多个稀释溶液室通过从对应于预定水的中间出口延伸的流路连接到平台的比混合室更远离平台中心的部分上的稀释溶液室 至少一次连续地接收在混合室中连续稀释的溶液。