公开(公告)号：US20160054273A1

公开(公告)日：2016-02-25

申请号：US14754336

申请日：2015-06-29

申请人： KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE

发明人： Seok-Won Hyung ,  Byungjoo Kim

IPC分类号： G01N30/14 ,  G01N30/72

CPC分类号： G01N30/463 ,  G01N30/38 ,  G01N30/72

摘要： Provided is a two-dimensional liquid chromatography system, and more particularly, a two-dimensional liquid chromatography system capable of performing both independent one-dimensional separation through a reversed-phase or normal-phase chromatography method and two-dimensional separation for removing a matrix effect in a single system.

摘要翻译： 本发明提供一种二维液相色谱系统，更具体地说，涉及能够通过反相色谱法或正相色谱法进行独立的一维分离的二维液相色谱系统和用于除去基质的二维分离 效果在一个单一的系统。

公开(公告)号：US20150357103A1

公开(公告)日：2015-12-10

申请号：US14758313

申请日：2013-12-27

申请人： KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE

发明人： Young Joo KIM ,  Dong Jin YOON

IPC分类号： H01F5/00

CPC分类号： H01F5/00

摘要： A coil according to one embodiment of the present invention relates to a coil having a multi-layer structure, comprising n winding wires (n≧2, n is natural number) which are spaced apart from a central axis and wound around the central axis, wherein a first winding of the n windings is wound to a first height in a direction perpendicular to a reference surface, a second winding is wound to a second height lower than the first height in a direction perpendicular to the reference surface, the first winding has a first radius from the central axis, the second winding has a second radius from the central axis, the second radius being smaller than the first radius, and the second winding wire is disposed in the first winding wire.

摘要翻译： 根据本发明的一个实施例的线圈涉及一种具有多层结构的线圈，包括与中心轴线间隔开并缠绕在中心轴线上的n根绕组线（n≥2，n是自然数） 其中所述n个绕组的第一绕组在垂直于参考表面的方向上缠绕到第一高度，第二绕组在垂直于所述参考表面的方向上缠绕到比所述第一高度低的第二高度，所述第一绕组具有 所述第二绕组具有从所述中心轴线的第一半径，所述第二绕组具有距所述中心轴线的第二半径，所述第二半径小于所述第一半径，所述第二绕组线设置在所述第一绕组线中。

公开(公告)号：US20150226813A1

公开(公告)日：2015-08-13

申请号：US14692294

申请日：2015-04-21

申请人： Korea Research Institute of Standards and Science

发明人： Kwon-Kyu Yu ,  Yong-Ho Lee ,  Hyukchan Kwon ,  Jin-Mok Kim ,  Kiwoong Kim ,  Sang-Kil Lee

IPC分类号： G01R33/035 ,  G01R33/00

CPC分类号： G01R33/0354 ,  A61B5/04005 ,  A61B5/05 ,  G01R33/0047 ,  G01R33/0082 ,  H05K7/02

摘要： Provided are a low-temperature cooling apparatus and a superconducting quantum interference device (SQUID) sensor module. The low-temperature cooling apparatus includes an outer container; an inner container disposed inside the outer container, the inner container including a neck portion having a first diameter and a body portion having a second diameter greater than the first diameter; an insert inserted into the neck portion of the inner container; and a plurality of SQUID sensor modules inserted into the body portion of the inner container. Each of the SQUID sensor modules is in the form of a fan-shaped pillar and is fixedly coupled with an inner bottom plate of the inner container.

摘要翻译： 提供低温冷却装置和超导量子干涉装置（SQUID）传感器模块。 低温冷却装置包括外容器; 内部容器，其设置在所述外部容器的内部，所述内部容器包括具有第一直径的颈部部分和具有大于所述第一直径的第二直径的主体部分; 插入到所述内部容器的颈部中的插入件; 以及插入到所述内部容器的主体部分中的多个SQUID传感器模块。 每个SQUID传感器模块都是扇形柱的形式，并与内部容器的内底板固定连接。

公开(公告)号：US20140302545A1

公开(公告)日：2014-10-09

申请号：US14345835

申请日：2012-09-18

申请人： KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE

发明人： Duk Jin Kang ,  Sang Ryoul Park ,  Sook-Kyung Kim

IPC分类号： C12Q1/37

CPC分类号： C12Q1/37 ,  C07K1/20 ,  C07K1/34 ,  C07K1/36 ,  C12M21/18 ,  C12M25/12 ,  C12P21/06

摘要： Provided are an enzyme treatment apparatus for proteins using a hollow fiber membrane and an on-line proteomics method using same. The enzyme treatment apparatus for proteins according to the present invention can increase a recovery rate of peptides, which are recovered through an enzyme treatment process, by basically solving the problem of low reproducibility of an enzyme activity which may occur during a conventional enzyme treatment process, and can also reduce a time for purification and provide higher yield by performing separation and purification through a single step. In particular, the present invention can be usefully applied for developing a disease-specific protein biomarker through a statistical analysis method having highly efficient detectability for proteins in research for finding biomarkers related to human diseases.

摘要翻译： 提供了使用中空纤维膜的蛋白质的酶处理装置和使用其的在线蛋白质组学方法。 根据本发明的蛋白质的酶处理装置可以通过基本上解决在常规酶处理过程中可能发生的酶活性的低再现性的问题来提高通过酶处理过程回收的肽的回收率， 并且还可以通过单步执行分离和纯化来减少纯化时间并提供更高的产率。 特别地，本发明可以有用地用于通过统计分析方法开发疾病特异性蛋白质生物标志物，所述统计分析方法在用于寻找与人类疾病相关的生物标志物的研究中具有高度可检测性的蛋白质。

公开(公告)号：US20140235996A1

公开(公告)日：2014-08-21

申请号：US14260750

申请日：2014-04-24

申请人： Korea Research Institute of Standards and Science

发明人： Kiwoong Kim ,  Hyukchan Kwon ,  Yong-Ho Lee ,  Kwon-Kyu Yu ,  Jin-Mok Kim

IPC分类号： A61B5/04 ,  A61B6/03 ,  A61B5/055

CPC分类号： A61B5/04011 ,  A61B5/04007 ,  A61B5/04012 ,  A61B5/0402 ,  A61B5/0522 ,  A61B5/055 ,  A61B6/03 ,  G16H50/50

摘要： A method for mapping of myocardial electric activity includes measuring electrocardiogram data or magnetocardiogram data and mapping the degree of electric activity of a myocardial surface using the electrocardiogram data or the magnetocardiogram data. A signal source of the electrocardiogram data or the magnetocardiogram data is a myocardial surface potential that is scalar quantity. The mapping uses a lead-field vector which represents the sensitivity between the myocardial surface potential and the electrocardiogram or magnetocardiogram data, and a modified lead-field vector which combines a constraint matrix with a constraint condition where no potential sources exist in a specific region.

摘要翻译： 用于映射心肌电活动的方法包括使用心电图数据或心电图数据测量心电图数据或磁心图数据并映射心肌表面的电活动程度。 心电图数据或心电图数据的信号源是标量量的心肌表面电位。 映射使用表示心肌表面电位和心电图或磁心图数据之间的灵敏度的引导场向量，以及将约束矩阵与在特定区域中不存在潜在源的约束条件组合的修改的引线域向量。

公开(公告)号：US08742336B2

公开(公告)日：2014-06-03

申请号：US13727018

申请日：2012-12-26

申请人： Korea Research Institute of Standards and Science

发明人： Young-Pil Kim ,  Tae Geol Lee

IPC分类号： H01J49/04

CPC分类号： H01J49/0409 ,  B82Y15/00 ,  G01N1/00 ,  H01J49/00 ,  H01J49/26 ,  Y10S977/902

摘要： There are provided a bio-chip for secondary ion mass spectrometry and a method of fabricating the same, the bio-chip, which is a bio-chip for analyzing a biochemical material using the secondary ion mass spectrometry, including: a substrate; and core-shell particles positioned above substrate, wherein the core-shell particles each include a metal nanoparticle as a core and a metal shell surrounding the metal nanoparticle.

摘要翻译： 提供了二次离子质谱法的生物芯片及其制造方法，该生物芯片是使用二次离子质谱法分析生化材料的生物芯片，其包括：底物; 以及位于基材上方的核 - 壳颗粒，其中核 - 壳颗粒各自包括作为芯的金属纳米颗粒和围绕金属纳米颗粒的金属壳。

公开(公告)号：US20130292561A1

公开(公告)日：2013-11-07

申请号：US13727018

申请日：2012-12-26

申请人： Korea Research Institute of Standards and Science

发明人： Young-Pil KIM ,  Tae Geol LEE

IPC分类号： G01N1/00 ,  H01J49/26

CPC分类号： H01J49/0409 ,  B82Y15/00 ,  G01N1/00 ,  H01J49/00 ,  H01J49/26 ,  Y10S977/902

摘要： There are provided a bio-chip for secondary ion mass spectrometry and a method of fabricating the same, the bio-chip, which is a bio-chip for analyzing a biochemical material using the secondary ion mass spectrometry, including: a substrate; and core-shell particles positioned above substrate, wherein the core-shell particles each include a metal nanoparticle as a core and a metal shell surrounding the metal nanoparticle.

摘要翻译： 提供了二次离子质谱法的生物芯片及其制造方法，该生物芯片是使用二次离子质谱法分析生化材料的生物芯片，其包括：底物; 以及位于基材上方的核 - 壳颗粒，其中核 - 壳颗粒各自包括作为芯的金属纳米颗粒和围绕金属纳米颗粒的金属壳。

公开(公告)号：US20240353459A1

公开(公告)日：2024-10-24

申请号：US18684882

申请日：2021-12-21

申请人： KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE

发明人： In Ho BAE ,  Seon Do LIM ,  No Weon KANG

IPC分类号： G01R29/08 ,  G01R29/12

CPC分类号： G01R29/0885 ,  G01R29/12

摘要： The present disclosure relates to an electromagnetically induced grating-based electric field detection system and method and, more particularly, to an electric field detection system and method which enable the creation of an electromagnetically induced transparency grating using a low-wavelength laser and enables real-time electromagnetic wave measurement by avoiding the frequency reprocessing of the signal that is essential in the existing Rydberg atom-based electric field measurement technology.
An electromagnetically induced grating-based electric field detection system according to an embodiment of the present disclosure may include a vapor cell; an irradiation light source which irradiates irradiation light to be incident on one end of the vapor cell; a combined light source which irradiates combined light to be incident on another end of the vapor cell; a reflector which reflects the combined light that has passed through the vapor cell and makes it incident on the one end of the vapor cell; an electromagnetic wave generator which generates an electromagnetic wave to be incident on one side surface of the vapor cell; and a reflected light detector which detects a reflected light released from the vapor cell.
According to one embodiment of the present disclosure, in the Rydberg atom-based electric field measurement technology, there is an advantage in that real-time electric field measurement is possible without signal frequency reprocessing.

公开(公告)号：US20240204475A1

公开(公告)日：2024-06-20

申请号：US18530590

申请日：2023-12-06

申请人： KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY ,  KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE

发明人： Hansuek LEE ,  In Hwan DO ,  Daewon SUK ,  Jae Hoon LEE ,  Hyun-Gue HONG ,  Dai-Hyuk YU

IPC分类号： H01S3/30 ,  H01S3/094 ,  H01S3/131 ,  H01S3/067 ,  H01S3/16

CPC分类号： H01S3/302 ,  H01S3/094053 ,  H01S3/1312 ,  H01S3/06716 ,  H01S3/1608 ,  H01S2301/085

摘要： An apparatus for generating optical frequency combs and solitons includes a pump laser configured to output a pump signal with a pump wavelength, and a resonator module connected to the pump laser through an optical path and including a resonator and a waveguide structured to adjust a degree of coupling. The resonator generates at least one of pump combs at the pump wavelength, Raman combs at a Raman scattering wavelength or solitons, through different nonlinear phenomena.

公开(公告)号：US12011223B2

公开(公告)日：2024-06-18

申请号：US17280284

申请日：2019-10-08

申请人： Korea Research Institute of Standards and Science

发明人： Sang Won Lee ,  Il Doh ,  Hyunji Lee

IPC分类号： A61B3/00 ,  A61B3/10 ,  A61B3/12

CPC分类号： A61B3/0025 ,  A61B3/102 ,  A61B3/1241

摘要： The present invention relates to an eye phantom for evaluating a retinal angiography image, and a manufacturing method therefor. A purpose of the present invention is to provide an eye phantom for evaluating a retinal angiography image, capable of simulating even the vascular structure and blood flow of a retina so as to be more similar to an actual retinal structure than a conventional eye phantom; and a manufacturing method therefor. More specifically, a purpose of the present invention is to provide an eye phantom for evaluating a retinal angiography image, including various shapes of fine fluid channel structures corresponding to the vascular structure formed in an actual retina; and a manufacturing method therefor.