公开(公告)号：US20170356936A1

公开(公告)日：2017-12-14

申请号：US15499973

申请日：2017-04-28

Applicant: MCMASTER UNIVERSITY

Inventor： Mahmoud ISMAIL ,  Saeid HABIBI ,  Samir ZIADA

IPC: G01R19/00 ,  G01M99/00

CPC classification number: G01R19/0053 ,  G01M13/04 ,  G01M13/045 ,  G01M99/005 ,  G01M99/008 ,  G06K9/0051 ,  G06K9/00523 ,  G06K9/6247

Abstract: Systems and methods relating to fault detection and diagnosis. Signals received from sensors are first filtered to remove noise and are then analyzed using wavelet packet transform (WPT) based PCA. The results of the PCA analysis are then automatically classified to thereby quickly and easily determine what issues there may be in a finished product or in a machine being monitored.

公开(公告)号：US09829744B2

公开(公告)日：2017-11-28

申请号：US15301866

申请日：2015-04-07

Applicant: MCMASTER UNIVERSITY

Inventor： Adrian Kitai

IPC: G02F1/1335

CPC classification number: G02F1/133603 ,  G02F1/133606 ,  G02F1/133621 ,  G02F2001/133612 ,  G02F2001/133626

Abstract: A display illumination module for the illumination of a rear-projection screen is provided in which a first array of light sources is positioned adjacent to a first face of an optical modulating array layer for modulating the transmission of light emitted by the first array light sources. The first array light sources emit light within a defined angular range, and the optical modulating array layer is positioned relative to the first array of light sources so that light from adjacent light sources does not overlap at the optical modulating array layer. A second array of light sources is positioned adjacent to a second side of the optical modulation array layer and is arranged such that light from the second array of light sources does not pass through said optical modulation array layer and said second array of light sources does not substantially block light from the first array of light sources passing through the optical modulating array layer. One or more display modules may be incorporated into a display system that includes a rear projection screen that is spatially offset from the optical modulating array layer so that light emitted from adjacent light sources in either the first or the second array of light sources overlaps on the screen.

公开(公告)号：US20170150036A1

公开(公告)日：2017-05-25

申请号：US15422456

申请日：2017-02-01

Applicant: McMaster University

Inventor： Shahram Shirani ,  Shadrokh Samavi ,  Sayedmohammadreza Soroushmehr ,  Hamed Sadeghi

IPC: H04N5/232 ,  G08B13/196 ,  H04N7/18

CPC classification number: H04N5/23216 ,  G08B13/19641 ,  H04N5/23229 ,  H04N5/247 ,  H04N7/18 ,  H04N7/181

Abstract: Technologies are generally described for automatically optimizing an efficiency of camera placement, numbers, and resolution in multi-camera monitoring and surveillance applications. In some examples, a fraction of a total area may be monitored at a higher resolution than the rest. Employing techniques such as combinatorial state Viterbi technique or combinatorial state trellis technique, a minimum number of cameras that provide the coverage at the needed resolution may be selected. Similarly, a number of points may be covered with at least a predefined number of cameras. For example, a subject of interest may be tracked in a public area, where specific camera(s) may be used to image the subject's face at a higher resolution than the background.

公开(公告)号：US20170071971A1

公开(公告)日：2017-03-16

申请号：US15343718

申请日：2016-11-04

Applicant: McMaster University

Inventor： Mickie Bhatia ,  Eleftherios Sachlos

IPC: A61K31/7068 ,  A61K31/5415

CPC classification number: A61K31/7068 ,  A61K31/5415 ,  A61K31/7052 ,  A61K31/706 ,  A61K31/7064 ,  A61K2300/00

Abstract: Described are methods and compositions for treating cancer that include a dopamine receptor (DR) antagonist such as thioridazine and a chemotherapeutic agent. Optionally, the chemotherapeutic agent is a DNA synthesis inhibitor such as cytarabine or a microtubule inhibitor such as paclitaxel or docetaxel. The methods and compositions are useful for the treatment of cancers such as acute myeloid leukemia.

Abstract translation: 描述了用于治疗癌症的方法和组合物，其包括多巴胺受体（DR）拮抗剂如硫利达嗪和化学治疗剂。 任选地，化学治疗剂是DNA合成抑制剂，例如阿糖胞苷或微管抑制剂如紫杉醇或多西他赛。 所述方法和组合物可用于治疗癌症如急性骨髓性白血病。

公开(公告)号：US20170021732A1

公开(公告)日：2017-01-26

申请号：US15088848

申请日：2016-04-01

Applicant: McMaster University

Inventor： Ali Emadi ,  Ruoyu Hou ,  Yinye Yang

IPC: B60L11/02 ,  H02K7/18 ,  H02K16/02

CPC classification number: B60L11/02 ,  B60L15/002 ,  B60L50/10 ,  B60L2200/26 ,  B60L2220/14 ,  B60L2220/18 ,  B60L2220/50 ,  H02K7/1815 ,  H02K16/02 ,  H02K19/22 ,  H02K21/12 ,  Y02T10/641 ,  Y02T10/645 ,  Y02T10/70

Abstract: Electric generators are described herein. The electric generators include an interior machine formed of an interior rotor and an interior portion of a stator, and an exterior machine substantially concentric to the interior machine. The exterior machine includes: an exterior rotor substantially concentric to the interior rotor, and an exterior portion of the stator. Each of the interior machine and the external machine are driven by an engine to produce a respective current. The described electric generators can be used in diesel electric locomotives.

Abstract translation: 发电机在这里描述。 发电机包括由内部转子和定子的内部形成的内部机器，以及与内部机器大致同心的外部机器。 外部机器包括：与内部转子基本同心的外部转子和定子的外部部分。 内部机器和外部机器中的每一个由发动机驱动以产生相应的电流。 所描述的发电机可用于柴油电力机车。

公开(公告)号：US20160281145A1

公开(公告)日：2016-09-29

申请号：US15079418

申请日：2016-03-24

Applicant: McMaster University

Inventor： John D. Brennan ,  Yingfu Li ,  Carmen Carrasquilla

IPC: C12Q1/68 ,  G01N33/53

CPC classification number: C12Q1/6818 ,  C12Q1/6816 ,  C12Q1/6825 ,  C12Q1/6834 ,  G01N33/5308 ,  C12Q2525/205 ,  C12Q2565/518 ,  C12Q2565/607

Abstract: The present application relates to biosensors, for example comprising an high-molecular weight, tandem repeating, structure-switching nucleic acid aptamers (concatemeric aptamers) to rapidly create patterned sensors via, for example, inkjet printing. These concatemeric aptamer reporters remain immobilized at the point of printing through strong adsorption but retain sufficient segmental mobility to undergo structure switching and reporter signalling to provide both qualitative and quantitative detection of one or more analytes. In certain embodiments, inkjet printing allows for the patterning of internally referenced sensors with multiplexed detection, and provides a generic platform for on-demand printing of sensors even in remote locations.

Abstract translation: 本申请涉及生物传感器，例如包括通过例如喷墨印刷快速形成图案化传感器的高分子量串联重复结构转换核酸适配体（并用适体）。 这些连接适体报告者通过强吸附保持固定在印刷点，但保留足够的分段迁移率进行结构切换和报告信号，以提供一种或多种分析物的定性和定量检测。 在某些实施例中，喷墨打印允许通过多路检测对内部参考的传感器进行图案化，并且为即使在偏远位置的传感器的按需打印提供通用平台。

公开(公告)号：US20160264935A1

公开(公告)日：2016-09-15

申请号：US15164528

申请日：2016-05-25

Applicant: McMaster University

Inventor： Mickie Bhatia ,  Tamra Werbowetski-Ogilvie ,  Eleftherios Sachlos ,  Daniela Fischer Russell ,  Sarah Laronde ,  JungBok Lee ,  Eva Szabo ,  Ruth Risueno

IPC: C12N5/0735 ,  C12Q1/04 ,  G01N33/50

CPC classification number: C12N5/0606 ,  C12N5/0695 ,  C12N2501/115 ,  C12Q1/04 ,  G01N33/5073 ,  G01N2500/10

Abstract: The present disclosure provides transformed human pluripotent stem cell (t-hPSC). t-hPSCs are not dependent on Oct4 for renewal and survival, however exhibit a sensitivity to reduced levels of the transcription factor Nanog. Also provided are methods of culturing cells for use in a cell-based screening assay comprising placing one or more transformed human pluripotent stem cells into a receptacle and culturing said stem cells in the receptacle to form a monolayer of stem cells without cell overlap. Methods of screening compounds using t-hPSCs are also described.

公开(公告)号：US09429205B2

公开(公告)日：2016-08-30

申请号：US14488053

申请日：2014-09-16

Applicant: McMaster University

Inventor： Michael Tait

IPC: F16F1/366 ,  E02D31/08 ,  E04H9/02 ,  E01D19/04 ,  B32B25/10

CPC classification number: F16F1/366 ,  B32B25/10 ,  B32B2262/0269 ,  B32B2262/101 ,  B32B2262/106 ,  B32B2419/00 ,  E01D19/041 ,  E02D31/08 ,  E04H9/022

Abstract: Unbonded fiber reinforced elastomeric isolators (FREIs) have desirable characteristics for seismic isolation, but the unbonded application also introduces several design limitations in comparison to bonded elastomeric isolators. Unbonded FREIs are not capable of resisting tensile forces, making this type of isolator inappropriate for situation where overturning is of concern or regions where large vertical accelerations are anticipated. Furthermore, since unbonded FREIs rely on friction to transfer horizontal forces, permanent slip could occur. Concerns over both transfer of tensile forces and permanent displacement can be obviated by partially bonding the FREI to the supports. In this way, partially bonded FREIs (PB-FREIs) retain the beneficial characteristics of an unbonded FREI, but also demonstrate characteristics of a bonded isolator, notably tensile forces can be transferred and potential permanent displacement is inhibited.

Abstract translation: 未结合的纤维增强弹性体隔离器（FREI）具有理想的隔震特性，但与粘结的弹性体隔离器相比，未粘合的应用也引入了几个设计限制。 未粘合的FREI不能抵抗拉伸力，使得这种类型的隔离器不适合于推翻倾覆的情况或预期具有大的垂直加速度的区域。 此外，由于未粘合的FREI依靠摩擦来转移水平力，因此可能会发生永久滑动。 通过将FREI部分地粘合到支撑件上，可以消除对张力和永久位移的转移的担心。 以这种方式，部分粘合的FREI（PB-FREI）保留了未结合的FREI的有益特征，而且还显示了粘合隔离器的特性，特别是可以传递张力并且阻止潜在的永久位移。

公开(公告)号：US20160209643A1

公开(公告)日：2016-07-21

申请号：US14915333

申请日：2014-08-08

Applicant: MCMASTER UNIVERSITY

Inventor： Anthony TSIKOURAS ,  Qiyin FANG

IPC: G02B26/10 ,  G01J1/42 ,  G01J3/28 ,  G02B26/08 ,  G02B21/00

CPC classification number: G02B26/101 ,  G01J1/42 ,  G01J3/2823 ,  G01J2001/4238 ,  G02B21/0036 ,  G02B26/0875

Abstract: A method and apparatus for performing foci array scanning using at least one adjustable or tilting medium is disclosed. The medium can be controllably tilted in order to translate a beam of electromagnetic radiation perpendicularly to its propagation, and upon exiting the medium, will propagate in the original, incoming direction. This allows the apparatus that emits the radiation, such as a laser, to remain stationary and still scan a 2D array. Additionally, the reflected fluorescence light undergoes the opposite shift to “reverse” the scanning shift and bring the beamlets back in line with a lenselet array. So the collection fibers can remain static and collect light from different spots on the sample from during the scan.

Abstract translation: 公开了一种用于使用至少一个可调节或倾斜介质执行焦点阵列扫描的方法和装置。 介质可以可控地倾斜以便垂直于其传播平移电磁辐射束，并且在离开介质时将以原始的输入方向传播。 这允许发射辐射的装置（例如激光）保持静止并仍然扫描2D阵列。 此外，反射的荧光发生相反的移动，以“反转”扫描偏移，并使子束返回与读数阵列一致。 因此，收集纤维可以保持静止，并在扫描期间从样品上的不同点收集光。

公开(公告)号：US20160086780A1

公开(公告)日：2016-03-24

申请号：US14891084

申请日：2014-05-14

Applicant: McMaster University

Inventor： Philip Britz-McKibbin

IPC: H01J49/00 ,  H01J49/04 ,  H01J49/16 ,  G01N27/447

CPC classification number: G01N27/44782 ,  G01N27/447 ,  G01N27/4473 ,  G01N27/44743 ,  G01N30/7266 ,  H01J49/0027 ,  H01J49/0404 ,  H01J49/165

Abstract: Various embodiments illustrating a multiplexed method for high throughput screening of ions in biological samples within a single capillary when using capillary electrophoresis mass spectrometry (CE-MS) are illustrated. The method includes sequential injection of multiple sample segments in series within a single capillary, the sample segments being separated by a spacer plug of buffer, and multiplexed analysis of the sample segments simultaneously within a single capillary electrophoresis (CE) run. The method also includes application of voltage to the single capillary subsequent to sequential injection and zonal separation of polar metabolites within each sample segment by CE such that each analyte zone migrates within its characteristic electrophoretic mobility offset in time by the spacer. The incorporation of a quality control/reference sample and the use of dilution patterning with specific injection configurations also enables encoding of information temporally for enhanced data processing with quality assurance.

Abstract translation: 示出了当使用毛细管电泳质谱（CE-MS）时，单个毛细管内的生物样品中离子生物样品的高通量筛选的多路复用方法。 该方法包括在单个毛细管内连续注射多个样品片段，样品片段由缓冲液的间隔塞隔开，并在单个毛细管电泳（CE）运行中同时对样品片段进行多重分析。 该方法还包括在CE之间顺序注射和每个样品区段内的极性代谢物的区域分离之后，向单个毛细管施加电压，使得每个分析物区域在其特征电泳迁移率偏移期间通过间隔物在时间上迁移。 质量控制/参考样品的并入以及使用具有特定注射配置的稀释图案化也可以使信息在时间上进行编码，从而提高质量保证的数据处理能力。