公开(公告)号：US20130100595A1

公开(公告)日：2013-04-25

申请号：US13643992

申请日：2011-05-10

Applicant: Kurt J. Koester ,  Chuladatta Thenuwara ,  Timothy Beerling ,  Mark B. Downing ,  David Stuursma ,  Logan P. Palmer

Inventor： Kurt J. Koester ,  Chuladatta Thenuwara ,  Timothy Beerling ,  Mark B. Downing ,  David Stuursma ,  Logan P. Palmer

IPC: A61N1/36 ,  H01R43/00 ,  H05K5/00

CPC classification number: A61N1/36032 ,  A61N1/36036 ,  A61N1/3754 ,  H01L23/045 ,  H01L23/49827 ,  H01L25/0655 ,  H01L25/16 ,  H01L2924/0002 ,  H01L2924/09701 ,  H01L2924/15311 ,  H01L2924/15313 ,  H01L2924/15787 ,  H01L2924/3512 ,  H01R43/005 ,  H05K5/0095 ,  Y10T29/49204 ,  H01L2924/00

Abstract: A device includes a hermetically sealed case with electronic circuitry housed within. One surface of the hermetically sealed case includes a metallic plate and a co-fired ceramic electrical feedthrough with a number of vias. The co-fired ceramic electrical feedthrough is hermetically joined to the metallic plate and a hybrid circuit is connected to the feedthrough.

Abstract translation: 一种装置包括一个密封的壳体，其中装有电子电路。 密封壳体的一个表面包括金属板和具有多个通孔的共烧陶瓷电馈电。 共烧陶瓷电馈通气密接合到金属板，并且混合电路连接到馈通。

公开(公告)号：US20120296405A1

公开(公告)日：2012-11-22

申请号：US13516982

申请日：2010-12-14

Applicant: Chuladatta Thenuwara ,  Timothy Beerling

Inventor： Chuladatta Thenuwara ,  Timothy Beerling

IPC: A61N1/05 ,  H01R43/16

CPC classification number: C25D11/34 ,  A61N1/0541 ,  A61N1/36036 ,  B23K26/38 ,  C25D7/0642 ,  H01R43/16 ,  Y10T29/49204 ,  Y10T29/49213 ,  Y10T29/49218 ,  Y10T29/49222

Abstract: A cochlear lead includes a plurality of electrode assemblies partially embedded in a flexible body configured to stimulate an auditory nerve from within a cochlea. Each of the electrode assemblies includes a flexible electrically conductive material forming a plurality of support structures and an electrode pad attached a support structure, the electrode pad having a surface that is configured to be exposed to cochlear tissue and fluids and has a charge transfer to the cochlear tissue and fluids that is higher than the flexible electrically conductive material.

Abstract translation: 耳蜗引线包括部分地嵌入柔性体中的多个电极组件，其构造成从耳蜗内刺激听觉神经。 每个电极组件包括形成多个支撑结构的柔性导电材料和附接有支撑结构的电极垫，电极垫具有被配置为暴露于耳蜗组织和流体的表面，并具有电荷转移到 耳蜗组织和高于柔性导电材料的流体。

公开(公告)号：US20110295352A1

公开(公告)日：2011-12-01

申请号：US12789264

申请日：2010-05-27

Applicant: Chuladatta Thenuwara ,  Timothy Beerling

Inventor： Chuladatta Thenuwara ,  Timothy Beerling

IPC: A61N1/04

CPC classification number: A61N1/0541 ,  A61N1/36036

Abstract: A cochlear lead includes a plurality of electrodes configured to stimulate an auditory nerve from within a cochlea and a flexible body supporting the plurality of electrodes along a length of the flexible body. A stiffening element is slidably encapsulated within the flexible body and positioned such that the stiffening element plastically deforms upon insertion into a curved portion of the cochlea.

Abstract translation: 耳蜗引线包括构造成从耳蜗内刺激听觉神经的多个电极和沿柔性体的长度支撑多个电极的柔性体。 加强元件可滑动地封装在柔性体内并且定位成使得加强元件在插入耳蜗的弯曲部分时塑性变形。

公开(公告)号：US20110022145A1

公开(公告)日：2011-01-27

申请号：US12506964

申请日：2009-07-21

Applicant: Timothy Beerling ,  Chuladatta Thenuwara

Inventor： Timothy Beerling ,  Chuladatta Thenuwara

IPC: A61N1/05

CPC classification number: A61N1/0541 ,  A61F11/004 ,  Y10T29/49185

Abstract: A method for forming a cochlear electrode array with a plurality of electrodes which are spaced so as to stimulate sites within a cochlea includes shaping a sheet of electrically conductive material to form a support structure and a plurality of electrodes, in which the electrodes are tethered to the support structure at the spacing of the cochlear electrode array. A cochlear lead includes a flexible body that has frictional characteristics that vary about its circumference. A cochlear lead includes a flexible body with a first region and a second region with different surface textures. This generates differential sliding forces during insertion of the cochlear lead which influence a motion of the cochlear lead during insertion. The cochlear lead having an electrode array with varying stiffness along its length is also provided.

Abstract translation: 用于形成具有间隔开以刺激耳蜗内的部位的多个电极的耳蜗电极阵列的方法包括成形导电材料片以形成支撑结构和多个电极，其中电极被束缚至 在耳蜗电极阵列的间隔处的支撑结构。 耳蜗引线包括具有围绕其周长变化的摩擦特性的柔性体。 耳蜗引线包括具有第一区域的柔性主体和具有不同表面纹理的第二区域。 这在耳蜗引线的插入期间产生差别的滑动力，其在插入期间影响耳蜗导线的运动。 还提供了具有沿其长度具有变化的刚度的电极阵列的耳蜗引线。

公开(公告)号：US20100277722A1

公开(公告)日：2010-11-04

申请号：US12237398

申请日：2008-09-25

Applicant: Karsten KRAICZEK ,  Beno MUELLER ,  Timothy BEERLING

Inventor： Karsten KRAICZEK ,  Beno MUELLER ,  Timothy BEERLING

IPC: G01N21/01 ,  G01N30/74 ,  G01N21/05 ,  G01N27/26 ,  H01L21/02

CPC classification number: G01N30/74 ,  B81B2201/058 ,  B81B2203/0338 ,  B81B2203/0392 ,  B81C1/00071 ,  H01L31/101

Abstract: An integrated flow cell, the flow cell comprising a semiconductor substrate, and a fluidic conduit having an at least partially transparent semiconductor oxide tubing, wherein the semiconductor oxide tubing is formed with the semiconductor substrate.

Abstract translation: 集成流通池，所述流动池包括半导体衬底和具有至少部分透明的半导体氧化物管的流体导管，其中所述半导体氧化物管与所述半导体衬底形成。

公开(公告)号：US20080264506A1

公开(公告)日：2008-10-30

申请号：US11796891

申请日：2007-04-30

Applicant: Timothy Beerling ,  Kevin P. Killeen

Inventor： Timothy Beerling ,  Kevin P. Killeen

IPC: F15C1/04 ,  G01N27/26

CPC classification number: B01L3/502792 ,  B01L2200/0673 ,  B01L2300/0816 ,  B01L2400/0427 ,  Y10T137/2191 ,  Y10T137/2213

Abstract: A system for controlling fluid flow in a microfluidic circuit includes at least one microfluidic channel having a first fluid, a switch element coupled to the microfluidic channel, the switch element comprising at least one inlet, at least one outlet and a second fluid, the second fluid being immiscible with respect to the first fluid. The system also includes an actuator configured to alter the position of the second fluid, such that when in a first position, the second fluid allows the first fluid to flow from the at least one inlet to the at least one outlet, and such that when in a second position, the second fluid prevents the first fluid from flowing from the at least one inlet to the at least one outlet.

Abstract translation: 用于控制微流体回路中的流体流动的系统包括至少一个具有第一流体的微流体通道，耦合到微流体通道的开关元件，该开关元件包括至少一个入口，至少一个出口和第二流体，第二流体 流体相对于第一流体是不混溶的。 该系统还包括被配置为改变第二流体的位置的致动器，使得当处于第一位置时，第二流体允许第一流体从至少一个入口流动到至少一个出口，并且使得当 在第二位置，第二流体防止第一流体从至少一个入口流到至少一个出口。

公开(公告)号：US20080236668A1

公开(公告)日：2008-10-02

申请号：US11691318

申请日：2007-03-26

Applicant: Timothy Beerling ,  Reld A. Brennen

Inventor： Timothy Beerling ,  Reld A. Brennen

IPC: F17D3/00 ,  F17D1/00

CPC classification number: F16K99/0001 ,  F16K13/10 ,  F16K31/025 ,  F16K99/0044 ,  Y10T137/0324 ,  Y10T137/86493

Abstract: A microfluidic valve. A microfluidic channel is formed in a substrate. A cooling element cools a substance in the channel to inhibit flow of the substance through the channel. A heating element warms the substance to overcome the effect of the cooling and enable the substance to flow through the channel. The valve may serve as a component of a microfluidic device that in turn may be part of a microfluidic system.

Abstract translation: 微流控阀。 在衬底中形成微流体通道。 冷却元件冷却通道中的物质以抑制物质通过通道的流动。 加热元件加热物质以克服冷却的影响并使物质流过通道。 该阀可以用作微流体装置的组件，微流体装置又可以是微流体系统的一部分。

公开(公告)号：US20080031782A1

公开(公告)日：2008-02-07

申请号：US11500234

申请日：2006-08-07

Applicant: Timothy Beerling ,  Reid A. Brennen

Inventor： Timothy Beerling ,  Reid A. Brennen

IPC: B01L11/00 ,  B01L3/00

CPC classification number: F16K99/0032 ,  B01L3/502707 ,  B01L3/502738 ,  B01L2300/1805 ,  B01L2300/1827 ,  B01L2400/0677 ,  F16K99/0001 ,  F16K99/0036 ,  F16K2099/0074 ,  F16K2099/0078 ,  F16K2099/0084

Abstract: The invention provides a microfluidic system, including an optional separation system for separating and preparing an analyte solution, a microfluidic device downstream from the separation system for dispensing and analyte solution, comprising a substrate having a channel defining a portion of a microfluidic channel; a polymeric substrate having a channel for contacting the substrate to define the second portion of the microfluidic channel; a cooling element associated with the substrate and channel for cooling an analyte solution in the microfluidic channel; and a heating element adjacent to the microfluidic channel for heating the analyte solution, wherein the cooling element operates to maintain the channel in a closed state by cooling the analyte solution in the channel and wherein the heating element may be activated to place the channel in an open state by heating the analyte solution in the channel; and a detector for detecting the dispensed analyte solutionThe invention also provides a microfluidic device and/or valve, including a substrate having a micro fluidic channel for carrying an analyte solution; a cooling element associated with the substrate and micro fluidic channel for cooling the analyte solution in the channel; and a heating element adjacent to the channel for heating the analyte solution in the channel wherein the cooling element operates to maintain the channel in a closed state by cooling the analyte solution in the channel and wherein the heating element may be activated to place the channel in an open state by heating the cooled analyte solution in the channel.The invention also provides a method of valve control in a microfluidic device, including maintaining a cooling element in an active state to freeze an analyte solution in a microfluidic channel and close the microfluidic channel; and engaging a heating element to thaw the analyte solution in the microfluidic channel and open the microfluidic channel to allow fluid flow through the channel.

公开(公告)号：US20070289853A1

公开(公告)日：2007-12-20

申请号：US11453166

申请日：2006-06-14

Applicant: Timothy Beerling ,  Ashish Tandon ,  Atul Goel

Inventor： Timothy Beerling ,  Ashish Tandon ,  Atul Goel

IPC: H01H29/00

CPC classification number: H01H1/0036 ,  H01H2029/008

Abstract: Embodiments of the invention provide for improved separation of switching material by creating a diversion of the activating force. In one embodiment at least one structural element is positioned in close proximity to an inlet for the actuating force to influence the actuating force to fully separate the switching material. Structural elements may include protrusions, either adjacent to the inlet or approximately across the channel from the inlet, as well as at least one additional inlet. The diversion can be created, if desired, by forces coming from opposite sides. Embodiments of the invention make use of non-wettable surfaces lining the channel in regions where switching material is to break into separate volumes, and wettable surfaces away from such regions. Embodiments of the invention provide for multi-pole, multi-throw switching.

Abstract translation: 本发明的实施例通过产生激活力的转移来提供切换材料的分离。 在一个实施例中，至少一个结构元件被定位成靠近用于致动力的入口以影响致动力以完全分离开关材料。 结构元件可以包括与入口相邻或者大致跨过入口的通道的突起，以及至少一个附加的入口。 如果需要，可以通过来自相对侧的力创建转移。 本发明的实施例利用在切换材料要分解成分开体积的区域中衬里通道的不可润湿表面以及远离这些区域的可润湿表面。 本发明的实施例提供了多极，多掷切换。

公开(公告)号：US20070193864A1

公开(公告)日：2007-08-23

申请号：US11358627

申请日：2006-02-21

Applicant: Timothy Beerling

Inventor： Timothy Beerling

IPC: H01H29/00

CPC classification number: H01H11/02

Abstract: The delivery of liquid to a device, for example, a microswitch, can be achieved without the application of external pressure to the liquid by using capillary action to cause the liquid to move as desired. In one embodiment, at least one channel having a wettable surface is created that allows liquid metal to flow into a measuring reservoir without the liquid metal being pressurized and without applying other external forces on the liquid metal to facilitate its movement. A portion of the channel between the wettable channel and the reservoir is non-wettable and this non-wettable area, while allowing the metal to flow into the reservoir, acts to prevent the liquid from back-flowing from the reservoir to the channel. In one embodiment pressurized gas can be generated and applied to the liquid in the reservoir to facilitate the movement of the liquid from the reservoir to the switch cavity.

Abstract translation: 可以通过使用毛细作用使液体根据需要移动而不向液体施加外部压力，从而实现将液体输送到装置，例如微动开关。 在一个实施例中，产生具有可润湿表面的至少一个通道，其允许液体金属流入测量容器，而不会使液体金属被加压，并且不在液体金属上施加其它外力以促进其运动。 可润湿通道和储存器之间的通道的一部分是不可润湿的，并且这种不可润湿区域同时允许金属流入储存器中起作用以防止液体从储存器回流到通道。 在一个实施例中，可以产生加压气体并将其施加到储存器中的液体，以便于液体从储存器移动到开关腔。