公开(公告)号：US20190175629A1

公开(公告)日：2019-06-13

申请号：US16301240

申请日：2017-05-18

Applicant: Universiteit Antwerpen

Inventor： Koen Augustyns ,  Jurgen Joossens ,  Pieter Van Der Veken ,  Paul Cos ,  Cedric Joossen ,  Benedicte Yvonne De Winter ,  Hannah Ceuleers ,  Hanne Van Spaendonk

IPC: A61K31/688 ,  A61P25/04 ,  A61P27/04

Abstract: The present invention relates to compounds for use in the prevention and/or treatment of PAR-related diseases, such as for example: pain and ocular disorders. More in particular, the present invention provides bis(acetamidophenyl) guanidinophenylethylphosphonates for use in the prevention and/or treatment of pancreatitis-related pain, IBS (irritable bowel syndrome), IBD (inflammatory bowel disease), dry eye disease and conjunctivitis sicca. These inhibitors were found to have a different inhibitory profile compared to diphenyl guanidinophenylethylphosphonates leading to a more pronounced effect on these conditions.

公开(公告)号：US10257630B2

公开(公告)日：2019-04-09

申请号：US15553798

申请日：2016-02-12

Applicant: UNIVERSITEIT ANTWERPEN

Inventor： Jonas Reijniers ,  Herbert Godelieve P Peremans ,  Bart Wilfried M Partoens

IPC: H04R29/00 ,  H04S7/00 ,  G06F3/01

Abstract: A method of estimating an individualized head-related transfer function (HRTF) and an individualized interaural time difference function (ITDF) of a particular person, comprising the steps of: a) obtaining a plurality of data sets (Li, Ri, Oi), each comprising a left and a right audio sample (Li, Ri) from a pair of in-ear microphones, and orientation information (Oi) from an orientation unit, measured in a test-arrangement whereby an acoustic test signal is rendered via a loudspeaker; b) storing the data sets in a memory; c) estimating the directions of the loudspeaker relative to the person based on the orientation data and the audio data; d) estimating the ITDF based on the data sets and on the estimated relative position/orientation; e) estimating the HRTF, based on the data sets and based on the estimated relative position/orientation.

公开(公告)号：US20180272323A1

公开(公告)日：2018-09-27

申请号：US15765212

申请日：2016-09-30

Applicant: VITO NV (VLAAMSE INSTELLING VOOR TECHNOLOGISCH ONDERZOEK NV) ,  UNIVERSITEIT ANTWERPEN

Inventor： Steven MULLENS ,  Lidia PROTASOVA ,  Jasper LEFEVERE

IPC: B01J29/40 ,  B01J37/00 ,  B01J29/08 ,  B01J29/70 ,  B28B1/00 ,  B28B3/20 ,  C07C1/20 ,  C07C11/02

CPC classification number: B01J29/40 ,  B01J2/08 ,  B01J2/20 ,  B01J27/14 ,  B01J29/084 ,  B01J29/18 ,  B01J29/7007 ,  B01J35/04 ,  B01J35/06 ,  B01J35/08 ,  B01J37/0009 ,  B01J37/038 ,  B28B1/001 ,  B28B3/20 ,  C04B35/01 ,  C04B35/622 ,  C04B38/008 ,  C04B2111/00181 ,  C04B2111/0081 ,  C07C1/20 ,  C07C11/02 ,  C07C2521/08 ,  C07C2521/16 ,  C07C2529/40 ,  C07C2529/80 ,  C07C2529/84 ,  C10G3/44 ,  C10G3/49 ,  C10G2400/20 ,  C04B35/00 ,  C04B38/0058 ,  C04B38/08

Abstract: A catalytic composition is built up from a ceramic material including a catalytic material and a first inorganic binder and a second inorganic binder and a catalytic structure made thereof. Preferably, the structure is made by a colloidal ceramic shaping technique. The structure is usable for catalytic or ion exchange applications as well. It is demonstrated that the catalytic structures have excellent mechanical, physicochemical and catalytic properties.

公开(公告)号：US10017527B2

公开(公告)日：2018-07-10

申请号：US15128446

申请日：2015-03-30

Applicant: Universiteit Antwerpen

Inventor： Jurgen Joossens ,  Koen Augustyns ,  Anne-Marie Lambeir ,  Pieter Van Der Veken ,  Jeroen Van Soom ,  Viktor Magdolen

IPC: C07F9/6561 ,  C07F9/40 ,  A61K49/00 ,  C07F9/58 ,  C07F9/655 ,  C07F9/6553 ,  C07F9/6509 ,  C07F9/6558 ,  C12Q1/37

CPC classification number: C07F9/6561 ,  A61K49/0052 ,  C07F9/4087 ,  C07F9/58 ,  C07F9/650952 ,  C07F9/6518 ,  C07F9/6539 ,  C07F9/65515 ,  C07F9/655345 ,  C07F9/65583 ,  C07F9/65586 ,  C12Q1/37 ,  G01N2333/96433

Abstract: The present invention relates to novel compounds and probes which have a common chemical structure necessary to obtain potent inhibitory activity against KLK4 and/or may be used for the detection of KLK4 peptides and their activity. It further relates to the use of these compounds and methods for inhibiting and/or detecting KLK4 activity in vitro and in vivo by making use of said probes or inhibitors. The compounds of the invention differ from prior art compounds at least in the presence of phenyl guanidine (instead of e.g. benzyl guanidine) and/or the presence of a heteroatom in the tail group, their combined presence unexpectedly leading to potent and selective KLK4 inhibitory activity.

公开(公告)号：US09594047B2

公开(公告)日：2017-03-14

申请号：US14254542

申请日：2014-04-16

Applicant: Universiteit Antwerpen

Inventor： Karolien De Wael ,  Lucien Nagels ,  Guido Van Camp

IPC: G01N27/327 ,  G01N27/333 ,  G01N27/40 ,  G01N33/543

CPC classification number: G01N27/3335 ,  G01N27/327 ,  G01N27/40 ,  G01N33/54353

Abstract: A coated-wire potentiometric sensor comprising an electronically conducting substrate electrode coated with an ionically conductive sensing layer and an outermost surface consisting of or comprising in and/or on a first molecular species which is capable of reversibly adsorbing a second molecular species and a method for measuring the affinity between a first molecular species and a second molecular species comprising the steps of: providing a potentiometric sensor of the coated-wire type having an outermost surface; adapting said outermost surface so that consists of or comprises said first molecular species; placing said sensor in a system for the recording of sensorgrams; recording a sensorgram of the adsorption of a second molecular species on said first molecular species of or comprised in and/or on said adapted outermost surface.

Abstract translation: 一种涂覆线电位传感器，其包括涂覆有离子导电感测层的电子导电基底电极和由能够可逆地吸附第二分子物质的第一分子物质组成或包含在其中和/或之上的最外表面，以及用于 测量第一分子物质和第二分子物质之间的亲和力，包括以下步骤：提供具有最外表面的涂覆线型电位计传感器; 使所述最外表面适应成由或包含所述第一分子种类; 将所述传感器放置在用于记录传感图的系统中; 记录第二分子物质在所述第一分子种类上或包含在所述适配的最外表面中和/或上的吸附的传感图。

公开(公告)号：US09018596B2

公开(公告)日：2015-04-28

申请号：US14366564

申请日：2012-12-19

Applicant: Universiteit Antwerpen

Inventor： Johan Verbeeck ,  Gustaaf Van Tendeloo

IPC: H01J37/04 ,  H01J37/26 ,  H01J3/02 ,  H01J37/06 ,  H01J37/08 ,  H01J37/256

CPC classification number: H01J37/04 ,  H01J3/02 ,  H01J3/021 ,  H01J37/06 ,  H01J37/08 ,  H01J37/256 ,  H01J37/261 ,  H01J2237/06383 ,  H01J2237/2614

Abstract: A device for imparting an orbital angular momentum to a charged particle wave propagating along a beam axis in a charged particle beam generating apparatus is described. The device comprises a support element having a target region adapted for transmitting a charged particle wave propagating along a beam axis and an induction means for inducing a magnetic flux along an elongated profile having a free end portion located in the target region and the induction means is adapted for providing a magnetic flux in the elongated profile in order to induce an angular gradient, relative to the beam axis, of the phase of the charged particle wave when transmitted through the target region. A corresponding method is also disclosed, as well as the use thereof in electron microscopy.

Abstract translation: 描述了一种用于对带电粒子束产生装置中沿着光束轴传播的带电粒子波进行轨道角动量的装置。 该装置包括支撑元件，该支撑元件具有适于传输沿着光束轴传播的带电粒子波的目标区域和用于沿着具有位于目标区域中的自由端部分的细长轮廓感应磁通量的感应装置，并且感应装置是 适于在细长轮廓中提供磁通量，以便当透射通过目标区域时引起带电粒子波相位相对于光束轴的角度梯度。 还公开了相应的方法，以及其在电子显微镜中的应用。

公开(公告)号：US20140307934A1

公开(公告)日：2014-10-16

申请号：US14355286

申请日：2012-10-30

Applicant: UNIVERSITEIT ANTWERPEN ,  CWI

Inventor： Kees Joost Batenburg ,  Jan Sijbers

IPC: G06T11/00

CPC classification number: G06T11/005 ,  A61B6/508 ,  A61B6/583 ,  G06T2211/424 ,  G06T2211/436

Abstract: A method for determining a projection angle for use in tomographic imaging comprises obtaining projection data including at least one projection view from at least one projection angle. The at least one projection view is generated by scanning a test object with a tomographic imaging device. Each projection view comprises at least one observation value obtained at least one detection location, providing a plurality of candidate projection angles, for each candidate projection angle, calculating a function value indicative of an amount of information that may be gained by adding to the projection data a further projection view generated by scanning of the test object with the tomographic imaging device from the candidate projection angle, and selecting a candidate projection angle from the plurality of candidate projection angles taking into account the function values. A corresponding system and computer program product also is provided.

Abstract translation: 用于确定用于断层成像成像的投影角度的方法包括从至少一个投影角度获得包括至少一个投影视图的投影数据。 所述至少一个投影视图是通过用断层图像成像装置扫描测试对象而产生的。 每个投影视图包括至少一个观察值，其至少一个检测位置获得，为每个候选投影角度提供多个候选投影角度，计算指示可以通过添加到投影数据获得的信息量的函数值 通过从候选投影角度用断层图像成像装置扫描测试对象而产生的另一投影视图，并且考虑到功能值，从多个候选投影角度中选择候选投影角度。 还提供了相应的系统和计算机程序产品。

公开(公告)号：US12249009B2

公开(公告)日：2025-03-11

申请号：US17779601

申请日：2020-11-23

Applicant: UNIVERSITEIT ANTWERPEN

Inventor： Alan Miranda ,  Jeroen Verhaeghe

IPC: G06T11/00 ,  A61B6/03 ,  G01T1/29

Abstract: A method for compensating motion in positron emission tomographic, PET, data comprising coincident lines of response from positron-emitting position markers, includes: detecting a slippage of one or more of the position markers; determining slippage correction parameters based on the detected slippage; and applying motion correction to the PET data by taking into account the slippage correction parameters, thereby obtaining a motion-compensated PET data.

公开(公告)号：US20250010261A1

公开(公告)日：2025-01-09

申请号：US18705237

申请日：2022-10-25

Applicant: UNIVERSITEIT ANTWERPEN

Inventor： Annemie BOGAERTS ,  Fanny GIRARD-SAHUN ,  Georgi TRENCHEV

IPC: B01J8/08 ,  B01J8/00 ,  B01J8/10 ,  B01J8/12 ,  C01B32/40

Abstract: The present disclosure relates to a device for gas conversion comprising a plasma reactor and a chamber configured for receiving a gas flow of converted and unconverted feed gas evacuated from the plasma reactor. The chamber comprises a supply throughput for filling the chamber with solid reactant material so as to form the fixed bed of solid reactant material, and at least one gas exhaust window for extracting a product gas. The device for gas conversion further comprises a silo for storing a stock of the solid reactant material and a connecting tube connecting a bottom opening of the silo with the supply throughput of the chamber. The silo and the connecting tube are configured such that, when the device is in operation and solid reactant material is being depleted in the chamber, a flow of solid reactant material from the silo to the chamber is induced so as to maintain the chamber filled with solid reactant material, and wherein the flow of solid reactant material from the silo to the chamber is induced by a gravitational force or at least partly by a gravitational force. The present disclosure also relates to a method for gas-conversion.

公开(公告)号：US20240407912A1

公开(公告)日：2024-12-12

申请号：US18701339

申请日：2022-10-24

Applicant: UNIVERSITEIT ANTWERPEN ,  UNIVERSITAIR ZIEKENHUIS ANTWERPEN

Inventor： Dirk VAN DYCK ,  Marie-José TASSIGNON ,  Laure GOBIN

IPC: A61F2/16

Abstract: An intraocular lens, which contributes to the focusing of incident light onto a user's retina, includes a first and second surfaces. The first surface is configured to focus the incident light refractively. The first surface exhibits a non-uniform refractive power. The second surface is provided with a diffraction generating profile configured to spatially separate the incident light into at least a first portion with a first spatial frequency characteristic and a second with a second spatial frequency characteristic. The spatial separation and the non-uniform refractive power of the first surface cause the first portion to be refracted by the first surface at a first level of refractive power and the second portion to be refracted by the first surface at a second level of refractive power. The first level of refractive power and the second level of refractive power are different.