公开(公告)号：US09824596B2

公开(公告)日：2017-11-21

申请号：US14453406

申请日：2014-08-06

Applicant: Insitu, Inc. ,  University of Washington through its Center for Commercialization

Inventor： Amy Claire Arbeit ,  Christopher W. Lum

IPC: G08G5/00 ,  G01C21/20 ,  G01C23/00 ,  G05D1/00 ,  G05D1/02 ,  B64C39/02

CPC classification number: G08G5/0069 ,  B64C39/024 ,  B64C2201/127 ,  B64C2201/14 ,  G01C21/20 ,  G01C23/00 ,  G05D1/0094 ,  G05D1/0202 ,  G08G5/0013 ,  G08G5/0021 ,  G08G5/0026 ,  G08G5/0034 ,  G08G5/0039 ,  G08G5/006

Abstract: A method of planning a flight path for a search can include receiving, by a control system, an indication of a search area boundary; receiving, by the control system, an indication of a selected search pattern; determining, by the control system, a flight path based on the search area boundary and the selected search pattern; and transmitting one or more indications of the flight path to an unmanned aerial vehicle.

公开(公告)号：US09809594B2

公开(公告)日：2017-11-07

申请号：US14917553

申请日：2014-09-10

Applicant: University of Washington Through its Center for Commercialization

Inventor： Samson A. Jenekhe ,  Haiyan Li ,  Taeshik Earmme ,  Guoqiang Ren

IPC: C07D471/22 ,  H01L51/00 ,  C09B5/62 ,  C09B57/00 ,  H01L51/05 ,  H01L51/42

CPC classification number: C07D471/22 ,  C09B5/62 ,  C09B57/00 ,  H01L51/0053 ,  H01L51/0072 ,  H01L51/0541 ,  H01L51/4253 ,  Y02E10/549

Abstract: Non-fullerene electron acceptors for highly efficient organic photovoltaic devices are described. The non-fullerene electron acceptors have an extended, rigid, π-conjugated electron-deficient framework that can facilitate exciton and charge derealization. The non-fullerene electron acceptors can physically mix with a donor polymer and facilitate improved electron transport. The non-fullerene electron acceptors can be incorporated into organic electronic devices, such as photovoltaic cells.

公开(公告)号：US20170274046A1

公开(公告)日：2017-09-28

申请号：US15617968

申请日：2017-06-08

Applicant: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

Inventor： Richard S. Morrison ,  David Boyu Wang

IPC: A61K38/17 ,  A01K67/027 ,  A61K9/00 ,  C07K14/47 ,  G01N33/68 ,  A61K48/00

CPC classification number: A01K67/0276 ,  A01K2217/052 ,  A01K2217/075 ,  A01K2217/15 ,  A01K2227/105 ,  A01K2267/0312 ,  A01K2267/0356 ,  A61K9/0085 ,  A61K38/1709 ,  A61K48/00 ,  A61K48/005 ,  C07K14/4747 ,  G01N33/6896 ,  G01N2333/4703 ,  G01N2800/28 ,  G01N2800/50 ,  G01N2800/52

Abstract: Provided herein are methods, assays and compositions relating to the treatment of neurological diseases and disorders, particularly by modulating expression and/or activity of Bif-1.

公开(公告)号：US09770710B2

公开(公告)日：2017-09-26

申请号：US14769314

申请日：2014-02-20

Applicant: University of Washington through its Center for Commercialization

Inventor： Karen I. Goldberg ,  D. Michael Heinekey ,  James M. Mayer ,  Alexander J. M. Miller ,  Timothy P. Brewster

IPC: B01J31/18 ,  C07C29/149 ,  C07C67/08 ,  B01J31/22

CPC classification number: B01J31/182 ,  B01J31/1815 ,  B01J31/183 ,  B01J31/2295 ,  B01J2231/643 ,  B01J2531/822 ,  B01J2531/827 ,  C07C29/149 ,  C07C67/08

Abstract: Improved catalytic methods are disclosed. The methods include both hydrogenation and disproportionation catalysis. While the reaction conditions for hydrogenation and disproportionation differ, the catalysts disclosed herein can be used for either process. In certain aspects, the methods utilize a catalyst: CpM(N—N)Ln; wherein Cp is a substituted or unsubstituted cyclopentadienyl ligand; wherein M is selected from the group consisting of Ir and Rh; wherein N—N is a substituted or unsubstituted bidentate ligand selected from the group consisting of a bipyridine ligand and a phenanthroline ligand; wherein n is 0 or 1; and wherein when n is 1 L is selected from the group consisting of an anion and a molecule of a solvent.

公开(公告)号：US20170231979A1

公开(公告)日：2017-08-17

申请号：US15586762

申请日：2017-05-04

Applicant: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

Inventor： Robert A. STEINER ,  Charles CHAVKIN ,  Donald K. CLIFTON ,  Susan REED ,  Victor NAVARRO

IPC: A61K31/485 ,  A61K31/40 ,  A61K31/439 ,  A61K45/06

CPC classification number: A61K31/485 ,  A61K31/40 ,  A61K31/439 ,  A61K31/47 ,  A61K45/06

Abstract: The present disclosure is generally directed to compositions and methods for treating or limiting development of vasomotor symptoms in a subject.

公开(公告)号：US09707280B2

公开(公告)日：2017-07-18

申请号：US15006341

申请日：2016-01-26

Applicant: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

Inventor： Justin Siegel ,  David Baker ,  Sydney Rin Anna Gordon ,  Ingrid Swanson Pultz ,  Elizabeth Joy Stanley ,  Sarah Jane Wolf

IPC: A61K38/48 ,  C12N9/50

CPC classification number: A61K38/482 ,  A61K38/48 ,  C12N9/50 ,  C12N9/52 ,  C12Y304/21

Abstract: The invention provides compositions and methods for treating celiac sprue.

公开(公告)号：US20170175174A1

公开(公告)日：2017-06-22

申请号：US15301798

申请日：2015-04-08

Applicant: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

Inventor： Daniel T. CHIU ,  Jason E. KREUTZ ,  Gloria S. YEN ,  Bryant S. FUJIMOTO

IPC: C12Q1/68 ,  G01N15/14 ,  G06K9/46 ,  G06K9/00 ,  G06T7/62 ,  G01N21/64 ,  G01N21/47

CPC classification number: C12Q1/6816 ,  G01N15/1434 ,  G01N21/47 ,  G01N21/6428 ,  G01N2015/1445 ,  G01N2021/6439 ,  G06K9/0014 ,  G06K9/4647 ,  G06T7/62 ,  G06T2207/10056 ,  G06T2207/30072 ,  C12Q2531/113 ,  C12Q2537/157 ,  C12Q2563/107 ,  C12Q2563/159

Abstract: Methods, devices, and systems for performing digital assays are provided. In certain aspects, the methods, devices, and systems can be used for the amplification and detection of nucleic acids. In certain aspects, the methods, devices, and systems can be used for the recognition, detection, and sizing of droplets in a volume. Also provided are compositions and kits suitable for use with the methods and devices of the present disclosure.

公开(公告)号：US20170165259A1

公开(公告)日：2017-06-15

申请号：US15387463

申请日：2016-12-21

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

Inventor： Dustin J. MALY ,  Bradley J. Backes ,  Scott A. Oakes ,  Feroz R. Papa ,  Rajarshi Ghosh ,  Likun Wang

IPC: A61K31/4985 ,  A61K45/06 ,  A61K31/381

CPC classification number: A61K31/4985 ,  A61K31/37 ,  A61K31/381 ,  A61K31/437 ,  A61K31/496 ,  A61K31/60 ,  A61K31/706 ,  A61K45/06 ,  A61K2300/00

Abstract: Described herein, inter alia, are combined compositions of an Ire1 kinase modulating compound and an Ire1 ribonuclease modulating compound and methods of using the same.

公开(公告)号：US09670495B2

公开(公告)日：2017-06-06

申请号：US14770074

申请日：2014-02-25

Applicant: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

Inventor： Maitreya Dunham ,  Ivan Liachko

IPC: C12Q1/68 ,  C12Q1/00 ,  C12N15/81 ,  C12N15/69

CPC classification number: C12N15/81 ,  C12N15/69 ,  C12N15/815

Abstract: A DNA sequence that functions as an origin in many different yeast species. From 1 to 17 mutations can be introduced into this sequence to improve its function across multiple yeasts. The resulting synthetic DNA sequence confers stable plasmid replication function in all yeast species tested, including but not limited to Saccharomyces cerevisiae, Lachancea kluyveri, Kluyveromyces lactis, Kluyveromyces wickerhammii, Hansenula polymorpha, and Pichia pastoris. Also provided are sequences that function as an optimal origin in the industrially useful Pichia pastoris.

公开(公告)号：US20170150912A1

公开(公告)日：2017-06-01

申请号：US15430334

申请日：2017-02-10

Applicant: University of Washington through its Center for Commercialization

Inventor： Kenneth Schenkman ,  Lorilee Arakaki ,  Wayne Ciesielski ,  Jeremy Shaver

IPC: A61B5/1455 ,  A61B5/145

CPC classification number: A61B5/14552 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14551 ,  A61B5/6801 ,  A61B5/7271 ,  A61B2090/3614 ,  A61B2562/0238 ,  A61B2562/043

Abstract: A system and method for noninvasively determining the oxygenation of a tissue, for example, a muscle, in vivo uses optical methods to optically interrogate the tissue in both a visible wavelength range and a near infrared (NIR) wavelength range. The illuminating light is sculpted in intensity to approximately match the absorbance spectrum, for example, with the visible light having an intensity an order of magnitude greater than the NIR light. Training data is obtained from healthy patients in both the visible and NIR ranges simultaneously and used to calculate muscle oxygenation.