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公开(公告)号：US10150963B2
公开(公告)日：2018-12-11
申请号：US15470814
申请日：2017-03-27
Applicant: 10X GENOMICS, INC.
Inventor： Benjamin Hindson , Serge Saxonov , Kevin Ness , Paul Hardenbol , Christopher Hindson , Donald Masquelier , Mirna Jarosz , Michael Schnall-Levin
IPC: C12N15/10 , C12Q1/6806 , C12N15/11 , C12Q1/6876 , G01N33/543 , C12Q1/6874
Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing.
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公开(公告)号：US20180265928A1
公开(公告)日：2018-09-20
申请号：US15985388
申请日：2018-05-21
Applicant: 10X Genomics, Inc.
Inventor： Michael Schnall-Levin , Mirna Jarosz , Christopher Hindson , Kevin Ness , Serge Saxonov , Benjamin Hindson , Xinying Zheng , Patrick Marks , John Stuelpnagel
IPC: C12Q1/6883 , C12Q1/6827 , G06F19/22
CPC classification number: C12Q1/6883 , C12Q1/6827 , C12Q2600/156 , G16B30/00 , C12Q2535/122 , C12Q2537/16 , C12Q2563/159 , C12Q2565/629
Abstract: The present disclosure relates to methods, compositions and systems for haplotype phasing and copy number variation assays. Included within this disclosure are methods and systems for combining the barcode comprising beads with samples in multiple separate partitions, as well as methods of processing, sequencing and analyzing barcoded samples.
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公开(公告)号：US20180236443A1
公开(公告)日：2018-08-23
申请号：US15958391
申请日：2018-04-20
Applicant: 10X Genomics, Inc.
Inventor： Donald A. Masquelier , Benjamin Hindson , Kevin Ness , Rajiv Bharadwaj
IPC: B01L3/00 , F16K99/00 , B01L9/00 , C12Q1/6874
CPC classification number: B01L3/50273 , B01L9/527 , B01L2200/027 , B01L2200/0673 , B01L2200/10 , B01L2300/043 , B01L2300/0609 , B01L2300/0636 , B01L2300/0864 , B01L2300/10 , B01L2300/14 , B01L2300/18 , B01L2400/0487 , B01L2400/0605 , C12Q1/6874 , F16K99/0057 , F16K2099/0084
Abstract: An integrated system for processing and preparing samples for analysis may include a microfluidic device including a plurality of parallel channel networks for partitioning the samples including various fluids, and connected to a plurality of inlet and outlet reservoirs, at least a portion of the fluids comprising reagents, a holder including a closeable lid hingedly coupled thereto, in which in a closed configuration, the lid secures the microfluidic device in the holder, and in an open configuration, the lid is a stand orienting the microfluidic device at a desired angle to facilitate recovery of partitions or droplets from the partitioned samples generated within the microfluidic device, and an instrument configured to receive the holder and apply a pressure differential between the plurality of inlet and outlet reservoirs to drive fluid movement within the channel networks.
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公开(公告)号：US20180094312A1
公开(公告)日：2018-04-05
申请号：US15831726
申请日：2017-12-05
Applicant: 10X Genomics, Inc.
Inventor： Benjamin Hindson , Christopher Hindson , Michael Schnall-Levin , Kevin Ness , Mirna Jarosz , Serge Saxonov , Paul Hardenbol , Rajiv Bharadwaj , Xinying Zheng , Phillip Belgrader
IPC: C12Q1/68
CPC classification number: C12Q1/6874 , C12Q1/6804 , C12Q1/6806 , C12Q1/683 , C12Q2525/191 , C12Q2537/143 , C12Q2563/179 , C12Q2535/122 , C12Q2563/149 , C12Q2563/159 , C12Q2565/629
Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing.
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65.发明申请公开(公告)号：US20180008984A1
公开(公告)日：2018-01-11
申请号：US15687856
申请日：2017-08-28
Applicant: 10X Genomics, Inc.
Inventor： Rajiv Bharadwaj , Kevin Ness , Debkishore Mitra , Donald Masquelier , Anthony Makarewicz , Christopher Hindson , Benjamin Hindson , Serge Saxonov
CPC classification number: B01L3/502761 , B01L3/0241 , B01L3/502784 , B01L2200/0673 , B01L2300/0816 , B01L2400/049 , B01L2400/086 , G01N35/085 , G01N2035/00237 , G01N2035/1034
Abstract: The disclosure provides devices, systems and methods for the generation of encapsulated reagents and the partitioning of encapsulated reagents for use in subsequent analyses and/or processing, such as in the field of biological analyses and characterization.
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Patent Agency Ranking
公开(公告)号：US20170335385A1
公开(公告)日：2017-11-23
申请号：US15392557
申请日：2016-12-28
Applicant: 10X GENOMICS, INC.
Inventor： Benjamin Hindson , Serge Saxonov , Kevin Ness , Paul Hardenbol
IPC: C12Q1/68
CPC classification number: C12Q1/6874 , C12Q1/6806 , C12Q1/683 , C12Q2525/191 , C12Q2537/143 , C12Q2563/179
Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing.
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公开(公告)号：US20160304860A1
公开(公告)日：2016-10-20
申请号：US15200928
申请日：2016-07-01
Applicant: 10X Genomics, Inc.
Inventor： Benjamin Hindson , Mirna Jarosz , Paul Hardenbol , Michael Schnall-Levin , Kevin Ness , Serge Saxonov
CPC classification number: C12N15/1065 , C12N15/11 , C12Q1/6806 , C12Q1/6874 , C12Q1/6876 , C12Q2600/112 , G01N33/5436
Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing. In some cases, this disclosure provides methods for the generation of polynucleotide barcode libraries, and for the attachment of such polynucleotides to target polynucleotides.
Abstract translation: 本公开提供了用于多核苷酸处理的组合物，方法，系统和装置。 这种多核苷酸处理可用于多种应用，包括多核苷酸测序。 在一些情况下，本公开提供了产生多核苷酸条形码文库以及将这些多核苷酸连接到靶多核苷酸的方法。
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公开(公告)号：US09410201B2
公开(公告)日：2016-08-09
申请号：US14680808
申请日：2015-04-07
Applicant: 10X Genomics, Inc.
Inventor： Benjamin Hindson , Serge Saxonov , Kevin Ness , Paul Hardenbol
CPC classification number: C12Q1/6874 , C12Q1/6806 , C12Q1/683 , C12Q2525/191 , C12Q2537/143 , C12Q2563/179
Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing.
Abstract translation: 本公开提供了用于多核苷酸处理的组合物，方法，系统和装置。 这种多核苷酸处理可用于多种应用，包括多核苷酸测序。
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公开(公告)号：US20250066851A1
公开(公告)日：2025-02-27
申请号：US18945323
申请日：2024-11-12
Applicant: 10x Genomics, Inc.
Inventor： Benjamin Hindson , Christopher Hindson , Michael Schnall-Levin , Kevin Ness , Mirna Jarosz , Serge Saxonov
IPC: C12Q1/6874 , C12Q1/6806 , C12Q1/6855 , C12Q1/6869
Abstract: This disclosure provides methods and compositions for sample processing, particularly for sequencing applications. Included within this disclosure are bead compositions, such as diverse libraries of beads attached to large numbers of oligonucleotides containing barcodes. Often, the beads provides herein are degradable. For example, they may contain disulfide bonds that are susceptible to reducing agents. The methods provided herein include methods of making libraries of barcoded beads as well as methods of combining the beads with a sample, such as by using a microfluidic device.
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公开(公告)号：US20250033054A1
公开(公告)日：2025-01-30
申请号：US18913548
申请日：2024-10-11
Applicant: 10x Genomics, Inc.
Inventor： Rajiv Bharadwaj , Kevin Ness , Tobias Daniel Wheeler
IPC: B01L3/00 , G01N1/28 , G01N33/487
Abstract: Microfluidic channels networks and systems are provided. One network includes a first fluid channel having a first depth dimension; at least a second channel intersecting the first channel at a first intersection; at least a third channel in fluid communication with the first intersection, at least one of the first intersection and the third channel having a depth dimension that is greater than the first depth dimension. Also provided is a flow control system for directing fluids in the network. Systems are additionally provided for flowing disrupted particles into a droplet formation junction, whereby a portion of the disrupted particles or the contents thereof are encapsulated into one or more droplets. Further provided is a method for controlling filling of a microfluidic network by controlling passive valving microfluidic channel network features.
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