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公开(公告)号：US10722354B2
公开(公告)日：2020-07-28
申请号：US16214561
申请日：2018-12-10
Applicant: Edwards Lifesciences Corporation
Inventor： Hanoch Cohen-Tzemach , Tamir S. Levi , Noam Nir , Bella Felsen
IPC: A61F2/24
Abstract: Embodiments of a prosthetic heart valve are disclosed. An implantable prosthetic valve may be radially collapsible to a collapsed configuration and radially expandable to an expanded configuration. The prosthetic valve may comprise an annular frame, a leaflet structure positioned within the frame and a plurality of outer skirts positioned around an outer surface of the frame, each outer skirt comprising an inflow edge secured to the frame and an outflow edge secured at intervals to the frame. The plurality of outer skirts may include a first outer skirt and a second outer skirt, wherein in the expanded configuration the first and second outer skirts include openings unsecured to the frame between the intervals. The inflow edge of the first annular outer skirt may be secured to the frame with sutures including radiopaque material. The first annular outer skirt may include radiopaque dye.
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公开(公告)号：US20160317305A1
公开(公告)日：2016-11-03
申请号：US15140387
申请日：2016-04-27
Applicant: Edwards Lifesciences Corporation
Inventor： Itai Pelled , Elena Sherman , Eran Goldberg , Kevin D. Rupp , Noam Nir
CPC classification number: B29C66/53245 , A61F2/2412 , A61F2/2415 , A61F2/2418 , A61F2/2433 , A61F2210/0076 , A61F2230/0069 , A61F2240/001 , A61F2250/0069
Abstract: The present disclosure relates to laminated sealing members for prosthetic valves and methods of making the same. In a representative embodiment, an implantable prosthetic valve that is radially collapsible to a collapsed configuration and radially expandable to an expanded configuration comprises an annular frame having an inflow end and an outflow end, a leaflet structure positioned within the frame and secured thereto, and a laminate sealing member comprising an encapsulating material. The laminate sealing member has a main portion that encapsulates at least a portion of the frame and an end portion extending from the inflow end of the frame, and the end portion of the laminate sealing member is folded to form a cuff adjacent the inflow end of the frame and secured to the main portion of the laminate sealing member.
Abstract translation: 本公开涉及用于人造瓣的层压密封构件及其制造方法。 在代表性的实施例中，可径向可折叠到收缩构造并且可径向扩张到扩张构造的可植入假体瓣包括具有流入端和流出端的环形框架，定位在框架内并固定到其上的小叶结构， 层压密封件包括封装材料。 层叠密封构件具有封闭框架的至少一部分的主要部分和从框架的流入端延伸的端部，并且层叠密封构件的端部折叠形成邻近流入端的套筒 框架并固定到层压密封件的主要部分。
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公开(公告)号：US20250127616A1
公开(公告)日：2025-04-24
申请号：US19007924
申请日：2025-01-02
Applicant: EDWARDS LIFESCIENCES CORPORATION
Inventor： Noam Nir , Elena Sherman , Michael Bukin , Tomer Saar
IPC: A61F2/24
Abstract: A prosthetic valve can include a radially expandable and compressible frame having a plurality of struts, each strut having a first end, a second end, and a length extending from the first end to the second end. Each strut further including a plurality of recesses disposed on one or more longitudinal edges of the strut and extending into a width of the strut. The prosthetic valve further including a valvular structure disposed within and coupled to the frame, the valvular structure comprising a plurality of leaflets, and a skirt mounted to the frame via one or more sutures. The recesses retain the one or more sutures and prevent the one or more sutures from sliding along the length of the strut.
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公开(公告)号：US20250041053A1
公开(公告)日：2025-02-06
申请号：US18920663
申请日：2024-10-18
Applicant: EDWARDS LIFESCIENCES CORPORATION
Inventor： Tamir S. Levi , Shahram Zamani , Michael Bukin , Ziv Yohanan , Noam Nir , Tyler Dale O'Dell , Elena Sherman
IPC: A61F2/24
Abstract: A method of assembling a valvular structure can include folding an upper tab of a first leaflet onto a lower tab of the first leaflet, disposing a first end of a reinforcing member on the upper tab, disposing a commissure member adjacent the lower tab, and coupling the first end of the reinforcing member, the tabs of the first leaflet, and the commissure member to one another. The method can further include folding an upper tab of a second leaflet onto a lower tab of the second leaflet, disposing the second leaflet adjacent the first leaflet such that the commissure member is positioned between the lower tabs, disposing a second end of the reinforcing member on the upper tab of the second leaflet, and coupling the reinforcing member, the upper and lower tabs of the second leaflet, and the commissure member to one another to form a commissure.
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公开(公告)号：US12201522B2
公开(公告)日：2025-01-21
申请号：US18207822
申请日：2023-06-09
Applicant: EDWARDS LIFESCIENCES CORPORATION
Inventor： Alexander Barash , Yair A. Neumann , Tomer Saar , Ziv Yohanan , Noam Nir
Abstract: In one embodiment, a method of assembling a prosthetic valve can comprise forming a radially expandable and compressible frame by pivotally joining together a plurality of struts without requiring individual rivets. In some embodiments, the frame is formed by interweaving the struts, which can be joined using integral hinges formed in the struts, such as by performing alternate cuts on the struts, bending the struts to form stopper tabs adjacent to joints and/or drilling holes in the struts to facilitate interconnecting struts at joints, or otherwise forming integral hinges and corresponding holes at junction points between the struts. In other embodiments, separate hinges are provided to interconnect the struts. In still other embodiments, separate flanged rivets are provided to connect the struts.
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Patent Agency Ranking
公开(公告)号：US20250009503A1
公开(公告)日：2025-01-09
申请号：US18891007
申请日：2024-09-20
Applicant: EDWARDS LIFESCIENCES CORPORATION
Inventor： Noa Axelrod Manela , Michael Bukin , Noam Nir , Eran Goldberg
Abstract: The present disclosure relates to prosthetic valves that include valvular structures retained between two frames coupled to each other. In an example, the prosthetic valve includes a main frame, an inner frame which is disposed radially inwardly from, and is coupled to, the main frame, and a valvular structure disposed between the main frame and the inner frame. The main frame is movable between a radially compressed state and a radially expanded state. The inner frame comprises a plurality of struts and a plurality of spikes extending from at least some of the plurality of struts. The plurality of spikes are engaged with the valvular structure.
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公开(公告)号：US20240415645A1
公开(公告)日：2024-12-19
申请号：US18817003
申请日：2024-08-27
Applicant: EDWARDS LIFESCIENCES CORPORATION
Inventor： Alexander Barash , Yair A. Neumann , Tomer Saar , Ziv Yohanan , Noam Nir
Abstract: In one embodiment, a method of assembling a prosthetic valve can comprise forming a radially expandable and compressible frame by pivotally joining together a plurality of struts without requiring individual rivets. In some embodiments, the frame is formed by interweaving the struts, which can be joined using integral hinges formed in the struts, such as by performing alternate cuts on the struts, bending the struts to form stopper tabs adjacent to joints and/or drilling holes in the struts to facilitate interconnecting struts at joints, or otherwise forming integral hinges and corresponding holes at junction points between the struts. In other embodiments, separate hinges are provided to interconnect the struts. In still other embodiments, separate flanged rivets are provided to connect the struts.
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公开(公告)号：US12121435B2
公开(公告)日：2024-10-22
申请号：US17851328
申请日：2022-06-28
Applicant: Edwards Lifesciences Corporation
Inventor： Noam Nir , Elena Sherman
CPC classification number: A61F2/2415 , A61F2/2418 , B29C65/62 , B29C66/1142 , A61F2220/0075 , A61F2240/001 , B29L2031/7534
Abstract: Assembly methods for installing a leaflet assembly to an expandable frame of a prosthetic heart valve are described. The leaflet assembly comprises a plurality of leaflets coupled together at adjacent tabs, which form respective commissure tab assemblies. The commissure tab assemblies are inserted into corresponding windows of support members of the expandable frame. One or more wedge members are inserted into the commissure tab assembly, e.g., between the adjacent tabs or with the adjacent tabs therebetween, to restrain radial motion of the commissure tab assembly with respect to the window. The window can be a closed window, and the wedge member insertion can be after the commissure tab assembly is inserted into the window. Alternatively, the window can be an open window or channel, and the wedge member insertion can be before the commissure tab assembly is installed in the window.
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公开(公告)号：US20240207046A1
公开(公告)日：2024-06-27
申请号：US18522551
申请日：2023-11-29
Applicant: EDWARDS LIFESCIENCES CORPORATION
Inventor： Nikolai Gurovich , Michael Bukin , Anatoly Dvorsky , Eran Grosu , Noam Nir , Joseph Mordechai Leichner , Elena Sherman , Guillermo W. Moratorio
IPC: A61F2/24
CPC classification number: A61F2/2418 , A61F2220/0008 , A61F2220/0025
Abstract: A prosthetic heart valve comprises a radially expandable frame comprising an outflow end and an inflow end, and a plurality of valve leaflets disposed within and coupled to the frame. Each leaflet comprises a main body having an outflow edge portion and an inflow edge portion, wherein the leaflets are configured to move between an open state and a closed state in which the outflow edge portions coapt with each other and block the flow of blood through the frame from the outlet end to the inlet end, wherein the inflow edge portion of each leaflet includes a movable portion that can move radially inwardly when the leaflets move to the closed state to assist with the coaptation of the outflow edge portions of the leaflets and radially outwardly when the leaflets move to the open state.
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公开(公告)号：US11931258B2
公开(公告)日：2024-03-19
申请号：US16863675
申请日：2020-04-30
Applicant: Edwards Lifesciences Corporation
Inventor： Boaz Manash , Oren Cohen , Noam Nir , Ilan Tamir , Eitan Atias , Ofir Witzman , Michal Aliza Ruchelsman
CPC classification number: A61F2/2436 , A61F2/2418 , A61F2/2433 , A61F2/2439 , A61M25/0029 , A61M25/0068 , A61M25/0138 , A61M25/09 , A61B1/0057 , A61B17/00234 , A61B2017/003 , A61B2017/00309 , A61B2017/00318 , A61B2017/00323 , A61F2002/9511 , A61F2/9517 , A61F2220/0008 , A61M2025/0039 , A61M25/0133 , A61M25/0147 , A61M2025/015
Abstract: Devices, systems and methods are described herein to provide improved steerability for delivering a prosthesis to a body location, for example, for delivering a replacement mitral valve to a native mitral valve location. The delivery system can include a number of advantageous steering and delivery features, in particular for the transseptal delivery approach.
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