公开(公告)号：US20200319176A1

公开(公告)日：2020-10-08

申请号：US16484678

申请日：2018-02-08

Applicant: Essenlix Corporation

Inventor： Stephen Y. Chou ,  Wei Ding ,  Yufan Zhang ,  Ji Qi ,  Ji LI

IPC: G01N33/543 ,  G01N33/558 ,  G01N1/40 ,  G01N21/64 ,  G01N21/65 ,  G01N21/69 ,  G01N21/76

Abstract: The present invention provides, among other things, QMAX card based assays in different forms for various analytes, offering simpler, fast, more sensitive assaying.

公开(公告)号：US20200254445A1

公开(公告)日：2020-08-13

申请号：US16640312

申请日：2018-08-01

Applicant: Essenlix Corporation

Inventor： Stephen Y. Chou ,  Wei Ding ,  Ji Qi ,  Jun Tian ,  Yuecheng Zhang

IPC: B01L3/00 ,  G01N1/28 ,  G01N33/50 ,  G01N15/14

Abstract: The present invention provides devices, systems, and methods, for performing biological and chemical assays.

公开(公告)号：US20200078792A1

公开(公告)日：2020-03-12

申请号：US16484998

申请日：2018-02-15

Applicant: Essenlix Corporation

Inventor： Stephen Y. Chou ,  Wei Ding ,  Yufan Zhang ,  Ji Qi

IPC: B01L7/00 ,  B01L3/00 ,  C12Q1/686

Abstract: The present invention provides devices, systems, and methods for rapid and easy-to-use in sample thermal cycling or temperature changes for the facilitation of reactions such as but not limited to PCR.

公开(公告)号：US20200033288A1

公开(公告)日：2020-01-30

申请号：US16484256

申请日：2018-02-08

Applicant: Essenlix Corporation

Inventor： Stephen Y. Chou ,  Wei Ding ,  Yufan Zhang

IPC: G01N27/403 ,  G01N33/49 ,  G01N35/00 ,  B01L3/00 ,  G01N1/28 ,  G01N1/38 ,  G01N33/543 ,  G01N21/84

Abstract: Described are methods and devices that can accelerate the process and quantify the parameters for bio/chemical material samples. In some embodiments, a QMAX (Q: quantification; M: magnifying; A: adding reagents; X: acceleration) device having two or more electrodes capable of accelerating the electrical measurement process of the samples. In addition, the electrical measurement technology of the QMAX device enables for extraction, separation, and purification of sample components, such as but not limited to nucleic acids. In some embodiments, the QMAX device includes a plate for hosting a small sensing chip to facilitate a bio/chemical sensing of the sensing chip.

公开(公告)号：US20250099965A1

公开(公告)日：2025-03-27

申请号：US18809075

申请日：2024-08-19

Applicant: Essenlix Corporation

Inventor： Stephen Y. Chou ,  Wei Ding ,  Hua Tan

IPC: B01L7/00 ,  B01L3/00

Abstract: The present invention provides, among other things, the devices and methods that can rapidly change or cycle (i.e. heat and cool) a sample temperature with high speed, less heating energy, high energy efficiency, a compact and simplified apparatus (e.g. handheld), easy and fast operation, and/or low cost.

公开(公告)号：US12120407B2

公开(公告)日：2024-10-15

申请号：US17896973

申请日：2022-08-26

Applicant: Essenlix Corporation

Inventor： Stephen Y. Chou ,  Wei Ding ,  Yufan Zhang ,  Ji Qi ,  Jun Tian ,  Wei Dong

IPC: H04N23/51 ,  G01N21/84 ,  H04N23/55 ,  H04N23/56 ,  H04N23/57

CPC classification number: H04N23/51 ,  G01N21/8483 ,  H04N23/55 ,  H04N23/56 ,  H04N23/57

Abstract: The present disclosure relates to devices, apparatus and methods of improving the accuracy of an image-based assay. One aspect of the present invention is to sandwich a sample between two plates and add reference marks in the sample areas of the plates, with at least one of the geometric and/optical properties of the reference marks being predetermined and known, and taking images of the sample with the reference marks, and applying a machine learning model in the analysis of the image-based assay.

公开(公告)号：US12007320B2

公开(公告)日：2024-06-11

申请号：US18215302

申请日：2023-06-28

Applicant: Essenlix Corporation

Inventor： Stephen Y. Chou ,  Wu Chou ,  Xing Li ,  Hongbing Li ,  Yuecheng Zhang ,  Mingquan Wu ,  Wei Ding ,  Jun Tian

IPC: G01N15/1433 ,  G06N20/00 ,  G06T7/00 ,  G06T7/10 ,  G06T7/40 ,  G06T7/62

CPC classification number: G01N15/1433 ,  G06N20/00 ,  G06T7/0012 ,  G06T7/10 ,  G06T7/40 ,  G06T7/62 ,  G06T2207/10056 ,  G06T2207/30004 ,  G06T2207/30024 ,  G06T2207/30204

Abstract: The present invention is related to, among other things, the devices and methods that improve the accuracy and reliability of an assay, even when the assay device and/or the operation of the assay device has certain errors, and in some embodiments the errors are random.

公开(公告)号：US11940382B2

公开(公告)日：2024-03-26

申请号：US16484803

申请日：2018-02-08

Applicant: Essenlix Corporation

Inventor： Stephen Y. Chou ,  Wei Ding ,  Yufan Zhang ,  Ji Qi ,  Ji Li

IPC: G01N21/65 ,  G01N21/64 ,  G01N21/66 ,  G01N33/543 ,  G01N33/58

CPC classification number: G01N21/65 ,  G01N21/64 ,  G01N21/66 ,  G01N33/54366 ,  G01N33/582 ,  G01N2201/06113

Abstract: A homogeneous assay method that employs a device is provided. In some embodiments, the device contains a pair of plates that can be opened and closed. The sample is placed between two plates. In some embodiments, the thickness of the sample in a closed configuration, the concentration of labels, and amplification factor of the amplification surface are configured to make the label(s) bound on the amplification surface visible without washing away of the unbound labels.

公开(公告)号：US11885952B2

公开(公告)日：2024-01-30

申请号：US16526864

申请日：2019-07-30

Applicant: Essenlix Corporation

Inventor： Stephen Y. Chou ,  Wei Ding ,  Ji Qi ,  Yuecheng Zhang ,  Wu Chou ,  Mingquan Wu ,  Xing Li ,  Jun Tian

IPC: G02B21/34 ,  G01N33/543 ,  G01N33/50

CPC classification number: G02B21/34 ,  G01N33/54386 ,  G01N33/5094 ,  G01N2496/05

Abstract: A method of assaying an analyte in a sample is disclosed. The method includes having a sample holder with a sample contact area for contacting a sample with an analyte, having a plurality of calibration structures on the sample contact area of the sample holder, imaging a part of the sample contact area that has the calibration structures, and using an algorithm that includes an image, calibration structures in the image, and artificial intelligence and/or machine learning to identify the analyte and/or determine the analyte concentration.

公开(公告)号：US11719618B2

公开(公告)日：2023-08-08

申请号：US17268847

申请日：2019-08-28

Applicant: Essenlix Corporation

Inventor： Stephen Y. Chou ,  Wei Ding ,  Wu Chou ,  Jun Tian ,  Yuecheng Zhang ,  Mingquan Wu ,  Xing Li

IPC: G01N15/14 ,  G02B21/34 ,  G06T7/00 ,  G06V10/34 ,  G06V10/44 ,  G06V20/69 ,  G06F18/2413 ,  G06V10/764 ,  G06V10/82 ,  G01N15/10

CPC classification number: G01N15/1475 ,  G02B21/34 ,  G06F18/24143 ,  G06T7/0012 ,  G06V10/34 ,  G06V10/44 ,  G06V10/454 ,  G06V10/764 ,  G06V10/82 ,  G06V20/69 ,  G01N2015/1006 ,  G06T2207/30004

Abstract: One aspect of the present invention is to provide systems and methods that improve the accuracy of an assay that comprise at least one or more parameters each having a random error.