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395 条记录 (耗时 0.071 秒)

    METHOD OF FABRICATION OF HIGHLY HEAT DISSIPATIVE SUBSTRATES
    63.
    发明申请
    METHOD OF FABRICATION OF HIGHLY HEAT DISSIPATIVE SUBSTRATES 有权
    高热耗散基板的制造方法

    公开(公告)号：US20080194084A1

    公开(公告)日：2008-08-14

    申请号：US11774201

    申请日：2007-07-06

    申请人： Oleg Kononchuk ,  Fabrice Letertre ,  Robert Langer

    发明人： Oleg Kononchuk ,  Fabrice Letertre ,  Robert Langer

    IPC分类号： H01L21/20 ,  H01L29/04

    CPC分类号： H01L21/76254

    摘要： The invention relates to a method for fabricating a composite structure having heat dissipation properties greater than a bulk single crystal silicon structure having the same dimensions. The structure includes a support substrate, a top layer and an oxide layer between the support substrate and the top layer. The method includes providing a top layer made of a crystalline material, providing a support substrate of a polycrystalline material having heat dissipation properties greater than that of a bulk single crystal silicon substrate of the same dimensions; providing an oxide layer on at least one of the top layer or the support substrate; bonding the top layer and support substrate together to obtain a composite structure having the top layer, the support substrate and the oxide layer located at a bonding interface between the top layer and support substrate, and heat treating the composite structure in a non-oxidizing atmosphere at a predetermined temperature and for a predetermined duration to dissolve at least part of the oxide layer and increase the heat dissipation properties of the composite structure compared to the composite structure prior to the heat treating.

    摘要翻译： 本发明涉及一种制造具有大于具有相同尺寸的体单晶硅结构的散热特性的复合结构的方法。 该结构包括在支撑基板和顶层之间的支撑基板，顶层和氧化物层。 该方法包括提供由结晶材料制成的顶层，提供具有大于相同尺寸的本体单晶硅衬底的散热特性的多晶材料的支撑衬底; 在顶层或支撑衬底中的至少一个上提供氧化物层; 将顶层和支撑衬底粘合在一起以获得具有位于顶层和支撑衬底之间的结合界面处的顶层，支撑衬底和氧化物层的复合结构，并且在非氧化性气氛中热处理复合结构 在预定温度和预定时间内溶解氧化物层的至少一部分，并且在热处理之前与复合结构相比增加了复合结构的散热性能。

    Polymers for functional particles
    67.
    发明申请
    Polymers for functional particles 有权
    功能颗粒聚合物

    公开(公告)号：US20080081074A1

    公开(公告)日：2008-04-03

    申请号：US11803843

    申请日：2007-05-15

    申请人： Frank Gu ,  Benjamin Teply ,  Robert Langer ,  Omid Farokhzad

    发明人： Frank Gu ,  Benjamin Teply ,  Robert Langer ,  Omid Farokhzad

    IPC分类号： A61K9/14 ,  A61K38/43 ,  C40B50/00 ,  A61K47/32

    CPC分类号： C08G63/912 ,  A61K9/5153 ,  A61K47/549 ,  A61K47/593 ,  A61K47/60 ,  A61K47/6935 ,  A61K47/6937 ,  A61K49/00 ,  A61K51/1244 ,  B82Y5/00 ,  Y10S977/773 ,  Y10S977/906 ,  Y10S977/915 ,  Y10T428/2982

    摘要： The present invention generally relates to polymers and macromolecules, in particular, to block polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. The moiety, in some embodiments, may have a molecular weight greater than about 1000 Da; for example, the moiety may include a polypeptide or a polynucleotide, such as an aptamer. The moiety may also be a targeting moiety, an imaging moiety, a chelating moiety, a charged moiety, or a therapeutic moiety. Another aspect of the invention is directed to systems and methods of producing such polymeric conjugates. In some embodiments, a solution containing a polymer is contacted with a liquid, such as an immiscible liquid, to form nanoparticles containing the polymeric conjugate. Other aspects of the invention are directed to methods using such libraries, methods of using or administering such polymeric conjugates, methods of promoting the use of such polymeric conjugates, kits involving such polymeric conjugates, or the like.

    摘要翻译： 本发明一般涉及聚合物和大分子，特别是阻止可用于颗粒如纳米颗粒的聚合物。 本发明的一个方面涉及一种开发具有所需性质的纳米颗粒的方法。 在一组实施方案中，该方法包括制备具有高度控制性质的纳米颗粒的文库，其可通过将两种或多种不同比例的大分子混合在一起形成。 一个或多个大分子可以是部分与生物相容性聚合物的聚合物缀合物。 在一些情况下，纳米颗粒可以含有药物。 在一些实施方案中，该部分可具有大于约1000Da的分子量; 例如，该部分可以包括多肽或多核苷酸，例如适体。 该部分还可以是靶向部分，成像部分，螯合部分，带电部分或治疗部分。 本发明的另一方面涉及制备这种聚合物缀合物的系统和方法。 在一些实施方案中，将含有聚合物的溶液与诸如不混溶液体的液体接触以形成含有聚合物缀合物的纳米颗粒。 本发明的其它方面涉及使用这种文库的方法，使用或施用这种聚合物缀合物的方法，促进使用这种聚合物缀合物的方法，涉及这种聚合物缀合物的试剂盒等。

    Compositions And Methods For Inhibiting Adhesions
    68.
    发明申请
    Compositions And Methods For Inhibiting Adhesions 审中-公开
    用于抑制粘合剂的组合物和方法

    公开(公告)号：US20080069857A1

    公开(公告)日：2008-03-20

    申请号：US11734537

    申请日：2007-04-12

    申请人： Yoon Yeo ,  Taichi Ito ,  Robert Langer ,  Daniel Kohane ,  George Kodokian

    发明人： Yoon Yeo ,  Taichi Ito ,  Robert Langer ,  Daniel Kohane ,  George Kodokian

    IPC分类号： A61K9/14 ,  A61K31/717 ,  A61P43/00 ,  A61K31/721

    CPC分类号： A61L31/145 ,  A61L31/041 ,  A61L31/129 ,  C08J3/075 ,  C08J3/246 ,  C08J2301/28 ,  C08J2305/02 ,  C08J2305/08 ,  C08L1/28 ,  C08L5/08 ,  C08L5/02

    摘要： The present invention provides compositions and methods for inhibiting adhesions. The methods involve administering solutions containing hydrogel precursors such as polysaccharide derivatives, e.g., derivatives of hyaluronic acid, cellulose, or dextran, to a subject at a site where adhesions may form, e.g., as a consequence of surgery, injury, or infection. The hydrogel precursors, e.g., polysaccharide derivatives, become crosslinked following their administration to form a hydrogel that maintains tissue separation. In certain embodiments of the invention one or both solutions contains particles, e.g., polymeric nanoparticles or microparticles, so that a composite hydrogel containing the particles is formed. The solution(s), particle(s), or both, may contain a biologically active agent such as an agent that contributes to inhibiting adhesions. The biologically active agent may be covalently attached to a hydrogel precursor.

    摘要翻译： 本发明提供抑制粘连的组合物和方法。 所述方法包括将诸如多糖衍生物例如透明质酸衍生物，纤维素或葡聚糖的水凝胶前体施用于在可能形成粘连的部位（例如作为手术，损伤或感染的结果）的受试者的溶液。 水凝胶前体，例如多糖衍生物在其施用后变得交联以形成维持组织分离的水凝胶。 在本发明的某些实施方案中，一种或两种溶液含有颗粒，例如聚合物纳米颗粒或微粒，使得形成含有颗粒的复合水凝胶。 溶液，颗粒或两者都可以含有生物活性剂，例如有助于抑制粘连的试剂。 生物活性剂可以共价连接到水凝胶前体。

    Method for Making Microchip Reservoir Device
    69.
    发明申请
    Method for Making Microchip Reservoir Device 审中-公开
    制作Microchip储存器件的方法

    公开(公告)号：US20080047926A1

    公开(公告)日：2008-02-28

    申请号：US11930328

    申请日：2007-10-31

    申请人： John Santini ,  Michael Cima ,  Robert Langer

    发明人： John Santini ,  Michael Cima ,  Robert Langer

    IPC分类号： C25F7/00 ,  A61K9/22

    CPC分类号： A61K9/0009 ,  A61K9/0024 ,  A61K9/0097 ,  A61M5/14276 ,  A61M37/00 ,  A61M2205/0244 ,  C25F5/00 ,  C25F7/00 ,  Y10T137/8242

    摘要： Methods are provide for fabricating a microchip device having containment reservoirs. In one embodiment, the method includes providing a substrate; forming a plurality of reservoirs in the substrate, each reservoir having an opening in a surface of the substrate; fabricating a plurality of metal reservoir caps, each of which closes off one of said openings; and sealing each of said reservoirs. The method may further include loading chemical molecules, such a drug, into each of said reservoirs before said sealing of the reservoirs.

    摘要翻译： 提供制造具有容纳储存器的微芯片装置的方法。 在一个实施例中，该方法包括提供基板; 在所述基板中形成多个储存器，每个储存器在所述基板的表面中具有开口; 制造多个金属容器盖，每个金属容器盖封闭所述开口中的一个; 并密封每个所述储存器。 该方法还可以包括在储存器的所述密封之前将化学分子（例如药物）加载到每个所述储存器中。