公开(公告)号：US10152049B2

公开(公告)日：2018-12-11

申请号：US14281773

申请日：2014-05-19

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Keith Nogueira ,  Xiaolong Li ,  Rajiv Shah ,  Brian T. Kannard

IPC: G05B23/00 ,  A61M5/172 ,  A61M5/142

Abstract: Infusion systems, infusion devices, and related operating methods are provided. An exemplary method of operating an infusion device capable of delivering fluid to a user involves determining one or more signal characteristics associated with a subset of the measurements corresponding to a monitoring period, determining a reliability metric for the monitoring period based on the one or more signal characteristics, and providing indication of a maintenance condition when the reliability metric violates a threshold.

公开(公告)号：US09989491B2

公开(公告)日：2018-06-05

申请号：US15472575

申请日：2017-03-29

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Catherine M. Szyman ,  Michael E. Miller ,  Rajiv Shah

IPC: A61B5/05 ,  G01N27/416 ,  G01R35/00 ,  A61B5/145 ,  A61B5/1473 ,  A61B5/00 ,  A61B5/053 ,  A61B5/1495 ,  G01N33/66 ,  A61B5/1459 ,  A61M5/158 ,  A61B5/1486 ,  A61M5/142 ,  G01N27/02 ,  G01N33/96 ,  G01N33/49 ,  A61M5/172

CPC classification number: G01N27/4163 ,  A61B5/0537 ,  A61B5/0538 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/6849 ,  A61B5/6852 ,  A61B5/7203 ,  A61B5/7221 ,  A61B5/7225 ,  A61B5/7242 ,  A61B5/746 ,  A61B2562/0214 ,  A61B2562/04 ,  A61M5/14244 ,  A61M5/14276 ,  A61M5/1582 ,  A61M5/1723 ,  A61M2005/1726 ,  G01N27/026 ,  G01N27/028 ,  G01N27/416 ,  G01N33/49 ,  G01N33/66 ,  G01N33/96 ,  G01R35/00 ,  G01R35/005

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

公开(公告)号：US09976978B2

公开(公告)日：2018-05-22

申请号：US15640888

申请日：2017-07-03

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Rajiv Shah ,  Wayne A. Morgan ,  David Y. Choy ,  James L. Henke ,  Bahar Reghabi ,  Gopikrishnan Soundararajan ,  Peter Schultz ,  Udo Hoss

IPC: A61B5/00 ,  G01N27/403 ,  A61B5/145 ,  G01N27/327 ,  G01N27/416 ,  A61B5/1473 ,  C12Q1/00

CPC classification number: G01N27/403 ,  A61B5/14532 ,  A61B5/1473 ,  A61B2560/0223 ,  A61B2562/02 ,  C12Q1/006 ,  G01N27/327 ,  G01N27/416

Abstract: A sensor system includes a sensor and a sensor electronics device. The sensor includes a plurality of electrodes. The sensor electronics device includes a connection detection device, a power source, and a delay circuit. The connection detection device determines if the sensor electronics device is connected to the sensor and transmits a connection signal. The delay circuit receives the connection signal, waits a preset hydration time, and couples the regulated voltage from the power source to an electrode in the sensor after the preset hydration time has elapsed. Alternatively, the sensor electronics device may include an electrical detection circuit and a microcontroller. The electrical detection circuit determines if the plurality of electrodes are hydrated and generates an interrupt if the electrodes are hydrated. A microcontroller receives the interrupt and transmits a signal representative of a voltage to an electrode of the plurality of electrodes.

公开(公告)号：US20170197030A1

公开(公告)日：2017-07-13

申请号：US15472575

申请日：2017-03-29

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Catherine M. Szyman ,  Michael E. Miller ,  Rajiv Shah

IPC: A61M5/172 ,  G01N27/416 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1473 ,  A61M5/142 ,  G01N27/02 ,  A61B5/053

CPC classification number: G01N27/4163 ,  A61B5/0537 ,  A61B5/0538 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/6849 ,  A61B5/6852 ,  A61B5/7203 ,  A61B5/7221 ,  A61B5/7225 ,  A61B5/7242 ,  A61B5/746 ,  A61B2562/0214 ,  A61B2562/04 ,  A61M5/14244 ,  A61M5/14276 ,  A61M5/1582 ,  A61M5/1723 ,  A61M2005/1726 ,  G01N27/026 ,  G01N27/028 ,  G01N27/416 ,  G01N33/49 ,  G01N33/66 ,  G01N33/96 ,  G01R35/00 ,  G01R35/005

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

公开(公告)号：US20170185733A1

公开(公告)日：2017-06-29

申请号：US14980293

申请日：2015-12-28

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Keith Nogueira ,  Taly G. Engel ,  Benyamin Grosman ,  Xiaolong Li ,  Bradley C. Liang ,  Rajiv Shah ,  Mike C. Liu ,  Andy Y. Tsai ,  Andrea Varsavsky ,  Jeffrey Nishida

IPC: G06F19/00 ,  G06N3/12 ,  G06N99/00

CPC classification number: G06N20/00 ,  A61B5/14532 ,  A61B5/14735 ,  A61B5/1495 ,  A61B5/6849 ,  G06N3/126 ,  G16H40/40

Abstract: A method for retrospective calibration of a glucose sensor uses stored values of measured working electrode current (Isig) to calculate a final sensor glucose (SG) value retrospectively. The Isig values may be preprocessed, discrete wavelet decomposition applied. At least one machine learning model, such as, e.g., Genetic Programming (GP) and Regression Decision Tree (DT), may be used to calculate SG values based on the Isig values and the discrete wavelet decomposition. Other inputs may include, e.g., counter electrode voltage (Vcntr) and Electrochemical Impedance Spectroscopy (EIS) data. A plurality of machine learning models may be used to generate respective SG values, which are then fused to generate a fused SG. Fused SG values may be filtered to smooth the data, and blanked if necessary.

公开(公告)号：US20170143276A1

公开(公告)日：2017-05-25

申请号：US15422329

申请日：2017-02-01

Applicant: Medtronic Minimed, Inc.

Inventor： Rebecca K. Gottlieb ,  Ying Luo ,  Raghavendhar Gautham ,  Bradley Liang ,  Anirban Roy ,  Kenneth W. Cooper ,  Rajiv Shah ,  Barry Keenan

IPC: A61B5/00 ,  A61M5/172 ,  A61B5/1495 ,  A61B5/145 ,  A61B5/1473

CPC classification number: A61B5/7221 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/1473 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/6849 ,  A61B5/7275 ,  A61B5/743 ,  A61M5/1723 ,  A61M2005/1726 ,  A61M2205/3303 ,  A61M2230/201

Abstract: Disclosed are a system and method for determining a metric and/or indicator of a reliability of a blood glucose sensor in providing glucose measurements. In one aspect, the metric and/or indicator may be computed based, at least in part, on an observed trend associated with signals generated by the blood glucose sensor.

公开(公告)号：US09625415B2

公开(公告)日：2017-04-18

申请号：US15154560

申请日：2016-05-13

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Ning Yang ,  Raghavendhar Gautham ,  Bradley C. Liang ,  Rajiv Shah

IPC: A61B5/1495 ,  G01N27/416 ,  G01N27/02 ,  G01R35/00 ,  A61B5/145 ,  A61B5/1473 ,  G01N33/66 ,  A61B5/1459 ,  A61M5/158 ,  A61B5/1486 ,  A61B5/00 ,  A61B5/053 ,  A61M5/172 ,  A61M5/142

CPC classification number: G01N27/4163 ,  A61B5/0537 ,  A61B5/0538 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/6849 ,  A61B5/6852 ,  A61B5/7203 ,  A61B5/7221 ,  A61B5/7225 ,  A61B5/7242 ,  A61B5/746 ,  A61B2562/0214 ,  A61B2562/04 ,  A61M5/14244 ,  A61M5/14276 ,  A61M5/1582 ,  A61M5/1723 ,  A61M2005/1726 ,  G01N27/026 ,  G01N27/028 ,  G01N27/416 ,  G01N33/49 ,  G01N33/66 ,  G01N33/96 ,  G01R35/00 ,  G01R35/005

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

公开(公告)号：US09625414B2

公开(公告)日：2017-04-18

申请号：US14933372

申请日：2015-11-05

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Ning Yang ,  Rajiv Shah

IPC: A61B5/1495 ,  G01N27/416 ,  G01N27/02 ,  G01R35/00 ,  A61B5/145 ,  A61B5/1473 ,  G01N33/66 ,  A61B5/1459 ,  A61M5/158 ,  A61B5/1486 ,  A61B5/00 ,  A61B5/053 ,  A61M5/172 ,  A61M5/142

CPC classification number: G01N27/4163 ,  A61B5/0537 ,  A61B5/0538 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/6849 ,  A61B5/6852 ,  A61B5/7203 ,  A61B5/7221 ,  A61B5/7225 ,  A61B5/7242 ,  A61B5/746 ,  A61B2562/0214 ,  A61B2562/04 ,  A61M5/14244 ,  A61M5/14276 ,  A61M5/1582 ,  A61M5/1723 ,  A61M2005/1726 ,  G01N27/026 ,  G01N27/028 ,  G01N27/416 ,  G01N33/49 ,  G01N33/66 ,  G01N33/96 ,  G01R35/00 ,  G01R35/005

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

公开(公告)号：US09360447B2

公开(公告)日：2016-06-07

申请号：US13964591

申请日：2013-08-12

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Rajiv Shah ,  Wayne A. Morgan ,  David Y. Choy ,  James L. Henke ,  Bahar Reghabi ,  Gopikrishnan Soundararajan ,  Peter Schultz ,  Udo Hoss

IPC: A61B5/00 ,  G01N27/403 ,  A61B5/145 ,  G01N27/327 ,  G01N27/416 ,  A61B5/1473

CPC classification number: G01N27/403 ,  A61B5/14532 ,  A61B5/1473 ,  A61B2560/0223 ,  A61B2562/02 ,  C12Q1/006 ,  G01N27/327 ,  G01N27/416

Abstract: A sensor system includes a sensor and a sensor electronics device. The sensor includes a plurality of electrodes. The sensor electronics device includes a connection detection device, a power source, and a delay circuit. The connection detection device determines if the sensor electronics device is connected to the sensor and transmits a connection signal. The delay circuit receives the connection signal, waits a preset hydration time, and couples the regulated voltage from the power source to an electrode in the sensor after the preset hydration time has elapsed. Alternatively, the sensor electronics device may include an electrical detection circuit and a microcontroller. The electrical detection circuit determines if the plurality of electrodes are hydrated and generates an interrupt if the electrodes are hydrated. A microcontroller receives the interrupt and transmits a signal representative of a voltage to an electrode of the plurality of electrodes.

公开(公告)号：US09357958B2

公开(公告)日：2016-06-07

申请号：US13778416

申请日：2013-02-27

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Ning Yang ,  Raghavendhar Gautham ,  Bradley C. Liang ,  Rajiv Shah

IPC: A61B5/1495 ,  G01N27/02 ,  G01R35/00 ,  A61B5/145 ,  A61B5/1473 ,  G01N33/66 ,  A61B5/1459 ,  A61M5/158 ,  A61B5/1486 ,  G01N27/416 ,  A61B5/00 ,  A61B5/053 ,  A61M5/172 ,  A61M5/142

CPC classification number: G01N27/4163 ,  A61B5/0537 ,  A61B5/0538 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/6849 ,  A61B5/6852 ,  A61B5/7203 ,  A61B5/7221 ,  A61B5/7225 ,  A61B5/7242 ,  A61B5/746 ,  A61B2562/0214 ,  A61B2562/04 ,  A61M5/14244 ,  A61M5/14276 ,  A61M5/1582 ,  A61M5/1723 ,  A61M2005/1726 ,  G01N27/026 ,  G01N27/028 ,  G01N27/416 ,  G01N33/49 ,  G01N33/66 ,  G01N33/96 ,  G01R35/00 ,  G01R35/005

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.