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公开(公告)号：US11982871B2
公开(公告)日：2024-05-14
申请号：US17492187
申请日：2021-10-01
发明人： Ian Chamberlin , Charles M. Clinton , Eli N. Glezer , Bandele Jeffrey-Coker , Manish Kochar , Sandor Kovacs , D. T. Le , Aaron Leimkuehler , George Sigal , Leo Tabakin , Jon Willoughby
CPC分类号： G02B7/36 , G01N21/253 , G01N21/6452 , G01N35/028
摘要： Apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation are described. They are particularly well suited for conducting automated analysis in a multi-well plate assay format.
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公开(公告)号：US11967410B2
公开(公告)日：2024-04-23
申请号：US15902597
申请日：2018-02-22
申请人： Meso Scale Technologies, LLC. , THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.
发明人： William F Blakely , Eli N. Glezer , John Kenten , Sudeep Kumar , Anu Mathew , Natalia I. Ossetrova , George Sigal
CPC分类号： G16H20/40 , G01N27/3273 , G01N33/6893 , G01N35/00 , G01T1/00 , G01T1/02 , G01N2333/70535 , G01N2333/70578 , G01N2800/40 , G01N2800/60
摘要： Methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. Also, algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.
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公开(公告)号：US11892455B2
公开(公告)日：2024-02-06
申请号：US17061095
申请日：2020-10-01
发明人： Charles M. Clinton , Eli N. Glezer , Bandele Jeffrey-Coker , Sandor L. Kovacs , Sudeep M. Kumar , George Sigal , Carl Stevens , Michael Vock
IPC分类号： G01N35/10 , B67B7/00 , G01N33/58 , G01N21/64 , G01N21/66 , G01N33/53 , G01N35/02 , B01L3/00 , G01N35/04
CPC分类号： G01N33/582 , B01L3/5085 , B01L3/50255 , B67B7/24 , G01N21/6452 , G01N21/66 , G01N33/5302 , G01N35/028 , G01N35/1011 , G01N35/1079 , G01N35/1081 , G01N35/1002 , G01N35/109 , G01N2035/0405 , G01N2035/0425 , G01N2035/1025 , Y10T83/9314
摘要： We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.
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公开(公告)号：US11686739B2
公开(公告)日：2023-06-27
申请号：US17412688
申请日：2021-08-26
发明人： Manish Kochar , Peter J. Bosco , Ian D. Chamberlin , Bandele Jeffrey-Coker , Eric M. Jones , Aaron H. Leimkuehler , Kim-Xuan Nguyen , Pankaj Oberoi , Louis W. Pang , Jennifer Parker , Victor Pellicier , Nicholas Sammons , George Sigal , Jacob N. Wohlstadter , Stanley T. Smith , Carl C. Stevens , Rodger D. Osborne , Kenneth E. Page
IPC分类号： G01N35/00 , B01L3/00 , B01L9/00 , G16H40/67 , G16H10/40 , G16H40/40 , F24F11/30 , G06K7/14 , G06Q10/087 , G06Q10/10 , H04B1/3827
CPC分类号： G01N35/0099 , B01L3/50853 , B01L9/523 , F24F11/30 , G06K7/1413 , G06Q10/087 , G06Q10/10 , G16H10/40 , G16H40/40 , G16H40/67 , B01L2200/143 , B01L2300/021 , G01N2035/00356 , G05B2219/40269 , H04B1/3827
摘要： The present invention relates to methods, devices and systems for associating consumable data with an assay consumable used in a biological assay. Provided are assay systems and associated consumables, wherein the assay system adjusts one or more steps of an assay protocol based on consumable data specific for that consumable. Various types of consumable data are described, as well as methods of using such data in the conduct of an assay by an assay system. The present invention also relates to consumables (e.g., kits and reagent containers), software, data deployable bundles, computer-readable media, loading carts, instruments, systems, and methods, for performing automated biological assays.
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公开(公告)号：US20220397579A1
公开(公告)日：2022-12-15
申请号：US17773896
申请日：2020-11-04
发明人： Sunsanee Kanjananimmanont , Sudeep Kumar , Navaratnam Manjula , Simone Barbero , Martin Stengelin , George Sigal
IPC分类号： G01N33/68 , G01N33/543
摘要： The invention relates to methods and kits for quantitating radiation exposure in a subject exposed to radiation, at risk of exposure to radiation or suspected of having been exposed to radiation. In embodiments, the present disclosure provides multiplexed immunoassays for quantifying amounts of biomarkers for assessing radiation exposure in a sample. Also provided herein are kits for performing the multiplexed assays.
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公开(公告)号：US20220283157A1
公开(公告)日：2022-09-08
申请号：US17531868
申请日：2021-11-22
发明人： Eli N. Glezer , Mikayla Higgins , John Kenten , George Sigal
IPC分类号： G01N33/564
摘要： The present disclosure relates to multiplexed assay formats configured to measure the level of a plurality of biomarkers that include a protein array for detecting autoreactive antibody levels against autoantigens.
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公开(公告)号：US11320366B2
公开(公告)日：2022-05-03
申请号：US16219030
申请日：2018-12-13
发明人： Nicholas Anderson , Jeffery Debad , Eli N. Glezer , Sudeep Kumar , Noel Lawrence , Kenneth Page , George Sigal , Sharon West
IPC分类号： B01L9/00 , G01N21/05 , G01N21/69 , G01N21/76 , B01L3/00 , G01N21/03 , G01F23/02 , G01F23/292 , G01N1/10 , B01L7/00
摘要： Assay cartridges are described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain embodiments, these cartridges are adapted to receive and analyze a sample collected on an applicator stick. Also described are kits including such cartridges and a cartridge reader configured to analyze an assay conducted using an assay cartridge.
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公开(公告)号：US11156801B2
公开(公告)日：2021-10-26
申请号：US16360257
申请日：2019-03-21
发明人： Ian Chamberlin , Charles M. Clinton , Eli N. Glezer , Bandele Jeffrey-Coker , Manish Kochar , Sandor Kovacs , D. T. Le , Aaron Leimkuehler , George Sigal , Leo Tabakin , Jon Willoughby
摘要： Apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation are described. They are particularly well suited for conducting automated analysis in a multi-well plate assay format.
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公开(公告)号：US20210109100A1
公开(公告)日：2021-04-15
申请号：US16937500
申请日：2020-07-23
发明人： Michael Tsionsky , Eli N. Glezer , Selen Stromgren , George Sigal , Jonathan K. Leland , Mark A. Billadeau , Svetlana Leytner , Mark Martin , Larry Helms
IPC分类号： G01N33/573 , C12Q1/48 , G01N33/543 , G01N33/58 , G01N21/76 , G01N33/53
摘要： The invention relates to improved electrochemiluminescence assay methods for phosphorylated peptides or proteins employing phospho-specific antibodies and buffer compositions that are substantially free of inorganic phosphate.
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公开(公告)号：US20210060567A1
公开(公告)日：2021-03-04
申请号：US17032524
申请日：2020-09-25
发明人： Eli N. Glezer , Stephen Higgins , Sandor Kovacs , Sudeep Kumar , Kenneth Page , Kristian Roth , George Sigal
摘要： Assay cartridges are described that have purification, reaction, and detection zones and other fluidic components which can include sample chambers, waste chambers, conduits, vents, reagent chambers, reconstitution chambers and the like. The assay cartridges are used to conduct multiplexed nucleic acid measurements. Also described are kits including such cartridges, methods of using the same, and a reader configured to analyze an assay conducted using an assay cartridge.
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