摘要:
Compounds are provided which are useful for the treatment of serotonin-affected neurological disorders which comprise Wherein: R1, R2 and R3 are each, independently, hydrogen, halogen, CF3, alkyl, alkoxy, MeSO2, or together can form a 5-7 membered carbocyclic or heterocyclic ring; R4 is hydrogen, halogen, or alkyl; R5 is hydrogen, alkyl, alkylaryl, or aryl; R6 is hydrogen, halogen, CF3, CN, carbamide, or alkoxy; X1, X2 and X3 are each carbon or one of X1, X2 or X3 may be nitrogen; Y is carbon or nitrogen; and Z is carbon or nitrogen; or pharmaceutically acceptable salts thereof.
摘要翻译:提供了可用于治疗受5-羟色胺影响的神经系统疾病的化合物,其包括:R 1,R 2和R 3各自独立地为氢,卤素,CF 3,烷基,烷氧基,MeSO 2或一起可以形成5-7元碳环 或杂环; R 4为氢,卤素或烷基; R 5为氢,烷基,烷基芳基或芳基; R 6为氢,卤素,CF 3,CN,脲或烷氧基; X 1,X 2和X 3为碳或 X1,X2或X3可以是氮; Y是碳或氮; Z为碳或氮; 其药学上可接受的盐。
摘要:
Navigation method and system are provided. The navigation method may include: a vehicle mounted system, which includes a storage device and a display, receiving a Turn-by-Turn navigation guidance instruction from a mobile device which has a navigation program running thereon; the vehicle mounted system selecting at least one guidance logo, stored in the storage device, according to the received Turn-by-Turn navigation guidance instruction; and the vehicle mounted system presenting on the display the at least one selected guidance logo. More vehicles can provide navigation with help of the mobile device.
摘要:
The invention provides a B-stageable adhesive composition, based on the total weight of the adhesive composition, comprising: 13-59 wt % of an epoxy resin; 18-69 wt % of a carboxyl terminated butadiene-acrylonitrile copolymer; and 3-34 wt % of a polyterpene modified phenol-formaldehyde resin. Additionally, the B-stageable adhesive composition may further comprise a hardener, an inorganic filler including a flame retardant agent, a thermal conductive filler or the like. According to the disclosure of the application, a new B-stageable adhesive composition having a high tackiness, a high temperature resistance, a high flame resistance and a high thermal conductivity can be provided.
摘要:
An apparatus such as a user equipment is in an embodiment of the invention configured to broadcast an access request to at least one neighboring node, the access request containing signature information indicating a user identifier, to check whether a collision indicator is received from a relay node, and to send another access request depending on a received collision indicator. The collision indicator may e.g. be a signature collision indicator, received from the node in case of colliding users, or a collision indicator of transmission received when transmissions of access requests are colliding at the node. A relay node may be configured to receive an access request from a user equipment, to detect a collision, and to inform the user equipment on a detected collision, indicating a type of collision.
摘要:
Basic coating compositions including inorganic oxide nanoparticles and an organic base are described. Methods of coating a substrate with the coating compositions, coated substrates prepared using the methods, and articles that include the coated substrates are also disclosed.
摘要:
Methods, apparatuses, and computer program products for dynamically determining a primary or slave assignment based on an order of cable connection between two devices are provided. Embodiments include detecting, by a first device, insertion of one end of a cable into a port of the first device; determining, by the first device, whether a power signal is received from the cable at the port of the first device; if the power signal is received, performing, by the first device, a data transfer operation over the cable as a slave device to a second device that is coupled to the other end of the cable; and if the power signal is not received, performing, by the first device, a data transfer operation over the cable as a primary device to the second device that is coupled to the other end of the cable.
摘要:
An apparatus for an improved operational amplifier. The disclosed improved operational amplifier comprises an operational amplifier, a first feedback circuit, and one or more secondary feedback circuits. The operational amplifier include a plurality of serially coupled gain stages and is configured so that an output of each gain stage drives an input of a next gain stage and an output of a last gain stage drives a load external to the improved operational amplifier. The first feedback circuit is coupled between an output of a designated gain stage and an output of a previous gain stage to provide a first feedback to the previous gain stage. Each secondary feedback circuit provides an additional feedback to the output of the previous gain stage.
摘要:
The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to PAQR polypeptides. Other aspects of the invention include vectors containing processes for producing novel human PAQR polypeptides, and antibodies specific for such polypeptides.
摘要:
The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles