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公开(公告)号：US20180357927A1
公开(公告)日：2018-12-13
申请号：US15514011
申请日：2015-09-24
Applicant: President and Fellows of Harvard College
Inventor： Kevin Kit Parker , Sung-Jin Park , Patrick Healy Campbell , Johan Ulrik Lind
CPC classification number: G09B23/28 , C12M21/08 , C12M25/02 , C12M31/10 , C12M41/46 , C12N5/0657 , G01N3/32 , G01N33/5091 , G01N2203/0089
Abstract: Exemplary embodiments provide systems, devices and methods for simultaneously measuring mechanical and electrophysiological tissue responses (e.g., contractile function, or the like).
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公开(公告)号：US10087422B2
公开(公告)日：2018-10-02
申请号：US14363105
申请日：2012-12-10
Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventor： Donald E. Ingber , Kevin Kit Parker , Geraldine A. Hamilton , Anthony Bahinski
Abstract: Disclosed herein are organ chips that can be individually used or integrated together to form different microphysiological systems, e.g., for use in cell culturing, drug screening, toxicity assays, personalized therapeutic treatment, scaffolding in tissue repair and/or replacement, and/or pharmacokinetic or pharmacodynamics studies.
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公开(公告)号：US09738046B2
公开(公告)日：2017-08-22
申请号：US14359005
申请日：2012-11-16
Applicant: President and Fellows of Harvard College
Inventor： Kevin Kit Parker , Mohammad Reza Badrossamay , Josue Adrian Goss
CPC classification number: B29D99/0078 , D01D5/00 , D01D5/0985 , D01D5/18 , D01F6/625 , Y10T428/249921
Abstract: In accordance with an exemplary embodiment, a method is provided for forming a micron, submicron and/or nanometer dimension polymeric fiber. The method includes providing a stationary deposit of a polymer. The method also includes contacting a surface of the polymer to impart sufficient force in order to decouple a portion of the polymer from the contact and to fling the portion of the polymer away from the contact and from the deposit of the polymer, thereby forming a micron, submicron and/or nanometer dimension polymeric fiber.
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公开(公告)号：US09725687B2
公开(公告)日：2017-08-08
申请号：US14362841
申请日：2012-12-10
Inventor： John P. Wikswo , Philip C. Samson , Frank Emmanuel Block, III , Ronald S. Reiserer , Kevin Kit Parker , John A. McLean , Lisa Joy McCawley , Dmitry Markov , Daniel Levner , Donald E. Ingber , Geraldine A. Hamilton , Josue A. Goss , Robert Cunningham , David E. Cliffel , Jennifer Robin McKenzie , Anthony Bahinski , Christopher David Hinojosa
IPC: A01N1/00 , C12M3/06 , C12M3/00 , A01N1/02 , G01N33/50 , B01L9/00 , C12M1/00 , C12M1/42 , B01L3/00 , C12M1/34
CPC classification number: C12M23/16 , A01N1/02 , A01N1/021 , A01N1/0247 , A01N1/0273 , B01L3/5027 , B01L3/502715 , B01L9/52 , B01L2200/0684 , B01L2200/0689 , B01L2200/146 , B01L2200/147 , B01L2300/044 , B01L2300/0636 , B01L2300/0654 , B01L2300/0663 , B01L2300/0867 , B01L2300/0877 , B01L2300/123 , B01L2300/18 , B01L2400/0487 , B01L2400/0622 , B01L2400/0644 , C12M21/08 , C12M23/42 , C12M29/10 , C12M35/04 , C12M35/08 , C12M41/00 , C12M41/12 , C12M41/46 , G01N33/5005 , G01N33/5082 , G01N33/5088
Abstract: The invention provides integrated Organ-on-Chip microphysiological systems representations of living Organs and support structures for such microphysiological systems.
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公开(公告)号：US09719982B2
公开(公告)日：2017-08-01
申请号：US14642906
申请日：2015-03-10
Applicant: President and Fellows of Harvard College
Inventor： Kevin Kit Parker , Adam W. Feinberg , Patrick W. Alford , Anna Grosberg , Mark Daniel Brigham , Josue A. Goss
CPC classification number: G01N33/5061 , C12Q1/025 , C40B30/06 , G01N33/5032 , G01N33/5088 , G01N2500/10
Abstract: The present invention provides high throughput assays for identifying compounds that modulate a contractile function, as well as devices suitable for use in these assays.
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Patent Agency Ranking
66.发明申请ANISOTROPIC MUSCULAR TISSUE DEVICES WITH INTEGRATED ELECTRICAL FORCE READOUTS 审中-公开具有集成电力准备工具的各向异性肌肉组织装置公开(公告)号：US20170016875A1
公开(公告)日：2017-01-19
申请号：US15116258
申请日：2015-02-18
Applicant: President and Fellows of Harvard College
Inventor： Kevin Kit Parker , Johan Ulrik Lind , Jennifer Ann Lewis , Joost Johan Vlassak , Hongyan Yuan , Travis Alexander Busbee , Ian Perkins , Christophe Chantre
IPC: G01N33/483
CPC classification number: G01N33/4833 , A61B5/053 , A61B5/4519
Abstract: Embodiments described herein are directed to devices for supporting growth of anisotropic muscle tissue layers and in vitro readout and quantification of force generated by the tissue layers using one or more strain-sensing elements integrated into the device. Embodiments also include multiplexed apparatuses of multiple independent devices, methods of fabricating the devices and apparatuses, and methods of using the devices and apparatuses.
Abstract translation: 本文描述的实施例涉及用于支持各向异性肌肉组织层的生长的装置，以及使用集成到装置中的一个或多个应变感测元件由组织层产生的力的体外读出和定量。 实施例还包括多个独立设备的复用设备，制造设备和设备的方法以及使用设备和设备的方法。
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67.发明申请公开(公告)号：US20150329604A1
公开(公告)日：2015-11-19
申请号：US14648375
申请日：2013-11-27
Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventor： Kevin Kit Parker , Leila F. Deravi , Evelyn Hu , Andrew Magyar
CPC classification number: C07K14/461 , C07K14/435 , G02B1/04 , Y10T428/249921
Abstract: The present invention provides synthetic pigment structures, isolated pigment granules, and pigment proteins, as well as methods of making and using them.
Abstract translation: 本发明提供合成颜料结构，分离的颜料颗粒和颜料蛋白，以及制备和使用它们的方法。
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公开(公告)号：US20150182679A1
公开(公告)日：2015-07-02
申请号：US14415945
申请日：2013-07-19
Inventor： Kevin Kit Parker , Josue A. Goss , Sung-Jin Park , Andrew Keith Capulli , Holly A. McIlwee , Janna C. Nawroth , John O. Dabiri
CPC classification number: A61M1/1003 , A61F2/2415 , A61M1/1037 , A61M1/1053 , A61M1/1098 , A61M1/12 , A61M1/122 , A61M1/127 , G01N33/5061 , G01N2500/04 , G01N2500/10 , Y10T29/49405
Abstract: The present invention provides tissue-engineered pumps and valves, methods of fabricating such pumps and valves, and methods of use of such pumps and valves.
Abstract translation: 本发明提供组织工程泵和阀，制造这种泵和阀的方法，以及这种泵和阀的使用方法。
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公开(公告)号：US20150004077A1
公开(公告)日：2015-01-01
申请号：US14362841
申请日：2012-12-10
Inventor： John P. Wikswo , Philip C. Samson , Frank Emmanuel Block, III , Ronald S. Reiserer , Kevin Kit Parker , John A. McLean , Lisa Joy McCawley , Dmitry Markov , Daniel Levner , Donald E. Ingber , Geraldine A. Hamilton , Josue A. Goss , Robert Cunningham , David E. Cliffel , Jennifer Robin McKenzie , Anthony Bahinski , Christopher David Hinojosa
IPC: G01N33/50
CPC classification number: C12M23/16 , A01N1/02 , A01N1/021 , A01N1/0247 , A01N1/0273 , B01L3/5027 , B01L3/502715 , B01L9/52 , B01L2200/0684 , B01L2200/0689 , B01L2200/146 , B01L2200/147 , B01L2300/044 , B01L2300/0636 , B01L2300/0654 , B01L2300/0663 , B01L2300/0867 , B01L2300/0877 , B01L2300/123 , B01L2300/18 , B01L2400/0487 , B01L2400/0622 , B01L2400/0644 , C12M21/08 , C12M23/42 , C12M29/10 , C12M35/04 , C12M35/08 , C12M41/00 , C12M41/12 , C12M41/46 , G01N33/5005 , G01N33/5082 , G01N33/5088
Abstract: The invention provides integrated Organ-on-Chip microphysiological systems representations of living Organs and support structures for such microphysiological systems.
Abstract translation: 本发明提供了用于这种微生物系统的活体器官和支持结构的集成的片上微生物系统表示。
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公开(公告)号：US20140342445A1
公开(公告)日：2014-11-20
申请号：US14363105
申请日：2012-12-10
Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventor： Donald E. Ingber , Kevin Kit Parker , Geraldine A. Hamilton , Anthony Bahinski
IPC: C12N5/071
Abstract: Disclosed herein are organ chips that can be individually used or integrated together to form different microphysiological systems, e.g., for use in cell culturing, drug screening, toxicity assays, personalized therapeutic treatment, scaffolding in tissue repair and/or replacement, and/or pharmacokinetic or pharmacodynamics studies.
Abstract translation: 本文公开了可以单独使用或整合在一起以形成不同的微生物系统的器官碎片，例如用于细胞培养，药物筛选，毒性测定，个性化治疗处理，组织修复和/或替代中的支架和/或药代动力学 或药效学研究。
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