公开(公告)号：US06323315B1

公开(公告)日：2001-11-27

申请号：US09539935

申请日：2000-03-31

申请人： George R. Pettit ,  Jayaram K. Srirangam ,  Michael D. Williams ,  Kieran P. M. Durkin ,  Teresa Barlozzari ,  Andreas Kling ,  Bernd Janssen ,  Andreas Haupt

发明人： George R. Pettit ,  Jayaram K. Srirangam ,  Michael D. Williams ,  Kieran P. M. Durkin ,  Teresa Barlozzari ,  Andreas Kling ,  Bernd Janssen ,  Andreas Haupt

IPC分类号： C07D20709

CPC分类号： C07K5/0202 ,  C07K5/0205 ,  C07K7/02

摘要： The present invention provides compounds of the formula where R1-R5 are each, independently, a hydrogen atom or a normal or branched C1-C6-alkyl group; A is a methionyl, phenylalanyl or phenylglycyl residue; n is 0 or 1; R6 is a hydrogen atom; and R7 is a carbocylic group, an aromatic group, a C1-C4-alkyl group, a pyridylalkyl group or a heterocyclic group. In another embodiment, R6 is benzyl or —C(O)OR8, where R8 is a C1-C6-alkyl group, and R7 is a heteroaromatic group, such as a 2-thiazolyl group.

摘要翻译： 本发明提供了式R 1 -R 5的化合物各自独立地为氢原子或正或支链的C 1 -C 6 - 烷基; A是甲硫氨酰基，苯丙氨酰基或苯基甘氨酰残基; n为0或1; R6是氢原子; 并且R 7是碳酰基，芳基，C 1 -C 4 - 烷基，吡啶基烷基或杂环基。 在另一个实施方案中，R 6为苄基或-C（O）OR 8，其中R 8为C 1 -C 6烷基，R 7为杂芳族基团，例如2-噻唑基。

公开(公告)号：US5872016A

公开(公告)日：1999-02-16

申请号：US665618

申请日：1996-06-18

申请人： John Edward Cunningham ,  Keith Wayne Goossen ,  William Young Jan ,  Michael D. Williams

发明人： John Edward Cunningham ,  Keith Wayne Goossen ,  William Young Jan ,  Michael D. Williams

IPC分类号： H01L31/0352 ,  H01L31/105 ,  H01L33/00 ,  H01L33/02 ,  H01L33/06 ,  H01S5/30 ,  H01S5/34 ,  H01L21/20

CPC分类号： H01L33/025 ,  B82Y20/00 ,  H01L31/0352 ,  H01L31/105 ,  H01L33/0012 ,  H01L33/06 ,  H01S5/34 ,  H01S2304/00 ,  H01S5/305

摘要： Optoelectronic devices such as photodetectors, modulators and lasers with improved optical properties are provided with an atomically smooth transition between the buried conductive layer and quantum-well-diode-containing intrinsic region of a p-i-n structure. The buried conductive layer is grown on an underlying substrate utilizing a surfactant-assisted growth technique. The dopant and dopant concentration are selected, as a function of the thickness of the conductive layer to be formed, so that a surface impurity concentration of from 0.1 to 1 monolayer of dopant atoms is provided. The presence of the impurities promotes atomic ordering at the interface between the conductive layer and the intrinsic region, and subsequently results in sharp barriers between the alternating layers comprising the quantum-well-diodes of the intrinsic layer.

摘要翻译： 具有改进的光学性质的诸如光电探测器，调制器和激光器的光电器件在掩埋导电层和含p-i-n结构的量子阱二极管的本征区域之间具有原子平滑的过渡。 使用表面活性剂辅助生长技术将掩埋的导电层生长在下面的衬底上。 选择掺杂剂和掺杂剂浓度作为要形成的导电层的厚度的函数，使得提供0.1至1个单层掺杂剂原子的表面杂质浓度。 杂质的存在促进在导电层和本征区之间的界面处的原子排序，并且随后在包含本征层的量子阱二极管的交替层之间产生尖锐的障碍。

公开(公告)号：US5665860A

公开(公告)日：1997-09-09

申请号：US671121

申请日：1996-06-13

申请人： George R. Pettit ,  Jayaram K. Srirangam ,  Michael D. Williams

发明人： George R. Pettit ,  Jayaram K. Srirangam ,  Michael D. Williams

IPC分类号： A61K38/00 ,  A61K35/56 ,  A61P35/00 ,  C07K5/02 ,  C07K5/027 ,  A61K38/04 ,  C07K5/00

CPC分类号： C07K5/0205 ,  A61K38/00

摘要： This application discloses seven newly synthesized pentapeptide amides andour tetrapeptide amides. The synthesis utilized both naturally occurring and modified amino acids; the modified amino acids are constituents of the well known dolastatin 10 and dolastatin 15 which are structurally distinct peptides with excellent antineoplastic activity. These peptides were constructed by introducing a peptide bond between selected amino acids and modified amino acids and coupling the resulting di- and tri-peptides to obtain peptides having a high anticancer activity against a series of human cancer cell lines. ##STR1##

摘要翻译： 该申请公开了七种新合成的五肽酰胺和四种四肽酰胺。 该合成使用天然存在和修饰的氨基酸; 修饰的氨基酸是众所周知的多拉司他汀10和多拉司他汀15的组分，其是具有优异抗肿瘤活性的结构上不同的肽。 通过在选择的氨基酸和修饰的氨基酸之间引入肽键并偶联得到的二肽和三肽以获得对一系列人类癌细胞系具有高抗癌活性的肽来构建这些肽。

公开(公告)号：US5508475A

公开(公告)日：1996-04-16

申请号：US293646

申请日：1994-08-22

申请人： Stanley J. Profiri ,  Michael D. Williams

发明人： Stanley J. Profiri ,  Michael D. Williams

IPC分类号： F16L33/207 ,  H01R4/64 ,  H01R9/05 ,  H02G15/02

CPC分类号： F16L33/2076 ,  H01R4/646 ,  H01R9/0518

摘要： This invention involves an apparatus for terminating conduit, cable, and braided bundle in which the termination is accomplished with an interference fit between a collar and an end fitting. Once assembled, the conduit, cable, or braided bundle is compressed between the collar and the end fitting such that the final assembly can withstand the required level of axial and transverse force for the application, but not so much that the conduit, cable, or braided bundle loses its structural integrity.

摘要翻译： 本发明涉及用于终止导管，电缆和编织束的装置，其中终端通过套环和端部配件之间的过盈配合来实现。 一旦组装，管道，电缆或编织束在套环和端部配件之间被压缩，使得最终组件可以承受用于应用的所需水平的轴向和横向力，但不能超过导管，电缆或 编织束失去其结构完整性。

公开(公告)号：US5504191A

公开(公告)日：1996-04-02

申请号：US283682

申请日：1994-08-01

申请人： George R. Pettit ,  Jayaram K. Srirangam ,  Michael D. Williams

发明人： George R. Pettit ,  Jayaram K. Srirangam ,  Michael D. Williams

IPC分类号： A61K38/00 ,  A61P35/00 ,  C07K5/02 ,  C07K7/02 ,  C07K5/00 ,  C07K7/00 ,  C07K17/00

CPC分类号： C07K5/0205

摘要： Herein disclosed are several pentapeptide methyl ester derivatives of dolatin 10, using both naturally occurring and modified amino acids. The selected modified amino acids are constituents of dolastatin 10 which is a structurally distinct peptide with excellent in vitro and in vivo antineoplastic activity. The structures of these compounds are as shown below: ##STR1##

摘要翻译： 本文公开了多拉司他汀10的几种五肽甲酯衍生物，其使用天然存在的和修饰的氨基酸。 所选修饰的氨基酸是多拉司他汀10的组分，其是具有优异体外和体内抗肿瘤活性的结构不同的肽。 这些化合物的结构如下：图像10a）R1 = i-Pr; R = NH（Me）2; R2 = CH2CH2CH2NH-cbz

公开(公告)号：US20180259223A1

公开(公告)日：2018-09-13

申请号：US15457740

申请日：2017-03-13

申请人： Shawn A. Reed ,  Mickey E. Batson ,  Michael D. Williams ,  Christopher R. Taylor ,  Tyson J. Cogburn

发明人： Shawn A. Reed ,  Mickey E. Batson ,  Michael D. Williams ,  Christopher R. Taylor ,  Tyson J. Cogburn

IPC分类号： F24H9/20 ,  F23L17/16 ,  F24H3/00

CPC分类号： F24H9/2085 ,  F23D14/04 ,  F23L17/005 ,  F23L17/16 ,  F24H3/006

摘要： A fuel-fired heating appliance comprises a fuel source, an air source, a chamber in which fuel and air mix, a burner downstream from the mixing chamber, an igniter proximate the burner, a heat exchanger, a blower and a flue pipe. An ambient air inlet may be defined by at least one of the outlet end of the blower and the flue pipe extending between the interior of the flue pipe and an area ambient to the flue pipe. A flow rate of combustion gas may be controlled to a level below a steady-state flow rate during appliance warm-up.

公开(公告)号：US09636115B2

公开(公告)日：2017-05-02

申请号：US11423934

申请日：2006-06-13

申请人： William S. Henry ,  Charles Daly ,  Russell Ford ,  Michael D. Williams ,  Hanh Duong ,  Hughie Devaney ,  Kamal Ramzipoor ,  Clifford Teoh ,  Richard Murphy ,  Andrew Huffmaster ,  Scott McGill

发明人： William S. Henry ,  Charles Daly ,  Russell Ford ,  Michael D. Williams ,  Hanh Duong ,  Hughie Devaney ,  Kamal Ramzipoor ,  Clifford Teoh ,  Richard Murphy ,  Andrew Huffmaster ,  Scott McGill

IPC分类号： A61M29/00 ,  A61B17/12 ,  A61M25/09

CPC分类号： A61B17/12022 ,  A61B17/12109 ,  A61B17/12113 ,  A61B17/12154 ,  A61B2017/1205 ,  A61B2017/12054 ,  A61B2017/12063 ,  A61M25/09 ,  A61M2025/09133

摘要： A device for delivering an occlusive element includes an elongate sheath having a lumen therein. An elongate core member is disposed within the lumen and is formed from a proximal portion and distal portion connected via a joint. The distal portion of the elongate member includes a severable junction secured to the occlusive element. A marker coil is coaxially arranged around the distal portion of the elongate core member and is partially disposed inside the sheath lumen. A coil member is coaxially arranged around the distal portion of the elongate core member and coaxially arranged around at least a portion of the marker coil extending outside the lumen of the sheath. The coil member is secured at a distal end thereof to the distal portion of the elongate core member. The device resists axial compression while allowing for radial bending.

公开(公告)号：US20170073079A1

公开(公告)日：2017-03-16

申请号：US14851511

申请日：2015-09-11

申请人： Michael D. Williams

发明人： Michael D. Williams

IPC分类号： B64D37/32 ,  B64D37/02

CPC分类号： B64D37/32 ,  B60K2015/03032 ,  B60K2015/03039 ,  B64D37/02 ,  B64D37/08

摘要： A process method utilizing customized, specifically-shaped pieces of reticulated polyurethane foam (RPF) to fill an aircraft fuel tank or tank compartment to provide ignition mitigation and prevent explosion in the tank. The process involves inserting the shaped pieces of RPF through existing access ports into a fuel tank in order to fill the tank, excepting minimal planned void spaces. This process effects ignition mitigation by acting as an ignition blocker, mechanically interfering with the compression wave that precedes the flame front in an explosion, and changing the vaporous mixture above the fuel level (ullage) in the tank. The foam pieces are assembled and fitted together throughout the tank in a pattern that replicates the shape of the tank. After the foam insertion is complete, the fuel tank is filled with purging fluid, drained through a filter until no debris is found, and the new maximum fuel quantity is recalibrated.

摘要翻译： 使用定制的特殊形状的网状聚氨酯泡沫（RPF）件填充飞机燃料箱或罐室以提供点火减轻并防止罐中的爆炸的加工方法。 该过程包括将成形的RPF通过现有的进入端口插入燃料箱中，以便填充油箱，除了最小的计划空隙。 该过程通过作为点火阻塞剂的作用来实现点火减轻，机械地干扰爆炸中火焰前面的压缩波，并且将蒸汽混合物改变在罐内的燃料水平（空位）之上。 泡沫块以整体形式复制箱体的形式组装在整个箱体中。 在泡沫插入完成之后，燃料箱中充满清洗液，通过过滤器排出，直到没有发现碎屑，并且新的最大燃料量被重新校准。

公开(公告)号：US09043798B2

公开(公告)日：2015-05-26

申请号：US12970754

申请日：2010-12-16

申请人： Jeffrey A. Calcaterra ,  Gregory R. Hintermeister ,  Michael D. Williams

发明人： Jeffrey A. Calcaterra ,  Gregory R. Hintermeister ,  Michael D. Williams

IPC分类号： G06F9/46 ,  G06F9/50

CPC分类号： G06F9/5011 ,  G06F11/3024 ,  G06F11/3447 ,  G06F2209/5019

摘要： A usage allocation of a hardware resource to each of a number of workloads over time is determined using a demand model. The usage allocation of the resource includes a current and past actual usage allocation of the resource, a future projected usage allocation of the resource, and current and past actual usage of the resource. A capacity allocation of the resource is determined using a capacity model. The capacity allocation of the resource includes a current and past capacity and a future projected capacity of the resource. Whether a gap exists between the usage allocation and the capacity allocation is determined using a mapping model. Where the gap exists between the usage allocation of the resource and the capacity allocation of the resource, a user is presented with options determined using the mapping model and selectable by the user to implement a remediation strategy to close the gap.

摘要翻译： 使用需求模型来确定硬件资源对于多个工作负载中的每一个的使用分配。 资源的使用分配包括资源的当前和过去的实际使用分配，资源的未来预计使用分配以及资源的当前和过去的实际使用。 使用容量模型确定资源的容量分配。 资源的能力分配包括当前和过去的能力以及资源的未来预计能力。 使用映射模型确定使用分配与容量分配之间是否存在差距。 在资源的使用分配和资源的容量分配之间存在差距的情况下，向用户呈现使用映射模型确定的选项，并且可由用户选择以实现修复策略来缩小差距。

公开(公告)号：US08822859B2

公开(公告)日：2014-09-02

申请号：US12768567

申请日：2010-04-27

申请人： Jerry R. Hoffman ,  Michael D. Williams

发明人： Jerry R. Hoffman ,  Michael D. Williams

IPC分类号： H01H23/02

CPC分类号： H01H23/04 ,  H01H23/145

摘要： In one embodiment, a system includes an electrical device, a frame adapted to be attached to and removed from the electrical device without removing the electrical device from an installed position, a rocker pivotally attached to the frame, a switch disposed within the electrical device, and a subrocker arranged to enable the rocker to actuate the switch. In another embodiment, an interchange kit includes a frame adapted to be attached to and removed from an electrical device without removing the electrical device from an installed position, and a rocker pivotally attached to the frame. The rocker may be adapted to engage a subrocker on the electrical device.

摘要翻译： 在一个实施例中，系统包括电气设备，适于附接到电气设备并从电气设备移除而不从安装位置移除电气设备的框架，枢转地附接到框架的摇杆，设置在电气设备内的开关， 以及设置成使摇臂能够致动开关的子路由器。 在另一个实施例中，交换工具包包括适于附接到电气装置并从电气装置移除的框架而不从安装位置移除电气装置，以及可枢转地附接到框架的摇杆。 摇杆可以适于接合电气设备上的子路由器。