公开(公告)号：US06824475B2

公开(公告)日：2004-11-30

申请号：US09898843

申请日：2001-07-03

申请人： Michael Scott Burnett ,  Benoit Vincent ,  Todd Beach ,  Stephen Kraus ,  Yong Ling ,  David Anderson

发明人： Michael Scott Burnett ,  Benoit Vincent ,  Todd Beach ,  Stephen Kraus ,  Yong Ling ,  David Anderson

IPC分类号： A63B5304

CPC分类号： A63B53/04 ,  A63B53/0466 ,  A63B60/00 ,  A63B2053/0408 ,  A63B2053/0412 ,  A63B2053/0416 ,  A63B2053/0458

摘要： A golf club head is provided having a substantially increased sweet spot across its club face. A preferred construction includes an annular area on a rear surface having increased thickness surrounding a central region with a balance point of the club face. The central region of the face has a generally reduced thickness that is less than the maximum of the annular area but greater than a minimum thickness at the peripheral area. The face material may be metallic, but in alternative embodiments the effective bending stiffness profiles represented by this annular area may be achieved by appropriate use of composites, for example. Methods for manufacturing a golf club head having a face with the bending stiffness profiles of the present invention include forging and machining techniques as well as laser deposition and inertia welding.

摘要翻译： 提供一种高尔夫球杆头，其在其球杆表面上具有显着增加的甜点。 优选的结构包括在后表面上的具有增加的厚度的环形区域，围绕具有球杆面的平衡点的中心区域。 面的中心区域具有小于环形区域的最大值但大于周边区域的最小厚度的通常减小的厚度。 表面材料可以是金属的，但是在替代实施例中，由该环形区域表示的有效弯曲刚度分布可以通过例如合适地使用复合材料来实现。 制造具有本发明的弯曲刚度分布的面的高尔夫球杆头的方法包括锻造和加工技术以及激光沉积和惯性焊接。

公开(公告)号：US06818654B2

公开(公告)日：2004-11-16

申请号：US10386816

申请日：2003-03-12

申请人： David Anderson ,  Bruce Beutel ,  Curt Cooper ,  Peter Dandliker ,  Caroline David ,  Yu-Gui Gu ,  Mira Hinman ,  Douglas Kalvin ,  Linda Lynch ,  Zhenkun Ma ,  Christopher Motter ,  Teresa Rosenberg ,  William Sanders ,  Michael Tufano ,  Rolf Wagner ,  Moshe Weitzberg ,  Hong Yong

发明人： David Anderson ,  Bruce Beutel ,  Curt Cooper ,  Peter Dandliker ,  Caroline David ,  Yu-Gui Gu ,  Mira Hinman ,  Douglas Kalvin ,  Linda Lynch ,  Zhenkun Ma ,  Christopher Motter ,  Teresa Rosenberg ,  William Sanders ,  Michael Tufano ,  Rolf Wagner ,  Moshe Weitzberg ,  Hong Yong

IPC分类号： C07D21500

CPC分类号： C07D471/04

摘要： Antibacterials having formula (I) and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates used in the processes, compositions containing the compounds, and methods of prophylaxis and treatment of bacterial infections using the compounds are disclosed.

摘要翻译： 公开了具有式（I）的抗菌剂及其前体药物的盐，前药和盐，用于制备本方法中使用的化合物和中间体的方法，含有该化合物的组合物，以及使用该化合物预防和治疗细菌感染的方法。

公开(公告)号：US06719642B2

公开(公告)日：2004-04-13

申请号：US10273584

申请日：2002-10-18

申请人： Bret Wahl ,  David Anderson ,  Benoit Vincent ,  Nick Frame ,  Charles Golden

发明人： Bret Wahl ,  David Anderson ,  Benoit Vincent ,  Nick Frame ,  Charles Golden

IPC分类号： A63B5304

CPC分类号： A63B53/04 ,  A63B53/047 ,  A63B53/0475 ,  A63B60/00 ,  A63B60/54 ,  A63B2053/005 ,  A63B2053/0408 ,  A63B2053/0416 ,  A63B2053/0458

摘要： A set of iron golf clubs is disclosed, each golf club having a head configured to provide enhanced flexibility for launching a golf ball. An upper portion of the body of each head has a reduced stiffness, while a lower portion of the body is configured with recesses that provide reduced stiffness toward the heel and the toe. A low central region supports the head at impact with the golf ball. The relative stiffness in the lower portion of the club head, varying from heel to toe, is designed in conjunction with a top to bottom difference in stiffness. Thus, the golf club head has enhanced flexibility and selectively increased stiffness, for improved performance and feel.

摘要翻译： 公开了一组铁高尔夫球杆，每个高尔夫球杆具有头部，该头部构造成提供用于发射高尔夫球的增强的灵活性。 每个头部的主体的上部具有减小的刚度，而主体的下部构造有凹部，该凹部朝向脚跟和脚趾提供降低的刚性。 低中心区域支撑头部与高尔夫球的冲击。 从脚跟到脚趾变化的球杆头下部的相对刚度被设计成与顶部到底部的刚度差异。 因此，高尔夫球杆头具有增强的灵活性和选择性地增加的刚度，以提高性能和感觉。

公开(公告)号：US06638621B2

公开(公告)日：2003-10-28

申请号：US10170237

申请日：2002-06-13

申请人： David Anderson

发明人： David Anderson

IPC分类号： B32B1502

CPC分类号： A01N25/26 ,  A61K9/1274 ,  A61K9/501 ,  A61K9/5015 ,  B01J13/02 ,  B82Y5/00 ,  Y10T428/2984 ,  Y10T428/2985 ,  Y10T428/2989 ,  Y10T428/31544

摘要： A particle coated with a nonlamellar material such as a nonlamellar crystalline material, a nonlamellar amorphous material, or a nonlamellar semi-crystalline material includes an internal matrix core having at least one a nanostructured liquid phase, or at least on nanostructured liquid crystalline phase or a combination of the two is used for the delivery of active agents such as pharmaceuticals, nutrients, pesticides, etc. The coated particle can be fabricated by a variety of different techniques where the exterior coating is a nonlamellar material such as a nonlamellar crystalline material, a nonlamellar amorphous material, or a nonlamellar semi-crystalline material.

摘要翻译： 涂覆有非水性材料如非晶体结晶材料，非平板非晶材料或非平板半结晶材料的颗粒包括具有至少一个纳米结构液相或至少在纳米结构的液晶相或 两者的组合用于递送活性剂如药物，营养物，农药等。涂覆的颗粒可以通过各种不同的技术制造，其中外部涂层是非水性材料，例如非平板结晶材料， 非层状无定形材料或非平板半结晶材料。

公开(公告)号：US06548632B1

公开(公告)日：2003-04-15

申请号：US09415765

申请日：1999-10-08

申请人： David Anderson ,  Beau Robert Peelle ,  Jakob Maria Bogenberger

发明人： David Anderson ,  Beau Robert Peelle ,  Jakob Maria Bogenberger

IPC分类号： C07K400

CPC分类号： C12N15/1044 ,  C07K14/43595 ,  C07K2319/00 ,  C07K2319/42 ,  C07K2319/60 ,  C07K2319/70 ,  C12N15/1034 ,  C12N15/1086 ,  C12N15/62 ,  C12Q1/6897

摘要： The invention relates to the use of scaffold proteins, particularly green fluorescent protein (GFP), in fusion constructs with random and defined peptides and peptide libraries, to increase the cellular expression levels, decrease the cellular catabolism, increase the conformational stability relative to linear peptides, and to increase the steady state concentrations of the random peptides and random peptide library members expressed in cells for the purpose of detecting the presence of the peptides and screening random peptide libraries. N-terminal, C-terminal, dual N- and C-terminal and one or more internal fusions are all contemplated. Novel fusions utilizing self-binding peptides to create a conformationally stabilized fusion domain are also contemplated.

摘要翻译： 本发明涉及在具有随机和定义的肽和肽文库的融合构建体中使用支架蛋白，特别是绿色荧光蛋白（GFP），以增加细胞表达水平，减少细胞分解代谢，增加相对于线性肽的构象稳定性 并且增加在细胞中表达的随机肽和随机肽文库成员的稳态浓度，以便检测肽的存在和筛选随机肽文库。 N-末端，C-末端，双N-和C-末端以及一个或多个内部融合物都被考虑。 还考虑利用自身结合肽产生构象稳定的融合结构域的新型融合体。

公开(公告)号：US06508832B1

公开(公告)日：2003-01-21

申请号：US09457774

申请日：1999-12-09

申请人： Marc M. Jalisi ,  David Anderson ,  Avijit Mukherjee

发明人： Marc M. Jalisi ,  David Anderson ,  Avijit Mukherjee

IPC分类号： A61F206

CPC分类号： A61L31/022 ,  A61L31/18 ,  Y10T29/496

摘要： The present invention is directed to a stainless steel stent which is substantially nickel-free and possesses improved elongation and mechanical properties, including resistance to corrosion. The stent can be embodied in a substrate with one or more metallic claddings overlaying the substrate. The substrate and claddings can include radiopaque materials and stainless steel.

摘要翻译： 本发明涉及一种不锈钢支架，其基本上不含镍，并具有改善的伸长率和机械性能，包括耐腐蚀性。 支架可以被实施在具有覆盖衬底的一个或多个金属包层的衬底中。 基材和包层可以包括不透射线的材料和不锈钢。

公开(公告)号：US06180343B2

公开(公告)日：2001-01-30

申请号：US09169015

申请日：1998-10-08

申请人： David Anderson ,  Jakob Maria Bogenberger

发明人： David Anderson ,  Jakob Maria Bogenberger

IPC分类号： C12N1563

CPC分类号： C12N15/1044 ,  C07K14/43595 ,  C07K2319/00 ,  C07K2319/42 ,  C07K2319/60 ,  C07K2319/70 ,  C12N15/1034 ,  C12N15/1086 ,  C12N15/62 ,  C12Q1/6897

摘要： The invention relates to the use of fluorescent proteins, particularly green fluorescent protein (GFP), in fusion constructs with random and defined peptides and peptide libraries, to increase the cellular expression levels, decrease the cellular catabolism, increase the conformational stability relative to linear peptides, and to increase the steady state concentrations of the random peptides and random peptide library members expressed in cells for the purpose of detecting the presence of the peptides and screening random peptide libraries. N-terminal, C-terminal, dual N- and C-terminal and one or more internal fusions are all contemplated. Novel fusions utilizing self-binding peptides to create a conformationally stabilized fusion domain are also contemplated.

公开(公告)号：US5949954A

公开(公告)日：1999-09-07

申请号：US480205

申请日：1995-06-07

申请人： Patrick Young ,  John H. Roop ,  Alan R. Ebright ,  Michael W. Faber ,  David Anderson

发明人： Patrick Young ,  John H. Roop ,  Alan R. Ebright ,  Michael W. Faber ,  David Anderson

IPC分类号： H04N5/7826 ,  B64C30/00 ,  G04G15/00 ,  G06F3/00 ,  G06F3/023 ,  G06F3/033 ,  G06F3/048 ,  G06F3/14 ,  G06F13/00 ,  G11B15/02 ,  G11B27/00 ,  G11B27/10 ,  G11B27/11 ,  G11B27/30 ,  G11B27/32 ,  G11B27/34 ,  G11B27/36 ,  G11B33/10 ,  H04N5/44 ,  H04N5/445 ,  H04N5/76 ,  H04N5/7617 ,  H04N5/765 ,  H04N5/775 ,  H04N5/782 ,  H04N5/91 ,  H04N7/025 ,  H04N7/03 ,  H04N7/035 ,  H04N7/088 ,  H04N7/16 ,  H04N21/41 ,  H04N21/422 ,  H04N21/431 ,  H04N21/433 ,  H04N21/436 ,  H04N21/458 ,  H04N21/47 ,  H04N21/472 ,  H04N21/482 ,  H04N21/485 ,  H04N21/84 ,  H04N21/858

CPC分类号： H04N21/4858 ,  B64C30/00 ,  G04G15/006 ,  G06F3/0482 ,  G06F3/04892 ,  G11B15/023 ,  G11B27/10 ,  G11B27/107 ,  G11B27/11 ,  G11B27/3054 ,  G11B27/324 ,  G11B27/328 ,  G11B27/34 ,  G11B27/36 ,  G11B33/10 ,  H04N21/4135 ,  H04N21/4314 ,  H04N21/4316 ,  H04N21/4334 ,  H04N21/43622 ,  H04N21/4583 ,  H04N21/47214 ,  H04N21/482 ,  H04N21/4821 ,  H04N21/4828 ,  H04N21/84 ,  H04N21/858 ,  H04N5/44543 ,  H04N5/765 ,  H04N5/775 ,  H04N5/782 ,  H04N7/025 ,  H04N7/088 ,  H04N7/0884 ,  H04N7/0887 ,  H04N7/0888 ,  H04N7/163 ,  H04N7/165 ,  G11B2220/41 ,  G11B2220/65 ,  G11B2220/80 ,  G11B2220/90 ,  H04N2005/4423 ,  H04N21/42204 ,  H04N21/47 ,  H04N21/485 ,  H04N5/44504

摘要： Screen (10) for a user interface of a television schedule system and process consists of an array (24) of irregular cells (26), which vary in length, corresponding to different television program lengths of one half hour to one-and-one half hours or more. The array is arranged as three columns (28) of one-half hour in duration, and twelve rows (30) of program listings. Some of the program listings overlap two or more of the columns (28) because of their length. Because of the widely varying length of the cells (26), if a conventional cursor used to select a cell location were to simply step from one cell to another, the result would be abrupt changes in the screen (10) as the cursor moved from a cell (26) of several hours length to an adjacent cell in the same row. An effective way of taming the motion is to assume that behind every array (24) is an underlying array of regular cells. By restricting cursor movements to the regular cells, abrupt screen changes will be avoided. With the cursor (32), the entire cell (26) is 3-D highlighted, using a conventional offset shadow (34). The offset shadow (34) is a black bar that underlines the entire cell and wraps around the right edge of the cell. To tag the underlying position--which defines where the cursor (32) is and thus, where it will move next--portions (36) of the black bar outside the current underlying position are segmented, while the current position is painted solid.

摘要翻译： 用于电视节目表系统和处理的用户界面的屏幕（10）由不规则小区（26）的阵列（24）组成，其长度不同，对应于一个半小时的不同电视节目长度到一对一 半个小时以上。 该阵列被排列成持续时间为半小时的三列（28），和十二行（30）的程序列表。 一些程序列表由于其长度而重叠两个或更多列（28）。 由于细胞（26）的长度变化很大，如果用于选择细胞位置的常规光标是简单地从一个细胞步进到另一个细胞，则结果将随着光标从...移动而在屏幕（10）中突然变化 具有数小时长度的细胞（26）到相同行中的相邻细胞。 驯服运动的有效方式是假设每个阵列（24）后面都是正则单元格的底层阵列。 通过将光标移动限制到正常单元格，将避免突然的屏幕更改。 利用光标（32），使用传统的偏移阴影（34）突出显示整个单元（26）的3-D。 偏移阴影（34）是一个黑条，下划线整个单元格并且围绕单元格的右边缘。 为了标记底层位置，其定义光标（32）的位置，并因此定位在当前底层位置之外的黑条的下一部分（36）的移动，而当前位置被画成固体。

公开(公告)号：US5514113A

公开(公告)日：1996-05-07

申请号：US212052

申请日：1994-03-14

申请人： David Anderson ,  Auville Krause

发明人： David Anderson ,  Auville Krause

IPC分类号： A61M5/32 ,  A61M5/34

CPC分类号： A61M5/32 ,  A61M2005/341

摘要： A syringe and adapter are constructed so as to provide a bend in the hypodermic needle allowing a dentist to reach hard to get to places inside the mouth. With a bend in the needle, the dentist can rotate the body of the syringe to point the needle in various directions while the body of the syringe is placed inside the mouth. Around the bend of the needle is a solid material to prevent the needle from breaking about the bend while in use.

摘要翻译： 构造注射器和适配器以便在皮下注射针中提供弯曲部，使得牙医能够难以到达口中的位置。 当针头弯曲时，牙科医生可以使注射器的主体旋转，使注射器的主体放置在口中，使针在各个方向上指向。 针的弯曲周围是固体材料，以防止针在使用过程中绕弯曲而折断。

公开(公告)号：US5360496A

公开(公告)日：1994-11-01

申请号：US44336

申请日：1993-04-07

申请人： G. William Kuhlman ,  Richard A. Beaumont ,  Daniel F. Carbaugh ,  David Anderson ,  Amiya K. Chakrabarti ,  Kenneth P. Kinnear

发明人： G. William Kuhlman ,  Richard A. Beaumont ,  Daniel F. Carbaugh ,  David Anderson ,  Amiya K. Chakrabarti ,  Kenneth P. Kinnear

IPC分类号： B21J1/06 ,  B21J5/00 ,  C21D7/13 ,  C21D8/00 ,  C22F1/10

CPC分类号： C22F1/10 ,  B21J1/06 ,  B21J5/00 ,  C21D8/005 ,  C21D7/13

摘要： Disclosed is a large alloy forging and method for making it. The forging having an alloy composition selected from one of a nickel base alloy, a cobalt-chromium-nickel base alloy, a nickel-cobalt base alloy and an iron-nickel-chromium-molybdenum alloy and having a grain size of ASTM grain size 4 or finer, as measured by ASTM method E112 and having a tensile strength in the range of 135 to 175 KSI. The process includes: (1) four upset forgings, (2) a rapid cooling after the final upset cooling, (3) a first and second upset forging with a reduction greater than 50%, (4) a third upset forging with a reduction greater than 25.%, and (5) a forging process with a fourth upset forging with a reduction greater than 50%.

摘要翻译： 公开了一种大型合金锻造及其制造方法。 具有选自镍基合金，钴 - 铬 - 镍基合金，镍 - 钴基合金和铁 - 镍 - 铬 - 钼合金之一并且具有ASTM晶粒尺寸4的晶粒尺寸的合金组成的锻造 或更细，如通过ASTM方法E112测量并且具有在135至175KSI范围内的拉伸强度。 该过程包括：（1）四个镦锻锻件，（2）最终镦锻冷却后的快速冷却，（3）第一和第二镦锻，压下率大于50％，（4） 大于25％，以及（5）锻造过程中，第四次锻造具有大于50％的压下率。