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170 条记录 (耗时 0.023 秒)

    Centrifuged material layer measurements taken in an evacuated tube
    62.
    发明授权
    Centrifuged material layer measurements taken in an evacuated tube 失效
    在真空管中进行离心材料层测量

    公开(公告)号：US5086784A

    公开(公告)日：1992-02-11

    申请号：US579274

    申请日：1990-09-05

    申请人： Robert A. Levine ,  Stephen C. Wardlaw

    发明人： Robert A. Levine ,  Stephen C. Wardlaw

    IPC分类号： G01N33/48 ,  A61B5/145 ,  A61B5/15 ,  A61M1/02 ,  B01L3/14 ,  G01N20060101 ,  G01N1/00 ,  G01N33/15 ,  G01N33/49

    CPC分类号： G01N33/491 ,  B01L3/50215 ,  G01N15/042 ,  G01N15/05 ,  A61B5/15003 ,  A61B5/150351 ,  A61B5/150389 ,  A61B5/150473 ,  A61B5/150755 ,  A61B5/153

    摘要： Centrifuged material layer measurements are made in an evacuated glass or clear plastic tube which contains a float. When possibly contaminated materials, such as blood, are being tested the use of the evacuated tube allows the measurements to be made without the technician being exposed to the blood. The tubes are large enough to hold approximately one ml of blood, and are filled with an inert gas at low pressure. Dimensional tolerances relative to those of a capillary tube are relaxed for the tube and float due to the larger sample capacity. The cell bands are stabilized by a layer of a flowable material which settles onto the plasma layer during centrifugation and forms a pellicle thereon.

    摘要翻译： 离心材料层的测量在包含浮子的真空玻璃或透明塑料管中进行。 当可能受污染的材料（例如血液）被测试时，使用真空管允许在没有技术人员暴露于血液的情况下进行测量。 管足够大以容纳约1ml血液，并在低压下填充惰性气体。 由于较大的样品容量，相对于毛细管的尺寸公差会因管和浮子而松弛。 细胞带通过可流动的材料层稳定，其在离心过程中沉降到等离子体层上并在其上形成防护薄膜组件。

    Device for occult blood testing
    63.
    发明授权
    Device for occult blood testing 失效
    潜血试验装置

    公开(公告)号：US4804518A

    公开(公告)日：1989-02-14

    申请号：US704962

    申请日：1985-02-25

    申请人： Robert A. Levine ,  Stephen C. Wardlaw

    发明人： Robert A. Levine ,  Stephen C. Wardlaw

    IPC分类号： G01N33/50 ,  C12Q1/28 ,  G01N33/48 ,  G01N33/52 ,  G01N33/72

    CPC分类号： G01N33/726 ,  G01N33/528 ,  Y10S435/805

    摘要： The device consists of a base sheet of impermeable plastic such as vinyl, or the like, and a guaiac stool receptor sheet adhesively secured thereto. The base sheet is sufficiently larger than the receptor sheet so to form an impermeable skirt which surrounds the receptor sheet so as to form an hermetic barrier protecting the receptor sheet on the underneath one of two of the devices when stacked one on top of the other. A performance/control monitor is included on the device. The monitor includes a peroxidatively active material such as hematin, or the like, which confirms the reactively of the guaiac-impregnated sheet, as well as the activity of the peroxide developing solution. The monitor material is kept out of reactive contact with the guaiac receptor sheet until the developer reagent is applied to the device. A stack of the devices is packed in a sealed container of plastic, or the like, so that the individual devices can be removed from the container one at a time. The devices are designed for use in the physician's office for reception of stool smears taken manually on a rubber glove or finger cot by the physician from patients.

    Self-calibrating gradient dilution in a constitutent assay and gradient dilution apparatus performed in a thin film sample
    64.
    发明授权
    Self-calibrating gradient dilution in a constitutent assay and gradient dilution apparatus performed in a thin film sample 有权
    在薄膜样品中进行的组分测定和梯度稀释仪中的自校准梯度稀释

    公开(公告)号：US09274094B2

    公开(公告)日：2016-03-01

    申请号：US13550131

    申请日：2012-07-16

    申请人： Stephen C. Wardlaw ,  Robert A. Levine

    发明人： Stephen C. Wardlaw ,  Robert A. Levine

    IPC分类号： G01N33/53 ,  G01N33/48 ,  G01N33/543 ,  G01N21/64

    CPC分类号： G01N33/48 ,  G01N21/6428 ,  G01N33/5304 ,  G01N33/54373 ,  G01N33/54386

    摘要： A method and apparatus for measuring antibody titers in a thin film sample in an automated system which does not require multiple dilutions. The system provides a simple method for creating an in-situ dilution within a sample analysis chamber without the use of any precision fluid-handling components, and further, to use the same principles to provide a wide range of sample dilutions within the chamber so as to obviate the need for additional dilution steps when dealing with samples possibly containing wide ranges of analyte concentrations.

    摘要翻译： 一种在不需要多次稀释的自动化系统中测量薄膜样品中抗体滴度的方法和装置。 该系统提供了一种用于在样品分析室内创建原位稀释而不使用任何精密流体处理组件的简单方法，此外，使用相同的原理在腔室内提供范围广泛的样品稀释度，以便 以避免在处理可能含有大范围分析物浓度的样品时需要额外的稀释步骤。

    Method and apparatus for determining the hematocrit of a blood sample utilizing the intrinsic pigmentation of hemoglobin contained within the red blood cells
    67.
    发明授权
    Method and apparatus for determining the hematocrit of a blood sample utilizing the intrinsic pigmentation of hemoglobin contained within the red blood cells 有权
    利用红细胞内含有的血红蛋白的内在色素沉淀来测定血液样品的血细胞比容的方法和装置

    公开(公告)号：US08361799B2

    公开(公告)日：2013-01-29

    申请号：US13418007

    申请日：2012-03-12

    申请人： Robert A. Levine ,  Stephen C. Wardlaw ,  Darryn Unfricht ,  Niten V. Lalpuria

    发明人： Robert A. Levine ,  Stephen C. Wardlaw ,  Darryn Unfricht ,  Niten V. Lalpuria

    IPC分类号： G01N33/48 ,  G01N33/86

    CPC分类号： G01N33/80 ,  A61B5/145 ,  G01N15/1463 ,  G01N15/1475 ,  G01N33/48 ,  G01N33/49 ,  G01N33/721 ,  G01N33/86

    摘要： A method for determining the hematocrit of a blood sample is provided that includes the steps of 1) depositing the sample into an analysis chamber adapted to quiescently hold the sample for analysis; 2) imaging at least a portion of the quiescent sample, which sample portion contains the red blood cells and one or more lacunae to determine an optical density of the imaged portion of the sample on a per image unit basis; 3) selecting optical density values of the image units aligned with the red blood cells; 4) selecting optical density values of the image units aligned with the one or more lacunae; and 5) determining the hematocrit of the sample using the selected optical density values of the image units aligned with the red blood cells and the lacunae.

    摘要翻译： 提供了一种用于确定血液样本的血细胞比容的方法，其包括以下步骤：1）将样品沉积到适于静态保持样品用于分析的分析室中; 2）对静止样品的至少一部分进行成像，该样品部分包含红细胞和一个或多个空隙，以基于每个图像单位确定样品的成像部分的光密度; 3）选择与红细胞对准的图像单元的光密度值; 4）选择与一个或多个空隙对准的图像单元的光密度值; 以及5）使用所选择的与红细胞和空隙对准的图像单元的光密度值来确定样品的血细胞比容。

    Method and apparatus for identifying reticulocytes within a blood sample
    68.
    发明授权
    Method and apparatus for identifying reticulocytes within a blood sample 有权
    用于鉴定血液样品内的网织红细胞的方法和装置

    公开(公告)号：US08310658B2

    公开(公告)日：2012-11-13

    申请号：US13039453

    申请日：2011-03-03

    申请人： Stephen C. Wardlaw ,  Robert A. Levine ,  Darryn W. Unfricht ,  Niten V. Lalpuria ,  Jeremy R. Hill

    发明人： Stephen C. Wardlaw ,  Robert A. Levine ,  Darryn W. Unfricht ,  Niten V. Lalpuria ,  Jeremy R. Hill

    IPC分类号： G01N33/48

    CPC分类号： G06T7/0012 ,  G01N15/05 ,  G01N33/49 ,  G01N2015/055

    摘要： A method and apparatus for identifying reticulocytes within a blood sample is provided. The method includes the steps of: a) depositing the sample into an analysis chamber adapted to quiescently hold the sample for analysis, and the chamber has a known or determinable height extending between the interior surfaces of panels, which height is such that at least one red blood cell, or an aggregate of red blood cells, within the sample contacts both of the interior surfaces; b) admixing a supravital dye with the sample, which dye is operable to cause reticulin to fluoresce when excited by light of one or more predetermined wavelengths; c) imaging the sample using light that includes the one or more predetermined wavelengths that cause reticulin to fluoresce; d) imaging the sample using light that is absorbed by hemoglobin to produce values of optical density on a per image unit basis; and e) identifying reticulocytes within the sample using the image of the sample created with light that causes the dyed reticulin to fluoresce, and using the per image unit optical density values.

    摘要翻译： 提供了一种用于鉴定血液样本内的网织红细胞的方法和装置。 该方法包括以下步骤：a）将样品沉积到适于静态保持样品进行分析的分析室中，并且室具有在面板的内表面之间延伸的已知或可确定的高度，其高度使得至少一个 样品内的红血细胞或红细胞聚集体接触两个内表面; b）将supravital染料与样品混合，该染料可操作以在由一种或多种预定波长的光激发时使网状蛋白发荧光; c）使用包括导致网状蛋白发荧光的一个或多个预定波长的光成像样品; d）使用被血红蛋白吸收的光进行成像，以产生基于每个图像单位的光密度值; 以及e）使用由导致染色的网状蛋白发荧光的光产生的样品的图像来识别样品内的网织红细胞，并且使用每个图像单位的光密度值。

    METHOD AND APPARATUS FOR DETECTING THE PRESENCE OF ANISOTROPIC CRYSTALS AND HEMOZOIN PRODUCING PARASITES IN LIQUID BLOOD
    70.
    发明申请
    METHOD AND APPARATUS FOR DETECTING THE PRESENCE OF ANISOTROPIC CRYSTALS AND HEMOZOIN PRODUCING PARASITES IN LIQUID BLOOD 失效
    用于检测液体血液中各向异性晶体和HEMOZOIN生产PARASITE的存在的方法和装置

    公开(公告)号：US20120021456A1

    公开(公告)日：2012-01-26

    申请号：US13190242

    申请日：2011-07-25

    申请人： Robert A. Levine ,  Darryn W. Unfricht ,  Stephen C. Wardlaw ,  Benjamin Ports

    发明人： Robert A. Levine ,  Darryn W. Unfricht ,  Stephen C. Wardlaw ,  Benjamin Ports

    IPC分类号： C12Q1/04 ,  G01N33/48 ,  B01L3/00 ,  G01N21/21

    CPC分类号： G01N21/23 ,  G01N21/6458

    摘要： An apparatus and method for detecting the presence of anisotropic crystals within a biologic fluid sample is provided. The method includes the steps of: a) disposing the sample within a sample chamber in a sample layer having a height riot greater than about fifteen microns (15μ); b) disposing the sample layer within the sample chamber between a polarizing filter and an analyzing filter; a) disposing the polarizing filter, sample chamber, and analyzing filter in a configuration relative to a light source such that polarized light passes through the sample, and subsequently impinges on the analyzing filter; and d) wherein polar orientations of the polarizing filter and the analyzing filter are such that the polarized light will not pass through the analyzing filter, and light passing through an anisotropic crystal disposed within the sample will pass through the analyzing filter and appear as a point of light.

    摘要翻译： 提供了一种用于检测生物液体样品中各向异性晶体的存在的装置和方法。 该方法包括以下步骤：a）将样品置于具有高于约十五微米（15μ）的高度骚乱的样品层中的样品室内; b）将样品层置于样品室内，在偏振滤光片和分析滤光片之间; a）将偏振滤光器，样品室和分析滤光片相对于光源配置成使得偏振光通过样品，随后撞击在分析滤光片上; 和d）其中偏振滤光器和分析滤光器的极性取向使得偏振光不会通过分析滤光器，并且通过设置在样品内的各向异性晶体的光将通过分析滤光器并显现为点 的光。