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公开(公告)号：US5356911A
公开(公告)日：1994-10-18
申请号：US970364
申请日：1992-11-02
申请人： Matthias Muller-Gliemann , Martin Beuck , Stanislav Kazda , Johannes-Peter Stasch , Andreas Knorr , Stefan Wohlfeil , Walter Hubsch , Jurgen Dressel , Peter Fey , Rudolf Hanko , Thomas Kramer , Ulrich Muller , Siegfried Zaiss
发明人： Matthias Muller-Gliemann , Martin Beuck , Stanislav Kazda , Johannes-Peter Stasch , Andreas Knorr , Stefan Wohlfeil , Walter Hubsch , Jurgen Dressel , Peter Fey , Rudolf Hanko , Thomas Kramer , Ulrich Muller , Siegfried Zaiss
IPC分类号： A61K31/41 , A61K31/44 , A61K31/4412 , A61K31/4418 , A61K31/4425 , A61K31/4427 , A61K31/4433 , A61K31/455 , A61P9/10 , A61P9/12 , C07D213/64 , C07D213/79 , C07D213/80 , C07D401/10 , C07D401/14 , C07D409/14
CPC分类号： C07D401/10
摘要： Substituted biphenylpyridones can be prepared by alkylating pyridones on the nitrogen. The substituted biphenylpyridones are suitable as active substances in medicaments, in particular in hypotensive and anti-atherosclerotic medicaments.
摘要翻译： 取代的联苯基吡啶酮可以通过在氮上烷基化吡啶酮来制备。 取代的联苯吡啶适合作为药物中的活性物质，特别是低血压和抗动脉粥样硬化药物。
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公开(公告)号：US5294633A
公开(公告)日：1994-03-15
申请号：US947869
申请日：1992-09-21
申请人： Thomas Kramer , Jurgen Dressel , Rudolf Hanko , Walter Hubsch , Ulrich Muller , Matthias Muller-Gliemann , Martin Beuck , Stanislav Kazda , Johannes-Peter Stasch , Andreas Knorr , Stefan Wohlfeil
发明人： Thomas Kramer , Jurgen Dressel , Rudolf Hanko , Walter Hubsch , Ulrich Muller , Matthias Muller-Gliemann , Martin Beuck , Stanislav Kazda , Johannes-Peter Stasch , Andreas Knorr , Stefan Wohlfeil
IPC分类号： A61K31/415 , A61K31/41 , A61P9/10 , A61P9/12 , C07D403/10 , C07D25/04
CPC分类号： C07D403/10
摘要： Imidazolyl-propenoic acid derivatives can be prepared by reaction of aldehydes with phosphonoacetic acid esters. The imidazolyl-propenoic acid derivatives are suitable as active substances in medicaments, in particular in hypotensive and anti-atherosclerotic medicaments.
摘要翻译： 咪唑基 - 丙烯酸衍生物可以通过醛与膦酰基乙酸酯的反应来制备。 咪唑基 - 丙烯酸衍生物适合作为药物中的活性物质，特别是低血压和抗动脉粥样硬化药物。
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公开(公告)号：US5242903A
公开(公告)日：1993-09-07
申请号：US771077
申请日：1991-10-02
IPC分类号： A61K38/00 , C07C229/34 , C07C271/22 , C07C311/19 , C07D207/08 , C07D209/48 , C07D233/54 , C07D263/26 , C07K5/02 , C07K5/078
CPC分类号： C07D209/48 , C07C229/34 , C07C271/22 , C07C311/19 , C07D207/08 , C07D233/54 , C07D233/64 , C07D263/26 , C07K5/0205 , C07K5/06147 , A61K38/00 , C07C2101/14
摘要： Renin-inhibiting peptides of the formula ##STR1## in which X represents a group of the formula ##STR2## represents hydroxyl, alkoxy having up to 8 carbon atoms, benzyloxy or a group of the formula --NR.sup.4 R.sup.5,A, B, D and E are identical or different and in each caserepresent a direct bond,represent a radical of the formula ##STR3## in which Z denotes oxygen, sulphur or the methylene grouprepresents a grouping of the formula ##STR4## m represents a number 0, 1 or 2, and L represents a group of the formula --CH.sub.2 --NR2R.sub.3and physiologically acceptable salts thereof.
摘要翻译： 式（I）的肾素抑制肽，其中X表示下式的基团：表示羟基，具有至多8个碳原子的烷氧基，苄氧基或式-NR4R5基团，A ，B，D和E相同或不同，并且在每种情况下都代表直接键，表示式为“IMAGE”的基团，其中Z表示氧，硫或亚甲基表示下式的基团：m表示 数字0,1或2，L表示式-CH 2 -NR 2 R 3的基团及其生理上可接受的盐。
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公开(公告)号：US5089487A
公开(公告)日：1992-02-18
申请号：US528667
申请日：1990-05-24
申请人： Klaus Frobel , Jan-Bernd Lenfers , Peter Fey , Andreas Knorr , Johannes-Peter Stasch , Hartwig Muller , Erwin Bischoff , Hans-Georg Dellweg
发明人： Klaus Frobel , Jan-Bernd Lenfers , Peter Fey , Andreas Knorr , Johannes-Peter Stasch , Hartwig Muller , Erwin Bischoff , Hans-Georg Dellweg
IPC分类号： C12N1/14 , A61K31/335 , A61K31/35 , A61K31/357 , A61K31/365 , A61K31/38 , A61K31/40 , A61K31/425 , A61K31/44 , A61K31/443 , A61K31/4433 , A61P3/00 , A61P9/00 , A61P9/04 , A61P9/06 , A61P9/12 , C07D321/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D407/04 , C07D407/12 , C07D409/04 , C07D417/04 , C07D493/14 , C07H9/04 , C07H15/26 , C12P17/08 , C12P17/16 , C12R1/80
CPC分类号： C07D405/12 , C07D321/12 , C07D407/04 , C07D407/12 , C07D493/14 , C07H15/26 , C12P17/08 , C12P17/16 , C12R1/80
摘要： Cardioactive compounds of the formula ##STR1## in which R.sup.1 and R.sup.8 and R.sup.14 and R.sup.15 can be hydrogen or various organic radicals.
摘要翻译： 其中R 1和R 8以及R 14和R 15可以是氢或各种有机基团的式（Ⅰ）的心脏活性化合物。
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公开(公告)号：US4808622A
公开(公告)日：1989-02-28
申请号：US1496
申请日：1987-01-07
IPC分类号： A61K31/455 , A61P9/10 , A61P9/12 , C07D211/90 , C07D413/04 , C07D211/86
CPC分类号： C07D413/04 , C07D211/90
摘要： Circulation active, e.g. antihypertensive novel methionine-substituted dihydropyridines of the formula ##STR1## in which R.sup.1 is phenyl or a heterocyclic radical, or a physiologically acceptable salt thereof.
摘要翻译： 循环活跃，例如 其中R1是苯基或杂环基的式“IMAGE”的抗高血压新型甲硫氨酸取代的二氢吡啶或其生理上可接受的盐。
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公开(公告)号：US4559350A
公开(公告)日：1985-12-17
申请号：US644093
申请日：1984-08-24
申请人： Egbert Wehinger , Stanislav Kazda , Andreas Knorr
发明人： Egbert Wehinger , Stanislav Kazda , Andreas Knorr
IPC分类号： A61K31/455 , A61P1/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/00 , A61P13/02 , A61P15/00 , A61P25/28 , C07D211/78 , C07D211/90 , C07D401/12 , C07D405/02
CPC分类号： C07D211/78
摘要： 1,2,3,4-Tetrahydropyridines of the formula ##STR1## in which R.sup.1 is optionally substituted aryl or heterocyclic,R.sup.2 is an organic radical, X is a nitrile or an esterR.sup.3 and R.sup.5 are identical or different and each represent hydrogen, a straight-chain or branched or salts thereof with physiologically tolerated acids are antihypertensives.
摘要翻译： 其中R 1为任选取代的芳基或杂环，R 2为有机基团，X为腈或酯，R 3和R 5相同或不同，各自表示氢， 其直链或支链或其盐与生理耐受酸是抗高血压药。
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公开(公告)号：US20140113900A1
公开(公告)日：2014-04-24
申请号：US14115871
申请日：2012-05-02
申请人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Alexander Straub , Jens Ackerstaff , Nils Griebenow , Andreas Knorr , Frank Wunder , Volkhart Min-Jian Li
发明人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Alexander Straub , Jens Ackerstaff , Nils Griebenow , Andreas Knorr , Frank Wunder , Volkhart Min-Jian Li
IPC分类号： C07D487/04 , A61K31/5025 , A61K45/06 , A61K31/53
CPC分类号： C07D487/04 , A61K31/5025 , A61K31/53 , A61K45/06
摘要： The present application relates to novel substituted imidazopyridazines, to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prophylaxis of diseases and to their use for production of medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新型取代的咪唑并哒嗪，其制备方法，其单独或组合用于治疗和/或预防疾病及其用于生产用于治疗和/或预防疾病的药物的用途 ，特别是用于治疗和/或预防心血管疾病。
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68.发明授权Substituted bipyridine derivatives and their use as adenosine receptor ligands 失效取代的联吡啶衍生物及其作为腺苷受体配体的用途公开(公告)号：US08653109B2
公开(公告)日：2014-02-18
申请号：US12440423
申请日：2007-08-30
IPC分类号： A61K31/444 , C07D211/60
CPC分类号： C07D417/14 , A61K31/444 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D213/85 , C07D401/14 , C07D409/14 , C07D413/14
摘要： The present invention relates to novel substituted 2,4′- and 3,4′-bipyridine derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of hypertension and other cardiovascular disorders.
摘要翻译： 本发明涉及新的取代的2,4'-和3,4'-联吡啶衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备治疗用药物和 /或预防疾病，优选用于治疗和/或预防高血压和其它心血管疾病。
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公开(公告)号：US08609727B2
公开(公告)日：2013-12-17
申请号：US12083814
申请日：2006-10-17
申请人： Stephan Bartel , Michael Hahn , Wahed Ahmed Moradi , Eva-Maria Becker , Thomas Rölle , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Andreas Knorr , Dieter Lang
发明人： Stephan Bartel , Michael Hahn , Wahed Ahmed Moradi , Eva-Maria Becker , Thomas Rölle , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Andreas Knorr , Dieter Lang
CPC分类号： C07C65/28
摘要： The present application relates to novel dicarboxylic acid derivatives, process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新型二羧酸衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于治疗和/或预防疾病，特别是用于治疗和/或预防疾病的药物的用途。 预防心血管疾病。
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70.发明申请RING-FUSED 4-AMINOPYRIMIDINES AND USE THEREOF AS STIMULATORS OF SOLUABLE GUANYLATE CYCLASES 失效环状4-氨基亚氨基嘧啶并用作可溶性冠状动脉疾病的刺激物公开(公告)号：US20130172372A1
公开(公告)日：2013-07-04
申请号：US13704980
申请日：2011-07-05
申请人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Jens Ackerstaff , Nils Griebenow , Andreas Knorr , Frank Wunder , Volkhart Min-Jian Li
发明人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Jens Ackerstaff , Nils Griebenow , Andreas Knorr , Frank Wunder , Volkhart Min-Jian Li
IPC分类号： A61K31/519 , C07D491/20 , A61K45/06 , C07D471/04
CPC分类号： A61K31/519 , A61K45/06 , C07D471/04 , C07D491/20 , C07D519/00
摘要： The present application relates to novel fused 4-aminopyrimidines, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases and to the use thereof for production of medicaments for the treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新型融合的4-氨基嘧啶，其制备方法，单独或组合用于治疗和/或预防疾病的用途及其用于生产用于治疗和/或治疗的药物的用途 预防疾病，特别是用于治疗和/或预防心血管疾病。
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