公开(公告)号：US07094594B2

公开(公告)日：2006-08-22

申请号：US10048553

申请日：2001-06-05

申请人： Akira Nishiyama ,  Miho Horikawa ,  Yoshihiko Yasohara ,  Noboru Ueyama ,  Kenji Inoue

发明人： Akira Nishiyama ,  Miho Horikawa ,  Yoshihiko Yasohara ,  Noboru Ueyama ,  Kenji Inoue

IPC分类号： C12P41/00

CPC分类号： C07D319/06 ,  C12P7/42 ,  C12P17/06

摘要： The present invention is to provide a production technology by which an optically active 2-[6-(hydroxymethyl)-1, 3-dioxan-4-yl]acetic acid derivative, which are of value as pharmaceutical intermediates, can be produced from inexpensive and readily available starting materials without using any extraordinary equipment such as an ultra-low-temperature reactor.The present invention is a production process of an optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl]acetic acid derivative which comprises reacting an enolate, prepared by permitting a base or a 0-valent metal to act on an acetic acid ester derivative with (S)-β-hydroxy-γ-butyrolactone at a temperature not lower than −30° C. to give a dihydroxyoxohexanoic acid derivative, treating the same with an acylating agent in the presence of a base to produce a dihydroxyoxohexanoic acid monoacyl derivative, reducing this compound with a microorganism to produce a trihydroxyhexanoic acid monoacyl derivative, treating this compound with an acetal-forming reagent in the presence of an acid catalyst to produce an acyloxymethyldioxanylacetic acid derivative, and finally, subjecting this compound to solvolysis in the presence of a base.

摘要翻译： 本发明提供一种生产技术，通过该技术，可以从廉价的方式制备价值为药物中间体的光学活性的2- [6-（羟甲基）-1,3-二恶烷-4-基]乙酸衍生物 和容易获得的起始材料，而不使用任何非常设备，例如超低温反应器。 本发明是光学活性的2- [6-（羟甲基）-1,3-二恶烷-4-基]乙酸衍生物的制备方法，该方法包括使通过使碱或0价金属 在不低于-30℃的温度下用（S）-β-羟基-γ-丁内酯在乙酸酯衍生物上作用，得到二羟基氧代己酸衍生物，在酰化剂存在下用酰化剂处理 碱化以制备二羟基氧己基单酰基衍生物，用微生物还原该化合物以产生三羟基己酸单酰基衍生物，在酸催化剂存在下用缩醛形成试剂处理该化合物，得到酰氧基甲基二恶烷基乙酸衍生物，最后， 该化合物在碱存在下溶剂解。

公开(公告)号：US20060155136A1

公开(公告)日：2006-07-13

申请号：US10563635

申请日：2004-07-05

申请人： Kazumi Okuro ,  Tatsuyoshi Tanaka ,  Masaru Mitsuda ,  Kenji Inoue

发明人： Kazumi Okuro ,  Tatsuyoshi Tanaka ,  Masaru Mitsuda ,  Kenji Inoue

IPC分类号： C07D301/27

CPC分类号： C07C67/29 ,  C07B2200/07 ,  C07C29/10 ,  C07D301/24 ,  C07C33/46

摘要： The present invention provides an industrially safe, easily operable process for producing an optically active epoxy alcohol derivative useful as an intermediate for pharmaceuticals from inexpensively available materials, and also provides a novel halohydrin derivative serving as an important intermediate for the epoxy alcohol derivative. Furthermore, the present invention provides a process for producing an intermediate for a triazole antifungal agent by allowing a halohydrin to react with a triazole sulfonamide, the process including a small number of steps. A process for producing an optically active epoxy alcohol derivative includes allowing an optically active α-substituted propionate derivative to react with a haloacetic acid derivative in the presence of a base to prepare an optically active haloketone derivative, allowing the resulting haloketone derivative to react with an aryl metal compound to stereoselectively prepare a halohydrin derivative, eliminating a substituent for the hydroxy group of the halohydrin derivative, and performing epoxidation with a base. Furthermore, a process for producing an intermediate for a triazole antifungal agent includes allowing a halohydrin derivative to react with a triazole sulfonamide, the process including a small number of steps.

公开(公告)号：US07075214B2

公开(公告)日：2006-07-11

申请号：US11061883

申请日：2005-02-22

申请人： Kenji Inoue ,  Hisatoshi Saito ,  Takao Noguchi

发明人： Kenji Inoue ,  Hisatoshi Saito ,  Takao Noguchi

IPC分类号： H01L41/08 ,  H03H9/54

CPC分类号： H03H9/589 ,  H03H9/584 ,  H03H9/585 ,  H03H9/588

摘要： A piezoelectric resonator according to an embodiment of the present invention is a piezoelectric resonator for obtaining a signal of a predetermined resonance frequency from a bulk acoustic wave propagating inside a piezoelectric film. This piezoelectric resonator has a plurality of transducers stacked in a predetermined direction, and a propagation area of the bulk acoustic wave varies in a propagation direction of the bulk acoustic wave.

摘要翻译： 根据本发明的实施例的压电谐振器是用于从在压电膜内传播的体声波获得预定谐振频率的信号的压电谐振器。 该压电谐振器具有沿预定方向堆叠的多个换能器，并且体声波的传播面积在体声波的传播方向上变化。

公开(公告)号：US20060125349A1

公开(公告)日：2006-06-15

申请号：US11352338

申请日：2006-02-13

申请人： Kenji Inoue ,  Seisuke Mochizuka

发明人： Kenji Inoue ,  Seisuke Mochizuka

IPC分类号： H03H9/25

CPC分类号： H03H9/6483 ,  H03H9/14588

摘要： A surface acoustic wave device is provided with an input signal electrode 15 and an output signal electrode 16 to and from which an electric signal is inputted or outputted; a first surface acoustic wave resonator 18 including an input terminal 18a connected to the input signal electrode 15 and having a plurality of comb electrodes, an output terminal 18b connected to the output signal electrode 16 and having a plurality of comb electrodes, a common terminal 18c which has a plurality of comb electrodes and which forms interdigital transducers A and B together with the comb electrodes of the input terminal 18a and the comb electrodes of the output terminal 18b; and a second surface acoustic wave resonator 19 connected between the common terminal 18c of the first surface acoustic wave resonator 18 and a pair of grounding terminals 17.

公开(公告)号：US20060105435A1

公开(公告)日：2006-05-18

申请号：US10515658

申请日：2003-06-05

申请人： Takahiro Ohishi ,  Hirokazu Nanba ,  Masanobu Sugawara ,  Masashi Izumida ,  Tatsuya Honda ,  Kohei Mori ,  Satohiro Yanagisawa ,  Nobuo Nagashima ,  Kenji Inoue

发明人： Takahiro Ohishi ,  Hirokazu Nanba ,  Masanobu Sugawara ,  Masashi Izumida ,  Tatsuya Honda ,  Kohei Mori ,  Satohiro Yanagisawa ,  Nobuo Nagashima ,  Kenji Inoue

IPC分类号： C12P13/12 ,  C12P17/00

CPC分类号： C12P13/12 ,  C07C319/06 ,  C07D233/76 ,  C12P17/04 ,  C12P17/10 ,  C12P41/009 ,  C07C323/58

摘要： The present invention provides a simple industrial process for producing an L- or D-optically active α-methylcysteine derivative or its salt, which is a useful pharmaceutical intermediate, from readily available, inexpensive raw materials. In a process for producing an L- or D-optically active α-methylcysteine derivative or its salt, a racemic N-carbamoyl-α-methylcysteine derivative or its salt is D-selectively cyclized with hydantoinase to produce a D-5-methyl-5-thiomethylhydantoin derivative or its salt and an N-carbamoyl-α-methyl-L-cysteine derivative or its salt, which are then subjected to deprotection of the amino group and the sulfur atom, and hydrolysis.

摘要翻译： 本发明提供了一种用于从容易得到的廉价原料生产L-或D-光学活性α-甲基半胱氨酸衍生物或其盐的简单工业方法，其是有用的药物中间体。 在制备L-或D-光学活性α-甲基半胱氨酸衍生物或其盐的方法中，外消旋的N-氨基甲酰基-α-甲基半胱氨酸衍生物或其盐与乙内酰脲酶D选择性环化以产生D-5-甲基 - 5-硫代甲基乙内酰脲衍生物或其盐和N-氨基甲酰基-α-甲基-L-半胱氨酸衍生物或其盐，然后对氨基和硫原子进行脱保护和水解。

公开(公告)号：US06998495B2

公开(公告)日：2006-02-14

申请号：US10492507

申请日：2002-10-24

申请人： Masanobu Sugawara ,  Kenji Inoue

发明人： Masanobu Sugawara ,  Kenji Inoue

IPC分类号： C07C51/36

CPC分类号： C07C67/31 ,  C07B2200/07 ,  C07C67/29 ,  C07C69/78 ,  C07C69/675

摘要： A method for producing an optically active 3,5-dihydroxyhexanoic acid derivative by stereoselectively reducing an optically active 3-oxo-5-hydroxyhexanoic acid derivative is provided. The method, which requires neither an ultralow-temperature reactor, an incubator, nor protection of the 5-position hydroxy group, is simple and economical.An optically active 3,5-dihydroxyhexanoic acid derivative is produced by asymmetrical hydrogenation of an optically active 3-oxo-5-hydroxyhexanoic acid derivative catalyzed by an RuBr2BINAP complex prepared from a ruthenium complex and a ruthenium-optically active phosphine complex, i.e., 2,2′-bisdiarylphosphino-1,1′-binaphthyl (BINAP), while using extremely inexpensive hydrogen as the reductant.

摘要翻译： 提供了通过立体选择性还原旋光性3-氧代-5-羟基己酸衍生物制备光学活性3,5-二羟基己酸衍生物的方法。 既不需要超低温反应器，培养箱也不需要保护5位羟基的方法简单经济。

公开(公告)号：US20050189846A1

公开(公告)日：2005-09-01

申请号：US11028992

申请日：2005-01-03

申请人： Hisatoshi Saito ,  Takao Noguchi ,  Kenji Inoue

发明人： Hisatoshi Saito ,  Takao Noguchi ,  Kenji Inoue

IPC分类号： H01L41/09 ,  H01L41/08 ,  H01L41/18 ,  H01L41/22 ,  H01L41/29 ,  H01L41/319 ,  H03H9/02 ,  H03H9/17

CPC分类号： H03H9/02094 ,  H03H9/175 ,  H03H9/176

摘要： A film bulk acoustic wave resonator of the invention includes a substrate; a resonant structure provided on the substrate constituted by a lower electrode, a piezoelectric film and an upper electrode; and an acoustic multilayer of a plurality of reflective films provided between the substrate and the resonant structure. At least one of the reflective films of the acoustic multilayer has a specified crystal plane orientation, and an X-ray rocking curve full width at half maximum that is preferably not greater than 10 degrees, and more preferably is not greater than 3 degrees. This makes it possible to obtain better resonance characteristics than in the case of the prior art, by increasing the efficiency with which bulk waves propagating towards the substrate are reflected.

摘要翻译： 本发明的薄膜体声波谐振器包括：基板; 设置在由下电极，压电膜和上电极构成的基板上的谐振结构; 以及设置在所述基板和所述谐振结构之间的多个反射膜的声学多层。 声学多层反射膜中的至少一个具有指定的晶面取向，并且X射线摇摆曲线半峰全宽优选不大于10度，更优选不大于3度。 这使得通过提高向衬底传播的体波的效率被反射，可以获得比现有技术的情况更好的谐振特性。

公开(公告)号：US20050151251A1

公开(公告)日：2005-07-14

申请号：US11013698

申请日：2004-12-17

申请人： Takuya Adachi ,  Kenji Inoue

发明人： Takuya Adachi ,  Kenji Inoue

IPC分类号： H01L23/12 ,  H01L21/60 ,  H01L23/31 ,  H01L23/48 ,  H01L23/498 ,  H03H9/02 ,  H03H9/10 ,  H03H9/17 ,  H03H9/25

CPC分类号： H03H9/059 ,  H01L23/3121 ,  H01L23/49805 ,  H01L23/49838 ,  H01L24/97 ,  H01L2224/16 ,  H01L2224/16235 ,  H01L2224/97 ,  H01L2924/01005 ,  H01L2924/01006 ,  H01L2924/01015 ,  H01L2924/01033 ,  H01L2924/01078 ,  H01L2924/01082 ,  H01L2924/19041 ,  H01L2924/19042 ,  H01L2924/19043 ,  H01L2924/30105 ,  H01L2924/30107 ,  H01L2924/3025 ,  H03H9/1085 ,  H01L2224/81

摘要： A mounting substrate of an embodiment of the present invention comprises a first main surface constituting a mounting surface on which an electric device is mounted, and having formed thereon an electrode pattern comprising a plurality of electrode pads that are electrically connected to the electronic device via a bump, and a second main surface which is positioned on the opposite side of the first main surface, and which has formed thereon a plurality of input/output terminals that are electrically connected to the electrode pads. All of the input/output terminals are formed in positions apart from the periphery of the mounting substrate.

摘要翻译： 本发明的实施例的安装基板包括构成安装表面的第一主表面，其上安装有电子装置，并且其上形成有电极图案，电极图案包括多个电极焊盘，电极焊盘通过 凸起，以及位于第一主表面的相反侧上的第二主表面，并且其上形成有多个电连接到电极焊盘的输入/输出端子。 所有的输入/输出端子形成在与安装基板的周边分开的位置。

公开(公告)号：US06896858B2

公开(公告)日：2005-05-24

申请号：US09781884

申请日：2001-02-12

申请人： Atsushi Tatani ,  Makoto Susaki ,  Kazuaki Kimura ,  Taku Shimizu ,  Toshikuni Sera ,  Kenji Inoue

发明人： Atsushi Tatani ,  Makoto Susaki ,  Kazuaki Kimura ,  Taku Shimizu ,  Toshikuni Sera ,  Kenji Inoue

IPC分类号： B01D53/50 ,  B01D53/52 ,  B01D53/73 ,  B01D53/96 ,  B01J8/22 ,  B01J10/00 ,  B01J19/18 ,  C01F11/46 ,  C10K1/26 ,  B01D53/34 ,  B01D53/48 ,  C01J3/00

CPC分类号： B01D53/73 ,  B01D53/501 ,  B01D53/52 ,  B01D53/96 ,  B01J8/222 ,  B01J10/002 ,  B01J19/0066 ,  B01J19/18 ,  B01J2208/00176 ,  B01J2219/00094 ,  C01F11/464 ,  C10K1/26

摘要： A gas refining method for adsorbing a reducing gas obtained by pressure gasification of coal or oil comprises introducing a reducing gas stream into an adsorbing and removing zone where it contacts an adsorbent. Sulfur-containing compounds are adsorbed onto the adsorbent and a first oxygen-containing gas stream is introduced into the adsorbing and removing zone in order to form a regeneration gas containing sulfur dioxide. The regeneration gas is contacted with a second oxygen-containing stream and a calcium-containing liquid slurry to effect absorption of sulfur dioxide by the slurry and precipitation of a gypsum compound. The temperature of the slurry is varied to cause selective precipitation of 60 -gypsum hemihydrate or gypsum dihydrate.

摘要翻译： 用于吸附通过煤或油的压力气化获得的还原气体的气体精炼方法包括将还原性气流引入到与吸附剂接触的吸附和去除区域中。 含硫化合物被吸附到吸附剂上，并且将第一含氧气流引入吸附和去除区，以形成含二氧化硫的再生气体。 使再生气体与第二含氧流和含钙液体浆料接触，以通过浆料吸收二氧化硫并沉淀石膏化合物。 改变浆液的温度以引起60-石膏半水合物或石膏二水合物的选择性沉淀。

公开(公告)号：US06714172B2

公开(公告)日：2004-03-30

申请号：US09113380

申请日：1998-07-10

申请人： Eiichi Matsuzaki ,  Akio Saito ,  Takashi Yamamoto ,  Hajime Morimoto ,  Yuichi Matsumoto ,  Kenji Inoue ,  Nobuharu Ichihashi

发明人： Eiichi Matsuzaki ,  Akio Saito ,  Takashi Yamamoto ,  Hajime Morimoto ,  Yuichi Matsumoto ,  Kenji Inoue ,  Nobuharu Ichihashi

IPC分类号： G09G500

CPC分类号： G06F3/1423 ,  G06F3/147 ,  G09G2310/04 ,  G09G2330/02 ,  G09G2330/026

摘要： The presence/absence of an image information request signal HSYNC output from each of a plurality of display devices is monitored. Based on the monitoring result, image information stored in an image memory of a display controller incorporated in a host computer is distributed to each display device.

摘要翻译： 监视从多个显示装置中的每一个输出的图像信息请求信号HSYNC的存在/不存在。 基于监视结果，将存储在主计算机中的显示控制器的图像存储器中的图像信息分配给每个显示装置。