公开(公告)号：US08852146B2

公开(公告)日：2014-10-07

申请号：US13285518

申请日：2011-10-31

申请人： Daniel J. Horn ,  John Jianhua Chen ,  Jan Weber ,  Thomas J. Holman

发明人： Daniel J. Horn ,  John Jianhua Chen ,  Jan Weber ,  Thomas J. Holman

IPC分类号： A61M25/10 ,  A61L29/12 ,  A61F2/958

CPC分类号： A61M25/104 ,  A61F2002/9583 ,  A61F2250/0068 ,  A61L29/126 ,  A61M2025/1086

摘要： The invention relates to medical balloons, and methods of modifying said balloons by forming a void pattern in their exterior surfaces and filling the voids with a material, such as a fiber or a nanomaterial (e.g., nanotubes, such as carbon nanotubes) and a matrix material, e.g., a polymer.

摘要翻译： 本发明涉及医用气囊，以及通过在其外表面上形成空隙图案并用诸如纤维或纳米材料（例如纳米管，例如碳纳米管）和基体 材料，例如聚合物。

公开(公告)号：US08747529B2

公开(公告)日：2014-06-10

申请号：US13261263

申请日：2010-10-01

申请人： Volker Backes ,  Achim Pfeiffer ,  Jan Weber

发明人： Volker Backes ,  Achim Pfeiffer ,  Jan Weber

IPC分类号： B01D53/02

CPC分类号： B01D53/261 ,  B01D2253/104 ,  B01D2253/106 ,  B01D2253/108 ,  B01D2259/4148 ,  B01J20/103 ,  B01J20/18 ,  B01J20/28052 ,  B01J2220/42

摘要： A device for drying medium flow (8), in particular an air flow, includes a device housing (2), in which at least first and second drying agents (4, 6) are received. The first and second drying agents have a high moisture absorption capacity in the case of low and high moisture values of the medium flow (8), respectively. The amount of the respective drying agent (4, 6) can be selectively set depending on the actual moisture present in the medium flow (8).

摘要翻译： 用于干燥介质流（8），特别是空气流的装置包括装置壳体（2），其中至少接收第一和第二干燥剂（4,6）。 第一和第二干燥剂分别在中等流量（8）的低和高水分值的情况下具有高的吸湿能力。 可以根据存在于介质流（8）中的实际水分来选择性地设定各干燥剂（4,6）的量。

公开(公告)号：US08703168B2

公开(公告)日：2014-04-22

申请号：US12109677

申请日：2008-04-25

申请人： Aiden Flanagan ,  Robert Herrmann ,  Ken Merdan ,  Michael Kuehling ,  Barry O'Brien ,  Rajesh Radhakishnan ,  Torsten Scheuermann ,  Scott Schewe ,  Anurag Singhal ,  Young-Ho Song ,  Mary Joe Timm ,  Jan Weber ,  Yixin Xu

发明人： Aiden Flanagan ,  Robert Herrmann ,  Ken Merdan ,  Michael Kuehling ,  Barry O'Brien ,  Rajesh Radhakishnan ,  Torsten Scheuermann ,  Scott Schewe ,  Anurag Singhal ,  Young-Ho Song ,  Mary Joe Timm ,  Jan Weber ,  Yixin Xu

IPC分类号： A61F2/00

CPC分类号： A61F2/91 ,  A61F2/3094 ,  A61F2002/30677 ,  A61F2002/3068 ,  A61F2210/0076 ,  A61F2230/0013 ,  A61F2240/001 ,  A61F2250/0067 ,  A61F2250/0068

摘要： An implantable medical device for releasing therapeutic agent having a medical device body and a plurality of reservoir-defining structures disposed on a surface of the body. A reservoir can be defined by the reservoir-defining structures and therapeutic agent may be located in the reservoir. A cover may extend over the reservoir so that the therapeutic agent is released from the reservoir when the medical device implanted. Methods for making the medical device may also include providing a medical device body, positioning a plurality of reservoir-defining structures on a surface of the body to form a reservoir, loading therapeutic agent into the reservoir, and covering the reservoir so that the therapeutic agent may release when the medical device is implanted. Alternatively, the reservoir may be covered with a cover and an opening formed in the cover so that the therapeutic agent may release when the medical device is implanted.

摘要翻译： 一种用于释放具有医疗装置主体的治疗剂的可植入医疗装置和设置在身体表面上的多个储存器限定结构。 储存器可以由储存器限定结构限定，并且治疗剂可以位于储存器中。 覆盖物可以延伸到储存器上方，使得当植入医疗装置时治疗剂从储存器释放。 用于制造医疗装置的方法还可以包括提供医疗装置主体，在身体的表面上定位多个储存器限定结构以形成储存器，将治疗剂装载到储存器中并覆盖储存器，使得治疗剂 当植入医疗器械时可能释放。 或者，储存器可覆盖有形成在盖中的盖和开口，使得治疗剂可以在植入医疗装置时释放。

公开(公告)号：US08620406B2

公开(公告)日：2013-12-31

申请号：US10763690

申请日：2004-01-23

申请人： Scott R. Smith ,  Steven E. Walak ,  Lixiao Wang ,  Jan Weber ,  Sheng-Ping Zhong

发明人： Scott R. Smith ,  Steven E. Walak ,  Lixiao Wang ,  Jan Weber ,  Sheng-Ping Zhong

IPC分类号： A61B5/05

CPC分类号： G01R33/285 ,  A61B2090/3954 ,  A61M25/0043 ,  A61M25/0127 ,  G01R33/286

摘要： Medical devices that are visible by magnetic resonance imaging (MRI), and optionally, other imaging techniques, are described. In some embodiments, a medical device adapted for insertion into the body includes an elongated shaft and an electrically conductive path extending spirally about a portion of the shaft. The conductive path is capable of being connected to a current source. The medical device can further include one or more contrast agents (such as MRI contrast agents, radiopaque materials, and/or ultrasound visible materials), which can be arranged in a predetermined manner.

摘要翻译： 描述了通过磁共振成像（MRI）可视的医疗装置，以及可选的其他成像技术。 在一些实施例中，适于插入到本体中的医疗装置包括细长轴和围绕轴的一部分螺旋地延伸的导电路径。 导电路径能够连接到电流源。 医疗装置还可以包括一种或多种可以以预定方式布置的造影剂（例如MRI造影剂，不透射线材料和/或超声可见材料）。

公开(公告)号：US08586072B2

公开(公告)日：2013-11-19

申请号：US11983796

申请日：2007-11-09

申请人： Jan Weber ,  Aiden Flanagan ,  Tim O'Connor ,  Barry J. O'Brien ,  John Clarke ,  David McMorrow

发明人： Jan Weber ,  Aiden Flanagan ,  Tim O'Connor ,  Barry J. O'Brien ,  John Clarke ,  David McMorrow

IPC分类号： A61F2/00 ,  A61L27/30 ,  A61L31/16 ,  A61N1/05

CPC分类号： A61F2/06 ,  A61F2250/0068 ,  A61L27/30 ,  A61L27/54 ,  A61L31/082 ,  A61L31/16 ,  A61L2300/00 ,  A61L2400/12 ,  A61N1/05

摘要： According to an aspect of the invention, medical devices are provided, which include a nanoparticle-derived inorganic layer disposed over a least a portion of structure that includes a substrate, and optionally, a therapeutic-agent-containing layer disposed over at least a portion of the substrate. In some embodiments, the inorganic layer is a nanoporous inorganic layer. Other aspects of the invention comprise methods for forming such medical device.

公开(公告)号：US20130150957A1

公开(公告)日：2013-06-13

申请号：US13708292

申请日：2012-12-07

申请人： Jan Weber

发明人： Jan Weber

IPC分类号： A61F2/24

CPC分类号： A61F2/2412 ,  A61F2/2415 ,  A61F2/2418 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61L31/10 ,  A61L31/145

摘要： Vascular valve systems for treating calcified vascular vessel valves by delivery of one or more calcium chelating agents are described. Methods of making the vascular valve systems are also described.

摘要翻译： 描述了通过递送一种或多种钙螯合剂治疗钙化的血管血管瓣膜的血管瓣膜系统。 还描述了制造血管瓣膜系统的方法。

公开(公告)号：US08435281B2

公开(公告)日：2013-05-07

申请号：US12421928

申请日：2009-04-10

申请人： Jan Weber

发明人： Jan Weber

IPC分类号： A61F2/06

CPC分类号： A61L27/047 ,  A61L31/022 ,  A61L31/148

摘要： A bioerodible, implantable medical device that includes a supersaturated magnesium alloy. The magnesium alloy includes magnesium and at least one alloying element present in a concentration in excess of the equilibrium solid solubility concentration of the alloying element in hexagonal close-packed magnesium [at 25° C.].

摘要翻译： 包含过饱和镁合金的生物蚀刻可植入医疗器械。 镁合金包括镁和至少一种合金元素，其浓度超过六方密堆积镁[25℃]中合金元素的平衡固溶度浓度。

公开(公告)号：US08267992B2

公开(公告)日：2012-09-18

申请号：US12715577

申请日：2010-03-02

申请人： Liliana Atanasoska ,  James Lee Shippy, III ,  Tom Holman ,  Michael S. Arney ,  Victor Schoenle ,  Frank Genovese ,  James Q. Feng ,  Aiden Flanagan ,  Jan Weber

发明人： Liliana Atanasoska ,  James Lee Shippy, III ,  Tom Holman ,  Michael S. Arney ,  Victor Schoenle ,  Frank Genovese ,  James Q. Feng ,  Aiden Flanagan ,  Jan Weber

IPC分类号： A61F2/06

CPC分类号： A61L31/148 ,  A61L27/34 ,  A61L27/446 ,  A61L27/54 ,  A61L27/58 ,  A61L31/10 ,  A61L31/128 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/604 ,  A61L2400/12 ,  A61L2420/04 ,  C08L67/04

摘要： A medical implant includes a bioerodible portion that includes a bioerodible polymer and a bioerodible metal. The bioerodible polymer matrix degrades under physiological conditions to form acidic degradation products. The bioerodible metal degrades under physiological conditions to form basic degradation products. The acidic degradation products and the basic degradation products buffer at least a portion of the medical implant. In one aspect, the bioerodible portion includes a bioerodible polymer matrix and a bioerodible metal within the bioerodible polymer matrix. In another aspect, the medical implant can include a body, a plurality of discrete deposits of the bioerodible polymer on the body, and a plurality of discrete deposits of the bioerodible metal on the body.

摘要翻译： 医疗植入物包括生物腐蚀性部分，其包括生物可蚀解聚合物和生物腐蚀性金属。 生物可蚀解聚合物基质在生理条件下降解形成酸性降解产物。 生物腐蚀金属在生理条件下降解形成碱性降解产物。 酸性降解产物和碱性降解产物缓冲至少一部分医用植入物。 在一个方面，生物可蚀解部分包括生物可腐蚀聚合物基质和生物可腐蚀的聚合物基质内的生物可腐蚀金属。 在另一方面，医疗植入物可以包括主体，身体上的生物可蚀解聚合物的多个离散沉积物，以及身体上的生物可腐蚀金属的多个离散沉积物。

公开(公告)号：US08158904B2

公开(公告)日：2012-04-17

申请号：US10918841

申请日：2004-08-13

申请人： Jan Weber ,  Thomas J. Holman

发明人： Jan Weber ,  Thomas J. Holman

IPC分类号： B23K26/38 ,  B23K26/06

CPC分类号： B23K26/066 ,  B23K26/073 ,  B23K26/384 ,  B23K26/389

摘要： A method and apparatus is provided for removing material from an outer surface of a workpiece such as a catheter or other medical device. The method begins by generating a laser beam having an intensity profile and directing the laser beam onto the outer surface of the workpiece. After the laser beam is generated, its intensity profile is adjusted by a component such as a diffractive optical element (DOE) or a holographic optical element (HOE) so that material can be removed from the workpiece by ablation in a prescribed manner.

摘要翻译： 提供了用于从诸如导管或其它医疗装置的工件的外表面去除材料的方法和装置。 该方法通过产生具有强度分布并将激光束引导到工件的外表面上的激光束开始。 在产生激光束之后，其强度分布由诸如衍射光学元件（DOE）或全息光学元件（HOE）的部件调节，使得可以通过以规定的方式通过烧蚀从材料中去除材料。

公开(公告)号：US08152759B2

公开(公告)日：2012-04-10

申请号：US12077603

申请日：2008-03-20

申请人： Liliana Atanasoska ,  Thomas J. Holman ,  Jan Weber ,  Robert Warner ,  Scott Schewe

发明人： Liliana Atanasoska ,  Thomas J. Holman ,  Jan Weber ,  Robert Warner ,  Scott Schewe

IPC分类号： A61M29/00

CPC分类号： A61N1/325 ,  A61N1/05 ,  A61N1/306 ,  A61N1/327

摘要： The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field. In another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of ion-conductive polymers and one or more types of charged therapeutic agents. In yet another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of electrically conductive polymers and one or more types of charged therapeutic agents.

摘要翻译： 本发明一般涉及含有以下物质的内部（例如，可植入，可插入等）药物递送装置：（a）一种或多种一种或多种治疗剂来源; （b）一个或多个第一电极，（c）一个或多个第二电极和（d）用于在第一和第二电极上施加电压的一个或多个电源。 电源可以适应于例如促进受试者内的电辅助治疗剂递送，包括电穿孔和/或离子电渗疗法。 在本发明的一个方面中，第一和第二电极适于在医疗装置在受试者内展开时使被检体的组织位于它们之间，使得可以产生被引导到组织中的电场。 此外，治疗剂源适于将治疗剂引入电场。 另一方面，治疗剂来源是含有一种或多种类型的离子导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。 在另一方面，治疗剂来源是含有一种或多种类型的导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。