公开(公告)号：US07748133B2

公开(公告)日：2010-07-06

申请号：US12324856

申请日：2008-11-27

申请人： Wei Liu

发明人： Wei Liu

IPC分类号： G01B5/02

CPC分类号： G01B3/14 ,  G01B3/30 ,  G01B3/32 ,  G01B5/02 ,  G01B5/06 ,  Y10S33/01

摘要： An exemplary workpiece inspecting device includes a base, a slider, a handle, a number of magnets, a number of probes and a measuring block. The slider is slidably mounted on the base and supports the handle thereon. The magnets are respectively embedded into the base for attracting and fixing a workpiece on the base. The probes are separately disposed on both the base and the slider for inspecting the perforations defined on a workpiece. The measuring block is attached on the slider for sliding and inspecting a thickness of the workpiece during the movement of the slider.

摘要翻译： 示例性的工件检查装置包括基座，滑块，手柄，多个磁体，多个探针和测量块。 滑块可滑动地安装在基座上并在其上支撑手柄。 磁体分别嵌入基座中，用于在基座上吸引和固定工件。 探针分别设置在基座和滑块上，用于检查在工件上限定的穿孔。 测量块安装在滑块上，用于在滑块移动期间滑动和检查工件的厚度。

公开(公告)号：US07745164B2

公开(公告)日：2010-06-29

申请号：US11645056

申请日：2006-12-26

申请人： Wei Liu ,  Bradley A. Ozenberger ,  Leeying Wu ,  Ching-Hsiung Frederick Lo ,  Steven A. Haney ,  Hemchand Sookdeo ,  Jee Hyung Lee

发明人： Wei Liu ,  Bradley A. Ozenberger ,  Leeying Wu ,  Ching-Hsiung Frederick Lo ,  Steven A. Haney ,  Hemchand Sookdeo ,  Jee Hyung Lee

IPC分类号： C12Q1/48

CPC分类号： C12N9/1205

摘要： The invention provides isolated protein kinase polypeptides related to novel brain-localized protein kinases homologous to known homeodomain-interacting protein kinases (HIPKs), isolated nucleic acid molecules that encode these polypeptides, inhibitors, and methods related thereto. The novel polypeptides and nucleic acid molecules of the invention are termed HIPK4. The invention also provides genetically engineered expression vectors, host cells, and transgenic animals comprising the novel nucleic acid molecules of the invention. The invention additionally provides antisense and RNAi molecules to the nucleic acid molecules of the invention, as well as inhibitors, activators, and antibodies capable of binding to the protein kinase polypeptides of the invention. The invention further provides uses of HIPK4 and its inhibitors, e.g., mutants of HIPK4 lacking protein kinase activity, for modulation of apoptosis, as well as the prevention and treatment of neurological disorders and cancers.

摘要翻译： 本发明提供与与已知同源结构域相互作用蛋白激酶（HIPK）同源的新型脑定位蛋白激酶相关的分离的蛋白激酶多肽，编码这些多肽的分离的核酸分子，抑制剂及其相关方法。 本发明的新型多肽和核酸分子称为HIPK4。 本发明还提供了遗传工程改造的表达载体，宿主细胞和包含本发明的新型核酸分子的转基因动物。 本发明还向本发明的核酸分子以及能够结合本发明的蛋白激酶多肽的抑制剂，激活剂和抗体提供反义和RNAi分子。 本发明还提供了HIPK4及其抑制剂（例如缺乏蛋白激酶活性的HIPK4的突变体）用于调节凋亡以及预防和治疗神经障碍和癌症的用途。

公开(公告)号：US20100137438A1

公开(公告)日：2010-06-03

申请号：US12441054

申请日：2007-09-12

申请人： Ernest Puil ,  Bernard Ansel MacLeod ,  Thomas Michael Stokes ,  Wei Liu

发明人： Ernest Puil ,  Bernard Ansel MacLeod ,  Thomas Michael Stokes ,  Wei Liu

IPC分类号： A61K31/197 ,  A61P25/02

CPC分类号： A61K31/198

摘要： The invention provides for the use of isovaline or a pharmaceutically acceptable salt thereof for the treatment of Pain in a mammalian subject in some preferred embodiments, the invention provides for the treatment of acute and chronic Pain syndromes where other drug therapies have limited efficacy or unacceptable toxicity in said subject.

摘要翻译： 本发明在一些优选实施方案中提供异缬氨酸或其药学上可接受的盐在哺乳动物受试者中用于治疗疼痛的用途，本发明提供治疗急性和慢性疼痛综合征，其中其它药物疗法具有有限的功效或不可接受的毒性 在所述主题。

公开(公告)号：US20090297418A1

公开(公告)日：2009-12-03

申请号：US12473577

申请日：2009-05-28

申请人： Wei Liu

发明人： Wei Liu

IPC分类号： B01D53/56 ,  B01J23/10

CPC分类号： B01J23/8892 ,  B01D53/8628 ,  B01D2251/204 ,  B01D2251/206 ,  B01D2251/208 ,  B01D2255/1021 ,  B01D2255/2045 ,  B01D2255/2047 ,  B01D2255/206 ,  B01D2255/2073 ,  B01D2255/20738 ,  B01D2255/20761 ,  B01D2255/9202 ,  B01J23/10 ,  B01J23/63 ,  B01J23/83 ,  B01J23/8946 ,  B01J29/146 ,  B01J29/166 ,  B01J29/46 ,  B01J29/48

摘要： Composite catalyst materials that may be used to reduce nitrogen oxides to nitrogen gas in the presence of other gasses without significant poisoning of the composite catalyst materials or reaction with the other gasses. The composite catalyst materials are formed of a matrix material comprised of cerium oxide doped with alkaline earth metal oxides, rare earth metal oxides, and combinations thereof wherein the cerium oxide comprises more than 50 atomic percent of the matrix material, and nanoparticles comprising transition metal oxides wherein the transition metal oxides comprise less than 20 atomic percent of the composite catalyst material. The composite catalyst materials may further contain noble metals dispersed in the matrix material.

摘要翻译： 可用于在其他气体存在下将氮氧化物还原成氮气的复合催化剂材料，而不会复合催化剂材料的显着中毒或与其它气体的反应。 复合催化剂材料由掺杂有碱土金属氧化物的氧化铈，稀土金属氧化物及其组合构成的基质材料形成，其中氧化铈包含基体材料的50原子％以上，纳米颗粒包含过渡金属氧化物 其中所述过渡金属氧化物包含小于20原子％的所述复合催化剂材料。 复合催化剂材料还可以含有分散在基体材料中的贵金属。

公开(公告)号：US07627392B2

公开(公告)日：2009-12-01

申请号：US11848214

申请日：2007-08-30

申请人： Wei Liu ,  Shifang Li ,  Weidung Yang ,  Manuel Madriaga

发明人： Wei Liu ,  Shifang Li ,  Weidung Yang ,  Manuel Madriaga

IPC分类号： G06F19/00

CPC分类号： G05B19/41875 ,  G01N21/4788 ,  G03F7/70625 ,  G05B2219/32182 ,  G05B2219/32186 ,  G05B2219/32188 ,  G05B2219/37224

摘要： Provided is a method of controlling a fabrication cluster using a machine learning system, the machine learning system trained developed using an optical metrology model. A simulated approximation diffraction signal is generated based on an approximation diffraction model of the structure. A set of difference diffraction signal is obtained by subtracting the simulated approximation diffraction signal from each of simulated fine diffraction signals and paired with the corresponding profile parameters. A first machine learning system is trained using the pairs of difference diffraction signal and corresponding profile parameters. A library of simulated fine diffraction signals and profile parameters is generated using the trained first machine learning system and using ranges and corresponding resolutions of the profile parameters. A measured diffraction signal is input into the trained second machine learning system to determine at least one profile parameter. The at least one profile parameter is used to adjust at least one process parameter or equipment setting of the fabrication cluster.

摘要翻译： 提供了一种使用机器学习系统来控制制造集群的方法，使用光学计量学模型训练的机器学习系统。 基于结构的近似衍射模型生成模拟近似衍射信号。 通过从每个模拟的细衍射信号中减去模拟近似衍射信号并与相应的轮廓参数配对来获得差分衍射信号。 使用差分衍射信号和相应的轮廓参数对来训练第一机器学习系统。 使用训练有素的第一机器学习系统并使用轮廓参数的范围和相应的分辨率来生成模拟的细衍射信号和轮廓参数的库。 测量的衍射信号被输入到训练有素的第二机器学习系统中以确定至少一个轮廓参数。 至少一个轮廓参数用于调整至少一个制造集群的过程参数或设备设置。

公开(公告)号：US20090214706A1

公开(公告)日：2009-08-27

申请号：US11887977

申请日：2005-07-07

申请人： Casper Tune Berg ,  Patrick M.F. Derkx ,  Carol Fioresi ,  Gijsbert Gerritse ,  Anja Hemmingen Kellet-Smith ,  Karsten Matthias Kragh ,  Wei Liu ,  Andrew Shaw ,  Bo Spange Sørensen ,  Charlotte Refdahl Thoudahl

发明人： Casper Tune Berg ,  Patrick M.F. Derkx ,  Carol Fioresi ,  Gijsbert Gerritse ,  Anja Hemmingen Kellet-Smith ,  Karsten Matthias Kragh ,  Wei Liu ,  Andrew Shaw ,  Bo Spange Sørensen ,  Charlotte Refdahl Thoudahl

IPC分类号： A21D2/26 ,  C12N9/28 ,  A21D13/06 ,  C12N15/56 ,  C12N15/74 ,  C12N1/21 ,  A23K1/165

CPC分类号： C12Y302/0106 ,  A21D8/042 ,  A23K20/189 ,  A23L7/107 ,  A23L29/35 ,  A23V2002/00 ,  C12N9/2417 ,  A23V2300/21

摘要： We describe a PS4 variant polypeptide derivable from a parent polypeptide having non-maltogenic exoamylase activity, in which the PS4 variant polypeptide comprises an amino acid mutation at one or more positions selected from the group consisting of: 121, 161, 223, 146, 157, 158, 198, 229, 303, 306, 309, 316, 353, 26, 70, 145, 188, 272, 339, with reference to the position numbering of a Pseudomonas saccharophilia exoamylase sequence shown as SEQ ID NO: 1.

摘要翻译： 我们描述了可从具有非麦芽糖苷外切酶活性的亲本多肽衍生的PS4变体多肽，其中PS4变体多肽在选自以下的一个或多个位置包含氨基酸突变：121,161,223,146,157 ，158,198,229,303,306,309,316,353,26,70,205,188,272,339，参考SEQ ID NO：1所示的假单胞菌属的嗜酸芽胞弧菌外切酶序列的位置编号。

公开(公告)号：US07560473B2

公开(公告)日：2009-07-14

申请号：US10466712

申请日：2002-01-21

申请人： Hai Wang ,  Liuhong Yun ,  Huasong Feng ,  Fulin Li ,  Xingchun Tang ,  Huamei He ,  Rifang Yang ,  Wenyu Cui ,  Qixiu Gao ,  Gang Hu ,  Rusheng Zhao ,  Wei Liu ,  Chaoliang Long ,  Lin Wang ,  Xinqiang Lu ,  Lijun Liu ,  Yuan Yan

发明人： Hai Wang ,  Liuhong Yun ,  Huasong Feng ,  Fulin Li ,  Xingchun Tang ,  Huamei He ,  Rifang Yang ,  Wenyu Cui ,  Qixiu Gao ,  Gang Hu ,  Rusheng Zhao ,  Wei Liu ,  Chaoliang Long ,  Lin Wang ,  Xinqiang Lu ,  Lijun Liu ,  Yuan Yan

IPC分类号： A61K31/44 ,  A61K31/405 ,  C07C211/00 ,  C07D211/70 ,  C07D209/18

CPC分类号： C07D213/82 ,  A61K31/13 ,  C07C211/08

摘要： The present invention provides amine derivatives represented by formula I, its isomers, racemes or optical isomers, pharmaceutical salts thereof, its amides or esters, pharmaceutical compositions containing said compounds and the preparation methods thereof. The invention also relates to the use of the above mentioned compounds in the preparation of drugs for the prophylaxis or treatment of cardiovascular diseases, diabetes, bronchial and urinary smooth muscle spasm as well as ischemic and anoxic nerve injury. The above compounds can be used to treat hypertension, angina diaphragmatic, myocardial infarction, congestive heart failure, arrhythmia, diabetes, spasmodic bronchial diseases, spasmodic bladder or ureter diseases, and depression.

摘要翻译： 本发明提供由式I表示的胺衍生物，其异构体，消旋体或光学异构体，其药用盐，其酰胺或酯，含有所述化合物的药物组合物及其制备方法。 本发明还涉及上述化合物在制备用于预防或治疗心血管疾病，糖尿病，支气管和尿平滑肌痉挛以及缺血性和缺氧性神经损伤的药物中的用途。 上述化合物可用于治疗高血压，心绞痛，心肌梗塞，充血性心力衰竭，心律失常，糖尿病，痉挛性支气管疾病，痉挛性膀胱或输尿管疾病以及抑郁症。

公开(公告)号：US20090159425A1

公开(公告)日：2009-06-25

申请号：US11960246

申请日：2007-12-19

申请人： Wei Liu ,  Johanes F. Swenberg ,  Hanh D. Nguyen ,  Son T. Nguyen ,  Roger Curtis ,  Philip A. Bottini

发明人： Wei Liu ,  Johanes F. Swenberg ,  Hanh D. Nguyen ,  Son T. Nguyen ,  Roger Curtis ,  Philip A. Bottini

IPC分类号： H05H1/24

CPC分类号： H01J37/321 ,  H01J37/3211 ,  H01J37/32174

摘要： The present invention generally provides apparatus and method for adjusting plasma density distribution in an inductively coupled plasma chamber. One embodiment of the present invention provides an apparatus configured for processing a substrate. The apparatus comprises a chamber body defining a process volume configured to process the substrate therein, and a coil assembly coupled to the chamber body outside the process volume, wherein the coil assembly comprises a coil mounting plate, a first coil antenna mounted on the coil mounting plate, and a coil adjusting mechanism configured to adjust the alignment of the first coil antenna relative to the process volume.

摘要翻译： 本发明通常提供了用于调整电感耦合等离子体室中的等离子体密度分布的装置和方法。 本发明的一个实施例提供了一种被配置用于处理衬底的装置。 该装置包括限定被配置成在其中处理衬底的处理体积的室主体和耦合到处理体积外的室主体的线圈组件，其中线圈组件包括线圈安装板，安装在线圈安装件上的第一线圈天线 板和线圈调整机构，被配置为调节第一线圈天线相对于处理体积的对准。

公开(公告)号：US20090156537A1

公开(公告)日：2009-06-18

申请号：US12257852

申请日：2008-10-24

申请人： Michael R. Bowman ,  Maximilliam T. Follettie ,  Hang Chen ,  Cara Williams ,  Aaron Winkler ,  Debra Ellis ,  Wei Liu

发明人： Michael R. Bowman ,  Maximilliam T. Follettie ,  Hang Chen ,  Cara Williams ,  Aaron Winkler ,  Debra Ellis ,  Wei Liu

IPC分类号： A61K31/7105 ,  A61P11/06 ,  A61P11/00 ,  A61K31/198

CPC分类号： C12N15/113 ,  A61K38/00 ,  C12N15/1137 ,  C12N2310/14 ,  C12Y305/03001 ,  G01N33/6893 ,  G01N2500/10 ,  G01N2800/122

摘要： The present invention provides compositions and methods useful for detecting or treating asthma or other allergic or inflammatory diseases. In one aspect, the methods of the present invention include inhibiting the activity or expression of a component of an arginine metabolic pathway in tissues affected by asthma or other allergic or inflammatory diseases. In many embodiments, the component being inhibited is a cationic amino acid transporter, an arginase, or a component downstream of the arginase. In many other embodiments, the activity or expression of the component is inhibited by an agent that binds to the component. In still many other embodiments, the activity or expression of the component is inhibited by an agent that binds a polynucleotide encoding the component.

摘要翻译： 本发明提供了用于检测或治疗哮喘或其它过敏性或炎性疾病的组合物和方法。 一方面，本发明的方法包括抑制受哮喘或其它过敏性或炎性疾病影响的组织中精氨酸代谢途径的成分的活性或表达。 在许多实施方案中，被抑制的组分是阳离子氨基酸转运蛋白，精氨酸酶或精氨酸酶下游的组分。 在许多其它实施方案中，组分的活性或表达被与组分结合的试剂抑制。 在许多其它实施方案中，组分的活性或表达被结合编码组分的多核苷酸的试剂抑制。

公开(公告)号：US20090154808A1

公开(公告)日：2009-06-18

申请号：US12331160

申请日：2008-12-09

申请人： Feng Gao ,  Na Zhou ,  Wei Liu ,  Huai Yuan

发明人： Feng Gao ,  Na Zhou ,  Wei Liu ,  Huai Yuan

IPC分类号： G06K9/34

CPC分类号： G06K9/3241 ,  G06K9/00791 ,  G06K2209/23 ,  G06T7/12 ,  G06T2207/30248

摘要： A method for segmenting an object region of interest from an image includes detecting each corner in a captured image; acquiring edges of the object from the captured image based on the detected corners; clustering the detected corners based on corners on the acquired edges; and segmenting the image region in the captured image formed by the clustered corners as a region of interest that likely includes the object. With this method and apparatus for the method, an object region of interest may be segmented from an image without utilizing features such as an object shadow and edges.

摘要翻译： 从图像中分割目标区域的方法包括：检测拍摄图像中的每个角; 基于检测到的拐角从捕获的图像获取对象的边缘; 基于所获取的边缘上的角聚类检测到的角; 并且将由聚集角形成的拍摄图像中的图像区域分割为可能包括对象的感兴趣区域。 利用该方法和该方法的装置，可以从图像中分割关注的对象区域，而不利用诸如对象阴影和边缘的特征。