公开(公告)号：US20170290895A1

公开(公告)日：2017-10-12

申请号：US15480345

申请日：2017-04-05

申请人： MERIAL INC.

发明人： Laurent Fischer

IPC分类号： A61K39/00 ,  C07K16/20

CPC分类号： A61K39/0003 ,  A61K39/0233 ,  C07K14/43536 ,  C07K14/4354 ,  C07K16/20

摘要： The present invention encompasses a vaccine composition and method of use for treating heartworm infestation in mammals. The vaccine composition includes chimeric antigens engineered and manufactured using the genetic code (i.e., the amino acid or protein sequence) of the target sequence. After introduction of the vaccine composition containing the target antigen into the host (e.g., a canine), the host will generate antibodies as part of its robust immune response to the antigen. As the antibodies circulate through the host's plasma, heartworm larvae will consume the antibodies as they feed on the plasma. The antibodies will then act on internal targets of the worm recognized as antigens.

公开(公告)号：US20170290803A1

公开(公告)日：2017-10-12

申请号：US15632705

申请日：2017-06-26

申请人： MERIAL, INC.

发明人： Charles Meng ,  Loïc Le Hir de Fallois

IPC分类号： A61K31/404 ,  C07D209/10 ,  C07D401/04 ,  C07D209/08

CPC分类号： A61K31/404 ,  C07D209/08 ,  C07D209/10 ,  C07D401/04 ,  C07D401/12 ,  H03K5/04 ,  H03K7/00

摘要： The invention relates to oral, topical or injectable compositions for combating liver fluke parasites in mammals, comprising at least one indole derivative active agent. The invention also provides for an improved method for eradicating and controlling liver fluke parasite infections and infestations in a mammal comprising administering the compositions of the invention to the mammal in need thereof.

公开(公告)号：US09770502B2

公开(公告)日：2017-09-26

申请号：US14682798

申请日：2015-04-09

申请人： Merial, Inc.

发明人： Michel Bublot ,  Teshome Mebatsion ,  Joyce Pritchard ,  Perry Linz

IPC分类号： A61K39/17 ,  C12N7/00 ,  A61K39/12 ,  A61K39/245 ,  A61K39/00 ,  A61K39/295

CPC分类号： A61K39/17 ,  A61K39/12 ,  A61K39/295 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/545 ,  A61K2039/55 ,  A61K2039/552 ,  A61K2039/70 ,  C12N7/00 ,  C12N2710/16043 ,  C12N2710/16334 ,  C12N2710/16343 ,  C12N2710/20034 ,  C12N2720/10034 ,  C12N2720/10071 ,  C12N2760/18134 ,  C12N2760/18171

摘要： The present invention provides recombinant Gallid herpesvirus 3 (MDV-2) vectors that contain and express antigens of avian pathogens, recombinant Gallid herpesvirus 3 (MDV-2) vectors that contain a mutated gC gene, compositions comprising the recombinant Gallid herpesvirus 3 (MDV-2) vectors, polyvalent vaccines comprising the recombinant Gallid herpesvirus 3 (MDV-2) vectors and one or more wild type viruses or recombinant vectors. The present invention further provides methods of vaccination against a variety of avian pathogens and method of producing the recombinant Gallid herpesvirus 3 (MDV-2) vectors.

公开(公告)号：US09756852B2

公开(公告)日：2017-09-12

申请号：US14600651

申请日：2015-01-20

申请人： MERIAL INC.

发明人： James Pate ,  Natalya Shub

IPC分类号： A01N25/34 ,  A01N25/10 ,  A01N43/56 ,  A01N53/00 ,  A61K9/00

CPC分类号： A01N25/10 ,  A01N43/56 ,  A01N53/00 ,  A61K9/0014

摘要： The invention is a pour-on antiparasitic formulation having superior water resistant properties. The pour-on formulation utilizes one or more polymers (water insoluble with or without water soluble) in the range of about 5 to about 40% w/w, one or more solvents in the range of about 50 to about 94% w/w, with or without additive (e.g., isopropanol or ethanol) in the range of about 5 to about 30% w/w, and optionally a plasticizer in the range of about 0.5 to about 25% w/w. The pour-on antiparasitic formulation features limited spreading when applied to animals (cattle, sheep, dogs and the like). The pour-on antiparasitic formulation further partially evaporates, leaving a water resistant polymer matrix that diffuses at least one active ingredient to the animal's skin.

公开(公告)号：US20170246897A1

公开(公告)日：2017-08-31

申请号：US15498933

申请日：2015-10-30

申请人： MERIAL INC.

发明人： Andy Brehm ,  Julie Campbell ,  Ed Schindler

IPC分类号： B41M5/24 ,  A61J1/18 ,  B41J3/407

CPC分类号： B41M5/24 ,  A61J1/18 ,  A61J2200/44 ,  B41J3/4075 ,  B41M5/26 ,  B41M5/267

摘要： This invention relates to an apparatus and method for applying writings and other markings to a frozen vial or ampoule, which is filled with biological material, and which is held at temperatures between about −70° C. and about −196° C. More particularly, the invention relates to a laser marking method that allows frozen vials to be labeled, while maintaining the integrity of the biological material contained therein.

公开(公告)号：US20170239218A1

公开(公告)日：2017-08-24

申请号：US15441297

申请日：2017-02-24

申请人： MERIAL INC.

发明人： Loic Patrick Le Hir de Fallois ,  Charles Q. Meng ,  Susan Mancini Cady ,  Peter Cheifetz ,  Izabela Galeska

IPC分类号： A61K31/415 ,  A61K9/00 ,  A61K47/10 ,  A01N43/80

CPC分类号： A61K31/415 ,  A01N43/80 ,  A61K9/0019 ,  A61K9/0095 ,  A61K9/08 ,  A61K9/10 ,  A61K9/107 ,  A61K31/42 ,  A61K31/422 ,  A61K47/10 ,  A61K47/14 ,  C07D261/04 ,  C07D413/04 ,  C07D471/04 ,  C07D491/107 ,  A01N25/02 ,  A01N25/22

摘要： This invention relates to long-acting injectable compositions for combating parasites in animals, comprising at least one isoxazoline active agent, a liquid PEG and/or a neutral oil, optionally a co-solvent, and optionally a pharmaceutically acceptable additive or excipient. This invention also provides new isoxazoline active agents with long-lasting efficacy against ectoparasites. The invention also provides for improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the novel isoxazoline compounds and long-acting injectable compositions of the invention to the animal in need thereof.

公开(公告)号：US20170216422A1

公开(公告)日：2017-08-03

申请号：US15419418

申请日：2017-01-30

申请人： MERIAL INC. ,  GENVEC INC. ,  THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by the Secretary of Homeland Security

发明人： Justin Widener ,  Leszlie Woodyward ,  Leonardo Siger ,  Douglas Brough ,  Damodar Ettyreddy ,  Jason Gall ,  Duncan McVey ,  Tom Burrage

IPC分类号： A61K39/12 ,  C12N7/00

CPC分类号： A61K39/12 ,  A61K2039/5256 ,  A61K2039/552 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/10034 ,  C12N2770/32134 ,  C12N2800/107

摘要： The present invention encompasses FMDV vaccines or compositions. The invention encompasses recombinant vectors encoding and expressing FMDV antigens, epitopes or immunogens which can be used to protect animals, in particular ovines, bovines, caprines, or swines, against FMDV.

公开(公告)号：US09706754B2

公开(公告)日：2017-07-18

申请号：US14488968

申请日：2014-09-17

申请人： Merial Limited

发明人： Todd Luepke Prescott ,  Rodney Gordon Walker ,  Gareth Nigel Lauchlan ,  David Andrew Trow

IPC分类号： A01K13/00 ,  A61D7/00 ,  A61M5/19 ,  B05C17/005 ,  B05C17/01 ,  A61M5/20 ,  A61M5/30 ,  A61M5/31

CPC分类号： A01K13/003 ,  A61D7/00 ,  A61M5/19 ,  A61M5/2066 ,  A61M5/3007 ,  A61M5/3148 ,  A61M2005/2026 ,  A61M2005/3103 ,  A61M2005/3115 ,  A61M2005/3128 ,  B05C17/002 ,  B05C17/00553 ,  B05C17/00576 ,  B05C17/01

摘要： The application discloses a multi-chamber, multi-formulation fluid delivery system, comprising a multi-chamber applicator in fluid communication with multi-chamber packaging. Applicators according to the instant disclosure have reduced squeeze-strength requirements, and are useful for dispensing fluids, including medicaments, to animals, including livestock animals. The multi-chamber packaging provides separate storage for formulations containing incompatible active ingredients, and is suitable for use with the multi-chamber applicator. The application also discloses methods for using the system to simultaneously deliver multiple active ingredients, at least some of which are not suitable for co-formulation, thus reducing the time, economic burden and animal stress involved with applying multiple, separate formulations to animals.

公开(公告)号：US20170165424A1

公开(公告)日：2017-06-15

申请号：US15440951

申请日：2017-02-23

申请人： MERIAL INC.

发明人： Robert William Lachlan Holmes ,  Rodney Gordon Walker ,  Todd Donald Ebbett ,  Colin Anthony Standing ,  Peter Robert Williams ,  Giovanni Ciampa ,  Michael Rossignuolo ,  Robert John Smith

IPC分类号： A61M5/178 ,  A61M5/31 ,  A61M5/24

CPC分类号： A61M5/178 ,  A61D17/00 ,  A61M5/00 ,  A61M5/24 ,  A61M5/2425 ,  A61M5/2459 ,  A61M5/3129 ,  A61M5/31511 ,  A61M5/3158 ,  A61M5/3204 ,  A61M2005/005 ,  A61M2005/2414 ,  A61M2005/2481 ,  A61M2005/31516 ,  A61M2250/00

摘要： A trigger operated syringe (100) for intramammary injection of antibiotics has a fluid containing syringe cartridge (203) activated by a plunger (206) which is inserted into the syringe cartridge (203A) and expels fluid when the trigger (205) is pulled. A syringe cartridge holding mechanism (223) holds the syringe cartridge in place until the trigger (205) is released and the plunger (206) retracted. Single syringe cartridge (203) and multiple syringe cartridge (204) versions are disclosed. The plunger moves in a direction which is effectively perpendicular to the direction of movement of the trigger, allowing for ease of injection to a cow's teats, and ejection of the spent cartridges.

公开(公告)号：US20170143819A1

公开(公告)日：2017-05-25

申请号：US15353727

申请日：2016-11-16

申请人： MERIAL INC.

发明人： Jean-Christophe Audonnet ,  Frédéric Reynard ,  Natalia Bomchil ,  Cécile Sigoillot-Claude

IPC分类号： A61K39/135 ,  C07K14/005 ,  C12N7/00 ,  A61K39/385

CPC分类号： A61K39/135 ,  A61K39/385 ,  A61K2039/5258 ,  A61K2039/545 ,  A61K2039/552 ,  A61K2039/55566 ,  A61K2039/6075 ,  C07K14/005 ,  C07K14/32 ,  C07K2319/40 ,  C07K2319/735 ,  C12N7/00 ,  C12N2770/24222 ,  C12N2770/32122 ,  C12N2770/32134 ,  C12N2770/32171

摘要： The present invention encompasses FMDV vaccines or compositions. The vaccine or composition may be a vaccine or composition containing FMDV antigens. The invention also encompasses recombinant vectors encoding and expressing FMDV antigens, epitopes or immunogens which can be used to protect animals, in particular ovines, bovines, caprines, or swines, against FMDV. The invention further encompasses methods of making or producing antigenic polypeptides or antigens.