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    N-acetyl L-cysteine chelates and methods for making and using the same
    64.
    发明授权
    N-acetyl L-cysteine chelates and methods for making and using the same 有权
    N-乙酰基L-半胱氨酸螯合物及其制备和使用方法

    公开(公告)号：US09062086B2

    公开(公告)日：2015-06-23

    申请号：US14142683

    申请日：2013-12-27

    申请人： Viva Pharmaceutical, Inc.

    发明人： Xueju Xie ,  Rhett Sean Daniels ,  Patricia Gahan

    IPC分类号： C07F15/02 ,  C07F1/08 ,  C07F3/02 ,  C07F3/06 ,  A23L1/304 ,  A23L1/305

    CPC分类号： A61K31/315 ,  A23L33/165 ,  A23L33/175 ,  A23L33/18 ,  A23V2002/00 ,  A61K31/555 ,  C07F1/08 ,  C07F3/02 ,  C07F3/06 ,  C07F15/025 ,  A23V2200/30 ,  A23V2200/322 ,  A23V2200/324 ,  A23V2250/156 ,  A23V2250/1586 ,  A23V2250/1588 ,  A23V2250/1592 ,  A23V2250/1608 ,  A23V2250/161 ,  A23V2250/1612 ,  A23V2250/1626 ,  A23V2250/1642 ,  A23V2250/55

    摘要： A nutritional supplement for a human, the supplement having a chelate comprised of an N-acetyl-L-cysteine ligand bonded to a metal to form a chelate ring. A method for preparing a chelate comprised of N-acetyl-L-cysteine ligand and a metal having the steps of: dissolving an amount of N-acetyl-L-cysteine in an aqueous solution, adding a metal to the aqueous solution, stifling and heating the aqueous solution, and removing the solvent under reduced pressure. A method of treating a human for one or more of oxidative stress, cardiovascular disease, cerebrovascular disease, neurodegenerative diseases, Alzheimer's disease, ADHD, bipolar, schizophrenia, autism, dementia, and HIV in a human comprising administering an effective amount of a composition having N-acetyl-L-cysteine in a chelate formation with a metal. A compound having a chelate formulation with a metal being chelated by an N-acetyl-L-cysteine ligand.

    摘要翻译： 一种人的营养补充剂，该补充物具有由与金属键合形成螯合环的N-乙酰基-L-半胱氨酸配体组成的螯合物。 一种制备由N-乙酰基-L-半胱氨酸配体和金属组成的螯合物的方法，其步骤为：将一定量的N-乙酰基-L-半胱氨酸溶解在水溶液中，向该水溶液中加入金属，窒息和 加热水溶液，并在减压下除去溶剂。 一种治疗人类患有氧化应激，心血管疾病，脑血管疾病，神经变性疾病，阿尔茨海默病，ADHD，双相，精神分裂症，孤独症，痴呆和HIV中的一种或多种的方法，包括给予有效量的具有 与金属螯合形成的N-乙酰基-L-半胱氨酸。 具有金属被N-乙酰基-L-半胱氨酸配体螯合的螯合剂的化合物。

    N-ACETYL L-CYSTEINE CHELATES AND METHODS FOR MAKING AND USING THE SAME
    65.
    发明申请
    N-ACETYL L-CYSTEINE CHELATES AND METHODS FOR MAKING AND USING THE SAME 有权
    N-乙酰基-L-胞嘧啶及其制备和使用方法

    公开(公告)号：US20150038577A1

    公开(公告)日：2015-02-05

    申请号：US14142683

    申请日：2013-12-27

    申请人： Xueju Xie ,  Rhett Sean Daniels ,  Patricia Gahan

    发明人： Xueju Xie ,  Rhett Sean Daniels ,  Patricia Gahan

    IPC分类号： C07F15/02 ,  C07F3/06 ,  C07F3/02 ,  C07F1/08

    CPC分类号： A61K31/315 ,  A23L33/165 ,  A23L33/175 ,  A23L33/18 ,  A23V2002/00 ,  A61K31/555 ,  C07F1/08 ,  C07F3/02 ,  C07F3/06 ,  C07F15/025 ,  A23V2200/30 ,  A23V2200/322 ,  A23V2200/324 ,  A23V2250/156 ,  A23V2250/1586 ,  A23V2250/1588 ,  A23V2250/1592 ,  A23V2250/1608 ,  A23V2250/161 ,  A23V2250/1612 ,  A23V2250/1626 ,  A23V2250/1642 ,  A23V2250/55

    摘要： A nutritional supplement for a human, the supplement having a chelate comprised of an N-acetyl-L-cysteine ligand bonded to a metal to form a chelate ring. A method for preparing a chelate comprised of N-acetyl-L-cysteine ligand and a metal having the steps of: dissolving an amount of N-acetyl-L-cysteine in an aqueous solution, adding a metal to the aqueous solution, stifling and heating the aqueous solution, and removing the solvent under reduced pressure. A method of treating a human for one or more of oxidative stress, cardiovascular disease, cerebrovascular disease, neurodegenerative diseases, Alzheimer's disease, ADHD, bipolar, schizophrenia, autism, dementia, and HIV in a human comprising administering an effective amount of a composition having N-acetyl-L-cysteine in a chelate formation with a metal. A compound having a chelate formulation with a metal being chelated by an N-acetyl-L-cysteine ligand.

    摘要翻译： 一种人的营养补充剂，该补充物具有由与金属键合形成螯合环的N-乙酰基-L-半胱氨酸配体组成的螯合物。 一种制备由N-乙酰基-L-半胱氨酸配体和金属组成的螯合物的方法，其步骤为：将一定量的N-乙酰基-L-半胱氨酸溶解在水溶液中，向该水溶液中加入金属，窒息和 加热水溶液，并在减压下除去溶剂。 一种治疗人类患有氧化应激，心血管疾病，脑血管疾病，神经变性疾病，阿尔茨海默病，ADHD，双相，精神分裂症，孤独症，痴呆和HIV中的一种或多种的方法，包括给予有效量的具有 与金属螯合形成的N-乙酰基-L-半胱氨酸。 具有金属被N-乙酰基-L-半胱氨酸配体螯合的螯合剂的化合物。

    INDUSTRIAL METHOD FOR PREPARING ALKALINE HYDROLYSATES OF VEGETABLE PROTEINS
    66.
    发明申请
    INDUSTRIAL METHOD FOR PREPARING ALKALINE HYDROLYSATES OF VEGETABLE PROTEINS 审中-公开
    制备蔬菜水解蛋白的工业方法

    公开(公告)号：US20140314944A1

    公开(公告)日：2014-10-23

    申请号：US14117232

    申请日：2012-05-16

    申请人： Sophie Duvet ,  Claire Dhalleine

    发明人： Sophie Duvet ,  Claire Dhalleine

    IPC分类号： A23J3/32 ,  A23L1/305

    CPC分类号： A23J3/32 ,  A23J3/14 ,  A23K20/147 ,  A23K20/158 ,  A23L29/10 ,  A23L33/185 ,  A23V2002/00 ,  A23V2200/222 ,  A23V2200/224 ,  A23V2250/1882 ,  A23V2250/5114 ,  A23V2250/55

    摘要： A method for preparing alkaline hydrolysates of vegetable proteins, includes the following steps: 1) placing the vegetable proteins in suspension in water so as to have a concentration of 15 to 30 dry weight %, at a temperature of 70 to 80° C. and a pH of 9.5 to 10.5 by adding an alkaline hydroxide selected from the group made up of sodium hydroxide and potassium hydroxide; 2) allowing the suspension to incubate for 10 to 15 hours, at a temperature of 70 to 80° C. and a pH of 9.5 to 10.5; 3) neutralizing the heated suspension with a mineral acid; and 4) drying the neutralized suspension so as to obtain the alkaline hydrolysate.

    摘要翻译： 一种制备植物蛋白碱性水解物的方法，包括以下步骤：1）将植物蛋白悬浮于水中，浓度为15〜30干重％，温度为70〜80℃， 通过加入选自氢氧化钠和氢氧化钾的碱性氢氧化物的pH为9.5至10.5; 2）允许悬浮液在70至80℃的温度和9.5至10.5的pH下孵育10至15小时; 3）用无机酸中和加热的悬浮液; 和4）干燥中和的悬浮液以获得碱性水解产物。

    Charged nutritive proteins and methods
    68.
    发明授权
    Charged nutritive proteins and methods 有权
    带电营养蛋白和方法

    公开(公告)号：US08809259B2

    公开(公告)日：2014-08-19

    申请号：US13836855

    申请日：2013-03-15

    申请人： Pronutria, Inc.

    发明人： David Arthur Berry ,  Brett Adam Boghigian ,  Nathaniel W. Silver ,  Geoffrey von Maltzahn ,  Mike Hamill ,  Rajeev Chillakuru

    IPC分类号： A23J3/04 ,  C07K14/435 ,  A23L1/305 ,  C07K14/415 ,  A23J3/00 ,  C12N15/82

    CPC分类号： C07K14/001 ,  A23J3/04 ,  A23L33/17 ,  A23L33/18 ,  A23L33/30 ,  A23V2002/00 ,  A61K31/198 ,  A61K38/00 ,  A61K38/16 ,  C07K14/415 ,  C12N15/8251 ,  Y02A50/473 ,  A23V2200/316 ,  A23V2250/55 ,  A61K2300/00

    摘要： Charged nutritive proteins are provided. In some embodiments the nutritive proteins an aqueous solubility of at least 12.5 g/L at pH 7. In some embodiments the nutritive proteins an aqueous solubility of at least 50 g/L at pH 7. In some embodiments the nutritive proteins an aqueous solubility of at least 100 g/L at pH 7. In some embodiments the nutritive proteins comprise at least one of a level of a) a ratio of branch chain amino acid residues to total amino acid residues present in the nutritive protein equal to or greater than the ratio of branch chain amino acid residues to total amino acid residues present in a benchmark protein; b) a ratio of leucine residues to total amino acid residues present in the nutritive protein equal to or greater than the ratio of leucine residues to total amino acid residues present in a benchmark protein; and c) a ratio of essential amino acid residues to total amino acid residues present in the nutritive protein equal to or greater than the ratio of essential amino acid residues to total amino acid residues present in a benchmark protein. Also provided are nucleic acids encoding the proteins, recombinant microorganisms that make the proteins, methods of making the proteins using recombinant microorganisms, compositions that comprise the proteins, and methods of using the proteins, among other things.

    摘要翻译： 提供带电的营养蛋白质。 在一些实施方案中，营养蛋白质在pH7下的水溶解度至少为12.5g / L。在一些实施方案中，营养蛋白质在pH7下具有至少50g / L的水溶解度。在一些实施方案中，营养蛋白质的水溶解度为 在一些实施方案中，营养蛋白质包含以下中的至少一种：a）支链氨基酸残基与存在于营养蛋白中的总氨基酸残基的比例等于或大于 支链氨基酸残基与基准蛋白中存在的总氨基酸残基的比例; b）营养蛋白中存在的亮氨酸残基与总氨基酸残基的比例等于或大于存在于基准蛋白中的亮氨酸残基与总氨基酸残基的比例; 和c）营养蛋白中存在的必需氨基酸残基与总氨基酸残基的比例等于或大于基本蛋白质中存在的必需氨基酸残基与总氨基酸残基的比例。 还提供编码蛋白质的核酸，制备蛋白质的重组微生物，使用重组微生物制备蛋白质的方法，包含蛋白质的组合物，以及使用蛋白质的方法等。

    Charged Nutritive Proteins and Methods
    69.
    发明申请
    Charged Nutritive Proteins and Methods 有权

    公开(公告)号：US20140212541A1

    公开(公告)日：2014-07-31

    申请号：US14219943

    申请日：2014-03-19

    申请人： Pronutria, Inc.

    发明人： David Arthur Berry ,  Brett Adam Boghigian ,  Nathaniel W. Silver ,  Geoffrey von Maltzahn ,  Michael Hamill ,  Rajeev Chillakuru

    IPC分类号： A23L1/29 ,  A23L1/305

    CPC分类号： C07K14/001 ,  A23J3/04 ,  A23L33/17 ,  A23L33/18 ,  A23L33/30 ,  A23V2002/00 ,  A61K31/198 ,  A61K38/00 ,  A61K38/16 ,  C07K14/415 ,  C12N15/8251 ,  Y02A50/473 ,  A23V2200/316 ,  A23V2250/55 ,  A61K2300/00

    摘要： Charged nutritive proteins are provided. In some embodiments the nutritive proteins an aqueous solubility of at least 12.5 g/L at pH 7. In some embodiments the nutritive proteins an aqueous solubility of at least 50 g/L at pH 7. In some embodiments the nutritive proteins an aqueous solubility of at least 100 g/L at pH 7. In some embodiments the nutritive proteins comprise at least one of a level of a) a ratio of branch chain amino acid residues to total amino acid residues present in the nutritive protein equal to or greater than the ratio of branch chain amino acid residues to total amino acid residues present in a benchmark protein; b) a ratio of leucine residues to total amino acid residues present in the nutritive protein equal to or greater than the ratio of leucine residues to total amino acid residues present in a benchmark protein; and c) a ratio of essential amino acid residues to total amino acid residues present in the nutritive protein equal to or greater than the ratio of essential amino acid residues to total amino acid residues present in a benchmark protein. Also provided are nucleic acids encoding the proteins, recombinant microorganisms that make the proteins, methods of making the proteins using recombinant microorganisms, compositions that comprise the proteins, and methods of using the proteins, among other things.

    COMPOSITIONS FOR THE MANAGEMENT OF GLYCATED HEMOGLOBIN AND BLOOD GLUCOSE
    70.
    发明申请
    COMPOSITIONS FOR THE MANAGEMENT OF GLYCATED HEMOGLOBIN AND BLOOD GLUCOSE 审中-公开
    用于治疗糖化血红蛋白和血糖的组合物

    公开(公告)号：US20140170128A1

    公开(公告)日：2014-06-19

    申请号：US13717305

    申请日：2012-12-17

    申请人： VIJAI K. PASUPULETI

    发明人： VIJAI K. PASUPULETI

    IPC分类号： A61K38/03 ,  A61K33/06 ,  A61K31/4188 ,  A61K31/385 ,  A61K36/54 ,  A61K33/24 ,  A61K38/16

    CPC分类号： A61K38/03 ,  A23L33/16 ,  A23L33/175 ,  A23L33/19 ,  A23L33/21 ,  A23V2002/00 ,  A61K31/385 ,  A61K31/4188 ,  A61K36/54 ,  A61K38/018 ,  A61K38/28 ,  A61K45/06 ,  A61K2300/00 ,  A23V2200/328 ,  A23V2250/5116 ,  A23V2250/55

    摘要： Disclosed herein are compositions, products, and methods that treat glycated hemoglobin- and blood glucose-affected conditions by improving insulin function for the control and maintenance of blood glucose levels, alleviating oxidative stress, minimizing the risk of developing disease complications, facilitating the loss of weight and maintenance of healthy weight, and at the same time fulfill cravings for pleasant-tasting items of consumption and in turn increase the likelihood of patient compliance with the relevant therapy regimen. The disclosed compositions, products, and methods implement proteins and peptides that provide insulinotropic metabolic products in a sustained manner, in combination with ingredients that, for example, provide sustained release of carbohydrates, steady energy, sustained antioxidant effect relieve oxidative stress, and promote satiety, in order to reduce A1c and blood glucose levels and avert weight gain among subjects in need.

    摘要翻译： 本文公开了通过改善胰岛素功能来控制和维持血糖水平，减轻氧化应激，最小化发生疾病并发症的风险，促进损失的风险来治疗糖化血红蛋白和血糖受损状况的组合物，产品和方法 体重和维持健康的体重，同时满足愉悦的消费项目的渴望，从而增加患者遵守相关治疗方案的可能性。 所公开的组合物，产品和方法实施以持续方式提供促胰岛素代谢产物的蛋白质和肽，其与例如提供碳水化合物的持续释放的稳定能量，持续的抗氧化作用缓解氧化应激并促进饱腹感 ，以减少A1c和血糖水平，并避免需要的受试者的体重增加。