公开(公告)号：US09688622B1

公开(公告)日：2017-06-27

申请号：US15436320

申请日：2017-02-17

Applicant: Shin-Etsu Chemical Co., Ltd.

Inventor： Takeshi Kinsho ,  Naoki Ishibashi ,  Yusuke Nagae

IPC: C07C69/52 ,  C07C309/66 ,  C07C309/73

CPC classification number: C07C309/66 ,  C07C67/287 ,  C07C67/293 ,  C07C67/297 ,  C07C69/63 ,  C07C69/65 ,  C07C309/73 ,  C07C315/04 ,  C07C317/04 ,  C07C317/14 ,  C07C2601/02 ,  C07C69/24 ,  C07C69/145

Abstract: Provided is a 1-(2-acyloxyethyl)cyclopropyl sulfonate compound of General Formula (2): wherein R1 is a monovalent hydrocarbon group having 1 to 10 carbon atoms and optionally containing one or more unsaturated bonds and Z is a monovalent hydrocarbon group having 1 to 10 carbon atoms and optionally containing one or more unsaturated bonds.

公开(公告)号：US09611211B2

公开(公告)日：2017-04-04

申请号：US14974052

申请日：2015-12-18

Applicant: Shin-Etsu Chemical Co., Ltd.

Inventor： Takeshi Kinsho ,  Naoki Ishibashi ,  Yusuke Nagae

IPC: C07C69/65 ,  C07C309/66 ,  C07C309/73 ,  C07C67/287 ,  C07C67/293 ,  C07C69/63 ,  C07C67/297 ,  C07C315/04 ,  C07C317/04 ,  C07C317/14

CPC classification number: C07C309/66 ,  C07C67/287 ,  C07C67/293 ,  C07C67/297 ,  C07C69/63 ,  C07C69/65 ,  C07C309/73 ,  C07C315/04 ,  C07C317/04 ,  C07C317/14 ,  C07C2601/02 ,  C07C69/24 ,  C07C69/145

Abstract: Provided is a simple, selective and efficient method for producing 4-alkyl-3-methylenebutyl carboxylates such as 7-methyl-3-methylene-7-octenyl propionate. More specifically, provided is, for example, a method for producing a 4-alkyl-3-methylenebutyl carboxylate compound, comprising an acyloxylation step of subjecting a 1-(2-haloethyl)cyclopropyl sulfonate compound (1) to acyloxylation to obtain a 1-(2-acyloxyethyl)cyclopropyl sulfonate compound (2), a halogenation step of subjecting the compound (2) to halogenation involving cyclopropyl-allyl rearrangement to obtain a 3-halomethyl-3-butenyl carboxylate compound (3), and a coupling step of subjecting the compound (3) to a coupling reaction with an organometallic reagent (4) to obtain the 4-alkyl-3-methylenebutyl carboxylate compound (5).

公开(公告)号：US20160152545A1

公开(公告)日：2016-06-02

申请号：US15016426

申请日：2016-02-05

Applicant: Asahi Glass Company, Limited

Inventor： Motoshi AOYAMA ,  Jumpei NOMURA

IPC: C07C67/287 ,  C08F116/12 ,  C07C41/18 ,  C07C67/14 ,  C07C51/58

CPC classification number: C07C67/287 ,  C07C41/18 ,  C07C41/24 ,  C07C51/58 ,  C07C67/14 ,  C08F116/12 ,  C08F216/1408 ,  C07C69/63 ,  C07C69/708 ,  C07C55/40 ,  C07C59/135 ,  C07C43/17

Abstract: To provide a process for producing a desired perfluorinated product at a high yield in a fluorination reaction of a partially fluorinated ester.A perfluorinated compound (4) is obtained by fluorinating in a liquid phase a compound (3) (wherein the fluorine content is at least 30 mass %) obtained by reacting a compound (1) and a compound (2), wherein the compound (1) is HOCH2—RA—CH2OH, the compound (2) is X1C(═O)—C(RB)(RC)(RD), RA is a bivalent saturated hydrocarbon group or the like which has no hetero atom such as an etheric oxygen atom, X1 is a halogen atom, and —C(RB)(RC)(RD) is a branched group.

Abstract translation: 提供在部分氟化酯的氟化反应中以高产率制备所需的全氟化产物的方法。 通过使化合物（1）和化合物（2）反应得到的化合物（3）（其中氟含量为30质量％以上）在液相中氟化得到全氟化合物（4），其中化合物 1）是HOCH 2 -RA-CH 2 OH，化合物（2）是X1C（= O）-C（RB）（RC）（RD），RA是不含杂原子的二价饱和烃基等， 醚氧原子，X1为卤原子，-C（RB）（RC）（RD）为支链基团。

公开(公告)号：US20150315136A1

公开(公告)日：2015-11-05

申请号：US14675900

申请日：2015-04-01

Applicant: DAIKIN INDUSTRIES, LTD. ,  NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY

Inventor： Masahiro HIGASHI ,  Yosuke KISHIKAWA ,  Atsushi SHIRAI ,  Takashi NAMIKAWA ,  Sumi ISHIHARA ,  Shoji HARA

IPC: C07C319/20 ,  C07C19/16 ,  C07C23/02 ,  C07C41/22 ,  C07C67/307

CPC classification number: C07C19/16 ,  B01J31/00 ,  C07B39/00 ,  C07C17/02 ,  C07C23/02 ,  C07C41/22 ,  C07C67/287 ,  C07C67/307 ,  C07C319/20 ,  C07C2101/14 ,  C07C2601/14 ,  C07C2601/20 ,  C08K5/3432 ,  C07C321/28 ,  C07C22/00 ,  C07C22/08 ,  C07C19/08 ,  C07C69/63 ,  C07C69/65 ,  C07C43/174 ,  C07C43/192 ,  C07C43/225 ,  C07C43/12

Abstract: Object: An object of the present invention is to provide a method for producing, with a high yield, a fluorinated organic compound, the fluorinated organic compound having not been produced with a sufficient yield by a conventional method for producing a fluorinated organic compound using a fluorinating agent containing IF5-pyridine-HF alone. Another object of the present invention is to provide a fluorinating reagent.Means for achieving the object: A method for producing a fluorinated organic compound comprising step A of fluorinating an organic compound by bringing the organic compound into contact with (1) IF5-pyridine-HF and (2) at least one additive selected from the group consisting of amine hydrogen fluorides, XaF (wherein Xa represents hydrogen, potassium, sodium, or lithium), oxidizers, and reducing agents.

Abstract translation: 发明目的本发明的目的是提供一种以高产率制备含氟有机化合物的方法，所述氟化有机化合物通过常规的氟化有机化合物的制备方法使用 单独含有IF5-吡啶-HF的氟化剂。 本发明的另一个目的是提供一种氟化试剂。 用于实现目的的方法：一种含氟有机化合物的制备方法，其包括通过使有机化合物与（1）IF5-吡啶-HF接触来氟化有机化合物的步骤A和（2）至少一种选自以下的添加剂： 由胺氟化氢，XaF（其中Xa表示氢，钾，钠或锂），氧化剂和还原剂组成。

公开(公告)号：US09051259B2

公开(公告)日：2015-06-09

申请号：US13885867

申请日：2011-11-17

Applicant: Vito Tortelli ,  Marco Galimberti

Inventor： Vito Tortelli ,  Marco Galimberti

IPC: C07D317/00 ,  C07C205/00 ,  C07C67/287 ,  C07D317/34 ,  C07D317/14 ,  C07C51/60 ,  C07C67/14 ,  C07D317/42 ,  C07C51/58

CPC classification number: C07C67/287 ,  C07C51/58 ,  C07C51/60 ,  C07C67/14 ,  C07C2601/14 ,  C07D317/14 ,  C07D317/34 ,  C07D317/42 ,  C07C69/63 ,  C07C53/50

Abstract: A process for producing a perfluorinated functional compound comprises the steps of: A) converting an at least partially hydrogenated alcohol into an at least partially hydrogenated ester compound; and B) reacting said at least partially hydrogenated ester compound with fluorine in the presence of at least one (per)haloolefin comprising at least one carbon-carbon double bond and having at least one fluorine or chlorine atom on either one of the carbon atoms of said double bond, to obtain a perfluorinated ester compound.

Abstract translation: 一种制备全氟化官能化合物的方法包括以下步骤：A）将至少部分氢化的醇转化成至少部分氢化的酯化合物; 和B）在至少一种包含至少一个碳 - 碳双键的卤代烯烃存在下使所述至少部分氢化的酯化合物与氟反应，并且在至少一个碳 - 碳双键的碳原子上具有至少一个氟或氯原子 所述双键，以获得全氟化酯化合物。

公开(公告)号：US20140243404A1

公开(公告)日：2014-08-28

申请号：US13823565

申请日：2011-09-13

Applicant: Scott Alan Snyder ,  Daniel S. Treitler ,  Alexandria P. Brucks ,  Andreas Gollner ,  Maria I. Chiriac ,  Nathan E. Wright ,  Jason J. Pflueger ,  Steven P. Breazzano

Inventor： Scott Alan Snyder ,  Daniel S. Treitler ,  Alexandria P. Brucks ,  Andreas Gollner ,  Maria I. Chiriac ,  Nathan E. Wright ,  Jason J. Pflueger ,  Steven P. Breazzano

IPC: C07D493/10 ,  C07C323/22 ,  C07C319/02 ,  C07C43/225 ,  C07D493/04 ,  C07D319/08 ,  C07C13/573 ,  C07C13/66 ,  C07D313/18 ,  C07D313/00 ,  C07C323/03 ,  C07D311/78

CPC classification number: C07D493/10 ,  C07C13/573 ,  C07C13/60 ,  C07C13/66 ,  C07C23/18 ,  C07C41/22 ,  C07C43/225 ,  C07C43/30 ,  C07C43/313 ,  C07C47/457 ,  C07C47/57 ,  C07C67/287 ,  C07C69/145 ,  C07C69/63 ,  C07C69/96 ,  C07C255/31 ,  C07C319/02 ,  C07C323/03 ,  C07C323/22 ,  C07C381/12 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2602/10 ,  C07C2603/86 ,  C07D311/78 ,  C07D311/82 ,  C07D313/00 ,  C07D313/18 ,  C07D319/08 ,  C07D493/04 ,  C07J63/008 ,  C07J75/005

Abstract: This disclosure is related to halonium compounds useful for cyclization of polyenes, alkenoic acids, and alkenyl alkyl ethers, and halogenation of aromatic compounds. The synthesis of such halonium compounds, compounds made using such halonium compounds, and synthesis of natural compounds, including decalins, using the halonium compounds is also disclosed. A representative halonium compound of the disclosure is:

Abstract translation: 本公开涉及可用于多烯，烯酸和烯基烷基醚的环化的卤化合物和芳族化合物的卤化。 还公开了这种卤化合物的合成，使用这种卤化合物制备的化合物，以及使用卤化合物合成天然化合物，包括十氢化萘。 本公开的代表性卤化物化合物是：

公开(公告)号：US08236975B2

公开(公告)日：2012-08-07

申请号：US13023783

申请日：2011-02-09

Applicant: Bruce D. Hook ,  John Briggs ,  Robert M. Campbell ,  William J. Kruper ,  David J. Schreck ,  Richard D. Varjian ,  Jeffrey G. Hippler

Inventor： Bruce D. Hook ,  John Briggs ,  Robert M. Campbell ,  William J. Kruper ,  David J. Schreck ,  Richard D. Varjian ,  Jeffrey G. Hippler

IPC: C07D301/24

CPC classification number: C07D301/27 ,  C07C29/62 ,  C07C67/287 ,  C07C69/003 ,  C07C69/63 ,  C07C31/36 ,  C07C31/42

Abstract: A process for converting a crude glycerol, crude mixtures of naturally derived multihydroxylated-aliphatic hydrocarbons or esters thereof to a chlorohydrin, by contacting the crude glycerol, crude mixtures of naturally derived multihydroxylated-aliphatic hydrocarbons or esters thereof starting material with a source of a superatmospheric partial pressure of hydrogen chloride for a sufficient time and at a sufficient temperature, and wherein such contracting step is carried out without substantial removal of water, to produce the desired chlorohydrin product; wherein the desired product or products can be made in high yield without substantial formation of undesired overchlorinated byproducts; wherein said crude glycerol, said ester of crude glycerol, or mixture thereof is derived from a renewable raw material. Chlorohydrins made by the process of the present invention are useful in preparing epoxides such as epichlorohydrins.

Abstract translation: 通过将粗甘油，天然衍生的多羟基化脂肪族烃或其酯的起始原料的粗混合物与超大气压源的原料甘油，天然衍生的多羟基化脂肪族烃或其酯的粗混合物与氯代醇反应， 氯化氢的分压足够的时间和足够的温度，并且其中这种收缩步骤在不基本除去水的情况下进行，以产生所需的氯代醇产物; 其中所需产物或产物可以以高产率制备而不显着形成不需要的过氯化副产物; 其中所述粗甘油，所述粗甘油酯或其混合物衍生自可再生原料。 通过本发明方法制备的氯代醇可用于制备环氧化物如表氯醇。

公开(公告)号：US20110312903A1

公开(公告)日：2011-12-22

申请号：US13130033

申请日：2009-11-20

Applicant: Tobias Ritter ,  Takeru Furuya ,  PingPing Tang

Inventor： Tobias Ritter ,  Takeru Furuya ,  PingPing Tang

IPC: A61K31/704 ,  A61K31/355 ,  C07D453/04 ,  A61K31/4709 ,  A61K31/34 ,  C07D205/08 ,  A61K31/397 ,  C07C271/22 ,  A61K31/27 ,  C07D498/08 ,  C07D311/70 ,  C07J17/00

CPC classification number: C07B39/00 ,  C07B2200/07 ,  C07C17/093 ,  C07C37/62 ,  C07C41/22 ,  C07C45/63 ,  C07C67/287 ,  C07C67/307 ,  C07C201/12 ,  C07C209/74 ,  C07C231/12 ,  C07C253/30 ,  C07C269/06 ,  C07C291/04 ,  C07C2601/16 ,  C07C2602/10 ,  C07D311/72 ,  C07D493/06 ,  C07D498/08 ,  C07J17/005 ,  C07J51/00 ,  C07K1/13 ,  C07C22/08 ,  C07C25/22 ,  C07C25/18 ,  C07C49/813 ,  C07C47/55 ,  C07C69/78 ,  C07C211/42 ,  C07C233/15 ,  C07C255/50 ,  C07C271/14 ,  C07C271/16 ,  C07C43/225 ,  C07C39/27 ,  C07C205/12

Abstract: Methods for fluorinating organic compounds are described herein.

Abstract translation: 本文描述了氟化有机化合物的方法。

公开(公告)号：US07906690B2

公开(公告)日：2011-03-15

申请号：US11710002

申请日：2007-02-22

Applicant: William J. Kruper, Jr. ,  Tina Arrowood ,  Bruce Michael Bell ,  John Briggs ,  Robert M. Campbell ,  Bruce D. Hook ,  Anh Nguyen ,  Curt Theriault ,  Ralf Fitschen

Inventor： William J. Kruper, Jr. ,  Tina Arrowood ,  Bruce Michael Bell ,  John Briggs ,  Robert M. Campbell ,  Bruce D. Hook ,  Anh Nguyen ,  Curt Theriault ,  Ralf Fitschen

IPC: C07C31/34

CPC classification number: C07D301/27 ,  C07C29/62 ,  C07C67/08 ,  C07C67/287 ,  C07C69/003 ,  C07C69/63 ,  C07C31/36 ,  C07C31/42

Abstract: The present invention relates to a process for converting a multihydroxylated-aliphatic hydrocarbon or ester thereof to a chlorohydrin, by contacting the multihydroxylated-aliphatic hydrocarbon or ester thereof starting material with a source of hydrogen chloride at superatmospheric, atmospheric and subatmospheric pressure conditions for a sufficient time and at a sufficient temperature, preferably wherein such contracting step is carried out without substantial removal of water, to produce the desired chlorohydrin product; wherein the desired product or products can be made in high yield without substantial formation of undesired overchlorinated byproducts; said process carried out without a step undertaken to specifically remove volatile chlorinated hydrocarbon by-products or chloroacetone, wherein the combined concentration of volatile chlorinated hydrocarbon by-products and chloroacetone is less than 2000 ppm throughout any stage of the said process.

Abstract translation: 本发明涉及一种将多羟基化脂肪族烃或其酯转化为氯代醇的方法，其通过使多羟基化的脂族烃或其起始原料与超大气压，大气压和低于大气压的条件下的氯化氢源接触足够的 时间和足够的温度，优选地其中这种收缩步骤在不基本除去水的情况下进行，以产生所需的氯代醇产物; 其中所需产物或产物可以以高产率制备而不显着形成不需要的过氯化副产物; 所述方法没有进行特别去除挥发性氯化烃副产物或氯丙酮的步骤，其中在所述方法的任何阶段，挥发性氯化烃副产物和氯丙酮的组合浓度小于2000ppm。

公开(公告)号：US07488847B2

公开(公告)日：2009-02-10

申请号：US11153438

申请日：2005-06-16

Applicant: Takashi Okazoe ,  Kunio Watanabe ,  Masahiro Ito ,  Eisuke Murotani ,  Kazuya Oharu ,  Shu-zhong Wang ,  Taiki Hoshino ,  Kimiaki Kashiwagi

Inventor： Takashi Okazoe ,  Kunio Watanabe ,  Masahiro Ito ,  Eisuke Murotani ,  Kazuya Oharu ,  Shu-zhong Wang ,  Taiki Hoshino ,  Kimiaki Kashiwagi

IPC: C07C63/00

CPC classification number: C07C51/60 ,  C07C67/14 ,  C07C67/287 ,  C07C67/307 ,  C07C2603/74 ,  C07C55/40 ,  C07C53/50 ,  C07C69/54 ,  C07C69/63 ,  C07C69/708 ,  C07C69/753 ,  C07C69/734

Abstract: The present invention provides a process A1 for producing a compound (5A), which comprises fluorinating a compound (3A-1) by liquid phase fluorination to a compound (4A-1), followed by a decomposition reaction of an ester bond; a process A2 for producing a compound (5A), which comprises fluorinating a compound (3A-2) by liquid phase fluorination to a compound (4A-2), followed by a decomposition reaction of an ester bond; and a process B for producing a compound (5B), which comprises fluorinating a compound (3B) by liquid phase fluorination to a compound (4B), followed by hydrolysis or alcoholysis. Further, the present invention provides a compound (5A) wherein n is 2 to 4, and a compound (5B) wherein n is 3 or 4. A(—CH2—OCO—R)n  (3A-1) Af(—CF2—OCO—Rf)n  (4A-1) A(—COOR)n  (3A-2) Af(—COORf)n  (4A-2) Af(—COF)n  (5A) A(—OCO—R)n  (3B) Af(—OCO—Rf)n  (4B) Af(—OH)n  (5B) provided that the carbon atom in adamantane to which —OCO—Rf is bonded, is a tertiary carbon atom, A is a n-valent group having n hydrogen atoms in adamantane converted to connecting bonds, R is a fluorinated monovalent organic group, n is an integer of from 1 to 4, Af is a group having at least one of hydrogen atoms in the group A substituted by a fluorine atom, and Rf is a fluorinated monovalent organic group.