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211 条记录 (耗时 0.021 秒)

    Redox reversible bipyridyl-osmium complex conjugates
    61.
    发明申请
    Redox reversible bipyridyl-osmium complex conjugates 失效
    氧化还原可逆联吡啶 - 锇络合物

    公开(公告)号：US20020090632A1

    公开(公告)日：2002-07-11

    申请号：US09999110

    申请日：2001-11-01

    发明人： Harvey B. Buck JR. ,  Zhi David Deng

    IPC分类号： C12Q001/68 ,  G01N033/53 ,  C07F015/00

    CPC分类号： C07F15/0026 ,  C07K5/101 ,  C07K7/02 ,  C07K7/06 ,  C07K9/001 ,  C07K14/805 ,  G01N27/3277 ,  G01N33/532 ,  G01N33/536 ,  G01N33/58 ,  G01N33/723 ,  G01N2333/805 ,  G01N2458/30 ,  Y10S436/805 ,  Y10S436/806 ,  Y10T436/105831

    摘要： Novel bipyridyl-osmium complex conjugates and their use in electrochemical assays are described. The redox reversible-osmium complexes can be prepared to exhibit unique reversible redox potentials and can thus be used in combination with other electroactive redox reversible species having redox potentials differing by at least 50 millivolts in electrochemical assays designed for use of multiple electroactive species in the same cell and in the same sample without interference between the two or more redox coupled conjugate systems.

    摘要翻译： 描述了新的联吡啶 - 锇络合物及其在电化学测定中的用途。 可以制备氧化还原可逆锇络合物以显示独特的可逆氧化还原电位，并且因此可以与设计用于使用多种电活性物质的电化学测定中的氧化还原电位相差至少50毫伏的其他电活性氧化还原可逆物质组合使用 在相同的样品中，两个或更多个氧化还原偶联共轭体系之间没有干扰。

    Method and device for electrochemical immunoassay of multiple analytes
    63.
    发明授权
    Method and device for electrochemical immunoassay of multiple analytes 有权
    多种分析物的电化学免疫测定方法和装置

    公开(公告)号：US06294062B1

    公开(公告)日：2001-09-25

    申请号：US09330422

    申请日：1999-05-28

    申请人： Harvey B. Buck, Jr. ,  Zhi David Deng ,  Eric R. Diebold

    发明人： Harvey B. Buck, Jr. ,  Zhi David Deng ,  Eric R. Diebold

    IPC分类号： G02N2726

    CPC分类号： C07F15/0026 ,  C07K5/101 ,  C07K7/02 ,  C07K7/06 ,  C07K9/001 ,  C07K14/805 ,  G01N27/3277 ,  G01N33/532 ,  G01N33/536 ,  G01N33/58 ,  G01N33/723 ,  G01N2333/805 ,  G01N2458/30 ,  Y10S436/805 ,  Y10S436/806 ,  Y10T436/105831

    摘要： A method and device for detection and quantification of biologically significant analytes in a liquid sample is described. The method includes contacting a volume of a liquid sample with predetermined amounts of at least a first and second redox reversible species having redox potentials differing by at least 50 millivolts. At least one of the redox reversible species comprises a liquid sample diffusible conjugate of a ligand analog of an analyte in the liquid sample and a redox reversible label. A predetermined amount of at least one specific binding partner for each analyte to be measured is combined with the sample and current flow is measured at first and second anodic and cathodic potentials and correlated with current flows for known concentrations of the respective diffusible redox reversible species. Diagnostic devices and kits, including such devices and the specified specific binding partner(s) and redox reversible species are also described.

    摘要翻译： 描述了用于在液体样品中检测和定量生物学显着性分析物的方法和装置。 该方法包括使体积的液体样品与预定量的至少50毫伏的氧化还原电位的至少第一和第二氧化还原可逆物质接触。 至少一种氧化还原可逆物质包括液体样品中分析物的配体类似物和氧化还原可逆标记的液体样品可扩散共轭物。 将待测量的每种待测量分析物的至少一个特定结合配偶体的预定量与样品组合，并且在第一和第二阳极和阴极电位处测量电流，并且与已知浓度的各个可扩散的氧化还原可逆物质的电流相关。 还描述了诊断装置和试剂盒，包括这些装置和指定的特异性结合配偶体和氧化还原可逆物质。

    Metal complex photosensitizer and photovoltaic cell
    64.
    发明授权
    Metal complex photosensitizer and photovoltaic cell 有权
    金属复合光敏剂和光伏电池

    公开(公告)号：US06245988B1

    公开(公告)日：2001-06-12

    申请号：US09423162

    申请日：1999-11-02

    申请人： Michael Grätzel ,  Mohammad Khaja Nazeeruddin ,  Péter Péchy

    发明人： Michael Grätzel ,  Mohammad Khaja Nazeeruddin ,  Péter Péchy

    IPC分类号： C07F1500

    CPC分类号： H01G9/2031 ,  C07F9/58 ,  C07F15/0026 ,  C07F15/0053 ,  C09B57/10 ,  H01G9/2059 ,  H01L51/0086 ,  Y02E10/542 ,  Y02E10/549

    摘要： A photosensitizer complex of formulae (Ia) MX3Lt or (Ib) MXYLt in which M is a transition metal selected from ruthenium, osmium, iron, rhenium and technetium, preferably ruthenium or osmium; each X is a co-ligand independently selected from NCS—, Cl—, Br—, I—, CN—, NCO—, H2O, NCN2−; pyridine unsubstituted or substituted by at least one group selected from vinyl, primary, secondary or tertiary amine, OH and C1-30 alkyl, preferably NCS—; and Lt is a tridentate ligand comprising heterocycles such as pyridine, thiophene, imidazole, pyrazole, triazole, carrying at least one carboxylic, phosphoric, hydoxamic acid or a chelating group. A photovoltaic cell comprising an electrically conductive layer deposited on a support to which at least one titanium dioxide layer has been applied and, as a photosensitizer applied to the titanium dioxide layer, a photosensitizer complex of formula (Ia) or Ib) as specified above.

    摘要翻译： 式（Ia）MX3Lt或（Ib）MXYLt的光敏剂配合物，其中M是选自钌，锇，铁，铼和锝的过渡金属，优选钌或锇; 每个X是独立地选自NCS，Cl，Br，I，CN，NCO，H 2 O，NCN 2 - 的共配体; 未取代或被至少一个选自乙烯基，伯，仲或叔胺的基团取代的吡啶，OH和C 1-3烷基，优选NCS-; Lt是含有至少一种羧酸，磷酸，羟肟酸或螯合基团的吡啶，噻吩，咪唑，吡唑，三唑等杂环的三齿配位体。 一种光伏电池，包括沉积在已经施加了至少一个二氧化钛层的载体上的导电层，作为施加到二氧化钛层的光敏剂，如上所述，式（1a）或（1b）的光敏剂配合物 。

    Luminescent metal chelate labels and means for detection
    66.
    发明授权
    Luminescent metal chelate labels and means for detection 失效
    发光金属螯合物标签和检测手段

    公开(公告)号：US5221605A

    公开(公告)日：1993-06-22

    申请号：US609072

    申请日：1990-10-30

    申请人： Allen J. Bard ,  George M. Whitesides

    发明人： Allen J. Bard ,  George M. Whitesides

    IPC分类号： C07F15/00 ,  G01N33/533

    CPC分类号： G01N33/533 ,  C07F15/0026 ,  C07F15/0053 ,  Y10S436/805 ,  Y10S436/806

    摘要： A chemical moiety is disclosed which comprises a chemical biochemical, or biological substance attached to one or more electrochemiluminescent organometallic compounds. In a preferred embodiment of the invention the substance is attached to one or more ruthenium-containing or osmiumcontaining luminescent organometallic compounds. Methods are disclosed for detecting very small amounts of the chemical moiety using chemiluminescent, electrochemiluminescent, and photoluminescent means. Compounds are disclosed which are useful for labelling substances of interest with ruthenium-containing and osmium-containing labels or other electrochemiluminescent labels. These labelled substances are useful in methods provided for detecting and quantifying analytes of interest in binding assays and competitive binding assays. The labelled substances are of particular use in homogeneous binding assays. These methods form the bases for systems designed to enable the rapid, efficient, and sensitive determination of a broad array of chemical, biochemical, and biological materials of interest.

    摘要翻译： 公开了一种化学部分，其包含与一种或多种电化学发光有机金属化合物连接的化学生物化学或生物物质。 在本发明的一个优选实施方案中，该物质与一种或多种含钌或含锇的发光有机金属化合物连接。 公开了使用化学发光，电化学发光和光致发光手段检测非常少量的化学部分的方法。 公开了可用于用含钌和含锇标记物或其他电化学发光标记物标记物质的化合物。 这些标记的物质可用于检测和定量结合测定和竞争性结合测定中感兴趣的分析物的方法。 标记物质在均一结合试验中特别有用。 这些方法形成了旨在实现快速，有效和敏感地确定所需感兴趣的化学，生物化学和生物材料的广泛系统的系统的基础。

    Process for the hydroformylation of olefins to produce linear aldehydes and alcohols
    68.
    发明授权
    Process for the hydroformylation of olefins to produce linear aldehydes and alcohols 失效
    用于烯烃加氢甲酰化以生产线性醛和醇的方法

    公开(公告)号：US4506101A

    公开(公告)日：1985-03-19

    申请号：US414565

    申请日：1982-09-02

    申请人： Biau-Hung Chang

    发明人： Biau-Hung Chang

    IPC分类号： B01J31/02 ,  B01J31/16 ,  B01J31/20 ,  B01J31/24 ,  C07C29/16 ,  C07C45/50 ,  C07F15/00 ,  C07F15/02

    CPC分类号： C07F15/025 ,  B01J31/0239 ,  B01J31/20 ,  B01J31/24 ,  C07C29/16 ,  C07C45/50 ,  C07F15/0026 ,  C07F15/0053 ,  B01J2231/321 ,  B01J2531/0211 ,  B01J2531/821 ,  B01J2531/825 ,  B01J2531/842

    摘要： A process for producing linear aldehydes or alcohols from olefins using a transition metal hydroformylation catalyst wherein the catalyst comprises an anionic transition metal catalyst wherein the transition metal is Fe, Ru or Os and the catalysts generally have a charge of at least -2. The formula of the anionic catalyst is generally defined as M.sup.+n [H.sub.y A.sub.x L.sub.z ].sup.-n wherein A represents Fe, Ru or Os, M is a cationic species, n is an integer greater than or equal to 2, x is an integer greater than or equal to 1, y is an integer greater than or equal to 0 and z is an integer generally corresponding to the number of available coordination bonding sites in the ruthenium complex. Monoanionic osmium catalysts are also included within the present invention. These hydroformylation catalysts exhibit greater selectivity toward straight chained aldehydes and alcohols than anionic catalysts having a charge of -1 or a neutral catalyst. The monoanionic osmium catalyst also exhibits an increased selectivity toward the straight chain product.The novel hydroformylation catalyst of the present invention is also disclosed.

    摘要翻译： 使用过渡金属加氢甲酰化催化剂从烯烃生产线性醛或醇的方法，其中催化剂包含阴离子过渡金属催化剂，其中过渡金属是Fe，Ru或Os，催化剂通常具有至少-2的电荷。 阴离子催化剂的配方通常定义为M + n [HyAxLz] -n，其中A表示Fe，Ru或Os，M为阳离子种类，n为大于或等于2的整数，x为大于 或等于1，y是大于或等于0的整数，并且z是通常对应于钌络合物中可用的配位键合位点的数目的整数。 单阴极锇催化剂也包括在本发明中。 与负电荷为-1或中性催化剂的阴离子催化剂相比，这些加氢甲酰化催化剂对直链醛和醇的选择性更高。 单阴离子锇催化剂对于直链产物也表现出增加的选择性。 还公开了本发明的新型加氢甲酰化催化剂。