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220 条记录 (耗时 0.036 秒)

    Protein Rim2
    62.
    发明申请
    Protein Rim2 失效
    蛋白质Rim2

    公开(公告)号：US20030049661A1

    公开(公告)日：2003-03-13

    申请号：US10180326

    申请日：2002-06-27

    申请人：

    发明人： Susumu Seino ,  Tadao Shibasaki ,  Nobuaki Ozaki

    IPC分类号： C12Q001/68 ,  G01N033/567 ,  C12N009/64 ,  C07K016/40

    CPC分类号： C07K14/4722

    摘要： Provided is a protein used in the development of a therapeutic agent for neuron- or endocrine cell-related diseases, in which the transport system is involved. The protein has an amino acid sequence with one or more amino acids deleted, substituted, inserted or added relative to the amino acid sequence set forth under SEQ ID NO: 1 in the Sequence Listing and which has a property to interact with GDP/GTP exchange factor II.

    摘要翻译： 提供了用于开发涉及运输系统的神经元或内分泌细胞相关疾病的治疗剂的蛋白质。 蛋白质具有相对于序列表中SEQ ID NO：1所示的氨基酸序列缺失，取代，插入或添加的一个或多个氨基酸的氨基酸序列，其具有与GDP / GTP交换相互作用的性质 因素二。

    Gustducin materials and methods
    64.
    发明申请
    Gustducin materials and methods 审中-公开
    Gustducin材料和方法

    公开(公告)号：US20030013119A1

    公开(公告)日：2003-01-16

    申请号：US09789996

    申请日：2001-02-21

    申请人： Linguagen Corporation

    发明人： Robert F. Margolskee

    IPC分类号： G01N033/53 ,  C07H021/04 ,  C07K014/435

    CPC分类号： C07K16/18 ,  C07K14/4722 ,  G01N2405/04 ,  G01N2500/00 ,  G01N2500/02

    摘要： A novel taste cell specific guanine nucleotide binding protein, gustducin, is disclosed as well as polynucleotide sequences encoding the null subunit of gustducin. Also disclosed are methods of modifying taste involving agents that inhibit or activate the gustducin null subunit, methods for identifying such taste modifying agents and various taste modifying agents.

    摘要翻译： 公开了一种新颖的味道细胞特异性鸟嘌呤核苷酸结合蛋白（gustducin），以及编码gustducin的α亚基的多核苷酸序列。 还公开了改变味道的方法，其涉及抑制或激活外排蛋白α亚基的试剂，用于鉴定这种调味剂和各种味觉调节剂的方法。

    Leptin induced genes
    66.
    发明申请
    Leptin induced genes 审中-公开
    瘦素诱导基因

    公开(公告)号：US20020119517A1

    公开(公告)日：2002-08-29

    申请号：US09804006

    申请日：2001-03-12

    申请人： Millennium Pharmaceuticals, Inc., Delaware corporation

    发明人： David White ,  Jianghong Zhou ,  Louis A. Tartaglia

    IPC分类号： C07K014/435 ,  C07H021/04 ,  C12P021/02 ,  C12N005/06

    CPC分类号： C07K14/4722 ,  A61K38/00 ,  C07K14/47 ,  C07K2319/00 ,  C12N9/1051

    摘要： Six genes whose expression is induced by leptin are disclosed (LIG46; LIG56; Tgtp, encoding a T cell-specific GTP-binding protein; LRG-47, encoding an interferon (IFN) inducible protein; RC10-II, encoding a subunit of a 20S brain proteasome; and Stra13, encoding a retinoic acid inducible protein). These six leptin-inducible genes and the proteins they encode represent targets for the development of therapeutic agents for use in modulating body weight. For example, agents that alter the expression or activity of one or more of the leptin-induced proteins can be used to modulate body weight. Such agents can be identified using cellular, in vitro, or in vivo assays which monitor the expression or activity of one or more of the six leptin-induced proteins. Potentially useful therapeutic agents can also be identified through the use of assays designed to identify agents that bind to one of the leptin-induced proteins. The leptin-induced genes of the invention and the proteins they encode may themselves be useful therapeutically and diagnostically.

    摘要翻译： 公开了表达由瘦蛋白诱导的六个基因（LIG46; LIG56; Tgtp，编码T细胞特异性GTP结合蛋白; LRG-47，编码干扰素（IFN）诱导蛋白; RC10-II，编码a 20S脑蛋白酶体;和Stra13，编码视黄酸诱导蛋白）。 这六种瘦蛋白可诱导基因及其编码的蛋白质代表用于开发用于调节体重的治疗剂的靶标。 例如，改变一种或多种瘦蛋白诱导蛋白质的表达或活性的试剂可用于调节体重。 可以使用监测六种瘦素诱导的蛋白质中的一种或多种的表达或活性的细胞，体外或体内测定来鉴定此类试剂。 潜在有用的治疗剂也可以通过使用设计用于鉴定结合瘦蛋白诱导蛋白之一的试剂的测定来鉴定。 本发明的瘦蛋白诱导的基因及其编码的蛋白本身可以在治疗和诊断上有用。

    Antagonists of G-protein-coupled receptor
    67.
    发明授权
    Antagonists of G-protein-coupled receptor 有权
    G蛋白偶联受体的拮抗剂

    公开(公告)号：US06300312B1

    公开(公告)日：2001-10-09

    申请号：US09582096

    申请日：2000-06-22

    申请人： Sylvain Chemtob ,  Krishna G. Peri ,  Michel Potier

    发明人： Sylvain Chemtob ,  Krishna G. Peri ,  Michel Potier

    IPC分类号： A61K3804

    CPC分类号： C07K14/70571 ,  A61K38/00 ,  C07K14/4722 ,  C07K2319/00

    摘要： The present invention relates to a new class of G-protein-coupled receptor antagonists which bind to the intracellular molecular interface between the receptor and the G-protein, thus hampering signal transduction. The present invention describes peptide sequences derived from the prostaglandin receptor F2&agr; and the G-protein, G&agr;q protein. produced by molecular biology techniques or chemical synthesis, as selective inhibitors of signal transduction involved in the stimulation of this receptor. Such peptides or molecules derived from their primary, secondary and tertiary structures may be used as effective tocolytics for the prevention of premature labor or be utilized for the treatment of dysmenorrhea.

    摘要翻译： 本发明涉及结合受体和G蛋白之间的细胞内分子界面的新一类G蛋白偶联受体拮抗剂，从而阻碍了信号转导。 本发明描述了衍生自前列腺素受体F2alpha和G蛋白Galphaq蛋白的肽序列。 由分子生物学技术或化学合成产生，作为参与刺激该受体的信号转导的选择性抑制剂。 衍生自其初级，次级和三级结构的这些肽或分子可以用作预防早产或用于治疗痛经的有效tocolytics。