公开(公告)号：US20100323064A1

公开(公告)日：2010-12-23

申请号：US12526260

申请日：2008-02-12

申请人： Mari Miura ,  Yasuyuki Seto ,  Masayuki Watanabe ,  Toshimitsu Yoshioka

发明人： Mari Miura ,  Yasuyuki Seto ,  Masayuki Watanabe ,  Toshimitsu Yoshioka

IPC分类号： A23C9/12 ,  C01B17/98

CPC分类号： C12N1/04 ,  A23C9/1322 ,  A23L2/44 ,  A23L3/358 ,  A23V2002/00 ,  A23V2200/10 ,  A23V2250/1612

摘要： An object of the present invention is to provide a novel agent for improving the viability of lactic acid bacteria, which has an excellent effect on the improvement of the viability of lactic acid bacteria in the product, has no adverse effect on the flavor of the product and requires less production cost. An agent for improving the viability of lactic acid bacteria characterized by using manganese as an effective ingredient. A manganese-containing material may be used as manganese. Manganese is preferably formulated at 5 μg/100 g or more in the final product.

摘要翻译： 本发明的目的是提供一种用于提高乳酸菌生存力的新型药剂，其对提高产品中乳酸菌的存活力具有优异的效果，对产品的风味没有不利影响 并且需要较少的生产成本。 用于改善以锰为有效成分的乳酸菌的生存力的试剂。 含锰材料可以用作锰。 锰最好在最终产品中配制成5μg/ 100g或更多。

公开(公告)号：US20100298228A1

公开(公告)日：2010-11-25

申请号：US12740709

申请日：2008-10-28

申请人： Atsushi Serizawa ,  Yoshikazu Morita ,  Daisuke Uetsuji ,  Aiko Ono ,  Hiroaki Matsuyama ,  Satoshi Higurashi

发明人： Atsushi Serizawa ,  Yoshikazu Morita ,  Daisuke Uetsuji ,  Aiko Ono ,  Hiroaki Matsuyama ,  Satoshi Higurashi

IPC分类号： A61K38/00 ,  A61P19/00

CPC分类号： A61K35/20 ,  A21D2/263 ,  A23C19/082 ,  A23C19/0917 ,  A23J1/20 ,  A23L2/66 ,  A23L33/19 ,  A23V2002/00 ,  A23V2300/30 ,  A23V2200/306 ,  A23V2250/5424

摘要： Disclosed is a bone-reinforcing agent which comprises a milk protein fraction having the following properties (1) to (4): (1) the milk protein fraction is derived from milk; (2) the milk protein fraction is a fraction containing a protein component having a molecular weight of 6,000 to 150,000 Daltons; (3) the milk protein fraction has a basic amino acid content of 12 to 14 wt % in the constitutional amino acid composition, and the ratio of the amount of a basic amino acid(s) to the amount of an acidic amino acid(s) is 0.5 to 0.7; and (4) the milk protein fraction has an activity of accelerating the calcification in an osteoblast.

摘要翻译： 公开了一种骨增强剂，其包含具有以下性质（1）至（4）的乳蛋白质级分：（1）乳蛋白质级分来自牛奶; （2）乳蛋白质级分是含有分子量为6,000至150,000道尔顿的蛋白质组分的级分; （3）在构成氨基酸组成中，乳蛋白质级分的碱性氨基酸含量为12〜14重量％，碱性氨基酸的量与酸性氨基酸的量（s ）为0.5〜0.7; 和（4）乳蛋白质级分具有促进成骨细胞钙化的活性。

公开(公告)号：US20100261883A1

公开(公告)日：2010-10-14

申请号：US12740711

申请日：2008-10-28

申请人： Atsushi Serizawa ,  Yoshikazu Morita ,  Daisuke Uetsuji ,  Aiko Ono ,  Hiroaki Matsuyama ,  Satoshi Higurashi

发明人： Atsushi Serizawa ,  Yoshikazu Morita ,  Daisuke Uetsuji ,  Aiko Ono ,  Hiroaki Matsuyama ,  Satoshi Higurashi

IPC分类号： C07K14/47

CPC分类号： A23K50/40 ,  A21D2/263 ,  A23C19/082 ,  A23J1/20 ,  A23J3/343 ,  A23K20/147 ,  A23L2/395 ,  A23L2/66 ,  A23L33/19 ,  A23V2002/00 ,  A61K35/20 ,  C07K14/4703 ,  A23V2250/5424 ,  A23V2200/306

摘要： A milk protein fraction having following properties (1) to (4) is excellent in bone resorption inhibitory effect, and is useful for preventing or treating bone diseases: (1) the milk protein fraction is derived from milk; (2) the milk protein fraction is a fraction containing a protein having a molecular weight of 12,000 to 16,000 Daltons; (3) the milk protein fraction has a basic amino acid content of 18 to 20 wt % in the constitutional amino acid composition, and the ratio of the amount of a basic amino acid(s) to the amount of an acidic amino acid(s) is 0.7 to 0.9; and (4) the milk protein fraction has a bone resorption inhibitory effect.

摘要翻译： 具有以下特性（1）〜（4）的乳蛋白质级分骨吸收抑制效果优异，可用于预防或治疗骨病：（1）乳蛋白质分数来自牛奶; （2）乳蛋白质级分是含有分子量为12,000至16,000道尔顿的蛋白质的级分; （3）在构成氨基酸组成中，乳蛋白质级分的碱性氨基酸含量为18〜20重量％，碱性氨基酸的量与酸性氨基酸的量（s ）为0.7〜0.9; 和（4）乳蛋白质分数具有骨吸收抑制作用。

公开(公告)号：US20100048493A1

公开(公告)日：2010-02-25

申请号：US12610896

申请日：2009-11-02

申请人： Hiroshi KAWAKAMI ,  Nobuhiro HANADA ,  Susumu IMAI

发明人： Hiroshi KAWAKAMI ,  Nobuhiro HANADA ,  Susumu IMAI

IPC分类号： A61K31/70

CPC分类号： A23K20/195 ,  A23K20/121 ,  A23L33/10 ,  A61K31/7028 ,  A61Q11/00

摘要： It is intended to provide an oral flora-improving agent capable of forming a favorable flora in the oral cavity and a food or a drink for improving the oral flora. An oral flora-improving agent containing as an active ingredient a ganglioside and a food, a drink, or a feed for improving the oral flora containing the ganglioside exhibit an antibacterial effect on harmful bacteria in the oral cavity, which are undesirable from the viewpoint of decay and diseases such as periodontal disease, and a growth-improving effect on useful bacteria to be preserved in the oral cavity. Further, the ganglioside is efficaciously used as an active ingredient in an antibacterial agent or an antibacterial drink, food, or feed, a growth promoter, or a food, a drink, or a feed for promoting growth.

摘要翻译： 旨在提供能够在口腔中形成有利菌群的口腔植物改良剂和用于改善口腔菌群的食品或饮料。 含有作为活性成分的神经节苷脂的口腔内植物改善剂和用于改善含有神经节苷脂的口腔菌群的食品，饮料或饲料，对口腔内的有害细菌表现出抗菌作用，从对 衰老和疾病如牙周病，以及对在口腔中保留的有用细菌的生长改善作用。 此外，神经节苷脂有效地用作抗菌剂或抗菌饮料，食品或饲料，生长促进剂或用于促进生长的食品，饮料或饲料中的活性成分。

公开(公告)号：US20100021445A1

公开(公告)日：2010-01-28

申请号：US12525172

申请日：2008-02-29

申请人： Hiroshi Kawakami ,  Yasuhiko Shiinoki ,  Yukio Kadooka

发明人： Hiroshi Kawakami ,  Yasuhiko Shiinoki ,  Yukio Kadooka

IPC分类号： A61K35/74 ,  C12N1/20 ,  A61P3/00 ,  A61P3/04

CPC分类号： A23C19/054 ,  A23C9/1234 ,  A23C9/18 ,  A23K10/18 ,  A23L33/135 ,  A23Y2220/49 ,  A61K35/744 ,  A61K35/747

摘要： Provide a visceral fat reducing agent for reducing the diseases and conditions associated with the metabolic syndrome which represents a condition where various risk factors such as those for hypertension, hyperlipemia, glucose tolerance dysfunction, etc., have accumulated, or simply reducing an accumulation of visceral fat, wherein the effective ingredient of said visceral fat reducing agent includes fungus bodies of lactic bacteria, especially lactic bacteria belonging to the Lactobacillus sp. and Lactococcus sp. and/or cultures thereof, while also providing a beverage, food or feed containing said visceral fat reducing agent.

摘要翻译： 提供一种内脏减脂剂，用于减少与代谢综合征相关的疾病和病症，代谢综合征是各种危险因素如高血压，高脂血症，葡萄糖耐量异常等积累的危险因素，或简单地减少内脏积累 脂肪，其中所述内脏脂肪还原剂的有效成分包括乳酸菌的真菌体，特别是属于乳杆菌属的乳酸菌。 和乳球菌属 和/或其培养物，同时还提供含有所述内脏脂肪还原剂的饮料，食品或饲料。

公开(公告)号：US20100021444A1

公开(公告)日：2010-01-28

申请号：US12439728

申请日：2007-08-30

申请人： Hiroshi Kawakami ,  Satoshi Higurashi ,  Hiroaki Matsuyama

发明人： Hiroshi Kawakami ,  Satoshi Higurashi ,  Hiroaki Matsuyama

IPC分类号： A61K35/76 ,  C12N1/20

CPC分类号： A23C9/1234 ,  A23C19/0323 ,  A23K10/16 ,  A23K10/18 ,  A23K50/40 ,  A23L2/52 ,  A23L33/135 ,  A23V2002/00 ,  A23Y2220/37 ,  A23Y2220/39 ,  A61K35/747 ,  A23V2250/064 ,  A23V2200/332

摘要： Disclosed is an agent for accelerating the increase in and/or preventing the decrease in the blood adiponectin level, or a food, beverage or animal feed for accelerating the increase in and/or preventing the decrease in the blood adiponectin level, which comprises a culture or cell of a lactic acid bacterium belonging to the genus Lactobacillus, particularly Lactobacillus gasseri or Lactobacillus helveticus as an active ingredient. Also disclosed is a visceral fat accumulation inhibitor or a food or beverage for inhibiting the accumulation of a visceral fat, which comprises a culture or cell of Lactobacillus helveticus as an active ingredient.

摘要翻译： 公开了用于加速血液中脂联素水平的降低和/或预防血液中脂联素水平降低的药剂，或用于加速血液脂联素水平降低和/或预防血液中脂联素水平降低的食品，饮料或动物饲料的药剂，其包括培养物 或属于乳杆菌属的乳酸菌的细胞，特别是加氏乳杆菌（Lactobacillus gasseri）或瑞士乳杆菌（Lactobacillus helveticus）作为活性成分。 还公开了一种内脏脂肪蓄积抑制剂或用于抑制内脏脂肪积累的食品或饮料，其包含作为活性成分的瑞士乳杆菌的培养物或细胞。

公开(公告)号：US20090176693A1

公开(公告)日：2009-07-09

申请号：US12304799

申请日：2007-06-13

申请人： Hiroshi Kawakami ,  Nobuhiro Hanada ,  Susumu Imai

发明人： Hiroshi Kawakami ,  Nobuhiro Hanada ,  Susumu Imai

IPC分类号： A61K38/40 ,  A61P19/00

CPC分类号： A61Q11/00 ,  A23L33/19 ,  A23V2002/00 ,  A61K8/19 ,  A61K8/64 ,  A23V2200/30 ,  A23V2250/54248

摘要： Provided are an agent for maintaining hardness of tooth substances and a food or drink for maintaining the hardness of tooth substances, both of which include lactoferrin and iron-lactoferrin as an active ingredient. Lactoferrin and iron-lactoferrin suppress decalcification of enamel by use or ingestion thereof, and hence is effective for the prevention of dental caries.

摘要翻译： 提供了用于保持牙齿物质的硬度的药剂和用于保持牙齿物质的硬度的食品或饮料，其包括乳铁蛋白和铁 - 乳铁蛋白作为活性成分。 乳铁蛋白和铁 - 乳铁蛋白通过使用或摄取抑制釉质的脱钙，因此对于预防龋齿是有效的。

公开(公告)号：US06951746B2

公开(公告)日：2005-10-04

申请号：US09514999

申请日：2000-02-29

申请人： Yoshihiro Tanimoto ,  Takafumi Yakabe ,  Taku Nakano ,  Masaharu Shimatani

发明人： Yoshihiro Tanimoto ,  Takafumi Yakabe ,  Taku Nakano ,  Masaharu Shimatani

IPC分类号： C07C209/62 ,  C07C211/09 ,  C07C211/14 ,  C12P13/00

CPC分类号： C12P13/001

摘要： After yeast somatic components are digested with nuclease or hydrolyzed with alkali, polyamine is recovered to obtain a polyamine composition in volume efficiently at a high recovery rate from yeast somatic components.

摘要翻译： 酵母体细胞成分用核酸酶消化或用碱水解后，回收多胺，从酵母体细胞成分以高回收率体积有效地获得多胺组合物。

公开(公告)号：US20030069183A1

公开(公告)日：2003-04-10

申请号：US10171791

申请日：2002-06-17

申请人： Snow Brand Milk Products Co., Ltd.

发明人： Katsumi Tanaka ,  Kanji Higashio ,  Eitaro Kumazawa

IPC分类号： A61K038/18

CPC分类号： A61K9/0019 ,  A61K9/19 ,  A61K38/1833 ,  A61K47/02 ,  A61K47/12 ,  A61K47/183 ,  A61K47/26 ,  A61K47/36

摘要： The invention relates to a lyophilized HGF preparation prepared by lyophilizing an aqueous solution containing HGF, and a lyophilized HGF preparation containing a stabilizer, sodium chloride, a buffer, and/or a surface active agent. According to the invention, HGF can be stabilized, and it can be stored for a long period.

摘要翻译： 本发明涉及通过将包含HGF的水溶液冻干制备的冻干HGF制剂和含有稳定剂，氯化钠，缓冲液和/或表面活性剂的冻干HGF制剂。 根据本发明，HGF可以稳定，并且可以长期储存。

公开(公告)号：US6143560A

公开(公告)日：2000-11-07

申请号：US179525

申请日：1998-10-27

申请人： Mio Imamura ,  Yasuharu Itagaki ,  Morimasa Tanimoto

发明人： Mio Imamura ,  Yasuharu Itagaki ,  Morimasa Tanimoto

IPC分类号： C12N15/09 ,  C12N5/071 ,  C12N5/10 ,  C12N5/00

CPC分类号： C12N5/0631 ,  C12N2503/00 ,  C12N2517/10

摘要： The present invention relates to a method of synchronizing epithelial cells into G.sub.0 phase, more specifically, a method of synchronizing epithelial cells into G.sub.0 phase characterized by culturing the cells in a synthetic medium for 5 days or more, wherein said synthetic medium is a medium with the lowered concentration of bovine fetal serum 5% or less and said epithelial cells is bovine mammary gland cells. Further, the present invention relates to a method of culturing cells characterized by using G.sub.0 phase synchronized cells obtained by the present invention, and a method of screening a related to differentiation and/or maturation of said cells by using G.sub.0 phase synchronized cells. The present invention is useful for easily synchronizing epithelial cells into G.sub.0 phase and for screening a factor related to differentiation and/or maturation of epithelial cells.

摘要翻译： 本发明涉及将上皮细胞同步至G0期的方法，更具体地说，涉及将上皮细胞同步至G0期的方法，其特征在于在合成培养基中培养细胞5天以上，其中所述合成培养基为 牛胎儿血清浓度降低5％以上，所述上皮细胞为牛乳腺细胞。 此外，本发明涉及一种培养细胞的方法，其特征在于使用通过本发明获得的G0相同步细胞，以及通过使用G0相同步细胞筛选与所述细胞的分化和/或成熟相关的方法。 本发明可用于容易地将上皮细胞同步化为G0期并筛选与上皮细胞的分化和/或成熟有关的因子。