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    ADJUVANTING MENINGOCOCCAL FACTOR H BINDING PROTEIN
    73.
    发明申请
    ADJUVANTING MENINGOCOCCAL FACTOR H BINDING PROTEIN 审中-公开

    公开(公告)号：US20190151430A1

    公开(公告)日：2019-05-23

    申请号：US16269370

    申请日：2019-02-06

    Applicant: GlaxoSmithKline Biologicals SA

    Inventor： Mario CONTORNI ,  Lorenzo TARLI

    IPC: A61K39/095 ,  A61K47/02

    CPC classification number: A61K39/095 ,  A61K47/02 ,  A61K2039/55505 ,  A61K2039/55583 ,  A61K2039/6018 ,  A61K2039/70

    Abstract: Factor H binding protein (fHBP) has been proposed for use in immunising against serogroup B meningococcus (‘MenB’). This antigen can be efficiently adsorbed to an aluminium hydroxyphosphate adjuvant by (i) ensuring that adsorption takes place at a pH which is equal to or below the adjuvant's point of zero charge (PZC), and/or (ii) selecting a fHBP and adjuvant with an isoelectric point/PZC within the range of 5.0 to 7, and/or (iii) selecting a fHBP with an isoelectric point above the adjuvant's PZC and using a buffer to bring the pH to within 1.2 pH units of the PZC. The adsorption is particularly useful for compositions which include multiple fHBP variants, and also in situations where an aluminium hydroxide adjuvant should be avoided. Buffered pharmaceutical compositions can include at least two different meningococcal fHBP antigens, both of which are at least 85% adsorbed to aluminium hydroxyphosphate adjuvant.

    Cationic oil-in-water emulsions
    74.
    发明授权
    Cationic oil-in-water emulsions 有权

    公开(公告)号：US10238733B2

    公开(公告)日：2019-03-26

    申请号：US15067216

    申请日：2016-03-11

    Applicant: GlaxoSmithKline Biologicals SA

    Inventor： Luis Brito ,  Andrew Geall ,  Derek O'Hagan ,  Manmohan Singh

    IPC: A61K39/395 ,  A61K39/385 ,  A61K9/107 ,  A61K39/39 ,  A61K39/00

    Abstract: This invention generally relates to cationic oil-in-water emulsions that can be used to deliver negatively charged molecules, such as an RNA molecule. The emulsion particles comprise an oil core and a cationic lipid. The cationic lipid can interact with the negatively charged molecule thereby anchoring the molecule to the emulsion particles. The cationic emulsions described herein are particularly suitable for delivering nucleic acid molecules (such as an RNA molecule encoding an antigen) to cells and formulating nucleic acid-based vaccines.

    Conjugation of Streptococcal capsular saccharides
    76.
    发明授权
    Conjugation of Streptococcal capsular saccharides 有权

    公开(公告)号：US10188719B2

    公开(公告)日：2019-01-29

    申请号：US15592339

    申请日：2017-05-11

    Applicant: GlaxoSmithKline Biologicals SA

    Inventor： Francesco Berti

    IPC: A61K39/09 ,  C07K14/315 ,  A61K39/385 ,  A61K47/64 ,  A61K39/00

    Abstract: Three conjugation methods for use with the capsular saccharide of Streptococcus agalactiae. In the first method, reductive amination of oxidized sialic acid residue side chains is used, but the aldehyde groups are first aminated, and then the amine is coupled to a carrier via a linker. In the second method, sialic acid residues and/or N-acetyl-glucosamine residues are de-N-acetylated to give amine groups, and the amine groups are coupled to a carrier protein via a linker. In the third method, linkage is via galactose residues in the capsular saccharide rather than sialic acid residues, which can conveniently be achieved using galactose oxidase.

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