公开(公告)号：US5091973A

公开(公告)日：1992-02-25

申请号：US572387

申请日：1990-08-27

申请人： Kiyoshi Watanabe

发明人： Kiyoshi Watanabe

IPC分类号： B41J2/485 ,  G06K15/02 ,  G06T3/00 ,  G06T5/30 ,  G06T11/20 ,  G09G5/28

CPC分类号： G09G5/28 ,  G06K15/02 ,  G06K2215/006 ,  G06K2215/0071

摘要： An image processing apparatus performs processing to input an original image pattern composed of dots, detect contour dots from the inputted original image pattern, and identify a pattern of dot rows formed by the contour dots detected. Editing is performed with regard to the location of a dot row at which the identified pattern is a pattern to undergo editing, whereby the inputted original image pattern is converted into an image pattern represented by intermediate brightness. The image pattern so edited is outputted as by a printer.

公开(公告)号：US5084584A

公开(公告)日：1992-01-28

申请号：US593586

申请日：1990-10-09

申请人： Kiyoshi Watanabe ,  Hideaki Kataoka ,  Kuniaki Goto

发明人： Kiyoshi Watanabe ,  Hideaki Kataoka ,  Kuniaki Goto

IPC分类号： C07C67/313 ,  C07C69/145 ,  C07J1/00 ,  C07J13/00 ,  C07J75/00

CPC分类号： C07J75/00 ,  C07C67/313 ,  C07J1/0048 ,  C07J13/005 ,  C07J13/007

摘要： There are disclosed a process for producing an .alpha.-acyloxy-.alpha.,.beta.-unsaturated carbonyl compound represented by the general formula (VI): ##STR1## wherein R.sub.1, R.sub.2 and R.sub.4 are independently hydrogen atoms or substituted or unsubstituted hydrocarbon residues, or R.sub.1 and R.sub.2, when taken together with one another in an optional combination, form a ring, R.sub.3 is a substituted or unsubstituted hydrocarbon residue, and indicates that the configuration may be either E-configuration or Z-configuration, in particular, a 20-acyloxy-17(20)-methylen-21-al-steroid represented by the partial structural formula (II): ##STR2## wherein R is a hydrocarbon residue, and indicates that the configuration of the acyloxy group and the formyl group bonded to the carbon atom at the 20-position may be either E-configuration or Z-configuration, which comprises oxidizing a propargyl ester represented by the general formula (V): ##STR3## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 have the same meanings as defined above; an al-steroid compound having the above partial structural formula which is an intermediate for producing a 21-acyloxy-20-keto-delta.sup.16 -steroid being extremely useful as an intermediate for important corticoids as drugs and obtained by being subjected said al-steroid to isomerization reaction; and a process for producing a 21-acyloxy-20-keto-delta.sup.16 -steroid which comprises oxidation reaction and isomerization reaction.

公开(公告)号：US5057538A

公开(公告)日：1991-10-15

申请号：US587147

申请日：1990-09-24

申请人： Tadayoshi Shiraishi ,  Keiji Kameyama ,  Takeshi Domoto ,  Naohiro Imai ,  Yoshio Shimada ,  Yutaka Ariki ,  Kazunoro Hosoe ,  Masaji Kawatsu ,  Ikuo Katsumi ,  Takayoshi Hidaka ,  Kiyoshi Watanabe

发明人： Tadayoshi Shiraishi ,  Keiji Kameyama ,  Takeshi Domoto ,  Naohiro Imai ,  Yoshio Shimada ,  Yutaka Ariki ,  Kazunoro Hosoe ,  Masaji Kawatsu ,  Ikuo Katsumi ,  Takayoshi Hidaka ,  Kiyoshi Watanabe

IPC分类号： B21B31/16 ,  A61K31/26 ,  A61K31/27 ,  A61K31/275 ,  A61K31/34 ,  A61K31/425 ,  B21B31/02 ,  B21B31/20 ,  B21B33/00 ,  B21B37/18 ,  B21B37/72 ,  C07C253/30 ,  C07C255/34 ,  C07C255/41 ,  C07C255/44 ,  C07C255/53 ,  C07D207/38 ,  C07D209/34 ,  C07D231/36 ,  C07D277/20 ,  C07D277/36 ,  C07D277/54 ,  C07D279/16 ,  C07D307/32 ,  C07D307/33 ,  C07D307/52 ,  C07D307/58 ,  C07D417/12 ,  C09K3/00 ,  C07C121/75

CPC分类号： C07D277/20 ,  B21B31/02 ,  B21B31/203 ,  C07C255/00 ,  C07C255/34 ,  C07D207/38 ,  C07D209/34 ,  C07D231/36 ,  C07D277/36 ,  C07D277/54 ,  C07D279/16 ,  C07D307/58 ,  C07D417/12

摘要： A hydroxystyrene derivative represented by the formula (I): ##STR1## Wherein when R.sup.1 and R.sup.2 : phenyl group, benzyl group or phenethyl group, or R.sup.1 : R.sup.5 O--(R.sup.5 : H, a C.sub.1 to C.sub.5 alkyl group or benzyl group) and R.sup.2 : benzyl group or PhSCH.sub.2, R.sup.3 and R.sup.4 are taken together to represent --CONH--CS--S--, ##STR2## (X.sub.1 : H, a halogen, methyl group, ethyl group, R.sup.7 O--(R.sup.7 : methyl or ethyl group), nitro group, aminosulfonyl group or amino group, m.sup.1 : 1 or 2), pyridyl group, furyl group or thienyl group, n.sup.1 : an integer of 0 to 3); when R.sup.1 and R.sup.2 : phenyl group, benzyl group or phenethyl group, or R.sup.1 : R.sup.5 O--(R.sup.5 : as defined above) and R.sup.2 : benzyl group, R.sup.3 : cyano group and R.sup.4 : a carbamoyl group, or R.sup.3 and R.sup.4 are taken together to represent --CO--Y--CH.sub.2 CH.sub.2 --(Y: O or --NH--) or ##STR3## and when R.sup.1 and R.sup.2 : a C.sub.1 to C.sub.3 alkyl group, R.sup.3 and R.sup.4 are taken together to represent ##STR4## (n.sup.1, R.sup.6 : as defined above), or a salt thereof. The hydroxystyrene derivative or a salt thereof is a compound which is useful as an active ingredient of an antiallergic agent, a 5-lipoxybenase inhibiting agent, an antibacterial agent, a tyrosine kinase inhibiting agent, an ultraviolet absorber or a reverse transcriptase inhibiting agent, and also is useful as an intermediate for preparing various organic compounds.

公开(公告)号：US4898822A

公开(公告)日：1990-02-06

申请号：US846436

申请日：1986-03-31

申请人： Masanori Asada ,  Shigeki Hamaguchi ,  Hidetoshi Katsuki ,  Yoshio Nakamura ,  Hideyuki Takahashi ,  Kenji Takahara ,  Yoshio Shimada ,  Takehisa Ohashi ,  Kiyoshi Watanabe

发明人： Masanori Asada ,  Shigeki Hamaguchi ,  Hidetoshi Katsuki ,  Yoshio Nakamura ,  Hideyuki Takahashi ,  Kenji Takahara ,  Yoshio Shimada ,  Takehisa Ohashi ,  Kiyoshi Watanabe

IPC分类号： C12P17/10 ,  C12P41/00

CPC分类号： C12P17/10 ,  C12P41/005 ,  Y10S435/83 ,  Y10S435/839 ,  Y10S435/843 ,  Y10S435/874 ,  Y10S435/897 ,  Y10S435/911 ,  Y10S435/921 ,  Y10S435/925

摘要： A process for preparing optically active indoline-2-carboxylic acid by an optical resolution, which comprises subjecting a racemic ester of (R,S)-indoline-2-carboxylic acid having the general formula [(R,S)-I] to the action of an enzyme or a microorganism having a stereo-selective esterase activity, which is capable of asymmetrically hydrolyzing the racemic ester [(R,S)-I] to give optically active indoline-2-carboxylic acid having the formula [II*] so as to produce the hydrolysis product, i.e. optically active indoline-2-carboxylic acid [II*] and an unreacted optically active ester of indoline-2-carboxylic acid having the general formula [I*], isolating each optically active form, and further, if necessary, hydrolyzing the obtained optically active ester [I*] to give an optical antipode of the acid [II*].According to the process of the present invention, optically active indoline-2-carboxylic acid with a high optical purity can be prepared in a simple process with a good yield.

摘要翻译： 通过光学拆分制备光学活性二氢吲哚-2-羧酸的方法，其包括使具有通式[（R，S）-I]的（R，S） - 二氢吲哚-2-羧酸的外消旋酯与 具有立体选择性酯酶活性的酶或微生物的作用，其能够不对称地水解外消旋酯[（R，S）-I]，得到具有式[II *]的光学活性二氢吲哚-2-羧酸， ]以产生水解产物，即具有通式[I *]的光学活性二氢吲哚-2-羧酸[II *]和未反应的二氢吲哚-2-羧酸的光学活性酯，分离每种光学活性形式， 此外，如果需要，水解得到的光学活性酯[I *]，得到酸[II *]的光学对映体。 根据本发明的方法，可以以简单的方法制备具有高光学纯度的光学活性二氢吲哚-2-羧酸，产率高。

公开(公告)号：US4859661A

公开(公告)日：1989-08-22

申请号：US75021

申请日：1987-07-13

申请人： Fumihiko Kano ,  Takehiko Yamane ,  Katsuji Yamashita ,  Kazunori Hosoe ,  Kiyoshi Watanabe

发明人： Fumihiko Kano ,  Takehiko Yamane ,  Katsuji Yamashita ,  Kazunori Hosoe ,  Kiyoshi Watanabe

IPC分类号： C07D498/18 ,  A61K31/365 ,  A61K31/535 ,  A61P31/04 ,  C07D498/14

CPC分类号： C07D498/18 ,  C07D519/00

摘要： A novel rifamycin derivative having the formula (I): ##STR1## wherein X.sup.1 is an alkyl group with 1 to 6 carbon atoms or a cycloalkyl group with 3 to 8 carbon atoms; X.sup.2 is a hydrogen atom or an alkyl group with 1 to 4 carbon atoms; R.sup.1 is hydrogen atom or acetyl group; A is a group represented by the formula: ##STR2## wherein R.sup.2 is an alkyl group with 1 to 4 carbon atoms or an alkoxyalkyl group with 2 to 6 carbon atoms and R.sup.3 is an alkyl group with 1 to 6 carbon atoms or an alkoxyalkyl group with 2 to 6 carbon atoms, or a group represented by the formula ##STR3## wherein ##STR4## is a 3 to 9 membered cyclic amino group with 2 to 8 carbon atoms, R.sup.4 is a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, or salts thereof, a process for preparing the same and antibacterial agents containing the same as an effective ingredient.The rifamycin derivative of the present invention having the formula (I) shows a strong antibacterial activity against the Gram-positive bacteria and the acid-fast bacteria.

公开(公告)号：US4853403A

公开(公告)日：1989-08-01

申请号：US890034

申请日：1986-07-28

申请人： Tadayoshi Shiraishi ,  Naohiro Imai ,  Takeshi Domoto ,  Keiji Kameyama ,  Ikuo Katsumi ,  Takayoshi Hidaka ,  Kazunori Hosoe ,  Kiyoshi Watanabe

发明人： Tadayoshi Shiraishi ,  Naohiro Imai ,  Takeshi Domoto ,  Keiji Kameyama ,  Ikuo Katsumi ,  Takayoshi Hidaka ,  Kazunori Hosoe ,  Kiyoshi Watanabe

IPC分类号： C12N9/99 ,  A61K31/10 ,  A61K31/165 ,  A61K31/19 ,  A61K31/195 ,  A61K31/215 ,  A61K31/235 ,  A61K31/275 ,  A61K31/34 ,  A61K31/341 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/415 ,  A61P3/00 ,  A61P11/00 ,  A61P35/00 ,  A61P37/08 ,  A61P43/00 ,  C07C67/00 ,  C07C313/00 ,  C07C317/44 ,  C07C323/16 ,  C07C323/29 ,  C07C323/56 ,  C07C323/65 ,  C07D207/26 ,  C07D207/267 ,  C07D207/38 ,  C07D231/32 ,  C07D231/36 ,  C07D231/56 ,  C07D307/33 ,  C07D307/58

CPC分类号： C07D207/267 ,  C07C323/00 ,  C07D231/32 ,  C07D307/33

摘要： A 3-phenylthiomethylstyrene derivative having the general formula (1): ##STR1## or salt thereof with a base, when X is hydroxyl group, R.sup.1 is hydrogen atom or R.sup.2 is hydrogen atom, a process for preparing the 3-phenylthiomethylstyrene derivative (1), and an antiallergic agent and a tyrosinekinase inhibiting agent containing the 3-phenylthiomethylstyrene derivative (1) as an effective component. The compound (1) of the present invention is a useful intermediate for preparing various organic compounds, and has excellent antiallergic and tyrosinekinase inhibiting activities.

摘要翻译： 具有通式（1）的3-苯基硫代甲基苯乙烯衍生物：其中X为羟基，R 1为氢原子或R 2为氢原子时，其碱为碱的3-苯基硫代甲基苯乙烯 衍生物（1）和含有3-苯基硫代甲基苯乙烯衍生物（1）作为有效成分的抗过敏剂和酪氨酸激酶抑制剂。 本发明的化合物（1）是制备各种有机化合物的有用的中间体，具有优异的抗过敏和酪氨酸激酶抑制活性。

公开(公告)号：US4816424A

公开(公告)日：1989-03-28

申请号：US928330

申请日：1986-11-10

申请人： Kiyoshi Watanabe ,  Tohru Takeuchi ,  Hideaki Ohtake ,  Ichiro Fujita

发明人： Kiyoshi Watanabe ,  Tohru Takeuchi ,  Hideaki Ohtake ,  Ichiro Fujita

IPC分类号： H01L21/28 ,  H01L21/3205 ,  H01L21/768 ,  H01L23/52 ,  H01L29/43 ,  H01L29/45 ,  H01L21/441

CPC分类号： H01L21/7685 ,  H01L21/76843 ,  H01L21/76886 ,  H01L29/456 ,  Y10S257/915

摘要： A triple-layer electrode structure or a multilayer interconnecting structure of a semiconductor device comprising a contact (a lower conductive) layer of aluminum or its alloy which comes into contact with a silicon substrate, a barrier layer of refractory metal nitride (e.g. titanium nitride) and refractory metal (e.g., tungsten), and a (upper) conductive layer of aluminum or its alloy. The TiN-W barrier layer prevents overdissolution of silicon into aluminum in spite of heat-treatment at a relatively elevated temperature. The barrier layer is formed by sintering a mixture of refractory metal nitride powder and refractory metal powder to form a target which is sputter deposited on the contact layer in an atomsphere excluding gaseous nitrogen.

摘要翻译： 一种半导体器件的三层电极结构或多层互连结构，包括与硅衬底接触的铝或其合金的接触（下导电）层，难熔金属氮化物（例如氮化钛）的阻挡层， 和难熔金属（例如钨）和（上）导电层的铝或其合金。 尽管在相对较高的温度下进行热处理，TiN-W阻挡层防止硅过度溶解于铝中。 通过烧结耐火金属氮化物粉末和难熔金属粉末的混合物来形成阻挡层，以形成溅射沉积在不含气态氮的原子团中的接触层上的靶。

公开(公告)号：US4814027A

公开(公告)日：1989-03-21

申请号：US171743

申请日：1988-03-22

申请人： Hakaru Masumoto, deceased ,  Kiyoshi Watanabe ,  Hiroshi Matushima, executor

发明人： Hakaru Masumoto, deceased ,  Kiyoshi Watanabe ,  Hiroshi Matushima, executor

IPC分类号： C21D6/00 ,  C22C30/00 ,  C22C38/00 ,  C22F1/14 ,  H01F1/04

CPC分类号： C21D6/00 ,  C22C30/00 ,  C22F1/14 ,  H01F1/04

摘要： The disclosed permanent magnet has a coercive force of larger than 500 Oe, a residual magnetic flux density of larger than 5 kG, and a maximum energy product of larger than 2 MGOe, and it consisting essentially of 48.about.66.9 Atm % of iron, 33.about.47 Atm % of platinum, and 0.1.about.10 Atm % of niobium. It includes a crystal structure of an incomplete single .gamma..sub.1 phase of a face-centered tetragonal system due to either the composition thereof or heat treatment applied thereto. The permanent magnet is made by heating an alloy of the above main composition at 900.degree..about.400.degree. for one minute to ten hours and quenching the alloy at a high speed of faster than 30.degree. C./minute but slower than 2,000.degree. C./sec.

摘要翻译： 所公开的永磁体具有大于500Oe的矫顽力，大于5kG的剩余磁通密度和大于2MGOe的最大能量乘积，并且其基本上由48差异66.9％的铁，33％ 差异47铂的百分比，和0.1的差异10 Atm％的铌。 由于其组成或施加于其上的热处理，它包括面心四方系的不完全单一γ1相的晶体结构。 通过将上述主组合物的合金在900℃-400℃下加热1分钟至10小时，并以高于30℃/分钟但低于2000℃的高速淬火来制造永久磁铁。 /秒。

公开(公告)号：US4791198A

公开(公告)日：1988-12-13

申请号：US810

申请日：1987-01-06

申请人： Takehisa Ohashi ,  Kazunori Kan ,  Noboru Ueyama ,  Isao Sada ,  Akimasa Miyama ,  Kiyoshi Watanabe

发明人： Takehisa Ohashi ,  Kazunori Kan ,  Noboru Ueyama ,  Isao Sada ,  Akimasa Miyama ,  Kiyoshi Watanabe

IPC分类号： C07D205/08 ,  C07F7/18

CPC分类号： C07D205/08 ,  C07F7/186

摘要： The present invention relates to .beta.-lactam compound having the formula (I): ##STR1## wherein R.sup.1 is a trialkylsilyl group, dimethyl-1,1,2-trimethylpropylsilyl group, acetyl group, benzyloxycarbonyl group, O-nitrobenzyloxycarbonyl group, p-nitrobenzyloxycarbonyl group or t-butyl group, R.sup.2, R.sup.3 and R.sup.4 are a member selected from the group consisting of a lower alkyl group having 1 to 6 carbon atoms, phenyl group and an aralkyl group and a process for preparing the compound which comprises reacting enolsilylethers having the formula (III): ##STR2## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as above, with chlorosulfonylisocyanate and then reducing the obtained product. The .beta.-lactam compound of the present invention is a useful intermediate for preparing carbapenem .beta.-lactam compound.

摘要翻译： 本发明涉及具有式（I）的β-内酰胺化合物：其中R1是三烷基甲硅烷基，二甲基-1,1,2-三甲基丙基甲硅烷基，乙酰基，苄氧基羰基，O-硝基苄氧基羰基 对硝基苄氧羰基或叔丁基，R2，R3和R4是选自具有1至6个碳原子的低级烷基，苯基和芳烷基的成员，以及制备该化合物的方法 包括使具有式（III）的烯醇醚：其中R 1，R 2，R 3和R 4如上所述与式（III）化合物反应，得到产物。 本发明的β-内酰胺化合物是制备碳青霉烯类β-内酰胺化合物的有用中间体。

公开(公告)号：US4716235A

公开(公告)日：1987-12-29

申请号：US900051

申请日：1986-08-25

申请人： Satomi Takahashi ,  Kenji Inoue ,  Yoshifumi Yanagida ,  Takehisa Ohashi ,  Kiyoshi Watanabe

发明人： Satomi Takahashi ,  Kenji Inoue ,  Yoshifumi Yanagida ,  Takehisa Ohashi ,  Kiyoshi Watanabe

IPC分类号： C07K14/81 ,  C07D207/16 ,  C07K1/02 ,  C07K5/02 ,  C07K5/06 ,  C07K14/435 ,  C07D207/09

CPC分类号： C07K5/0222

摘要： A process for preparing N-[1(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanyl-L-proline, which comprises reacting N-carboxyanhydride of N-[1(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine with L-proline in the presence of a base. According to the process, enalapril can be prepared economically, easily and effectively.

摘要翻译： 制备N- [1（S） - 乙氧基羰基-3-苯丙基] -L-丙氨酰-L-脯氨酸的方法，其包括使N- [1（S） - 乙氧基羰基-3-苯基丙基] -L-脯氨酸的N-羧酸酐 - 丙氨酸与L-脯氨酸在碱的存在下。 根据该过程，依那普利可以经济，容易和有效地制备。