公开(公告)号：US20120180608A1

公开(公告)日：2012-07-19

申请号：US13005577

申请日：2011-01-13

Applicant: ROYDEN H. GIBSON ,  MARCUS E. NORDEN ,  SAM D. HECTOR ,  JIM H. BENNETT ,  CARL R. WALKER

Inventor： ROYDEN H. GIBSON ,  MARCUS E. NORDEN ,  SAM D. HECTOR ,  JIM H. BENNETT ,  CARL R. WALKER

IPC: B25G1/10 ,  B25G3/28 ,  B29C45/14

CPC classification number: B29C45/14549 ,  B25D1/00 ,  B25G1/10 ,  B29K2711/14 ,  Y10T29/49938

Abstract: The disclosed and claimed concept provides for an overmold that is applied to substantially all of the exposed portions of a wood handle for a tool.

Abstract translation: 所公开和要求保护的概念提供了用于工具的木柄的基本上所有暴露部分的包覆成型。

公开(公告)号：US20100101510A1

公开(公告)日：2010-04-29

申请号：US12260224

申请日：2008-10-29

Applicant: Emadeddin Y. Tanbour ,  Rodney Ray Syler ,  Mark Allan Murphy ,  Marcus E. McAnally

Inventor： Emadeddin Y. Tanbour ,  Rodney Ray Syler ,  Mark Allan Murphy ,  Marcus E. McAnally

IPC: F24H9/02 ,  F24H1/00 ,  B23P19/04

CPC classification number: F24H1/205 ,  F23M5/025 ,  F23M7/00 ,  F23M2900/05005 ,  F24H9/0026 ,  F24H9/1836 ,  Y10T29/53

Abstract: A water heater door assembly includes a base plate sized and shaped to substantially sealingly cover an access opening in a water heater combustion chamber and having at least one opening through which a fuel supply line extends at least partly between a burner in the combustion chamber and a fuel control valve, and a seal positioned at least partly within the opening and having a through hole that is sized and shaped to receive the fuel supply line, the seal comprising a plurality of complementary deformed seal pieces sealed together, to the opening and to the fuel supply line by a deforming force.

Abstract translation: 热水器门组件包括基板，其尺寸和形状基本上密封地覆盖热水器燃烧室中的进入开口，并且具有至少一个开口，燃料供应管线至少部分地延伸在燃烧室中的燃烧器和 燃料控制阀和至少部分地位于开口内的密封件，并且具有通孔，其尺寸和形状被设计成容纳燃料供应管线，该密封件包括多个彼此密封在一起的互补变形的密封件， 燃料供应线由变形力。

公开(公告)号：US20100101508A1

公开(公告)日：2010-04-29

申请号：US12260259

申请日：2008-10-29

Applicant: Emadeddin Y. Tanbour ,  Rodney R. Syler ,  Mark A. Murphy ,  Marcus E. McAnally

Inventor： Emadeddin Y. Tanbour ,  Rodney R. Syler ,  Mark A. Murphy ,  Marcus E. McAnally

IPC: F24H1/34 ,  E06B7/16

CPC classification number: F24H9/02 ,  F16J3/041 ,  F16L5/14 ,  F23M7/00 ,  F23M11/02 ,  F24H1/186 ,  F24H9/0026

Abstract: A water heater door assembly includes a base plate sized and shaped to substantially sealingly cover an access opening in a water heater combustion chamber and has at least one opening through which a fuel supply line extends at least partly between a burner in the combustion chamber and a gas control valve, and a flexible seal positioned at least partly within the opening including an engaging portion substantially sealed to an edge portion of the opening, and a through hole that is shaped to receive the fuel supply and has a size slightly smaller than the size of an outer dimension of the fuel supply line such that the flexible seal and the fuel supply line are friction fit together to form a seal.

Abstract translation: 热水器门组件包括基板，其尺寸和形状基本上密封地覆盖热水器燃烧室中的进入开口，并且具有至少一个开口，燃料供应管线至少部分地延伸在燃烧室中的燃烧器和 气体控制阀和至少部分地位于开口内的柔性密封件，其包括基本上密封到开口的边缘部分的接合部分，以及形成为接收燃料供应并具有略小于尺寸的尺寸的通孔 所述燃料供应管线的外部尺寸使得所述柔性密封件和所述燃料供应管线摩擦配合在一起以形成密封件。

公开(公告)号：US20090155342A1

公开(公告)日：2009-06-18

申请号：US11884363

申请日：2006-02-15

Applicant: Robert F. Diegelmann ,  Kevin R. Ward ,  Marcus E. Carr ,  Gary Lee Bowlin

Inventor： Robert F. Diegelmann ,  Kevin R. Ward ,  Marcus E. Carr ,  Gary Lee Bowlin

IPC: A61K9/70 ,  A61K33/00 ,  A61F13/00 ,  B29C47/00

CPC classification number: A61L15/18 ,  A61L26/0004

Abstract: Compositions comprising clay minerals and methods for their use in promoting hemostasis are provided. The compositions comprise clay minerals such as bentonite, and facilitate blood clotting when applied to a hemorrhaging wound. Electrospun or electrosprayed materials (e.g. bandages, micron beads, etc.) which include clay minerals, and methods for the treatment of acute hemorrhage, are also provided.

Abstract translation: 提供了包含粘土矿物的组合物及其用于促进止血的方法。 组合物包括粘土矿物如膨润土，并且当应用于出血伤口时促进凝血。 还提供了包括粘土矿物的电纺丝或电喷雾材料（例如绷带，微米珠等）和治疗急性出血的方法。

公开(公告)号：US07262318B2

公开(公告)日：2007-08-28

申请号：US11012139

申请日：2004-12-16

Applicant: Ernest S. Hamanaka ,  Marcus E. Kehrli, Jr.

Inventor： Ernest S. Hamanaka ,  Marcus E. Kehrli, Jr.

IPC: C07C321/00 ,  A61K8/64 ,  A01N65/00

CPC classification number: C07C311/21 ,  C07C311/44 ,  C07C323/49 ,  C07C2601/04 ,  C07C2601/14 ,  C07D213/75 ,  C07D215/12 ,  C07D231/12 ,  C07D231/56 ,  C07D233/68 ,  C07D263/32 ,  C07D263/57 ,  C07D271/06 ,  C07D271/07 ,  C07D271/10 ,  C07D271/107 ,  C07D271/113 ,  C07D277/24 ,  C07D277/26 ,  C07D277/62 ,  C07D277/66 ,  C07D285/01 ,  C07D285/06 ,  C07D307/79 ,  C07D333/58 ,  C07D413/06

Abstract: The present invention is directed at substituted heteroaryl- and phenylsulfamoyl compounds, pharmaceutical compositions containing such compounds and the use of such compounds as peroxisome proliferator activator receptor (PPAR) agonists. PPAR alpha activators, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases, in mammals, including humans. The compounds are also useful for the treatment of negative energy balance (NEB) and associated diseases in ruminants.

Abstract translation: 本发明涉及取代的杂芳基 - 和苯基氨磺酰基化合物，含有这些化合物的药物组合物以及这些化合物如过氧化物酶体增殖物激活受体（PPAR）激动剂的用途。 PPARα激活剂，含有这些化合物的药物组合物以及使用这些化合物来提高某些血浆脂质水平，包括高密度脂蛋白胆固醇和降低某些其他血浆脂质水平，如低密度脂蛋白胆固醇和甘油三酸酯，从而治疗 由哺乳动物（包括人类）中低密度脂蛋白胆固醇和/或高水平的低密度脂蛋白胆固醇和甘油三酯（如动脉粥样硬化和心血管疾病）而加剧。 该化合物也可用于治疗反能动物中的负能量平衡（NEB）和相关疾病。

公开(公告)号：US5293772A

公开(公告)日：1994-03-15

申请号：US982652

申请日：1992-12-01

Applicant: Marcus E. Carr, Jr.

Inventor： Marcus E. Carr, Jr.

IPC: G01N33/487 ,  G01N33/49 ,  G01N33/86 ,  G01N33/48

CPC classification number: G01N33/4905

Abstract: The performance of platelets can be best understood by monitoring both the force development and the elastic modulus of the blood clot during both clotting and dissolution of the blood clot. Intermittent application and removal of a compressive force on a blood sample (8) positioned between a pair of plates (12 and 14) throughout clot formation and dissolution provides a standard for using voltage output from a transducer (22) to determine force and elastic modulus parameters. Force development arises from the internal actions of the platelets during clot retraction. Elastic modulus provides a measure of the stiffness of the clot. Clotting can be measured as an increase in force development and clot elastic modulus. Clot dissolution can be determined by a dramatic decrease in force development and in elastic modulus. Providing the blood sample with a clot dissolving agent such as tPA allows determining the fibrinolytic potential of whole blood and, thus, aids in identifying patients at risk for thrombosis due to a decreased ability to dissolve clots. Clot elastic modulus provides a measure of erythrocyte flexibility.

Abstract translation: 通过监测血块凝血和溶解期间血块的力发展和弹性模量，可以最好地了解血小板的表现。 在凝块形成和溶解过程中，定位在一对板（12和14）之间的血液样品（8）上的间歇施加和去除压缩力提供了使用来自换能器（22）的电压输出来确定力和弹性模量的标准 参数。 力发展起因于凝血块收缩期间血小板的内部作用。 弹性模量提供了凝块刚度的量度。 可以测量凝块的力发展和凝块弹性模量的增加。 凝血块溶解可以通过力发展和弹性模量的显着降低来确定。 为血液样本提供诸如tPA的凝块溶解剂允许确定全血的纤维蛋白溶解潜力，因此有助于鉴定由于溶血凝块的能力降低而导致血栓形成风险的患者。 凝块弹性模量提供了红细胞灵活性的量度。

公开(公告)号：US5234810A

公开(公告)日：1993-08-10

申请号：US764466

申请日：1991-09-20

Applicant: Marcus E. Kehrli, Jr. ,  Dale E. Shuster

Inventor： Marcus E. Kehrli, Jr. ,  Dale E. Shuster

IPC: C12Q1/68

CPC classification number: C12Q1/6883 ,  C12Q2600/156

Abstract: A point mutation in the CD18 gene responsible for causing bovine leukocyte adhesion deficiency (BLAD) and a silent mutation linked thereto have been identified. Nucleic acid sequences encompassing these mutations serve as bases for testing and identifying cattle alleles attributable to BLAD using any of a variety of diagnostic assays. Suitable nucleic acid probes and primers have also been designed for use in such assays.

Abstract translation: 已经鉴定了引起牛白细胞粘附缺陷（BLAD）的CD18基因中的点突变和与其相关的沉默突变。 包含这些突变的核酸序列用作使用各种诊断测定中的任一种测试和鉴定归因于BLAD的牛等位基因的基础。 合适的核酸探针和引物也被设计用于这种测定。

公开(公告)号：US5205159A

公开(公告)日：1993-04-27

申请号：US822415

申请日：1992-01-17

Applicant: Marcus E. Carr, Jr.

Inventor： Marcus E. Carr, Jr.

IPC: G01N33/49

CPC classification number: G01N33/49

Abstract: The compression elastic modulus of a blood sample is determined by compressing a blood sample (12) between plates (14 and 16) and comparing the voltage signal (32) output from the transducer (22) with a displacement calibration constant C.sub.d. The compression elastic modulus is determined on the same sample as the platelet mediated force development.

Abstract translation: 通过压缩板（14和16）之间的血液样本（12）并将从换能器（22）输出的电压信号（32）与位移校准常数Cd进行比较来确定血液样本的压缩弹性模量。 在与血小板介导的力发育相同的样品上测定压缩弹性模量。

公开(公告)号：US5106186A

公开(公告)日：1992-04-21

申请号：US516426

申请日：1990-04-30

Applicant: Marcus E. Carr, Jr.

Inventor： Marcus E. Carr, Jr.

IPC: C12Q1/56 ,  G01N15/02 ,  G01N21/59

CPC classification number: G01N15/0205 ,  C12Q1/56 ,  G01N21/59 ,  G01N2333/75 ,  G01N2333/974

Abstract: Experiments have been conducted which demonstrate that gel optical density is a linear function of the fibrin fiber mass/length ratio (.mu.). Once the linear function is known, knowledge of a gel optical density at one wavelength is adequate to determine .mu.. Such measurements allow quantitative monitoring of fibrin structure, and are clinically relevant.

Abstract translation: 已经进行了实验，其证明凝胶光密度是纤维蛋白纤维质量/长度比（μ）的线性函数。 一旦已知线性函数，在一个波长处的凝胶光密度的知识足以确定mu。 这些测量可以定量监测纤维蛋白结构，并且在临床上是相关的。

公开(公告)号：US4986964A

公开(公告)日：1991-01-22

申请号：US511040

申请日：1990-04-19

Applicant: Marcus E. Carr, Jr. ,  Sheryl L. Zekert

Inventor： Marcus E. Carr, Jr. ,  Sheryl L. Zekert

IPC: G01N3/00 ,  G01N33/49

CPC classification number: G01N33/4905 ,  G01N2203/0089

Abstract: An instrument for measuring the internal force characteristics of a blood sample (12) during clotting has been developed. The blood sample (12) is held between a cup (10) and a plate (16). The plate (16) is connected to a force displacement transducer (22). As the clot forms, platelets contract and exert an inward pulling force on the plate (16). This inward pulling force is sensed by the transducer (22) which outputs a corresponding voltage signal. The voltage signal is amplified (24) and recorded on strip chart paper (28). The voltage signal (32) can be directly translated into force parameters by first calibrating the instrument with standard weights. It has been found that the maximum force measurements are obtained under controlled temperature, ionic strength and calcium concentration conditions which approximate those of the blood while in the body. A particular feature of the invention includes a water jacket (14) which is used to maintain the temperature of the blood sample (12) at 37.degree. C. (body temperature).

Abstract translation: 已经开发了用于在凝血期间测量血液样品（12）的内部力特征的仪器。 血液样品（12）保持在杯（10）和板（16）之间。 板（16）连接到力位移传感器（22）。 当凝块形成时，血小板收缩并在板（16）上施加向内的拉力。 该向内的拉力由换能器（22）感测，其输出相应的电压信号。 电压信号被放大（24）并记录在条形图纸（28）上。 可以通过首先用标准重量校准仪器，将电压信号（32）直接转换成力参数。 已经发现，在受控温度，离子强度和钙浓度条件下获得最大力测量值，其在身体中与血液相似。 本发明的一个特征包括用于将血液样品（12）的温度维持在37℃（体温）的水套（14）。