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    TREATMENT PLANNING FOR ELECTROPORATION-BASED THERAPIES
    72.
    发明申请
    TREATMENT PLANNING FOR ELECTROPORATION-BASED THERAPIES 审中-公开
    电子治疗治疗计划

    公开(公告)号：US20150327944A1

    公开(公告)日：2015-11-19

    申请号：US14808679

    申请日：2015-07-24

    申请人： Virginia Tech Intellectual Properties, Inc.

    发明人： Robert E. Neal, II ,  Paulo A. Garcia ,  Rafael V. Davalos ,  John H. Rossmeisl ,  John L. Robertson

    IPC分类号： A61B19/00 ,  A61B18/12 ,  A61N1/04

    摘要： The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.

    摘要翻译： 本发明提供了用于基于电穿孔的疗法（EBT）的系统，方法和装置。 实施例提供了通过从组织拍摄的图像对目标组织进行3D重建的数值模拟得出的患者特异性治疗方案，并且可选地考虑物理约束或动态组织属性中的一种或多种。 本发明还涉及用于递送用于不可逆电穿孔的双极电脉冲的系统，方法和装置，其显示对EBT诱导的递送至组织的过量电荷通常相关的组织的减少或不损伤。

    Hybrid Interleaving Structure with Adaptive Phase Locked Loop for Variable Frequency Controlled Switching Converter
    73.
    发明申请
    Hybrid Interleaving Structure with Adaptive Phase Locked Loop for Variable Frequency Controlled Switching Converter 有权
    混合交错结构与可变频率开关转换器的自适应锁相环

    公开(公告)号：US20150277460A1

    公开(公告)日：2015-10-01

    申请号：US14674680

    申请日：2015-03-31

    申请人： Virginia Tech Intellectual Properties, Inc.

    发明人： Pei-Hsin Liu ,  Qiang Li ,  Fred C. Lee

    IPC分类号： G05F1/56

    CPC分类号： G05F1/56 ,  H02M3/1584 ,  H02M2003/1586 ,  H03L7/06

    摘要： In a multi-phase power converter using a phase-locked loop (PLL) arrangement for interleaving of pulse frequency modulated (PFM) pulses of the respective phases, improved transient response, improved stability of high bandwidth output voltage feedback loop, guaranteed stability of the PLL loop and avoidance of jittering and phase cancellation issues are achieved by anchoring the bandwidth at the frequency of peak phase margin. This methodology is applicable to multi-phase power conveners of any number of phases and any known or foreseeable topology for individual phases and is not only applicable to power converters operating under constant on-time control, but is extendable to ramp pulse modulation (RPM) control and hysteresis control. Interleaving of pulses from all phases is simplified through use of phase managers with a reduced number of PLLS using hybrid interleaving arrangements that do not exhibit jittering even when ripple is completely canceled.

    摘要翻译： 在使用锁相环（PLL）布置用于交错各相的脉冲频率调制（PFM）脉冲的多相功率转换器中，改进的瞬态响应，改进的高带宽输出电压反馈回路的稳定性，保证了 通过将带宽锚定在峰值相位裕度的频率来实现PLL环路和避免抖动和相位消除问题。 该方法适用于任何阶段的任何阶段的多相功率调节器以及用于各个相的任何已知或可预见的拓扑，并且不仅适用于在恒定导通时间控制下工作的功率转换器，而且可扩展到斜坡脉冲调制（RPM） 控制和滞后控制。 通过使用具有减少数量的PLLS的相位管理器来简化来自所有相的脉冲的交错，即使在纹波被完全取消时也不会出现抖动的混合交错布置。

    Jellyfish-inspired tilt sensor and artificial mesoglea
    74.
    发明授权
    Jellyfish-inspired tilt sensor and artificial mesoglea 有权
    海蜇灵敏的倾斜传感器和人造mesoglea

    公开(公告)号：US09146104B2

    公开(公告)日：2015-09-29

    申请号：US13731378

    申请日：2012-12-31

    申请人： Virginia Tech Intellectual Properties, Inc.

    发明人： Colin Smith ,  Shashank Priya

    IPC分类号： G01C9/10 ,  G01C9/06

    CPC分类号： G01C9/10 ,  G01C2009/068 ,  G01C2009/107

    摘要： Components of an unmanned undersea vehicle are inspired by jellyfish that uses its flexible body and tilt sensing to achieve efficient swimming and turning. A tilt sensor, based on a statocyst, has a metal ball in a chamber lined with resistors. The tilt is sensed in accordance with which resistors the ball contacts. A composition of polyvinyl alcohol hydrogel with ferritin particles dispersed therein mimics the qualities of a jellyfish's mesoglea.

    摘要翻译： 无人海底车辆的组成部分灵感来源于水母，使用其灵活的身体和倾斜感应来实现有效的游泳和转动。 一个倾斜传感器，基于一个统计学，在一个内有电阻的一个室内有一个金属球。 根据球接触的哪个电阻来感测倾斜。 其中分散有铁蛋白颗粒的聚乙烯醇水凝胶的组合物模仿水母的中肠的质量。

    Power-Cell Switching-Cycle Capacitor Voltage Control for Modular Multi-Level Converters
    76.
    发明申请
    Power-Cell Switching-Cycle Capacitor Voltage Control for Modular Multi-Level Converters 有权
    用于模块化多电平转换器的功率单元开关周期电容电压控制

    公开(公告)号：US20150207434A1

    公开(公告)日：2015-07-23

    申请号：US14578651

    申请日：2014-12-22

    申请人： Virginia Tech Intellectual Properties, Inc.

    发明人： Jun Wang ,  Rolando Burgos ,  Dushan Boroyevich ,  Bo Wen

    IPC分类号： H02M7/797

    CPC分类号： H02M7/483 ,  H02M2001/0003 ,  H02M2007/4835

    摘要： In a modular multi-level power converter, additional switching states are interleaved between main switching states that control output voltage or waveform. The additional switching states provide current from a DC-link to charge capacitors in respective modules or cells to an offset voltage from which the capacitor voltages are controlled toward a reference voltage during each switching cycle rather than being allowed to build up over a period of an output waveform of variable line frequency, possibly including zero frequency. Since the switching cycle is much shorter than the duration of a line frequency cycle and the capacitor voltages are balanced during each switching cycle, output voltage ripple can be limited as desired with a capacitor of much smaller value and size than would otherwise be required.

    摘要翻译： 在模块化多电平功率转换器中，额外的开关状态在控制输出电压或波形的主开关状态之间交错。 额外的开关状态提供来自DC链路的电流，以将各个模块或单元中的电容器充电到偏移电压，在每个开关周期期间电容器电压从该偏置电压控制到参考电压，而不是允许在 可变线路频率的输出波形，可能包括零频率。 由于开关周期比线路频率周期的持续时间短得多，并且在每个开关周期期间电容器电压平衡，因此可以根据需要以比其它方式要求的更小的值和尺寸的电容器来限制输出电压纹波。

    Multi-channel two-stage controllable constant current source and illumination source
    78.
    发明授权
    Multi-channel two-stage controllable constant current source and illumination source 有权
    多通道两级可控恒流源和照明源

    公开(公告)号：US09000673B2

    公开(公告)日：2015-04-07

    申请号：US13930200

    申请日：2013-06-28

    申请人： Virginia Tech Intellectual Properties, Inc.

    发明人： Weiyi Feng ,  Fred C. Lee

    IPC分类号： H05B33/08 ,  H02M3/335

    CPC分类号： H05B33/0839 ,  H02M3/335 ,  H05B33/0815 ,  H05B33/0851 ,  Y02B20/347

    摘要： A multi-channel constant current source particularly suitable for driving an array of light-emitting diodes as an illumination apparatus provides a power source stage voltage regulator for providing a variable voltage using pulse width modulation as an input to a plurality of constant current driver channels to regulate the constant current provided. Pulse width modulation thus allows both the power source stage and the constant current driver operating frequencies to be decoupled and individually optimized to maintain efficiency while emulating dimming effects of, for example, incandescent bulbs, over a full range of light output flux. Pulse width modulation can also be employed in the constant current channel drivers to avoid chromaticity shift during dimming.

    摘要翻译： 特别适用于驱动发光二极管阵列作为照明装置的多通道恒流源提供电源级电压调节器，用于使用脉冲宽度调制提供可变电压作为多个恒定电流驱动器通道的输入， 调节提供的恒定电流。 因此，脉冲宽度调制允许功率源级和恒定电流驱动器工作频率两者被解耦并分别优化，以在模拟全光范围的光输出通量的同时模拟例如白炽灯泡的调光效果的同时保持效率。 在恒流通道驱动器中也可采用脉冲宽度调制，以避免调光过程中的色度偏移。

    High Frequency Integrated Point-of-Load Power Converter with Embedded Inductor Substrate
    79.
    发明申请
    High Frequency Integrated Point-of-Load Power Converter with Embedded Inductor Substrate 有权
    具有嵌入式电感基板的高频集成点负载电源转换器

    公开(公告)号：US20150062989A1

    公开(公告)日：2015-03-05

    申请号：US14177531

    申请日：2014-02-11

    申请人： Virginia Tech Intellectual Properties, Inc.

    发明人： Yipeng Su ,  Qiang Li ,  Fred C. Lee ,  Wenli Zhang

    IPC分类号： H05K7/02

    CPC分类号： H01F17/0033 ,  H01F2017/008 ,  H02M3/155 ,  H05K1/0233 ,  H05K1/0373 ,  H05K1/165 ,  H05K2201/0209 ,  H05K2201/0245 ,  H05K2201/086 ,  H05K2201/10015

    摘要： A low profile power converter structure is provide wherein volume is reduced and power density is increased to approach 1 KW/in3 by at least one of forming an inductor as a body of magnetic material embedded in a substrate formed by a plurality of printed circuit board (PCB) lamina and forming inductor windings of PCB cladding and vias which may be of any desired number of turns and may include inversely coupled windings and which provide a lateral flux path, forming the body of magnetic material from high aspect ratio flakes of magnetic material which are aligned with the inductor magnetic field in an insulating organic binder and hot-pressed and providing a four-layer architecture comprising two layers of PCB lamina including the embedded body of magnetic material, a shield layer and an additional layer of PCB lamina, including cladding for supporting and connecting a switching circuit, a capacitor and the inductor.

    摘要翻译： 通过形成作为嵌入由多个印刷电路板形成的基板中的磁性材料的主体的电感器中的至少一个，提供体积减小并且功率密度增加到接近1KW / in 3的低剖面功率转换器结构（ PCB）层并且形成可以具有任何所需匝数的PCB包层和通孔的电感器绕组，并且可以包括反耦合绕组并且提供横向磁通路径，从磁性材料的高纵横比薄片形成磁性材料体 与绝缘有机粘合剂中的电感器磁场对准并热压，并提供包括两层PCB层的四层结构，包括磁性材料的嵌入体，屏蔽层和附加的PCB层的层，包括包层 用于支持和连接开关电路，电容器和电感器。

    Optimal Trajectory Control for LLC Resonant Converter for Soft Start-Up
    80.
    发明申请
    Optimal Trajectory Control for LLC Resonant Converter for Soft Start-Up 有权
    用于软启动的LLC谐振转换器的最佳轨迹控制

    公开(公告)号：US20140313790A1

    公开(公告)日：2014-10-23

    申请号：US14087076

    申请日：2013-11-22

    申请人： Virginia Tech Intellectual Properties, Inc.

    发明人： Weiyi Feng ,  Fred C. Lee

    IPC分类号： H02M1/36

    CPC分类号： H02M1/36 ,  H02M3/3376 ,  H02M2001/0058 ,  Y02B70/1433 ,  Y02B70/1491

    摘要： By setting switching instants of a switching circuit of a resonant power converter based on current in a resonant circuit reaching a current limit of a current limitation band, soft start-up of the power converter can be achieved to avoid or limit electrical stress with full control over a trade-off between time required to settle to a full load steady-state mode of operation and the amount of electrical stress permitted while soft start up switching frequency is automatically optimized.

    摘要翻译： 通过基于达到电流限制带的电流限制的谐振电路中的电流来设置谐振功率转换器的开关电路的开关时刻，可以实现功率转换器的软启动，以完全控制以避免或限制电应力 在软启动切换频率自动优化的同时，在满足稳定状态运行所需的时间和允许的电压之间进行权衡。