公开(公告)号：US20150328313A1

公开(公告)日：2015-11-19

申请号：US14650208

申请日：2013-12-18

Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA ,  CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Robert H. Chow ,  Mark S. Humayun ,  Harry B. Gray ,  Robert H. Grubbs ,  Dennis Dougherty ,  Mark Thompson ,  Oliver Shafaat ,  Erin Lamb

IPC: A61K41/00 ,  C12N13/00

CPC classification number: A61K41/00 ,  A61B3/113 ,  A61K41/0023 ,  A61N5/062 ,  A61N2005/0648 ,  C12N13/00

Abstract: Methods and compositions modulate the activity of electrically excitable cells. Photovoltaic compounds which, upon exposure to light energy, increase or decrease the electrical activity of cells. These supplement and/or replace of vision based on the conversion of light energy to electrical energy within certain cells of the visual system. A “patch” or bridge to circumvent one or more defective, damaged, or diseased cells in the visual system. Additionally, in several embodiments, subjects with normal vision can benefit from the methods, compositions, systems, and/or devices disclosed herein as normal visual acuity can be heightened. The exposure induces an energy (e.g., a receipt of light energy, conversion to electrical energy, and passage of that electrical energy) from the photovoltaic compound to the cell, thereby altering the transmembrane potential of the cell and/or the opening of one or more ion channels, thereby modulating the activity of the electrically excitable cell.

Abstract translation: 方法和组合物调节电可兴奋细胞的活性。 在暴露于光能下，增加或减少细胞的电活动的光伏化合物。 这些补充和/或替代视觉基于视觉系统的某些单元内的光能转换为电能。 用于规避视觉系统中一个或多个缺陷，损坏或病变细胞的“补丁”或桥梁。 另外，在几个实施例中，具有正常视力的受试者可以受益于本文公开的方法，组合物，系统和/或装置，因为可以提高正常视力。 曝光引起能量（例如，光能的接收，电能的转换和电能的传递）从光伏化合物到细胞，从而改变细胞的跨膜电位和/或开放一个或 更多的离子通道，从而调节电可激发细胞的活性。

公开(公告)号：US09127173B2

公开(公告)日：2015-09-08

申请号：US13940693

申请日：2013-07-12

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Choon Woo Lee ,  Robert H. Grubbs ,  Mark Humayun

IPC: A01N25/34 ,  C09D5/14 ,  D06M16/00 ,  A01N33/12 ,  C08G73/02 ,  C09D5/16 ,  C09D179/02

CPC classification number: C09D5/14 ,  A01N33/12 ,  C08G73/0206 ,  C08G73/0226 ,  C09D5/1637 ,  C09D179/02 ,  D06M16/00 ,  Y10T428/31721 ,  Y10T428/31725 ,  A01N25/34 ,  A01N2300/00

Abstract: The disclosure provides methods and materials suitable for preparing coating layers on substrates. The coatings comprise quaternary amine groups and therefore impart anti-bacterial properties to the substrate. in one embodiment, for example, there is provided a quaternary amine-containing polymeric coating comprising propylene and ethylene repeat units.

Abstract translation: 本公开提供了适合于在基底上制备涂层的方法和材料。 涂层包含季胺基，因此赋予基底抗菌性能。 在一个实施方案中，例如，提供了包含丙烯和乙烯重复单元的含季铵的聚合物涂层。

公开(公告)号：US09096519B2

公开(公告)日：2015-08-04

申请号：US14149924

申请日：2014-01-08

Applicant: California Institute of Technology

Inventor： Bill Morandi ,  Robert H. Grubbs ,  Zachary K. Wickens ,  Michael M. Lerch

IPC: C07C303/30 ,  C07C303/40 ,  C07D209/48 ,  C07C45/28 ,  C07C67/29 ,  C07C201/12 ,  C07C231/12 ,  C07C247/04 ,  C07C67/313 ,  C07C51/373 ,  C07B41/06

CPC classification number: C07D209/48 ,  C07B41/06 ,  C07C45/28 ,  C07C51/373 ,  C07C67/29 ,  C07C67/313 ,  C07C201/12 ,  C07C231/12 ,  C07C247/04 ,  C07C303/30 ,  C07C303/40 ,  C07C2601/14 ,  C07C49/255 ,  C07C49/175 ,  C07C49/173 ,  C07C235/74 ,  C07C311/16 ,  C07C205/57 ,  C07C309/73 ,  C07C49/403 ,  C07C49/04 ,  C07C49/84 ,  C07C49/784 ,  C07C69/14 ,  C07C69/84 ,  C07C69/78 ,  C07C59/76 ,  C07C69/716

Abstract: The present invention is directed to methods for oxidizing internal olefins to ketones. In various embodiments, each method comprising contacting an organic substrate, having an initial internal olefin, with a mixture of (a) a biscationic palladium salt; and (b) an oxidizing agent; dissolved or dispersed in a solvent system to form a reaction mixture, said solvent system comprising at least one C2-6 carbon nitrile and optionally at least one secondary alkyl amide, said method conducted under conditions sufficient to convert at least 50 mol % of the initial internal olefin to a ketone, said ketone positioned on a carbon of the initial internal olefin. The transformation occurs at room temperature and shows wide substrate scope. Applications to the oxidation of seed oil derivatives and a bioactive natural product are described.

Abstract translation: 本发明涉及将内烯烃氧化成酮的方法。 在各种实施方案中，每种方法包括使具有初始内烯烃的有机基质与（a）双阳离子钯盐的混合物接触; 和（b）氧化剂; 溶解或分散在溶剂体系中以形成反应混合物，所述溶剂体系包含至少一种C 2-6碳腈和任选的至少一种仲烷基酰胺，所述方法在足以将至少50mol％的初始 内部烯烃与酮反应，所述酮位于初始内烯烃的碳上。 转化在室温下发生，显示出宽的底物范围。 描述了种子油衍生物和生物活性天然产物的氧化应用。

公开(公告)号：US20150203977A1

公开(公告)日：2015-07-23

申请号：US14603332

申请日：2015-01-22

Applicant: The California Institute of Technology

Inventor： Oana R. Luca ,  Raymond Weitekamp ,  Robert H. Grubbs ,  Harry A. Atwater ,  Slobodan Mitrovic

IPC: C25B11/04 ,  C25B3/04

CPC classification number: C25B3/04 ,  C25B1/003 ,  C25B11/0405 ,  C25B11/0489

Abstract: A CO2 reduction electrode includes an active layer on an electrode base. The active layer includes a polymer that includes one or more reaction components selected from a group consisting of a CO2 reduction catalyst and an activator that bonds CO2 so as to form a CO2 reduction intermediate.

Abstract translation: CO 2还原电极在电极基体上具有活性层。 活性层包括聚合物，其包含一种或多种选自CO 2还原催化剂和键合CO 2的活化剂的反应组分以形成CO 2还原中间体。

公开(公告)号：US08968789B2

公开(公告)日：2015-03-03

申请号：US14178592

申请日：2014-02-12

Applicant: California Institute of Technology ,  Children's Hospital of Los Angeles

Inventor： Carl M. Blumenfeld ,  Harry B. Gray ,  Robert H. Grubbs ,  Karn Sorasaenee

IPC: A61K49/08 ,  C07D487/22 ,  C07F5/00 ,  C07F5/06 ,  A61K49/00

CPC classification number: C07F7/28 ,  A61K49/0021 ,  A61K49/0065 ,  A61K49/0067 ,  B01J2531/025 ,  C07D487/22 ,  C07F5/003 ,  C07F5/069

Abstract: The present invention is directed to sulfonic esters of metal oxides including those of formulas I and II:

Abstract translation: 本发明涉及包括式I和II的金属氧化物的磺酸酯：

公开(公告)号：US20140243483A1

公开(公告)日：2014-08-28

申请号：US14188961

申请日：2014-02-25

Applicant: California Institute of Technology

Inventor： Robert H. Grubbs ,  Garret M. Miyake ,  Raymond Weitekamp ,  Victoria Piunova

IPC: G02B5/30

CPC classification number: G02B1/005 ,  G02B5/3016 ,  G02B6/1225

Abstract: Described herein are copolymers constructed from chiral, non-racemic monomers, which self-assemble to photonic crystals. The difficulty of incorporating chiral elements into photonic crystals has limited the ability to generate unique bandstructures for different circular polarizations of light. The materials and methods described herein relate to easily, predictably fabricating chiral photonic crystals having desirable optical properties.

Abstract translation: 本文描述的是由手性非外消旋单体构成的共聚物，其自组装成光子晶体。 将手性元素掺入光子晶体的困难限制了为不同的光的圆偏振产生独特的带结构的能力。 本文所述的材料和方法涉及容易地，可预测地制造具有期望的光学性质的手性光子晶体。

公开(公告)号：US11844724B2

公开(公告)日：2023-12-19

申请号：US17509641

申请日：2021-10-25

Applicant: California Institute of Technology ,  The Regents of the University of California ,  United States Government represented by the Department of Veterans Affairs

Inventor： Robert H. Grubbs ,  Marshall L Stoller ,  Ying Han ,  Frank L. Brodie

IPC: A61F9/007

CPC classification number: A61F9/00745

Abstract: A surgical method of cataract fragmentation and extraction via microbubble cavitation is described. In particular, gas-filled microbubbles are injected into a lens capsule of a subject's eye, and cavitation of the microbubbles is activated by applied ultrasound energy. The ultrasound energy can be applied from an external device. The cavitation fragments cataract tissues without damaging other tissue, such as the lens capsule. Fragmented lens material is then aspirated from the lens capsule. The method can be used alone or in conjunction with other methods, such as phacoemulsification.

公开(公告)号：US11773116B2

公开(公告)日：2023-10-03

申请号：US17192129

申请日：2021-03-04

Applicant: California Institute Of Technology

Inventor： Anton A. Toutov ,  Kerry N. Betz ,  Andrew M. Romine ,  Robert H. Grubbs

IPC: C07F7/10

CPC classification number: C07F7/10

Abstract: The present disclosure is directed to hydrosilyl amines and fluorosilyl amines and methods of making the same.

公开(公告)号：US20230114064A1

公开(公告)日：2023-04-13

申请号：US17933234

申请日：2022-09-19

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Christopher Martin Waldmann ,  Anton A. Toutov ,  Jennifer Marie Murphy ,  Robert H. Grubbs

IPC: C07F7/12 ,  C07B59/00 ,  A61K51/10

Abstract: The present disclosure sets forth novel compounds and compositions including heteroaromatic silicon-fluoride-acceptors, which are useful for PET scanning. The present disclosure further includes novel methods of 8F imaging for PET scanning, the methods comprising the preparation of conjugates and bioconjugates of biological ligands of interest with heteroaromatic silicon-fluoride-acceptors. In certain embodiments the invention is practiced in the form of a kit.

公开(公告)号：US20220218791A1

公开(公告)日：2022-07-14

申请号：US17484656

申请日：2021-09-24

Applicant: California Institute of Technology ,  The Regents of the University of California

Inventor： Robert H. Grubbs ,  Daniel M. Schwartz

IPC: A61K38/18 ,  A61B3/12 ,  A61P27/02 ,  A61B3/10 ,  A61K9/00

Abstract: Disclosed herein include methods, kits, formulations, and compositions for increasing choroidal or retinal perfusion or promoting non-leaking or minimally-leaking choroidal or retinal revascularization in a subject in need thereof. An effective amount of an angiogenesis factor (e.g., a pro-angiogenic factor and/or a vascular maturation factor) can be administered to the subject.