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206 条记录 (耗时 0.105 秒)

    Antibodies to natural killer cell activating factor II
    71.
    发明授权
    Antibodies to natural killer cell activating factor II 失效
    自然杀伤细胞激活因子II的抗体

    公开(公告)号：US07309780B2

    公开(公告)日：2007-12-18

    申请号：US11378243

    申请日：2006-03-20

    申请人： Jian Ni ,  Haodong Li ,  Guo-Liang Yu ,  Reiner L. Gentz

    发明人： Jian Ni ,  Haodong Li ,  Guo-Liang Yu ,  Reiner L. Gentz

    IPC分类号： C07K16/00 ,  C12P21/08 ,  C12N5/06 ,  C12N5/16

    CPC分类号： C07K16/28 ,  A61K38/00 ,  C07K14/52

    摘要： The invention relates to NKAF II polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.

    摘要翻译： 本发明涉及NKAF II多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。 本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。

    Human endometrial specific steroid-binding factor I, II, and III
    75.
    发明申请
    Human endometrial specific steroid-binding factor I, II, and III 失效
    人子宫内膜特异性类固醇结合因子I，II和III

    公开(公告)号：US20050026179A1

    公开(公告)日：2005-02-03

    申请号：US10820136

    申请日：2004-04-08

    申请人： Jian Ni ,  Guo-Liang Yu ,  Reiner Gentz

    发明人： Jian Ni ,  Guo-Liang Yu ,  Reiner Gentz

    IPC分类号： C07K14/47 ,  C12Q1/68 ,  C07H21/04 ,  C07K14/72

    CPC分类号： C07K14/4702

    摘要： The invention relates to hESF I, II and III polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.

    摘要翻译： 本发明涉及hESF I，II和III多肽，编码多肽的多核苷酸，特别是通过表达多核苷酸产生多肽的方法，以及多肽的激动剂和拮抗剂。 本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。

    Method of assaying Neutrokine-&agr; mRNA level
    76.
    发明授权
    Method of assaying Neutrokine-&agr; mRNA level 有权
    测定中性粒细胞αmRNA水平的方法

    公开(公告)号：US06716576B1

    公开(公告)日：2004-04-06

    申请号：US09255794

    申请日：1999-02-23

    申请人： Guo-Liang Yu ,  Reinhard Ebner ,  Jian Ni

    发明人： Guo-Liang Yu ,  Reinhard Ebner ,  Jian Ni

    IPC分类号： C12Q168

    CPC分类号： C07H21/04 ,  A61K38/00 ,  C07K14/52

    摘要： The present invention relates to a novel Neutrokine-a, and a splice variant thereof designated Neutrokine-aSV, polynucleotides and polypeptides which are members of the TNF family. In particular, isolated nucleic acid molecules are provided encoding the human Neutrokine-a and/or Neutrokine-aSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-a and/or Neutrokine-aSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine-a and/or Neutrokine-aSV activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.

    摘要翻译： 本发明涉及一种名为Neutrokine-aSV的新型Neutrokine-a及其剪接变体，其是TNF家族成员的多核苷酸和多肽。 特别地，提供了分离的核酸分子，其编码人Neutrokine-a和/或Neutrokine-aSV多肽，包括细胞外结构域的可溶形式。 还提供了中和型和/或Neutrokine-aSV多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明进一步涉及用于鉴定Neutrokine-a和/或Neutrokine-aSV活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

    Antibodies that specifically bind Cytostatin III
    77.
    发明授权
    Antibodies that specifically bind Cytostatin III 失效
    特异性结合细胞抑素III的抗体

    公开(公告)号：US06413726B1

    公开(公告)日：2002-07-02

    申请号：US09734036

    申请日：2000-12-12

    申请人： Jian Ni ,  Guo-Liang Yu ,  Reiner Gentz ,  Patrick J. Dillon

    发明人： Jian Ni ,  Guo-Liang Yu ,  Reiner Gentz ,  Patrick J. Dillon

    IPC分类号： G01N3350

    CPC分类号： C07K14/475 ,  C07K2319/00

    摘要： The invention relates to Cytostatin III polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.

    摘要翻译： 本发明涉及细胞抑制素III多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。 本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。