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    Method and system for implantable glucose monitoring and control of a glycemic state of a subject
    72.
    发明授权
    Method and system for implantable glucose monitoring and control of a glycemic state of a subject 失效
    监测和控制受试者血糖状态的方法和系统

    公开(公告)号：US08348842B1

    公开(公告)日：2013-01-08

    申请号：US13135375

    申请日：2011-07-01

    申请人： Ivan Osorio ,  Mark G. Frei

    发明人： Ivan Osorio ,  Mark G. Frei

    IPC分类号： A61B5/00 ,  A61B5/05

    CPC分类号： A61B5/4839 ,  A61B5/14528 ,  A61B5/14532 ,  A61B5/686 ,  A61M5/14244 ,  A61M5/16877 ,  A61M5/1723 ,  A61M2205/50 ,  A61M2230/201

    摘要： A method and system for monitoring and/or controlling a glycemic state of a subject, comprising a housing device having one or more chambers, extendable and retractable sensors, extendable and retractable catheters, insulin reservoir, neuroprotective agent reservoir, release mechanism for releasing insulin and neuroprotective agent into the subject, and a control mechanism with a processor for receiving and analyzing outputs from the sensors and for controlling the release mechanism, a clock mechanism for providing logging and/or circadian information to the processor.

    摘要翻译： 一种用于监测和/或控制受试者血糖状态的方法和系统，包括具有一个或多个腔室，可伸缩和可伸缩传感器，可伸缩导管，胰岛素储存器，神经保护剂储存器，用于释放胰岛素的释放机构的壳体装置和 神经保护剂，以及具有处理器的控制机构，用于接收和分析来自传感器的输出和用于控制释放机构的时钟机构，用于向处理器提供记录和/或昼夜节律信息。

    Probabilistic neurological disorder treatment
    75.
    发明授权
    Probabilistic neurological disorder treatment 有权
    概率神经障碍治疗

    公开(公告)号：US08209018B2

    公开(公告)日：2012-06-26

    申请号：US11380752

    申请日：2006-04-28

    申请人： Ivan Osorio ,  Mark G. Frei

    发明人： Ivan Osorio ,  Mark G. Frei

    IPC分类号： A61N1/18 ,  A61B5/02

    CPC分类号： G16H50/20 ,  A61B5/0006 ,  A61B5/0476 ,  A61B5/4094 ,  A61N1/36082 ,  A61N1/361 ,  G06F19/00 ,  G06F19/3481

    摘要： Disclosed are probabilistic approaches to patient evaluation, warning and treatment of a neurological disorder. Disclosed techniques estimate probability distribution functions or cumulative distribution functions, determined by relying on representative historical profiles, comprising information in short and/or long timescales obtained at times that may be intermittent or temporally discontinuous from each other or from other events of interest. The patient may thereby be treated based on the determined probability information.

    摘要翻译： 公开了患者评估，警告和治疗神经障碍的概率方法。 披露的技术估计概率分布函数或累积分布函数，其通过依赖于代表性历史概况确定，包括在可能彼此间断或间断不连续的时间或从其他感兴趣事件的时间获得的短时间和/或长时间尺度的信息。 因此，可以基于所确定的概率信息来对患者进行治疗。

    QUANTITATIVE MULTIVARIATE ANALYSIS OF SEIZURES
    76.
    发明申请
    QUANTITATIVE MULTIVARIATE ANALYSIS OF SEIZURES 审中-公开
    定量多元分析

    公开(公告)号：US20110295332A1

    公开(公告)日：2011-12-01

    申请号：US13116873

    申请日：2011-05-26

    申请人： Ivan Osorio

    发明人： Ivan Osorio

    IPC分类号： A61N1/00 ,  A61B5/00 ,  G06F19/00

    CPC分类号： A61B5/0476 ,  A61B5/4094 ,  A61B5/4833 ,  A61N1/36064 ,  A61N1/36139 ,  G06F19/00 ,  G16H50/20

    摘要： Methods, including a method, comprising selecting a plurality of dependent variables relating to each of a plurality of seizures in a patient; selecting a plurality of independent variables, wherein each independent variable comprises a therapy parameter, a therapy delivery parameter, a temporal factor, an environmental factor, or a patient factor; quantifying at least one relationship between each of at least two dependent variables and each of at least two independent variables; and performing an action in response to said quantifying, selected from reporting said at least one relationship, assessing an efficacy of a therapy, assessing an adverse effect of said therapy, providing a therapy modification recommendation, or adjusting said therapy. A medical device system capable of implementing a method. A non-transitory computer readable program storage medium containing instructions that, when executed by a computer, perform a method.

    摘要翻译： 方法，包括方法，包括选择与患者中的多个癫痫发作中的每一个有关的多个因变量; 选择多个独立变量，其中每个独立变量包括治疗参数，治疗递送参数，时间因子，环境因素或患者因素; 量化至少两个因变量中的每个与至少两个独立变量中的每一个之间的至少一个关系; 以及响应于从报告所述至少一种关系中选择的所述量化来执行动作，评估治疗的功效，评估所述治疗的不良作用，提供治疗改变推荐或调整所述治疗。 一种能够实现方法的医疗装置系统。 一种非暂时的计算机可读程序存储介质，其包含当被计算机执行时执行方法的指令。

    Multi-modal system for detection and control of changes in brain state
    77.
    发明授权
    Multi-modal system for detection and control of changes in brain state 有权
    用于检测和控制脑状态变化的多模态系统

    公开(公告)号：US07204833B1

    公开(公告)日：2007-04-17

    申请号：US10909488

    申请日：2004-08-02

    申请人： Ivan Osorio ,  Naresh C. Bhavaraju

    发明人： Ivan Osorio ,  Naresh C. Bhavaraju

    IPC分类号： A61B18/02

    CPC分类号： A61F7/12 ,  A61B5/031 ,  A61B5/0478 ,  A61B5/14553 ,  A61B5/4094 ,  A61F2007/0056 ,  A61F2007/0075

    摘要： A multi-purpose device mechanism for sensing and control of changes in brain state includes a shaft portion and extendible elements structured for insertion into target tissue of the brain of a subject patient, cooling means configured to operatively apply cooling therapy to the target tissue, stimulation means having at least one electrical contact structured to operatively apply electrical stimulation therapy to the target tissue, sensing means including at least one sensor monitoring a biological signal of the subject patient, control means responsive to the sensing means wherein the control means is structured to, in response to signals from the sensing means that indicate the presence of a pre-determined physiological condition or occurrence of an undesirable state change, automatically cause the cooling means and/or the stimulation means to initiate or terminate the cooling therapy and/or the electrical stimulation therapy respectively and an energy source for powering the various components of the multi-purpose device mechanism. A modified embodiment includes a least one spiral conduit and at least one return conduit for cycling coolant or refrigerant to and from the shaft portion and an external reservoir. Another modified embodiment includes pressurizing means for extending at least one extendable tube into brain tissue surrounding the shaft portion.

    摘要翻译： 用于感测和控制脑状态变化的多用途装置机构包括轴部分和被构造用于插入到受试者患者的脑的目标组织中的可延伸元件，构造成可操作地将冷却治疗应用于靶组织的刺激 具有至少一个构造成可以对目标组织施加电刺激治疗的电触点的感测装置，感测装置，包括至少一个传感器，其监测对象患者的生物信号，响应于感测装置的控制装置，其中控制装置被构造成， 响应于来自感测装置的指示预先确定的生理状况的存在或不期望的状态变化的发生的信号，自动使冷却装置和/或刺激装置启动或终止冷却治疗和/或电气 刺激疗法和为能量供电的能量源 的多用途设备机构的组件。 改进的实施例包括至少一个螺旋导管和至少一个用于将冷却剂或制冷剂循环到轴部分和从轴部分循环的至少一个回流管道和外部储存器。 另一个改进的实施例包括用于将至少一个可延伸管延伸到围绕轴部分的脑组织中的加压装置。

    Signal quality monitoring and control for a medical device system
    78.
    发明授权
    Signal quality monitoring and control for a medical device system 有权
    医疗器械系统的信号质量监测和控制

    公开(公告)号：US07146211B2

    公开(公告)日：2006-12-05

    申请号：US10687348

    申请日：2003-10-15

    申请人： Mark G. Frei ,  Ivan Osorio

    发明人： Mark G. Frei ,  Ivan Osorio

    IPC分类号： A61N1/00

    CPC分类号： A61B5/04012 ,  A61B5/048 ,  A61B5/4094 ,  A61B5/7203 ,  A61B5/7217 ,  A61B5/7221 ,  A61N1/36014 ,  A61N1/36064 ,  A61N1/36082 ,  A61N1/36135 ,  A61N1/3702 ,  A61N1/37229 ,  A61N1/37252

    摘要： Method and apparatus for detecting possible interference in a neurological signal received from a monitoring element of a medical device system. The monitoring element monitors a condition or a symptom of a nervous system disorder being treated and provides a neurological signal to the medical device system for purposes of providing closed-loop feedback control. The system analyzes various parameters of the received signal by taking instantaneous measurements of data points in moving window and thereby determining whether the signal is of poor quality. If the signal is of determined poor quality, it is removed from consideration in the closed-loop feedback control system until it is determined that the signal quality has sufficiently been restored.

    摘要翻译： 用于检测从医疗装置系统的监视元件接收的神经信号中的可能的干扰的方法和装置。 监测元件监测被治疗的神经系统疾病的状况或症状，并且为了提供闭环反馈控制的目的而向医疗装置系统提供神经信号。 该系统通过对移动窗口中的数据点进行瞬时测量，从而确定信号质量差，分析接收信号的各种参数。 如果信号确定质量差，则在闭环反馈控制系统中将其去除，直到确定信号质量已被充分恢复为止。

    Synchronization and calibration of clocks for a medical device and calibrated clock
    79.
    发明授权
    Synchronization and calibration of clocks for a medical device and calibrated clock 有权
    用于医疗设备和校准时钟的时钟的同步和校准

    公开(公告)号：US07079977B2

    公开(公告)日：2006-07-18

    申请号：US10687566

    申请日：2003-10-15

    申请人： Ivan Osorio ,  Naresh C. Bhavaraju ,  Thomas E. Peters ,  Mark G. Frei ,  Jonathan C. Werder

    发明人： Ivan Osorio ,  Naresh C. Bhavaraju ,  Thomas E. Peters ,  Mark G. Frei ,  Jonathan C. Werder

    IPC分类号： G04F1/00 ,  A61B5/00 ,  A61B1/36

    CPC分类号： A61N1/37229 ,  A61B5/0006 ,  A61B5/048 ,  A61B5/4094 ,  A61N1/025 ,  A61N1/36025 ,  A61N1/36082 ,  A61N1/37 ,  A61N1/372 ,  G04G7/00 ,  G06F19/00

    摘要： Apparatus and method support the synchronization and calibration of a plurality of clocks in a medical device system that may provide treatment to a patient with a nervous system disorder. The plurality of clocks, which may be located at different components of the medical device system, includes a first clock and a second clock. The second clock may be synchronized to a first clock by disabling a run mode operation and setting the second clock to a selected time. When a reference time of the first clock approximately equals the selected time, the second clock enables the run mode operation. Additionally, a drift time that is indicative of a time difference between the first clock and the second clock is determined. If the drift time is greater than a predetermined amount, an indication to resynchronize the first and second clocks is provided.

    摘要翻译： 装置和方法支持医疗装置系统中的多个时钟的同步和校准，其可以向神经系统障碍的患者提供治疗。 可以位于医疗装置系统的不同部件的多个时钟包括第一时钟和第二时钟。 第二时钟可以通过禁用运行模式操作并将第二时钟设置到所选择的时间来同步到第一时钟。 当第一个时钟的参考时间大致等于所选择的时间时，第二个时钟使能运行模式操作。 此外，确定指示第一时钟和第二时钟之间的时间差的漂移时间。 如果漂移时间大于预定量，则提供重新同步第一和第二时钟的指示。

    Stimulation methodologies and apparatus for control of brain states
    80.
    发明授权
    Stimulation methodologies and apparatus for control of brain states 有权
    刺激方法和控制脑状态的装置

    公开(公告)号：US06934580B1

    公开(公告)日：2005-08-23

    申请号：US10622239

    申请日：2003-07-18

    申请人： Ivan Osorio ,  Naresh C. Bhavaraju

    发明人： Ivan Osorio ,  Naresh C. Bhavaraju

    IPC分类号： A61B5/0484 ,  A61N1/36 ,  A61B5/04

    CPC分类号： A61B5/0484 ,  A61B5/4094 ,  A61N1/36 ,  A61N1/36064 ,  A61N1/36067

    摘要： A system of accessing the brain of a subject to record and/or stimulate brain stares thereof. The system includes control means, first accessing means having a plurality of contact surfaces configured to operatively connect the control means to the brain of the subject to provide three-dimensional stimulation thereof; second accessing means having a plurality of contact surfaces to operatively connect the control means to the brain of the subject to provide access thereto for the purposes of obtaining three-dimensional recordings of the brain electrical activity of the subject; and a waveform bank containing a plurality of stimulating waveforms. The control means is configured to operative apply a first at least one of the stimulating waveforms of the waveform bank to the brain of the subject through the first accessing means and to assess acceptability within defined limits, as determined by preset criteria, of the subject's response to the application of the at first least one of the stimulating waveforms.

    摘要翻译： 访问受试者脑部以记录和/或刺激其脑神经的系统。 该系统包括控制装置，第一存取装置具有多个接触表面，其被配置为将控制装置可操作地连接到受试者的脑部以提供其三维刺激; 第二存取装置具有多个接触表面，以将控制装置可操作地连接到受试者的大脑以提供对其的访问，以获得对象的脑电活动的三维记录; 以及包含多个刺激波形的波形组。 控制装置被配置为通过第一访问装置将波形组的刺激波形中的第一至少一个刺激波形应用于受试者的大脑，并且根据预设的标准来确定受试者的反应所确定的限定范围内的可接受性 涉及至少一个刺激波形的应用。