摘要:
The present invention relates generally to amide group containing pharmaceutical agents, and in particular, to amide containing heterobicyclic metalloprotease inhibitor compounds. More particularly, the present invention provides a new class of heterobicyclic MMP-13 inhibiting and MMP-3 inhibiting compounds, that exhibit an increased potency in relation to currently known MMP-13 and MMP-3 inhibitors.
摘要:
A memory cell includes a selection transistor and a trench capacitor. The trench capacitor is filled with a conductive trench filling on which an insulating covering layer is arranged. The insulating covering layer is laterally overgrown, proceeding from the substrate with a selectively grown epitaxial layer. The selection transistor is formed in the selectively grown epitaxial layer, comprises a source region connected to the trench capacitor and a drain region connected to a bit line. The junction depth of the source region is chosen so that the source region reaches as far as the insulating covering layer. Optionally, the thickness of the epitaxial layer can be reduced to a thickness by oxidation and a subsequent etching. Afterwards, a contact trench is etched through the source region down to the conductive trench filling, which trench is filled with a conductive contact and electrically connects the conductive trench filling to the source region.
摘要:
The present invention relates generally to pyrrolidine and thiazolidine DPP-IV inhibitor compounds. The present invention also provides synthetic methods for preparation of such compounds, methods of inhibiting DPP-IV using such compounds and pharmaceutical formulations containing them for treatment of DPP-IV mediated diseases, in particular, Type-2 diabetes.
摘要:
The invention relates to a field effect transistor in which the planar channel region on the upper surface of the elevation is extended in width by means of additional vertical channel regions on the lateral surfaces of the elevation. Said additional vertical channel regions connect directly to the planar channel region (vertical extended channel regions). Said field effect transistor has the advantage that a significant increase in the effective channel width for the current flow ION can be guaranteed relative to conventional transistor structures used up until the present, without having to accept a reduction in the achievable integration density. Said field effect transistor furthermore has a low reverse current IOFF. The above advantages are achieved without the thickness of the gate insulators up to the region of the charge transfer tunnels having to be reduced or a reduced stability.
摘要:
The present invention relates generally to bis-amide group containing pharmaceutical agents, and in particular, to multicyclic bis-amide MMP-13 inhibitor compounds. More particularly, the present invention provides a new class of MMP-13 inhibiting compounds, containing a pyrimidinyl bis-amide group in combination with a heterocyclic moiety, that exhibit an increased potency and solubility in relation to currently known bis-amide group containing MMP-13 inhibitors.
摘要:
The present invention relates to a process for preparing blocked polyisocyanates wherein at least 50 mole % of the NCO groups have been blocked with sterically hindered phenols by reacting a) one or more organic polyisocyanates with b) one or more sterically hindered phenols in the presence of c) at least one catalyst selected from i) heterocyclic amines in which at least one nitrogen atom is part of an aliphatic, olefinic or aromatic ring, ii) tetraorganoammonium and tetraorganophosphonium salts of weak acids (pka≧2.0), with nitrogen- and/or phosphorus-attached aliphatic, cycloaliphatic, araliphatic and/or aromatic radicals, and iii) zinc(II) compounds. The present invention also relates to the resulting blocked polyisocyanates and to their use for producing coatings, adhesives or sealants suitable for contact with foods and/or drinking water.
摘要:
The invention relates to a field effect transistor in which the planar channel region on the upper surface of the elevation is extended in width by means of additional vertical channel regions on the lateral surfaces of the elevation. Said additional vertical channel regions connect directly to the planar channel region (vertical extended channel regions). Said field effect transistor has the advantage that a significant increase in the effective channel width for the current flow ION can be guaranteed relative to conventional transistor structures used up until the present, without having to accept a reduction in the achievable integration density. Said field effect transistor furthermore has a low reverse current IOFF. The above advantages are achieved without the thickness of the gate insulators up to the region of the charge transfer tunnels having to be reduced or a reduced stability.
摘要:
A locking assembly for the telescopic jib of a crane, or mobile crane, includes a plurality of telescopic sections wherein locking pins are supported in an inner telescopic section and are biased outwardly by means of a spring for engagement within receiving apertures in an outer telescopic section surrounding the inner telescopic section. A release device is provided for engaging the inner end of a locking pin in order to release the locked position thereof against the spring biased. Preferably two locking pin are provided for each locking unit and are disposed on the inner telescopic section so that they will engage two oppositely located receiving apertures in the vertical side webs of the outer telescopic section. The engagement of the locking pins is located in the middle portion of the side webs where bending stresses are minimal, so that any weakening of the telescopic sections caused by the provision of the locking pin mounting structure and pin receiving portions will have negligible effect on the bending strength of the jib.
摘要:
Novel microcapsules are characterized in that the walls thereof consist of reaction products of crosslinking agents with iminooxadiazinedione isocyanates or the walls thereof contain such reaction products. A process for the production of such microcapsules has also been found, as have carbonless copying papers containing such microcapsules.
摘要:
The invention relates to an axial spring element (6) having two peripheral ring elements (61, 62) that are spaced from one another in the axial direction and are connected to one another in a spring-elastic manner, wherein at least one of the ring elements (61) comprises one or more retaining elements (64) in order to brace the spring element with a rotor (5) and thereby hold the spring element on the rotor (5).