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    Crystalline N-acetyl neuraminic acid derivatives and process for their preparation
    75.
    发明授权
    Crystalline N-acetyl neuraminic acid derivatives and process for their preparation 有权
    结晶N-乙酰神经氨酸衍生物及其制备方法

    公开(公告)号：US06294572B1

    公开(公告)日：2001-09-25

    申请号：US09346583

    申请日：1999-07-02

    申请人： Christopher Williamson ,  William James White ,  Vipulkumar Patel

    发明人： Christopher Williamson ,  William James White ,  Vipulkumar Patel

    IPC分类号： A61K31351

    CPC分类号： C07D309/28

    摘要： Two useful crystal hydrates of 5-acetamido-2,3,4,5-tetradeoxy-4-guanidino-D-glycero-D-galacto-non-2-enopyranosonic acid have either a low or high aspect ratio. These crystalline N-acetyl neurominic acid derivatives are favored for pharmaceutical formulation because of their physical properties. For example, the low aspect ratio crystal has good flow properties, and the high aspect ratio crystal has a stable water content over time.

    摘要翻译： 5-乙酰氨基-2,3,4,5-四脱氧-4-胍基-D-甘油基-D-半乳-N-壬-2-吡喃糖酸的两种有用的晶体水合物具有低或高纵横比。 这些结晶N-乙酰神经氨酸衍生物由于其物理性质而优于药物制剂。 例如，低纵横比的晶体具有良好的流动特性，高长宽比的晶体随着时间的推移具有稳定的水分含量。

    NOVEL COMPOUNDS
    76.
    发明申请
    NOVEL COMPOUNDS 审中-公开
    新型化合物

    公开(公告)号：US20080004295A1

    公开(公告)日：2008-01-03

    申请号：US11548343

    申请日：2006-10-11

    申请人： Paul Gore ,  Vipulkumar Patel ,  Ann Walker

    发明人： Paul Gore ,  Vipulkumar Patel ,  Ann Walker

    IPC分类号： A61K31/519 ,  A61P11/00 ,  A61P11/02 ,  A61P19/02 ,  A61P37/08 ,  A61P9/10 ,  C07D487/04

    CPC分类号： C07D487/04

    摘要： Pyrrolopyrimidine derivatives of formula (I) are inhibitors of Spleen Tyrosine kinase (Syk) and therefore of potential therapeutic benefit in the treatment of diseases and conditions associated with inappropriate Syk activity, in particular in the treatment of inflammatory and allergic diseases.

    摘要翻译： 式（I）的吡咯并嘧啶衍生物是脾脏酪氨酸激酶（Syk）的抑制剂，因此在治疗与不适当的Syk活性相关的疾病和病症方面具有潜在的治疗益处，特别是治疗炎性和过敏性疾病。

    SOI-based opto-electronic device including corrugated active region
    77.
    发明申请
    SOI-based opto-electronic device including corrugated active region 有权
    基于SOI的光电器件包括波纹状的有源区

    公开(公告)号：US20070297709A1

    公开(公告)日：2007-12-27

    申请号：US11807959

    申请日：2007-05-31

    申请人： Robert Montgomery ,  Vipulkumar Patel

    发明人： Robert Montgomery ,  Vipulkumar Patel

    IPC分类号： G02F1/035

    CPC分类号： G02F1/025 ,  G02F1/2257

    摘要： The surface silicon layer (SOI layer) of an SOI-based optical modulator is processed to exhibit a corrugated surface along the direction of optical signal propagation. The required dielectric layer (i.e., relatively thin “gate oxide”) is formed over the corrugated structure in a manner that preserves the corrugated topology. A second silicon layer, required to form the modulator structure, is then formed over the gate oxide in a manner that follows the corrugated topology, where the overlapping portion of the corrugated SOI layer, gate oxide and second silicon layer defines the active region of the modulator. The utilization of the corrugated active region increases the area over which optical field intensity will overlap with the free carrier modulation region, improving the modulator's efficiency.

    摘要翻译： 处理基于SOI的光调制器的表面硅层（SOI层）沿着光信号传播的方向呈现波纹状表面。 所需的电介质层（即相对较薄的“栅极氧化物”）以保持波纹拓扑的方式形成在波纹状结构上。 形成调制器结构所需的第二硅层然后以跟随波纹拓扑的方式形成在栅极氧化物上，其中波纹SOI层，栅极氧化物和第二硅层的重叠部分限定了 调制器。 波纹有源区域的利用增加了光场强度将与自由载波调制区域重叠的面积，从而提高了调制器的效率。

    SYSTEM AND METHOD FOR DIAGNOSIS OF ENGINE COMPONENT CONDITION
    80.
    发明申请
    SYSTEM AND METHOD FOR DIAGNOSIS OF ENGINE COMPONENT CONDITION 审中-公开
    用于诊断发动机部件条件的系统和方法

    公开(公告)号：US20120324989A1

    公开(公告)日：2012-12-27

    申请号：US13169817

    申请日：2011-06-27

    申请人： Vipulkumar Patel ,  Lonny E. Johnson ,  Francis L. Clark, III ,  Darrel W. Berglund

    发明人： Vipulkumar Patel ,  Lonny E. Johnson ,  Francis L. Clark, III ,  Darrel W. Berglund

    IPC分类号： G01M15/08

    CPC分类号： G01M15/08

    摘要： A diagnostic system for an internal combustion engine includes a pressure sensor configured to measure pressure within a combustion cylinder. An electronic controller is configured to receive a pressure signal from the pressure sensor, analyze the pressure signal by at least partially comparing the pressure signal to a predetermined pressure signal, and diagnose a failure of one or more piston ring seal(s), an intake valve, and an exhaust valve of the engine based on a difference between the pressure signal and the predetermined pressure signal.

    摘要翻译： 用于内燃机的诊断系统包括被配置成测量燃烧气缸内的压力的压力传感器。 电子控制器被配置为从压力传感器接收压力信号，通过至少部分地将压力信号与预定压力信号进行比较来分析压力信号，并且诊断一个或多个活塞环密封件，进气口 阀和排气阀，基于压力信号和预定压力信号之间的差。