Patent search ap:("President AND Fellows of Harvard College") AND inv:"Daniel Levner" Page 8

71.

发明申请
Compositions and Methods for Analyte Detection 审中-公开

公开(公告)号：US20190241941A1

公开(公告)日：2019-08-08

申请号：US16393215

申请日：2019-04-24

Applicant: President and Fellows of Harvard College

Inventor： Daniel Levner , Je-hyuk Lee , George M. Church , Michael Super

IPC: C12Q1/6837 , C12Q1/6804 , C12Q1/6816

CPC classification number: C12Q1/6837 , C12Q1/6804 , C12Q1/6816 , G01N33/53 , G01N2458/10 , C12Q2535/122 , C12Q2537/143 , C12Q2563/107 , C12Q2563/179 , C12Q2565/514

Abstract: The inventions provided herein relate to detection reagents, compositions, methods, and kits comprising the detection reagents for use in detection, identification, and/or quantification of analytes in a sample. Such detection reagents and methods described herein allow multiplexing of many more labeled species in the same procedure than conventional methods, in which multiplexing is limited by the number of available and practically usable colors.

72.

发明授权
Microfluidic cartridge assembly 有权

公开(公告)号：US10293339B2

公开(公告)日：2019-05-21

申请号：US15844562

申请日：2017-12-17

Applicant: President and Fellows of Harvard College

Inventor： Donald E. Ingber , Daniel Levner , Guy Thompson, II , Christopher David Hinojosa

IPC: B01L3/00 , B01L99/00

Abstract: According to aspects of the present invention, a cartridge assembly for transporting fluid into or out of one or more fluidic devices includes a first layer and a second layer. The first layer includes a first surface. The first surface includes at least one partial channel disposed thereon. The second layer abuts the first surface, thereby forming a channel from the at least one partial channel. At least one of the first layer and the second layer is a resilient layer formed from a pliable material. At least one of the first layer and the second layer includes a via hole. The via hole is aligned with the channel to pass fluid thereto. The via hole is configured to pass fluid through the first layer or the second layer substantially perpendicularly to the channel. Embossments are also used to define aspects of a fluidic channel.

73.

发明授权
Compositions and methods for analyte detection 有权

公开(公告)号：US10227639B2

公开(公告)日：2019-03-12

申请号：US14366486

申请日：2012-12-21

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： Daniel Levner , Je-Hyuk Lee , George M. Church , Michael Super

IPC: G01N33/52 , G01N33/53 , C12Q1/6804 , C12Q1/6837 , C12Q1/6816

Abstract: The inventions provided herein relate to detection reagents, compositions, methods, and kits comprising the detection reagents for use in detection, identification, and/or quantification of analytes in a sample. Such detection reagents and methods described herein allow multiplexing of many more labeled species in the same procedure than conventional methods, in which multiplexing is limited by the number of available and practically usable colors.

74.

发明申请
Incubating Enclosure 审中-公开

公开(公告)号：US20180049430A1

公开(公告)日：2018-02-22

申请号：US15558103

申请日：2016-03-17

Applicant: President and Fellows of Harvard College

Inventor： Jacob Freake , Josh Gomes , Christopher David Hinojosa , Daniel Levner , Doug Sabin , Guy Thompson, II

IPC: A01N1/02 , C12M1/00 , B01L1/00

CPC classification number: A01N1/0252 , A01N1/0242 , B01L1/00 , C12M41/14 , C12N5/00

Abstract: An incubator assembly includes an incubator enclosure having an internal chamber in which a controlled environment is maintained and which is defined by one or more walls. The incubator assembly further includes a jacket assembly mounted adjacent to at least one of the walls and having an internal airspace in which an internal fluid is enclosed for maintaining a homogenous temperature within the internal chamber. The jacket assembly further has a vent movable between a plurality of positions including an open position in which the internal fluid is allowed to exit the internal airspace into an ambient environment.

75.

发明授权
Integrated human organ-on-chip microphysiological systems 有权

公开(公告)号：US09725687B2

公开(公告)日：2017-08-08

申请号：US14362841

申请日：2012-12-10

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE , VANDERBILT UNIVERSITY

Inventor： John P. Wikswo , Philip C. Samson , Frank Emmanuel Block, III , Ronald S. Reiserer , Kevin Kit Parker , John A. McLean , Lisa Joy McCawley , Dmitry Markov , Daniel Levner , Donald E. Ingber , Geraldine A. Hamilton , Josue A. Goss , Robert Cunningham , David E. Cliffel , Jennifer Robin McKenzie , Anthony Bahinski , Christopher David Hinojosa

IPC: A01N1/00 , C12M3/06 , C12M3/00 , A01N1/02 , G01N33/50 , B01L9/00 , C12M1/00 , C12M1/42 , B01L3/00 , C12M1/34

CPC classification number: C12M23/16 , A01N1/02 , A01N1/021 , A01N1/0247 , A01N1/0273 , B01L3/5027 , B01L3/502715 , B01L9/52 , B01L2200/0684 , B01L2200/0689 , B01L2200/146 , B01L2200/147 , B01L2300/044 , B01L2300/0636 , B01L2300/0654 , B01L2300/0663 , B01L2300/0867 , B01L2300/0877 , B01L2300/123 , B01L2300/18 , B01L2400/0487 , B01L2400/0622 , B01L2400/0644 , C12M21/08 , C12M23/42 , C12M29/10 , C12M35/04 , C12M35/08 , C12M41/00 , C12M41/12 , C12M41/46 , G01N33/5005 , G01N33/5082 , G01N33/5088

Abstract: The invention provides integrated Organ-on-Chip microphysiological systems representations of living Organs and support structures for such microphysiological systems.

76.

发明申请
ORGANOMIMETIC DEVICES AND METHODS OF USE AND MANUFACTURING THEREOF 审中-公开
Title translation: 有机装置及其使用和制造方法

公开(公告)号：US20160326477A1

公开(公告)日：2016-11-10

申请号：US15105388

申请日：2014-12-19

Applicant: Jose FERNANDEZ-ALCON , Norman WEN , Richard NOVAK , PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： Jose Fernandez-Alcon , Norman Wen , Richard Novak , Donald E. Ingber , Geraldine A. Hamilton , Christopher Hinojosa , Karel Domansky , Daniel Levner , Guy Thompson, II , Kambez Hajipouran Benam , Remi Villenave , Thomas Umundum , Alfred Paris , Georg Bauer

IPC: C12M3/06 , C12M1/12 , C12M1/00 , C12M1/42 , C12M1/34

CPC classification number: C12M23/16 , C12M21/08 , C12M23/26 , C12M25/02 , C12M35/04 , C12M41/00 , C12M41/46

Abstract: An organomimetic device includes a microfluidic device that can be used to culture cells in its microfluidic channels. The organomimetic device can be part of dynamic system that can apply mechanical forces to the cells by modulating the microfluidic device and the flow of fluid through the microfluidic channels. The membrane in the organomimetic device can be modulated mechanically via pneumatic means and/or mechanical means. The organomimetic device can be manufactured by the fabrication of individual components separately, for example, as individual layers that can be subsequently laminated together.

Abstract translation: 有机模拟装置包括可用于在其微流体通道中培养细胞的微流体装置。有机模拟装置可以是动态系统的一部分，其可以通过调节微流体装置和通过微流体通道的流体流而将机械力施加到细胞。有机模拟装置中的膜可以通过气动装置和/或机械装置机械调节。有机模拟装置可以通过单独制造各个组件来制造，例如，作为随后层压在一起的各个层。

77.

发明申请
Microfluidic Cartridge Assembly 有权
Title translation: 微流控盒装配

公开(公告)号：US20160175840A1

公开(公告)日：2016-06-23

申请号：US14906335

申请日：2014-07-22

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： Donald E. Ingber , Daniel Levner , Guy Thompson, II , Christopher David Hinojosa

IPC: B01L3/00

CPC classification number: B01L3/502715 , B01L3/502707 , B01L3/56 , B01L2200/027 , B01L2200/0684 , B01L2200/0689 , B01L2200/12 , B01L2300/0645 , B01L2300/0816 , B01L2300/0874 , B01L2300/0887 , B01L2300/123 , B01L2400/0481 , B01L2400/0655

Abstract: According to aspects of the present invention, a cartridge assembly for transporting fluid into or out of one or more fluidic devices includes a first layer and a second layer. The first layer includes a first surface. The first surface includes at least one partial channel disposed thereon. The second layer abuts the first surface, thereby forming a channel from the at least one partial channel. At least one of the first layer and the second layer is a resilient layer formed from a pliable material. At least one of the first layer and the second layer includes a via hole. The via hole is aligned with the channel to pass fluid thereto. The via hole is configured to pass fluid through the first layer or the second layer substantially perpendicularly to the channel. Embossments are also used to define aspects of a fluidic channel.

Abstract translation: 根据本发明的方面，用于将流体输送进出一个或多个流体装置的盒组件包括第一层和第二层。第一层包括第一表面。第一表面包括设置在其上的至少一个部分通道。第二层邻接第一表面，从而形成来自至少一个部分通道的通道。第一层和第二层中的至少一层是由柔韧材料形成的弹性层。第一层和第二层中的至少一层包括通孔。通孔与通道对准以将流体传递到其上。通孔被配置为使流体基本上垂直于通道传送通过第一层或第二层。压花也用于定义流体通道的方面。

78.

发明申请
RAPID ANTIBIOTIC SUSCEPTIBILITY TESTING 有权
Title translation: 快速抗生素测试

公开(公告)号：US20150064703A1

公开(公告)日：2015-03-05

申请号：US14382043

申请日：2013-02-28

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： Michael Super , Donald E. Ingber , Mark J. Cartwright , Alexander Watters , John Samuel Workman , Daniel Levner , Martin Rottman

IPC: G01N33/569

CPC classification number: G01N33/56938 , C12Q1/18 , G01N33/56911 , G01N33/56916 , G01N2333/245 , G01N2333/31 , G01N2500/10

Abstract: Embodiments of various aspects described herein are directed to methods, compositions, kits and systems for rapid determination of antibiotic susceptibility of a microbe within hours after a sample is collected. In some embodiments, the methods, compositions, kits and systems described herein can allow determination of antibiotic susceptibility of a microbe based on a small number of microbes, e.g., as few as 5-10 microbes bound to a microbe-targeting substrate described herein.

Abstract translation: 本文描述的各个方面的实施方案涉及用于在收集样品后几小时内快速测定微生物的抗生素敏感性的方法，组合物，试剂盒和系统。在一些实施方案中，本文所述的方法，组合物，试剂盒和系统可以允许基于少量微生物测定微生物的抗生素敏感性，例如与本文所述的微生物靶向底物结合的少至5-10微克。