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138 条记录 (耗时 0.052 秒)

    ORGANIC ELECTROLUMINESCENT DEVICE
    74.
    发明申请
    ORGANIC ELECTROLUMINESCENT DEVICE 审中-公开
    有机电致发光器件

    公开(公告)号：US20120025180A1

    公开(公告)日：2012-02-02

    申请号：US13258967

    申请日：2010-03-31

    申请人： Toshio Matsumoto

    发明人： Toshio Matsumoto

    IPC分类号： H01L51/52 ,  H01L51/54

    CPC分类号： H01L51/5096 ,  H01L51/0071 ,  H01L51/0079 ,  H01L51/5278

    摘要： Provided is a structure of an organic EL element capable of reducing the product cost by drastically simplifying the fabrication process as compared with a conventional multi-photon organic EL element. An insulating organic layer having a low dielectric constant is interposed to smooth the transfer of electron charges between a strong electron-accepting material and an electron transport layer included in a charge generation layer of the conventional multi-photon organic EL element.

    摘要翻译： 提供了与常规的多光子有机EL元件相比，通过大大简化制造工艺，能够降低产品成本的有机EL元件的结构。 插入具有低介电常数的绝缘有机层以平滑电子电荷在强电子接受材料与包含在常规多光子有机EL元件的电荷产生层中的电子传输层之间的转移。

    Image sensing apparatus with electronic shutter function and mechanical shutter function, and image sensing method
    75.
    发明授权
    Image sensing apparatus with electronic shutter function and mechanical shutter function, and image sensing method 有权
    具有电子快门功能和机械快门功能的图像感测装置，以及图像感测方法

    公开(公告)号：US08107003B2

    公开(公告)日：2012-01-31

    申请号：US12035537

    申请日：2008-02-22

    申请人： Toshio Matsumoto

    发明人： Toshio Matsumoto

    IPC分类号： G03B7/083 ,  G03B15/03 ,  G03B7/093 ,  H04N5/238 ,  H04N3/14 ,  H04N5/335

    CPC分类号： H04N5/2353 ,  H04N5/2351

    摘要： An image sensing apparatus having an electronic shutter for controlling the charge accumulation time of an image sensing element and a mechanical shutter for releasing/shielding an optical path to the image sensing element includes an electronic shutter mode of controlling the image sensing time mainly by the electronic shutter and a mechanical shutter mode of controlling the image sensing time mainly by the mechanical shutter. In the electronic shutter mode, the operations of the electronic and mechanical shutters are controlled to overlap each other, and a charge reading period of the image sensing element and part of a release operation period of the mechanical shutter are controlled to overlap each other.

    摘要翻译： 具有用于控制图像感测元件的电荷累积时间的电子快门和用于释放/屏蔽到图像感测元件的光路的机械快门的图像感测装置包括主要通过电子控制的电子快门模式来控制图像感测时间 快门和主要通过机械快门控制图像感测时间的机械快门模式。 在电子快门模式中，电子和机械快门的操作被控制为彼此重叠，并且控制图像感测元件的电荷读取周期和机械快门的释放操作时段的一部分彼此重叠。

    Remedy For Chemotherapy-Resistant Cancer Containing HLA Class I-Recognizing Antibody as the Active Ingredient and Use of the Same
    76.
    发明申请
    Remedy For Chemotherapy-Resistant Cancer Containing HLA Class I-Recognizing Antibody as the Active Ingredient and Use of the Same 审中-公开
    包含HLA I类识别抗体作为其有效成分和使用的抗化学药物治疗的补救措施

    公开(公告)号：US20100092461A1

    公开(公告)日：2010-04-15

    申请号：US12530670

    申请日：2008-03-12

    申请人： Toshio Matsumoto ,  Shuji Ozaki ,  Masahiro Abe

    发明人： Toshio Matsumoto ,  Shuji Ozaki ,  Masahiro Abe

    IPC分类号： A61K39/395 ,  A61P35/00

    CPC分类号： C07K16/2833 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/622 ,  C07K2317/626 ,  C07K2317/73 ,  A61K2300/00

    摘要： The present invention describes therapeutic agents for chemotherapeutic agent-resistant cancers that include an HLA class I-recognizing antibody as an active ingredient. A further objective of the present invention is to provide methods for treating chemotherapeutic agent-resistant cancers that include the step of administering an HLA class I-recognizing antibody to a subject. It is herein demonstrated that cytotoxic activity due to C3B3 diabody is induced at a lower concentration in chemotherapeutic agent-resistant hematological tumor cell lines having high MDR1 and HLA class IA protein expression, than in their parent cell lines. It was also found that when the chemotherapeutic agent-resistant hematological tumor cell line is pretreated with a C3B3 diabody, cell injury associated with sole use of chemotherapeutic agent is enhanced and the amount of pharmaceutical agents taken up into cells are increased. More specifically, it was discovered that the C3B3 diabody exhibits anti-tumor activity on MDR1-expressing tumor cells having high HLA class I expression, and thereby is effective in overcoming drug resistance.

    摘要翻译： 本发明描述了包含HLA I类识别抗体作为活性成分的化学治疗剂抗性癌症的治疗剂。 本发明的另一个目的是提供用于治疗耐化学药物的癌症的方法，其包括向受试者施用HLA I类识别抗体的步骤。 在本文中证明，在具有高MDR1和HLA类别IA蛋白表达的化学治疗剂抗性血液肿瘤细胞系中，比在其亲本细胞系中，以较低浓度诱导由C3B3双抗体引起的细胞毒性活性。 还发现当化学治疗剂抗性血液肿瘤细胞系用C3B3双抗体预处理时，与单独使用化学治疗剂相关的细胞损伤增强，并且吸收到细胞中的药剂的量增加。 更具体地，发现C3B3双抗体对具有高HLA I类表达的MDR1表达的肿瘤细胞表现出抗肿瘤活性，从而有效克服耐药性。

    Light Formation Apparatus and Control Method of Light Information Apparatus
    77.
    发明申请
    Light Formation Apparatus and Control Method of Light Information Apparatus 有权
    光信息装置的光形成装置及控制方法

    公开(公告)号：US20070253068A1

    公开(公告)日：2007-11-01

    申请号：US11568014

    申请日：2005-06-20

    申请人： Katsuhiko Yasuda ,  Hidenori Wada ,  Takeharu Yamamoto ,  Toshio Matsumoto

    发明人： Katsuhiko Yasuda ,  Hidenori Wada ,  Takeharu Yamamoto ,  Toshio Matsumoto

    IPC分类号： G02B27/10

    CPC分类号： G11B7/1263 ,  G11B7/13925

    摘要： When a spherical aberration generated on an optical recording medium is optically corrected, there has been a problem of irradiation power change of an output on an objective lens side due to a change of a signal level detected by a light quantity detector in response to the correction value. An optical information device is provided with a laser (2) for projecting optical beams; an objective lens (9) and the like for focusing the optical beams projected from the laser (2) on an optical recording medium (10); a spherical aberration correcting means (24), which is arranged on an optical axis of the optical beams connecting the laser (2) and the objective lens (9) and corrects a spherical aberration generated on the optical recording medium (10); a polarization beam splitter (5) for splitting the optical beams projected from the laser (2) into a plurality of beams; a light quantity detector (15) which receives one of the optical beams split by the polarization beam splitter (5) and outputs an electric signal corresponding to the receiving light quantity; a laser power control means (21), which controls the projection power of the laser beam source based on the electric signal from the light quantity detector (15); and a controller (23), which performs correction, such as to change the projection power of the laser (2) in response to a correction quantity of the spherical aberration correcting means (24).

    摘要翻译： 当在光学记录介质上产生的球面像差被光学校正时，由于由光量检测器响应于校正而检测到的信号电平的变化，存在物镜侧的输出的照射功率变化的问题 值。 光信息装置设置有用于投射光束的激光器（2） 用于将从激光器（2）投影的光束聚焦在光学记录介质（10）上的物镜（9）等; 球面像差校正装置（24），其布置在连接激光器（2）和物镜（9）的光束的光轴上，并校正在光学记录介质（10）上产生的球面像差; 用于将从激光器（2）投影的光束分成多个光束的偏振分束器（5） 光量检测器（15），其接收由所述偏振分束器（5）分离的光束中的一个，并输出与所述接收光量对应的电信号; 激光功率控制装置（21），其基于来自光量检测器（15）的电信号来控制激光束源的投影功率; 以及控制器（23），其执行校正，诸如响应于球面像差校正装置（24）的校正量来改变激光器（2）的投影功率。

    Optical disc drive for controlling laser emission
    80.
    发明授权
    Optical disc drive for controlling laser emission 失效
    用于控制激光发射的光盘驱动器

    公开(公告)号：US07177253B2

    公开(公告)日：2007-02-13

    申请号：US10524896

    申请日：2003-10-06

    申请人： Hiromichi Ishibashi ,  Tetsuya Shihara ,  Hisashi Senga ,  Toshio Matsumoto

    发明人： Hiromichi Ishibashi ,  Tetsuya Shihara ,  Hisashi Senga ,  Toshio Matsumoto

    IPC分类号： G11B7/00

    CPC分类号： G11B7/126

    摘要： In an optical disc drive, a laser light source emits a laser beam having an intensity changeable with the amount of drive current supplied. A first photodetector receives the laser beam reflected from an optical disc, thereby generating a readout signal. A second photodetector receives the laser beam, generates an electric signal representing the power of the laser beam received, and outputs the electric signal as a light quantity detection signal. A feedback control loop compares the level of the light quantity detection signal with a predetermined target value and regulates the drive current such that the level of the light quantity detection signal approaches the target value. In reading data from the optical disc, the target value is changed so as to compensate for a variation of the sensitivity of the second photodetector, thereby controlling the power of the laser beam emitted from the laser light source.

    摘要翻译： 在光盘驱动器中，激光光源发射具有随供给的驱动电流量而变化的强度的激光束。 第一光电检测器接收从光盘反射的激光束，从而产生读出信号。 第二光电检测器接收激光束，产生表示所接收的激光束的功率的电信号，并将该电信号作为光量检测信号输出。 反馈控制环路将光量检测信号的电平与预定目标值进行比较，并且调节驱动电流，使得光量检测信号的电平接近目标值。 在从光盘读取数据时，改变目标值以补偿第二光电检测器的灵敏度的变化，从而控制从激光光源发射的激光束的功率。