公开(公告)号：US20150301000A1

公开(公告)日：2015-10-22

申请号：US14675865

申请日：2015-04-01

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： Michael O. Fogwill ,  Joseph D. Michienzi ,  James P. Murphy

IPC: G01N30/68

CPC classification number: G01N30/68

Abstract: The present disclosure relates to flame based detection methods for compressed mobile phase chromatography. In particular, the present disclosure relates to the operation of a flame ionization detector for carbon dioxide based chromatography, such as supercritical fluid chromatography. The present disclosure includes a method of matching a chromatographic column with a flame ionization detector inner burner including providing a chromatographic column with an internal diameter, determining an optimal mobile phase flow rate for the chromatographic column, calculating an optimal inner diameter of the inner burner that combined with the internal diameter and flow rate of the column produces optimal detector performance, and providing a flame ionization detector inner burner having an inner diameter substantially equal to the calculated optimal inner diameter.

Abstract translation: 本公开涉及用于压缩流动相色谱法的基于火焰的检测方法。 特别地，本公开涉及用于二氧化碳基色谱的火焰离子化检测器的操作，例如超临界流体色谱法。 本公开内容包括将色谱柱与火焰离子化检测器内部燃烧器匹配的方法，包括提供具有内径的色谱柱，确定色谱柱的最佳流动相流速，计算内部燃烧器的最佳内径， 结合柱的内径和流速产生最佳的检测器性能，并提供具有基本上等于计算的最佳内径的内径的火焰离子化检测器内燃烧器。

公开(公告)号：US20150079691A1

公开(公告)日：2015-03-19

申请号：US14484350

申请日：2014-09-12

Applicant: Waters Technologies Corporation

Inventor： Michael O. Fogwill ,  Joseph D. Michienzi ,  James P. Murphy

IPC: G01N30/84 ,  G01N30/68 ,  G01N27/62

CPC classification number: G01N30/84 ,  G01N27/626 ,  G01N30/68 ,  G01N2030/8435

Abstract: The present disclosure relates to an oxidizer, and related methods, for oxidizing polar modifiers in chromatographic mobile phases. The oxidizer enables the use of flame-based detection in chromatographic separations, such as carbon dioxide based chromatography, which employ polar modifiers, such as methanol. Upon exiting a chromatographic column, the mobile phase containing the polar modifier is flowed through an oxidizer that contains a catalyst to oxidize at least a portion of the polar modifier to a species that does not interfere with the function of the flame-based detector. The oxidizer allows for flame-based detection, such as flame ionization detection, in applications in which a polar modifier with a reduced form of carbon is used.

Abstract translation: 本公开内容涉及用于在色谱流动相中氧化极性改性剂的氧化剂和相关方法。 氧化剂使得能够在色谱分离中使用基于火焰的检测，例如使用极性改性剂如甲醇的基于二氧化碳的色谱法。 在离开色谱柱时，含有极性改性剂的流动相流过含有催化剂的氧化剂，以将至少一部分极性改性剂氧化成不干扰基于火焰的检测器的功能的物质。 在使用具有还原形式的碳的极性改性剂的应用中，氧化剂允许基于火焰的检测，例如火焰离子化检测。

公开(公告)号：US20150078962A1

公开(公告)日：2015-03-19

申请号：US14483389

申请日：2014-09-11

Applicant: Waters Technologies Corporation

Inventor： Michael O. Fogwill ,  Joseph D. Michienzi ,  James P. Murphy ,  Geoff Gerhardt

IPC: G01N30/68

CPC classification number: G01N30/68 ,  G01N30/6095

Abstract: The present disclosure relates to a microfluidic flame ionization detector for use in small scale separations, such as, for example, microfluidic gas chromatography and microfluidic carbon dioxide based fluid chromatography. In some arrangements, the microfluidic counter-current flame ionization detector employs a non-parallel arrangement for the introduction of combustion gases into the combustion chamber. In other arrangements, the detector housing is configured to incorporate at least one of the detector electrodes within the housing using electrically isolating fittings.

Abstract translation: 本公开内容涉及用于小规模分离的微流体火焰离子化检测器，例如微流体气相色谱法和基于微流体二氧化碳的流体色谱法。 在一些布置中，微流控逆流火焰离子化检测器采用非平行布置来将燃烧气体引入燃烧室。 在其他布置中，检测器壳体构造成使用电隔离配件将至少一个检测器电极并入外壳内。

公开(公告)号：US12259369B2

公开(公告)日：2025-03-25

申请号：US17057361

申请日：2019-05-20

Applicant: Waters Technologies Corporation

Inventor： Martin Gilar ,  Thomas S. McDonald ,  Joseph D. Michienzi ,  Jeffrey Musacchio ,  Rachel Mumma ,  Keith Fadgen ,  Geoff C. Gerhardt

IPC: G01N30/06 ,  B01D15/16 ,  B01D15/22 ,  B01D15/38 ,  B01J20/24 ,  B01J20/28 ,  B01J20/288 ,  B01J20/32 ,  G01N1/40 ,  G01N30/00 ,  G01N30/54 ,  G01N30/60 ,  G01N30/88

Abstract: Sample preparation and separation can be performed using a sample cartridge (201). The cartridge includes a barrel (204) with a first and second end, a column segment (209) connected to the second end of the barrel, and a column (205) containing a sorbent material. The sorbent material includes particles that have antibodies attached to them to selectively retain analytes, proteins attached to them to retain certain classes of antibodies, or enzymes attached to them to perform specific modifications to certain classes of molecules. The column segment can be in thermal communication with a temperature control device in order to control the temperature of the column.

公开(公告)号：US12247962B2

公开(公告)日：2025-03-11

申请号：US17057242

申请日：2019-05-20

Applicant: Waters Technologies Corporation

Inventor： Martin Gilar ,  Thomas S. McDonald ,  Joseph D. Michienzi ,  Jeffrey Musacchio ,  Rachel Mumma ,  Keith Fadgen ,  Geoff C. Gerhardt

IPC: G01N30/60 ,  G01N30/00 ,  G01N30/06

Abstract: Methods and devices for the washing, extraction, and separation of a sample in a disposable chromatography cartridge (201) comprising a barrel (204) and a column (205), and especially including reinforcement to the column permitting high-pressure separation.

公开(公告)号：US12222339B2

公开(公告)日：2025-02-11

申请号：US18491132

申请日：2023-10-20

Applicant: Waters Technologies Corporation

Inventor： Wade P. Leveille ,  Joseph D. Michienzi ,  Joseph D. Antocci ,  Jeffrey Musacchio

IPC: G01N30/60

Abstract: A clamp assembly includes a rail extending along the length and configured to receive a first fluidic assembly, and a carriage movably attachable to the rail such that the carriage moves along the rail, the carriage configured to receive a second fluidic assembly, the carriage including an actuator and a stop mechanism. The stop mechanism is configured to selectively prevent and allow movement of the carriage relative to the rail. The stop mechanism is configured to be independently operable from the actuator assembly, and the actuator is configured: to move a chromatography column received by the clamp assembly relative to the rail to create a first fluid tight seal between the chromatography column and the first fluidic assembly, and move the second fluidic assembly relative to the carriage body to create a second fluid tight seal between the second fluidic assembly and the chromatography column.

公开(公告)号：US12181453B2

公开(公告)日：2024-12-31

申请号：US17512864

申请日：2021-10-28

Applicant: Waters Technologies Corporation

Inventor： Wade P. Leveille ,  Joseph D. Michienzi ,  Jeffrey Musacchio ,  Michael O. Fogwill

IPC: G01N30/60 ,  B01D15/22 ,  G01N30/46

Abstract: The exemplary embodiments provide chromatography column positioning assemblies that can ensure that the distance between face seals or other sealing surfaces/mechanisms at the respective ends of a liquid chromatography column is a desired distance (i.e., the length of the liquid chromatography column). The exemplary embodiments can adjust the separation between the face seals to accommodate different length liquid chromatography columns. For example, a chromatography column positioning assembly of an exemplary embodiment can set the distance between face seals to accommodate a 25 mm column, a 50 mm column or a 100 mm column.

公开(公告)号：US20240302335A1

公开(公告)日：2024-09-12

申请号：US18598803

申请日：2024-03-07

Applicant: Waters Technologies Corporation

Inventor： Michael Scanlon ,  Wade P. Leveille ,  Joseph D. Michienzi

IPC: G01N30/60 ,  B01D15/10 ,  F16L19/00 ,  G01N30/02

CPC classification number: G01N30/6026 ,  B01D15/10 ,  F16L19/00 ,  G01N2030/027

Abstract: Threaded conventional column end fittings for liquid chromatography columns do not have face seals that enable them to be used with clamping fluidic connectors. The exemplary embodiments may provide adapters that interface with conventional threaded column end fittings so that the column assembly may now be used with the clamping fluidic connectors. The adapters of the exemplary embodiments may include lock nuts for securing the adapters to column end fittings of a liquid chromatography columns. The lock nuts may include threads that bear the load of the adapter rather than the column end fitting of the chromatography column. The threads of the lock nut become the load bearing surfaces, and the load is distributed over the surfaces where the threads of the adapter engage with the threads of the lock nut.

公开(公告)号：US20240079223A1

公开(公告)日：2024-03-07

申请号：US18468380

申请日：2023-09-15

Applicant: Waters Technologies Corporation

Inventor： Michael O. Fogwill ,  Joseph D. Michienzi ,  Sylvain Gilles Cormier

IPC: H01J49/04 ,  G01N30/72 ,  H01J49/00 ,  H01J49/16

CPC classification number: H01J49/0495 ,  G01N30/7206 ,  G01N30/7233 ,  H01J49/0009 ,  H01J49/165

Abstract: Exemplary embodiments may deploy a valve that introduces a sample of a calibrant coaxially with flow exiting a source of a mobile phase flow, such as a liquid chromatography (LC) column, on a path to an ion source for the mass spectrometer (MS). The valve may be positioned remotely on a branch that has a junction with the path leading form the source of the mobile phase flow to the ion source. Alternatively, the valve may be positioned in line on the flow path from the source of the mobile phase flow to the ion source of the MS. A novel five port valve design may be employed. With this valve design, a first position of the valve allows a sample loop for the calibrant to be filled. In a second position, the calibrant is added coaxially to the flow from the source of the mobile phase to the MS. In a third position of the valve, diversion of or infusion to a post-source flow is enabled.

公开(公告)号：US20240033756A1

公开(公告)日：2024-02-01

申请号：US18467937

申请日：2023-09-15

Applicant: Waters Technologies Corporation

Inventor： Wade P. Leveille ,  Joseph D. Michienzi ,  Jeffrey Musacchio ,  Emrys Jones ,  Steven Derek Pringle ,  Stephen Hattan ,  Gregory T. Roman

IPC: B05B5/03 ,  B05B12/32

CPC classification number: B05B5/03 ,  B05B12/32

Abstract: A sprayer assembly for an ion source is disclosed. The sprayer includes a capillary having an outlet, a sheath for the capillary, and an elastic member. The sheath can move relative to the capillary between a first position in which the sheath covers the outlet of the capillary and a second position in which the outlet of the capillary is exposed. When the sheath moves from the first position to or towards the second position, the elastic member provides a restoring force that acts to restore the position of the sheath to or towards the first position.