公开(公告)号：US20050169957A1

公开(公告)日：2005-08-04

申请号：US10815421

申请日：2004-03-31

申请人： Syed Hossainy

发明人： Syed Hossainy

IPC分类号： A61K31/445 ,  A61L31/10 ,  A61L31/12 ,  A61L31/16 ,  A61F2/00

CPC分类号： A61L31/16 ,  A61K31/445 ,  A61K31/74 ,  A61L31/10 ,  C08L33/06

摘要： A composition is disclosed comprising a structural component comprising linear acrylic homopolymers or linear acrylic copolymers and a biobeneficial component comprising copolymers having an acrylate moiety and a biobeneficial moiety.

摘要翻译： 公开了包含包含线性丙烯酸均聚物或线性丙烯酸共聚物的结构组分和包含具有丙烯酸酯部分和生物有益部分的共聚物的生物有益成分的组合物。

公开(公告)号：US20050033412A1

公开(公告)日：2005-02-10

申请号：US10912025

申请日：2004-08-04

申请人： Steven Wu ,  Sameer Harish ,  Deborra Sanders-Millare ,  Judy Guruwaiya ,  Daryush Mirzaee ,  Syed Hossainy ,  Charlene Chen

发明人： Steven Wu ,  Sameer Harish ,  Deborra Sanders-Millare ,  Judy Guruwaiya ,  Daryush Mirzaee ,  Syed Hossainy ,  Charlene Chen

IPC分类号： A61F2/00 ,  A61F2/06 ,  A61F2/90

CPC分类号： A61F2/0077 ,  A61F2/848 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91533 ,  A61F2230/0013 ,  A61F2250/0067 ,  A61F2250/0068 ,  Y10S623/901

摘要： An implantable medical device, such as a stent or graft, having asperities on a designated region of its outer surface is disclosed. The asperities can serve to improve retention of one or more layers of a coating on the device and to increase the amount of coating that can be carried by the device. The asperities can be formed by using a stream of pressurized grit to roughen the surface. The asperities can also be formed by removing material from the outer surface, for example, by chemical etching with or without a patterned mask. Alternatively, the asperities can be formed by adding material to the outer surface, for example, by welding powder particles to the outer surface or sputtering.

摘要翻译： 公开了一种在其外表面的指定区域上具有凹凸的可植入医疗装置，例如支架或移植物。 粗糙度可用于改善设备上一层或多层涂层的保留性并增加该装置可承载的涂层量。 可以通过使用加压砂粒流粗糙表面来形成凹凸。 也可以通过从外表面去除材料来形成凹凸，例如通过具有或不具有图案化掩模的化学蚀刻来形成。 或者，可以通过向外表面添加材料，例如通过将粉末颗粒焊接到外表面或溅射来形成凹凸。

公开(公告)号：US09572795B2

公开(公告)日：2017-02-21

申请号：US13572507

申请日：2012-08-10

申请人： Syed Hossainy ,  Dariush Davalian ,  Mikael Trollsas ,  John Stankus ,  Jinping Wan

发明人： Syed Hossainy ,  Dariush Davalian ,  Mikael Trollsas ,  John Stankus ,  Yuet Mei Khong ,  Jinping Wan

IPC分类号： A61M37/00 ,  A61K31/409 ,  A61K9/00 ,  A61K9/127 ,  A61K9/51 ,  A61L29/16 ,  A61K41/00 ,  A61M25/00 ,  A61M25/10

CPC分类号： A61K31/409 ,  A61K9/0009 ,  A61K9/0019 ,  A61K9/1272 ,  A61K9/5146 ,  A61K41/0071 ,  A61L29/16 ,  A61L2300/224 ,  A61L2300/626 ,  A61M25/0045 ,  A61M25/10 ,  A61M2025/105 ,  A61M2025/1086

摘要： This invention relates to photodynamic therapy (PDT) of vulnerable plaque using two pluralities of nanoparticles, one plurality comprising a PDT agent that is sensitive to blue-green light wherein the nanoparticles are capable of penetrating only into the fibrous cap of the vulnerable plaque and one plurality comprising a PDT agent that is sensitive to red light wherein the nanoparticles are capable of penetrating into the core of the vulnerable plaque.

摘要翻译： 本发明涉及使用两种纳米颗粒的易损斑块的光动力疗法（PDT），其一个包括对蓝绿色光敏感的PDT剂，其中纳米颗粒仅能穿透易损斑块的纤维帽和一个 多个包含对红光敏感的PDT剂，其中纳米颗粒能够渗入易损斑块的核心。

公开(公告)号：US08916188B2

公开(公告)日：2014-12-23

申请号：US12106212

申请日：2008-04-18

申请人： Mikael O. Trollsas ,  Michael H. Ngo ,  Syed Hossainy ,  David J. Sherman

发明人： Mikael O. Trollsas ,  Michael H. Ngo ,  Syed Hossainy ,  David J. Sherman

IPC分类号： A61K9/00 ,  A61L31/10 ,  A61L31/16

CPC分类号： A61L31/10 ,  A61L31/047 ,  A61L31/06 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/606 ,  C08L71/02 ,  C08L67/04

摘要： The present invention provides a block copolymer for a coating on an implantable device for controlling release of drug and methods of making and using the same.

摘要翻译： 本发明提供了用于控制药物释放的可植入装置上的涂层的嵌段共聚物及其制备和使用方法。

公开(公告)号：US08568471B2

公开(公告)日：2013-10-29

申请号：US13015488

申请日：2011-01-27

申请人： Mikael Trollsas ,  Michael H. Ngo ,  Boris Anukhin ,  Alexander Nikanorov ,  Syed Hossainy ,  John E. Papp ,  Dudley Jayasinghe ,  Zella Solter

发明人： Mikael Trollsas ,  Michael H. Ngo ,  Boris Anukhin ,  Alexander Nikanorov ,  Syed Hossainy ,  John E. Papp ,  Dudley Jayasinghe ,  Zella Solter

IPC分类号： A61F2/82

CPC分类号： A61F2/958 ,  A61F2/82 ,  A61F2/844 ,  A61F2/86 ,  A61F2/89 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/825 ,  A61F2002/91558 ,  A61F2002/91566 ,  A61F2002/91575 ,  A61F2002/9522 ,  A61F2210/0004 ,  A61F2210/0014 ,  A61F2210/0019 ,  A61F2210/0076 ,  A61F2230/0006 ,  A61F2230/0008 ,  A61F2250/0067 ,  A61F2250/0096 ,  A61F2250/0098 ,  A61L27/00 ,  A61L31/06 ,  A61L31/14 ,  B21D39/046 ,  B29C35/08 ,  B29C2035/0838 ,  B29K2067/046 ,  B29L2023/00 ,  B29L2031/7543 ,  Y10T29/49826 ,  Y10T29/4987 ,  Y10T29/49908 ,  Y10T29/49925 ,  Y10T29/49927 ,  C08L67/04 ,  C08L71/02

摘要： A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. The scaffold, after being deployed by the balloon, provides a crush recovery of about 90% after the diameter of the scaffold has been pinched or crushed by 50%. The scaffold has a pattern including an asymmetric closed cell connecting links connecting the closed cells.

摘要翻译： 医疗装置包括压接到具有膨胀气囊的导管的聚合物构架。 支架在被气囊部署之后，在支架的直径被挤压或压碎50％后，提供约90％的压碎回收率。 支架具有图案，其包括连接连接封闭单元的链接的非对称封闭单元。

公开(公告)号：US08465773B2

公开(公告)日：2013-06-18

申请号：US13472328

申请日：2012-05-15

申请人： Syed Hossainy ,  Michael Ngo ,  Mikael Trollsas ,  John Stankus ,  Gene Michal

发明人： Syed Hossainy ,  Michael Ngo ,  Mikael Trollsas ,  John Stankus ,  Gene Michal

IPC分类号： A61K35/28 ,  A61K47/48 ,  A61K47/42 ,  A61K9/00 ,  A61K9/08 ,  C07K17/08 ,  A61F2/00 ,  C08L89/00

CPC分类号： A61K47/42 ,  A61K9/0024 ,  A61K47/34 ,  A61L27/3804 ,  A61L27/3839 ,  A61L27/3895 ,  A61L27/48 ,  A61L27/52 ,  Y10S530/812 ,  Y10S530/815 ,  C08L89/00 ,  C08L71/02

摘要： Compositions for forming a self-reinforcing composite biomatrix, methods of manufacture and use therefore are herein disclosed. Kits including delivery devices suitable for delivering the compositions are also disclosed. In some embodiments, the composition can include at least three components. In one embodiment, a first component can include a first functionalized polymer, a second component can include a second functionalized polymer and a third component can include silk protein or constituents thereof. In some embodiments, the composition can include at least one cell type and/or at least one growth factor. In some embodiments, the composition can include a biologic encapsulated, suspended, disposed within or loaded into a biodegradable carrier. In some embodiments, the composition(s) of the present invention can be delivered by a dual lumen injection device to a treatment area in situ, in vivo, as well as ex vivo applications.

公开(公告)号：US20120225040A1

公开(公告)日：2012-09-06

申请号：US13472324

申请日：2012-05-15

申请人： Syed Hossainy ,  Michael Ngo ,  Mikael Trollsas ,  John Stankus ,  Gene Michal

发明人： Syed Hossainy ,  Michael Ngo ,  Mikael Trollsas ,  John Stankus ,  Gene Michal

IPC分类号： A61K35/12 ,  A61K35/34 ,  A61P9/10 ,  A61K35/44 ,  A61K35/32 ,  A61K35/28 ,  A61K35/54

CPC分类号： A61K47/42 ,  A61K9/0024 ,  A61K47/34 ,  A61L27/3804 ,  A61L27/3839 ,  A61L27/3895 ,  A61L27/48 ,  A61L27/52 ,  Y10S530/812 ,  Y10S530/815 ,  C08L89/00 ,  C08L71/02

摘要： Compositions for forming a self-reinforcing composite biomatrix, methods of manufacture and use therefore are herein disclosed. Kits including delivery devices suitable for delivering the compositions are also disclosed. In some embodiments, the composition can include at least three components. In one embodiment, a first component can include a first functionalized polymer, a second component can include a second functionalized polymer and a third component can include silk protein or constituents thereof. In some embodiments, the composition can include at least one cell type and/or at least one growth factor. In some embodiments, the composition can include a biologic encapsulated, suspended, disposed within or loaded into a biodegradable carrier. In some embodiments, the composition(s) of the present invention can be delivered by a dual lumen injection device to a treatment area in situ, in vivo, as well as ex vivo applications.

公开(公告)号：US20110190872A1

公开(公告)日：2011-08-04

申请号：US13015474

申请日：2011-01-27

申请人： Boris Anukhin ,  Michael H. Ngo ,  Mikael Trollsas ,  Syed Hossainy ,  John Papp

发明人： Boris Anukhin ,  Michael H. Ngo ,  Mikael Trollsas ,  Syed Hossainy ,  John Papp

IPC分类号： A61F2/82 ,  B29C55/24 ,  B29C69/00

CPC分类号： A61F2/89 ,  A61F2/82 ,  A61F2/915 ,  A61F2002/91508 ,  A61F2002/91575 ,  A61F2240/002 ,  A61M25/1034 ,  B23P11/005 ,  B29C55/24 ,  B29C69/00 ,  Y10T29/49908

摘要： A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. The scaffold, after being deployed by the balloon, provides a crush recovery of about 90% after the diameter of the scaffold has been pinched or crushed by 50%. The scaffold also has a reduced crimped profile and a modification of the scaffold's ring structure at the crowns that contributes to the reduced crimped profile.

摘要翻译： 医疗装置包括压接到具有膨胀气囊的导管的聚合物构架。 支架在被气囊部署之后，在支架的直径被挤压或压碎50％后，提供约90％的压碎回收率。 支架还具有减小的卷边轮廓和在冠部处的支架环形结构的改进，其有助于减小卷曲轮廓。

公开(公告)号：US07674416B2

公开(公告)日：2010-03-09

申请号：US11020826

申请日：2004-12-22

申请人： James Hong ,  Rahul Bhagat ,  Syed Hossainy ,  Santosh Prabhu ,  K. T. Venkateswara Rao ,  Ashok Shah ,  Srinivasan Sridharan

发明人： James Hong ,  Rahul Bhagat ,  Syed Hossainy ,  Santosh Prabhu ,  K. T. Venkateswara Rao ,  Ashok Shah ,  Srinivasan Sridharan

IPC分类号： B32B38/08

CPC分类号： A61F2/915 ,  A61F2/07 ,  A61F2/91 ,  A61F2002/072 ,  A61F2002/91533 ,  A61F2002/91558 ,  A61F2002/91575 ,  A61F2220/0058 ,  A61F2230/0013 ,  A61F2230/0054 ,  A61L31/10 ,  A61L31/16 ,  Y10S623/901

摘要： A hybrid stent is formed which exhibits both high flexibility and high radial strength. The expandable hybrid stent for implantation in a body lumen, such as a coronary artery, consists of radially expandable cylindrical rings generally aligned on a common longitudinal axis and interconnected by one or more links. In one embodiment, a dip-coated covered stent is formed by encapsulating cylindrical rings within a polymer material. In other embodiments, at least some of the rings and links are formed of a polymer material which provides longitudinal and flexural flexibility to the stent. These polymer rings and links are alternated with metallic rings and links in various configurations to attain sufficient column strength along with the requisite flexibility in holding open the target site within the body lumen. Alternatively, a laminated, linkless hybrid stent is formed by encapsulating cylindrical rings within a polymer tube.

摘要翻译： 形成具有高柔性和高径向强度的混合支架。 用于植入体腔（例如冠状动脉）中的可扩张混合支架由径向可扩展的圆柱形环构成，其通常在公共纵向轴线上对齐并且由一个或多个连杆相互连接。 在一个实施例中，通过将圆柱形环封装在聚合物材料内而形成浸涂的覆盖支架。 在其它实施例中，至少一些环和链节由聚合物材料形成，该聚合物材料向支架提供纵向和弯曲的柔性。 这些聚合物环和链环与金属环和各种结构的链接交替，以获得足够的柱强度以及在体腔内保持打开靶部位所需的灵活性。 或者，通过在聚合物管内封装圆柱形环来形成层压的无环式混合支架。

公开(公告)号：US07416558B2

公开(公告)日：2008-08-26

申请号：US11497706

申请日：2006-08-01

申请人： Philip S. Yip ,  James Jacobs ,  Syed Hossainy ,  Jon Becker ,  Timothy A. Limon

发明人： Philip S. Yip ,  James Jacobs ,  Syed Hossainy ,  Jon Becker ,  Timothy A. Limon

IPC分类号： A61F2/06

CPC分类号： A61F2/91 ,  A61F2/90 ,  A61F2/915 ,  A61F2002/91508 ,  A61F2002/91516 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2210/0076 ,  A61F2220/005 ,  A61F2250/0036 ,  A61F2250/0067 ,  A61F2250/0071 ,  Y10S623/903

摘要： An intravascular stent includes an eluting sheath fabricated from a mesh for controlled release of therapeutic drugs and for delivery of the therapeutic drugs in localized drug therapy in a blood vessel. The eluting sheath is attached to at least a portion of an outside surface area of the stent structure and is fabricated from a mesh designed to neck down in response to a radially outward directed force resulting in the uniform expansion of the stent. The eluting sheath can be loaded with at least one therapeutic drug for the release thereof at a treatment site to facilitate repair of a damaged vessel. The stent has a high degree of flexibility in the longitudinal direction, yet has adequate vessel wall coverage and radial strength sufficient to hold open an artery or other body lumen.

摘要翻译： 血管内支架包括由用于控制释放治疗药物的网格和用于在血管中局部药物治疗中递送治疗药物的筛网制成的洗脱鞘。 洗脱鞘附着到支架结构的外表面区域的至少一部分上，并且由设计成颈部向下的网眼制成，以适应径向向外的力，导致支架的均匀膨胀。 洗脱鞘可以装载至少一种用于在治疗部位释放的治疗药物，以便于修复受损血管。 支架在纵向具有高度的柔性，但具有足够的容器壁覆盖和径向强度足以保持打开动脉或其他体腔。