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1309 条记录 (耗时 0.063 秒)

    METHODS FOR ASSESSING ENDOMETRIUM RECEPTIVITY OF A PATIENT
    74.
    发明申请
    METHODS FOR ASSESSING ENDOMETRIUM RECEPTIVITY OF A PATIENT 有权
    评估患者内膜受体的方法

    公开(公告)号：US20130072748A1

    公开(公告)日：2013-03-21

    申请号：US13699814

    申请日：2011-05-27

    申请人： Samir Hamamah ,  Delphine Haouzi

    发明人： Samir Hamamah ,  Delphine Haouzi

    IPC分类号： C12Q1/68 ,  A61B17/435 ,  C40B40/08

    CPC分类号： C12Q1/6837 ,  A61B17/435 ,  C12Q1/6883 ,  C12Q2600/158 ,  C40B40/08

    摘要： The present invention relates to a method for assessing the endometrium receptivity of a patient, comprising a step consisting of measuring the expression level of eleven genes in an endometrial biopsy sample obtained from said patient wherein said genes are MFAP5, ANGPTL1, PROK1, NLF2, LAMB3, BCL2L10, CD68, TRPC4, SORCS1, FST and KRT80.

    摘要翻译： 本发明涉及一种用于评估患者的子宫内膜接受性的方法，包括测量从所述患者获得的子宫内膜活检样品中11种基因的表达水平的步骤，其中所述基因是MFAP5，ANGPTL1，PROK1，NLF2，LAMB3 ，BCL2L10，CD68，TRPC4，SORCS1，FST和KRT80。

    Method for cloning cognate antibodies
    76.
    发明授权
    Method for cloning cognate antibodies 有权
    克隆同源抗体​​的方法

    公开(公告)号：US08283294B2

    公开(公告)日：2012-10-09

    申请号：US12074066

    申请日：2008-02-29

    申请人： Jesper Kastrup ,  Lars S. Nielsen ,  Per-Johan Meijer

    发明人： Jesper Kastrup ,  Lars S. Nielsen ,  Per-Johan Meijer

    IPC分类号： C40B40/08 ,  C40B50/06

    CPC分类号： C12N15/1093 ,  C07K16/005 ,  C07K16/1282 ,  C07K16/2863 ,  C07K2317/24 ,  C07K2317/73

    摘要： The invention relates to a procedure for linking cognate pairs of VH and VL encoding sequences from a population of cells enriched in particular surface antigen markers. The linking procedure involves a multiplex molecular amplification procedure capable of linking nucleotide sequences of interest in connection with the amplification, in particular polymerase chain reaction (multiplex PCR). The method is particularly advantageous for the generation of cognate pair libraries as well as combinatorial libraries of variable region encoding sequences from immunoglobulins. The invention also relates to methods for generation of chimeric human/non-human antibodies and expression libraries generated by such methods.

    摘要翻译： 本发明涉及从富集特定表面抗原标记的细胞群中连接VH和VL编码序列的同源对的方法。 连接方法涉及能够连接与扩增有关的核苷酸序列的多重分子扩增方法，特别是聚合酶链式反应（多重PCR）。 该方法特别有利于产生同源对文库以及来自免疫球蛋白的可变区编码序列的组合文库。 本发明还涉及用于产生嵌合人/非人抗体的方法和通过这些方法产生的表达文库。

    Antibody diversity generation
    77.
    发明授权
    Antibody diversity generation 失效
    抗体多样性生成

    公开(公告)号：US08252727B2

    公开(公告)日：2012-08-28

    申请号：US12026412

    申请日：2008-02-05

    申请人： Erik Karrer ,  Steven H. Bass ,  Robert Whalen ,  Philip A. Patten

    发明人： Erik Karrer ,  Steven H. Bass ,  Robert Whalen ,  Philip A. Patten

    IPC分类号： C07K1/00 ,  C12N15/00 ,  C40B30/00 ,  C40B30/02 ,  C40B30/04 ,  C40B40/08 ,  C40B50/00

    CPC分类号： C07K16/1271 ,  C07K16/00 ,  C07K16/1275 ,  C07K2317/24

    摘要： Methods for improving antibodies by a variety of DNA diversification and selection procedures are provided. Improvements include increases in affinity, alterations in specificity and effector function, as well as reduced antigenicity, e.g. humanization. Libraries of recombinant antibody sequences are provided, as are cells expressing members of such libraries. Novel phage display vectors are provided. Methods for the coevolution of an antibody and its cognate antigen are provided. Coevolution is used to evolve HIV envelope proteins with increased antigenicity and broadly neutralizing antibodies that interact therewith. Methods of improving antibodies for use in the detection of biological warfare agents are provided.

    摘要翻译： 提供了通过多种DNA多样化和选择程序改进抗体的方法。 改善包括亲和力的增加，特异性和效应子功能的改变，以及降低的抗原性，例如。 人性化。 提供重组抗体序列的文库，以及表达这些文库成员的细胞。 提供了新的噬菌体展示载体。 提供了抗体及其同源抗原共转化方法。 共转化用于发展具有增加的抗原性的HIV包膜蛋白和与之相互作用的广泛中和抗体。 提供了改进用于检测生物战剂的抗体的方法。

    HIGH THROUGHPUT METHOD AND SYSTEM FOR IN VIVO SCREENING
    78.
    发明申请
    HIGH THROUGHPUT METHOD AND SYSTEM FOR IN VIVO SCREENING 审中-公开
    高渗透方法和体内筛查的系统

    公开(公告)号：US20120178646A1

    公开(公告)日：2012-07-12

    申请号：US13382702

    申请日：2010-07-08

    申请人： Herman Pieter Spaink ,  Ronald Petronella Hubertus Dirks

    发明人： Herman Pieter Spaink ,  Ronald Petronella Hubertus Dirks

    IPC分类号： C40B30/04 ,  C40B40/08 ,  C07H21/04 ,  C40B60/12

    CPC分类号： G01N33/5082 ,  G01N33/5011 ,  G01N33/5023 ,  G01N33/5088

    摘要： Provided is a method and system for screening chemical compounds or compositions, wherein replicating entities are introduced into the yolk of an (un)fertilized egg or embryo. The method may be extended to elucidate the mechanism-of-action of functional chemical compounds or compositions in the same method and system. The method and system may also be employed for identifying marker genes, marker proteins or marker metabolites.

    摘要翻译： 提供了用于筛选化合物或组合物的方法和系统，其中将复制实体引入（未）受精卵或胚胎的蛋黄中。 该方法可以扩展以阐明功能性化合物或组合物在相同方法和系统中的作用机理。 该方法和系统也可以用于鉴定标记基因，标记蛋白或标记物代谢物。

    MEANS AND METHODS FOR RECOGNIZING THE DEVELOPMENT OF CARDIOVASCULAR DISEASE IN AN INDIVIDUAL
    79.
    发明申请
    MEANS AND METHODS FOR RECOGNIZING THE DEVELOPMENT OF CARDIOVASCULAR DISEASE IN AN INDIVIDUAL 审中-公开
    识别个体发生心血管疾病的手段和方法

    公开(公告)号：US20120122720A1

    公开(公告)日：2012-05-17

    申请号：US13318804

    申请日：2010-05-05

    申请人： Irun R. Cohen ,  Eytan Domany ,  Eli Sahar ,  Noam Shental

    发明人： Irun R. Cohen ,  Eytan Domany ,  Eli Sahar ,  Noam Shental

    IPC分类号： C40B30/04 ,  C40B40/12 ,  C40B40/04 ,  C40B40/10 ,  C40B40/08

    CPC分类号： G01N33/6893 ,  G01N33/564 ,  G01N2333/47 ,  G01N2500/04 ,  G01N2800/324

    摘要： A method of recognizing the development of an Acute Myocardial Infarction (AMI) process in an individual, wherein the method comprises steps of: profiling specific antibody reactivities or biomarkers associated with AMI susceptibility, the profiling comprises steps of: attaching a set of defined antigens to a substrate; obtaining a biological fluid derived specimen from an individual, the specimen containing a specific antibody repertoire; and binding said antibodies of the biological fluid specimen to the attached antigens thereby forming bound antibody antigen complexes; and analyzing results obtained, wherein the presence of the complexes is indicative of AMI.

    摘要翻译： 识别个体中急性心肌梗死（AMI）过程的发展的方法，其中所述方法包括以下步骤：分析与AMI易感性相关的特异性抗体反应性或生物标志物，所述分析包括以下步骤：将一组限定的抗原连接到 底物; 从个体获得生物流体衍生标本，含有特异性抗体库的样本; 并将所述生物流体标本的所述抗体结合至附着的抗原，从而形成结合的抗体抗原复合物; 并分析获得的结果，其中复合物的存在表示AMI。

    Nucleic Acid Analysis Using Sequence Tokens
    80.
    发明申请
    Nucleic Acid Analysis Using Sequence Tokens 有权
    使用序列标记进行核酸分析

    公开(公告)号：US20120108467A1

    公开(公告)日：2012-05-03

    申请号：US13211113

    申请日：2011-08-16

    申请人： Sydney Brenner

    发明人： Sydney Brenner

    IPC分类号： C40B40/08 ,  C40B60/12 ,  C07H21/00 ,  C40B70/00

    CPC分类号： C12Q1/6837 ,  C12Q1/6827 ,  C12Q2563/179 ,  C12Q2537/113 ,  C12Q2525/186

    摘要： The present invention provides methods and compositions for tagging nucleic acid sequence fragments, e.g., a set of nucleic acid sequence fragments from a single genome, with one or more unique members of a collection of oligonucleotide tags, or sequence tokens, which, in turn, can be identified using a variety of readout platforms. As a general rule, a given sequence token is used once and only once in any tag sequence. In addition, the present invention also provides methods for using the sequence tokens to efficiently determine variations in nucleotide sequences in the associated nucleic acid sequence fragments.

    摘要翻译： 本发明提供了用于标记核酸序列片段的方法和组合物，例如，来自单个基因组的一组核酸序列片段，与寡核苷酸标签或序列标记的集合的一个或多个唯一成员， 可以使用各种读出平台来识别。 作为一般规则，给定的序列令牌在任何标签序列中使用一次且仅一次。 此外，本发明还提供了使用序列令牌有效地确定相关核酸序列片段中的核苷酸序列变异的方法。