公开(公告)号：US07402472B2

公开(公告)日：2008-07-22

申请号：US11067257

申请日：2005-02-25

Applicant: Sangwoo Lim ,  Paul A. Grudowski ,  Tien Ying Luo ,  Olubunmi O. Adetutu ,  Hsing H. Tseng

Inventor： Sangwoo Lim ,  Paul A. Grudowski ,  Tien Ying Luo ,  Olubunmi O. Adetutu ,  Hsing H. Tseng

IPC: H01L21/336

CPC classification number: H01L21/02329 ,  H01L21/02181 ,  H01L21/0234 ,  H01L21/28185 ,  H01L21/28202 ,  H01L21/3141 ,  H01L21/3144 ,  H01L21/3185 ,  H01L29/4908 ,  H01L29/511 ,  H01L29/6659 ,  H01L29/7833

Abstract: A gate dielectric is treated with a nitridation step and an anneal. After this, an additional nitridation step and anneal is performed. The second nitridation and anneal results in an improvement in the relationship between gate leakage current density and current drive of the transistors that are ultimately formed.

Abstract translation: 用氮化步骤和退火处理栅极电介质。 之后，进行另外的氮化步骤和退火。 第二次氮化和退火导致栅极漏电流密度与最终形成的晶体管的电流驱动之间的关系得到改善。

公开(公告)号：US20080161361A1

公开(公告)日：2008-07-03

申请号：US11958353

申请日：2007-12-17

Applicant: Jun Wu ,  Ying Luo ,  Tieling Zhou

Inventor： Jun Wu ,  Ying Luo ,  Tieling Zhou

IPC: A61K31/44 ,  A61P43/00

CPC classification number: A61K31/4418 ,  A61K31/704 ,  A61K31/7064 ,  A61N5/10

Abstract: The present invention is directed to a novel use of pyridone derivatives such as pirfenidone for the prevention and treatment of damages to tissues or organs induced by various cytotoxic agents, such as chemotherapeutic agents, biologics, immunosuppressants and radiation. Such prophylactic and/or therapeutic effects of the pyridone derivatives make it possible to increase therapeutic dosages of the cytotoxic agent, thereby enhancing the therapeutic efficacy of the cytotoxic agent and radiation therapy.

Abstract translation: 本发明涉及吡吡酮衍生物如吡非尼酮的新用途，用于预防和治疗由各种细胞毒剂如化学治疗剂，生物制剂，免疫抑制剂和辐射诱导的组织或器官的损伤。 吡啶酮衍生物的这种预防和/或治疗效果使得可以增加细胞毒性剂的治疗剂量，从而增强细胞毒剂和放射治疗的治疗功效。

公开(公告)号：US20080021202A1

公开(公告)日：2008-01-24

申请号：US11739267

申请日：2007-04-24

Applicant: Ying Luo ,  Betty Huang ,  Mary Shen ,  Pei Yu

Inventor： Ying Luo ,  Betty Huang ,  Mary Shen ,  Pei Yu

IPC: C07K16/18

CPC classification number: C07K14/4747 ,  A61K38/00

Abstract: The present invention is directed to novel apoptosis polypeptides such as the Apop1, Apop2, and Apop3 proteins and related molecules which are involved in modulating apoptosis and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are method for identifying novel compositions which modulate the biological activity of Apop1, Apop2, and Apop3, and the use of such compositions in diagnosis and treatment of disease.

Abstract translation: 本发明涉及新的凋亡多肽，例如参与调节凋亡的Apop1，Apop2和Apop3蛋白和相关分子以及编码这些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本发明还提供了鉴定调节Apop1，Apop2和Apop3的生物学活性的新组合物的方法，以及这些组合物在疾病诊断和治疗中的用途。

公开(公告)号：US20080013803A1

公开(公告)日：2008-01-17

申请号：US11457273

申请日：2006-07-13

Applicant: PETER Z. LO ,  BEHNAM BAVARIAN ,  YING LUO

Inventor： PETER Z. LO ,  BEHNAM BAVARIAN ,  YING LUO

IPC: G06K9/00

CPC classification number: G06K9/00067 ,  G06K9/036

Abstract: A method, apparatus and computer-readable storage element for determining quality of a print image, with the method including the steps of: estimating a centroid point of the physical print; setting dimensions of a quality computation frame based at least on a characteristic of the print image; centering the quality computation frame around the centroid point; determining, within the frame, a set of quality features; and computing a quality measure for the print image based on the set of quality features.

Abstract translation: 一种用于确定打印图像的质量的方法，装置和计算机可读存储元件，方法包括以下步骤：估计物理打印的质心点; 至少基于打印图像的特性设置质量计算帧的尺寸; 围绕质心点的质量计算框中心; 在框架内确定一组质量特征; 以及基于所述一组质量特征来计算所述打印图像的质量度量。

公开(公告)号：US20070269969A1

公开(公告)日：2007-11-22

申请号：US11419304

申请日：2006-05-19

Applicant: Leo Mathew ,  Rode R. Mora ,  Tab A. Stephens ,  Tien Ying Luo

Inventor： Leo Mathew ,  Rode R. Mora ,  Tab A. Stephens ,  Tien Ying Luo

IPC: H01L21/22 ,  H01L21/38 ,  H01L21/8234 ,  H01L21/336

CPC classification number: H01L29/785 ,  H01L29/66795 ,  Y10S438/942

Abstract: Forming structures such as fins in a semiconductor layer according to a pattern formed by oxidizing a sidewall of a layer of oxidizable material. In one embodiment, source/drain pattern structures and a fin pattern structures are patterned in the oxidizable layer. The fin pattern structure is then masked from an oxidation process that grows oxide on the sidewalls of the channel pattern structure and the top surface of the source/drain pattern structures. The remaining oxidizable material of the channel pattern structure is subsequently removed leaving a hole between two portions of the oxide layer. These two portions are used in one embodiment as a mask for patterning the semiconductor layer to form two fins. This patterning also leaves the source/drain structures connected to the fins.

Abstract translation: 根据通过氧化可氧化材料层的侧壁形成的图案在半导体层中形成诸如翅片的结构。 在一个实施例中，在可氧化层中图案化源极/漏极图案结构和鳍状图案结构。 然后从在沟道图案结构的侧壁和源极/漏极图案结构的顶表面上生长氧化物的氧化过程掩蔽鳍状图案结构。 随后去除沟道图案结构的剩余可氧化材料，留下氧化物层的两个部分之间的孔。 这两个部分在一个实施例中用作用于图案化半导体层以形成两个散热片的掩模。 该图案化还使得源极/漏极结构连接到鳍片。

公开(公告)号：US07144825B2

公开(公告)日：2006-12-05

申请号：US10687271

申请日：2003-10-16

Applicant: Olubunmi O. Adetutu ,  Tien Ying Luo ,  Hsing H. Tseng

Inventor： Olubunmi O. Adetutu ,  Tien Ying Luo ,  Hsing H. Tseng

IPC: H01L21/00

CPC classification number: H01L21/28202 ,  H01L29/513 ,  H01L29/518

Abstract: A method for forming a dielectric is disclosed. The method comprises forming a first dielectric layer over semiconductor material. A diffusion barrier material is introduced into the first dielectric layer. Lastly, a second dielectric layer is formed over the first dielectric layer after the introducing.

Abstract translation: 公开了形成电介质的方法。 该方法包括在半导体材料上形成第一介电层。 扩散阻挡材料被引入到第一介电层中。 最后，在引入之后，在第一电介质层上形成第二电介质层。

公开(公告)号：US20050245019A1

公开(公告)日：2005-11-03

申请号：US10836149

申请日：2004-04-30

Applicant: Tien-Ying Luo ,  Olubunmi Adetutu ,  Hsing-Huang Tseng

Inventor： Tien-Ying Luo ,  Olubunmi Adetutu ,  Hsing-Huang Tseng

IPC: H01L21/28 ,  H01L21/314 ,  H01L21/316 ,  H01L21/8238 ,  H01L29/51

CPC classification number: H01L21/02255 ,  H01L21/02299 ,  H01L21/28185 ,  H01L21/28194 ,  H01L21/28202 ,  H01L21/28211 ,  H01L21/3141 ,  H01L21/31645 ,  H01L29/513

Abstract: A high quality thin dielectric layer is achieved by annealing a substrate and base oxide layer at a first temperature in a first ambient and subsequently annealing the substrate and base oxide layer at a second temperature in a second ambient, the base oxide layer overlying a top surface of the substrate. Prior to the first anneal, the base oxide layer has an initial thickness and density. The first anneal causes a first density and thickness change in the base oxide layer from the initial thickness and density to a first thickness and density, with no incorporation of a component of the ambient within the base oxide layer. The first thickness is less than the initial thickness and the first density is greater than the initial density. The second anneal causes a second density and thickness change in the base oxide layer from the first thickness and density to a second thickness and density. The second thickness is larger than the first thickness and the second density is on the order of the greater than or equal to the first density.

Abstract translation: 通过在第一环境中的第一温度下退火衬底和基底氧化物层，随后在第二环境中的第二温度下对衬底和氧化层进行退火来实现高质量的薄介电层，所述基底氧化物层覆盖在顶表面 的基底。 在第一退火之前，基底氧化物层具有初始厚度和密度。 第一次退火导致基底氧化物层中的初始密度和厚度从初始厚度和密度变化到第一厚度和密度，而不会在基底氧化物层内引入环境的成分。 第一厚度小于初始厚度，第一密度大于初始密度。 第二退火导致基础氧化物层中的第二密度和厚度从第一厚度和密度变化到第二厚度和密度。 第二厚度大于第一厚度，第二密度大于或等于第一密度。

公开(公告)号：US06709839B1

公开(公告)日：2004-03-23

申请号：US09404967

申请日：1999-09-24

Applicant: Ying Luo ,  Helena Mancebo

Inventor： Ying Luo ,  Helena Mancebo

IPC: C12N1512

CPC classification number: C07K14/47

Abstract: The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.

Abstract translation: 本发明涉及对细胞周期有影响或与细胞周期有关的新型多肽，核酸和相关分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本发明还提供了鉴定介导细胞周期生物活性的新型组合物的方法，以及这些组合物在疾病诊断和治疗中的应用。

公开(公告)号：US06696263B1

公开(公告)日：2004-02-24

申请号：US09404408

申请日：1999-09-23

Applicant: Ying Luo ,  Betty Huang

Inventor： Ying Luo ,  Betty Huang

IPC: G01N33566

CPC classification number: C07K16/40 ,  G01N33/5011

Abstract: The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.

Abstract translation: 本发明涉及对细胞周期有影响或与细胞周期有关的新型多肽，核酸和相关分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本发明还提供了鉴定介导细胞周期生物活性的新型组合物的方法，以及这些组合物在疾病诊断和治疗中的应用。

公开(公告)号：US06623980B1

公开(公告)日：2003-09-23

申请号：US09255920

申请日：1999-02-23

Applicant: Joseph Fisher ,  James Lorens ,  David Anderson ,  Ying Luo ,  Chao Bai (Betty) Huang ,  Mary Shen

Inventor： Joseph Fisher ,  James Lorens ,  David Anderson ,  Ying Luo ,  Chao Bai (Betty) Huang ,  Mary Shen

IPC: G01N33566

CPC classification number: C07K14/4703

Abstract: The present invention is directed to novel exocytotic polypeptides, such as Exo1 and Exo2 polypeptides and related molecules, which have an inhibitory effect on exocytosis and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are method for identifying novel compositions which mediate exocytotic polypeptide bioactivity, and the use of such compositions in diagnosis and treatment of disease.

Abstract translation: 本发明涉及新颖的胞吐多肽，例如Exo1和Exo2多肽及相关分子，其对胞吐作用具有抑制作用，以及编码这些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本发明还提供了鉴定介导胞吐多肽生物活性的新组合物的方法，以及这些组合物在疾病诊断和治疗中的应用。