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公开(公告)号：US20180051321A1
公开(公告)日：2018-02-22
申请号：US15718893
申请日：2017-09-28
Applicant: 10X Genomics, Inc.
Inventor： Benjamin Hindson , Christopher Hindson , Michael Schnall-Levin , Kevin Ness , Mirna Jarosz , Donald Masquelier , Serge Saxonov , Landon Merrill , Andrew Price , Paul Hardenbol , Yuan Li
CPC classification number: C12Q1/6806 , B01J2219/005 , B01J2219/00547 , B01J2219/00572 , B01J2219/00722 , C12N15/1006 , C12N15/1065 , C12Q2535/122 , C12Q2563/159
Abstract: This disclosure provides methods and compositions for sample processing, particularly for sequencing applications. Included within this disclosure are bead compositions, such as diverse libraries of beads attached to large numbers of oligonucleotides containing barcodes. Often, the beads provides herein are degradable. For example, they may contain disulfide bonds that are susceptible to reducing agents. The methods provided herein include methods of making libraries of barcoded beads as well as methods of combining the beads with a sample, such as by using a microfluidic device.
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82.发明申请公开(公告)号：US20180015472A1
公开(公告)日：2018-01-18
申请号：US15717840
申请日：2017-09-27
Applicant: 10X Genomics, Inc.
Inventor： Rajiv Bharadwaj , Kevin Ness , Debkishore Mitra , Donald Masquelier , Anthony Makarewicz , Christopher Hindson , Benjamin Hindson , Serge Saxonov
CPC classification number: B01L3/502761 , B01L3/0241 , B01L3/502784 , B01L2200/0673 , B01L2300/0816 , B01L2400/049 , B01L2400/086 , G01N35/085 , G01N2035/00237 , G01N2035/1034
Abstract: The disclosure provides devices, systems and methods for the generation of encapsulated reagents and the partitioning of encapsulated reagents for use in subsequent analyses and/or processing, such as in the field of biological analyses and characterization.
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83.发明申请公开(公告)号：US20170348691A1
公开(公告)日：2017-12-07
申请号：US15596754
申请日：2017-05-16
Applicant: 10X Genomics, Inc.
Inventor： Rajiv Bharadwaj , Kevin Ness , Debkishore Mitra , Donald Masquelier , Anthony Makarewicz , Christopher Hindson , Benjamin Hindson , Serge Saxonov
CPC classification number: B01L3/502761 , B01L3/0241 , B01L3/502784 , B01L2200/0673 , B01L2300/0816 , B01L2400/049 , B01L2400/086 , G01N35/085 , G01N2035/00237 , G01N2035/1034
Abstract: The disclosure provides devices, systems and methods for the generation of encapsulated reagents and the partitioning of encapsulated reagents for use in subsequent analyses and/or processing, such as in the field of biological analyses and characterization.
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公开(公告)号：US20170342404A1
公开(公告)日：2017-11-30
申请号：US15470814
申请日：2017-03-27
Applicant: 10X GENOMICS, INC.
Inventor： Benjamin Hindson , Serge Saxonov , Kevin Ness , Paul Hardenbol , Christopher Hindson , Donald Masquelier , Mirna Jarosz , Michael Schnall-Levin
IPC: C12N15/10 , C12Q1/68 , C12N15/11 , G01N33/543
CPC classification number: C12N15/1065 , C12N15/11 , C12Q1/6806 , C12Q1/6874 , C12Q1/6876 , C12Q2600/112 , G01N33/5436
Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing.
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公开(公告)号：US20170321252A1
公开(公告)日：2017-11-09
申请号：US15598898
申请日：2017-05-18
Applicant: 10X Genomics, Inc.
Inventor： Benjamin Hindson , Serge Saxonov , Michael Schnall-Levin
Abstract: This disclosure provides microwell capsule array devices. The microwell capsule array devices are generally capable of performing one or more sample preparation operations. Such sample preparation operations may be used as a prelude to one more or more analysis operations. For example, a device of this disclosure can achieve physical partitioning and discrete mixing of samples with unique molecular identifiers within a single unit in preparation for various analysis operations. The device may be useful in a variety of applications and most notably nucleic-acid-based sequencing, detection and quantification of gene expression and single-cell analysis.
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Patent Agency Ranking
公开(公告)号：US09567631B2
公开(公告)日：2017-02-14
申请号：US14104650
申请日：2013-12-12
Applicant: 10X Genomics, Inc.
Inventor： Benjamin Hindson , Serge Saxonov , Kevin Ness , Paul Hardenbol
IPC: C12Q1/68
CPC classification number: C12Q1/6874 , C12Q1/6806 , C12Q1/683 , C12Q2525/191 , C12Q2537/143 , C12Q2563/179
Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing.
Abstract translation: 本公开提供了用于多核苷酸处理的组合物，方法，系统和装置。 这种多核苷酸处理可用于多种应用，包括多核苷酸测序。
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公开(公告)号：US20250146047A1
公开(公告)日：2025-05-08
申请号：US18960947
申请日：2024-11-26
Applicant: 10x Genomics, Inc.
Inventor： Benjamin Hindson , Christopher Hindson , Michael Schnall-Levin , Kevin Ness , Mirna Jarosz , Donald Masquelier , Serge Saxonov , Landon Merrill , Andrew Price , Paul Hardenbol , Yuan Li
IPC: C12Q1/6806 , C12N15/10
Abstract: This disclosure provides methods and compositions for sample processing, particularly for sequencing applications. Included within this disclosure are bead compositions, such as diverse libraries of beads attached to large numbers of oligonucleotides containing barcodes. Often, the beads provides herein are degradable. For example, they may contain disulfide bonds that are susceptible to reducing agents. The methods provided herein include methods of making libraries of barcoded beads as well as methods of combining the beads with a sample, such as by using a microfluidic device.
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公开(公告)号：US20250129406A1
公开(公告)日：2025-04-24
申请号：US18680949
申请日：2024-05-31
Applicant: 10x Genomics, Inc.
Inventor： Benjamin Hindson , Serge Saxonov , Michael Schnall-Levin
IPC: C12Q1/6806 , B01J19/00 , B01L3/00 , C12N15/10
Abstract: This disclosure provides microwell capsule array devices. The microwell capsule array devices are generally capable of performing one or more sample preparation operations. Such sample preparation operations may be used as a prelude to one more or more analysis operations. For example, a device of this disclosure can achieve physical partitioning and discrete mixing of samples with unique molecular identifiers within a single unit in preparation for various analysis operations. The device may be useful in a variety of applications and most notably nucleic-acid-based sequencing, detection and quantification of gene expression and single-cell analysis.
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公开(公告)号：US20250059606A1
公开(公告)日：2025-02-20
申请号：US18934042
申请日：2024-10-31
Applicant: 10x Genomics, Inc.
Inventor： Michael Schnall-Levin , Mirna Jarosz , Christopher Hindson , Kevin Ness , Serge Saxonov , Benjamin Hindson , Xinying Zheng , Patrick Marks , John Stuelpnagel
IPC: C12Q1/6883 , C12Q1/6827 , G16B30/00 , G16B30/10 , G16B30/20
Abstract: The present disclosure relates to methods, compositions and systems for haplotype phasing and copy number variation assays. Included within this disclosure are methods and systems for combining the barcode comprising beads with samples in multiple separate partitions, as well as methods of processing, sequencing and analyzing barcoded samples.
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公开(公告)号：US20240384348A1
公开(公告)日：2024-11-21
申请号：US18786391
申请日：2024-07-26
Applicant: 10X GENOMICS, INC.
Inventor： Michael SCHNALL-LEVIN , Mirna Jarosz , Christopher Hindson , Kevin Ness , Serge Saxonov , Benjamin Hindson , Xinying Zheng , Patrick Marks , John Stuelpnagel
IPC: C12Q1/6883 , C12Q1/6827 , G16B30/00 , G16B30/10 , G16B30/20
Abstract: The present disclosure relates to methods, compositions and systems for haplotype phasing and copy number variation assays. Included within this disclosure are methods and systems for combining the barcode comprising beads with samples in multiple separate partitions, as well as methods of processing, sequencing and analyzing barcoded samples.
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