公开(公告)号：US10606059B2

公开(公告)日：2020-03-31

申请号：US16404633

申请日：2019-05-06

Applicant: Alentic Microscience Inc.

Inventor： Alan Marc Fine

IPC: G02B21/36 ,  G01N21/49 ,  G01N1/38 ,  G01N21/31 ,  G01N1/28 ,  B01L3/00 ,  G01N15/06 ,  G02B21/34 ,  G02B21/00 ,  G01N33/49 ,  G01N15/00 ,  B01L3/02 ,  G01N1/40 ,  G01N15/14 ,  G01N35/10 ,  G01N35/00

Abstract: In some instances, an apparatus can include a light sensitive imaging sensor having a surface to receive a fluid sample, a body to be moved relative to the light sensitive imaging sensor and having a surface to touch a portion of the fluid sample, and a carrier to move the body toward the surface of the light sensitive imaging sensor to cause the surface of the body to touch the portion of the fluid sample, so that as the surface of the body touches the portion of the fluid, the surface of the body (i) is parallel to the surface of the light sensitive imaging sensor, and (ii) settles on top of the fluid sample independently of motion of the carrier.

公开(公告)号：US10520711B2

公开(公告)日：2019-12-31

申请号：US16439333

申请日：2019-06-12

Applicant: Alentic Microscience Inc.

Inventor： Alan Marc Fine ,  Peter Hodges Gregson

IPC: G02B21/00

Abstract: Among other things, an imaging device has a photosensitive array of pixels, and a surface associated with the array is configured to receive a specimen with at least a part of the specimen at a distance from the surface equivalent to less than about half of an average width of the pixels.

公开(公告)号：US10466457B2

公开(公告)日：2019-11-05

申请号：US16157671

申请日：2018-10-11

Applicant: Alentic Microscience Inc.

Inventor： Alan Marc Fine

IPC: G01N15/10 ,  G01N15/14 ,  G01N33/80 ,  G02B21/00 ,  G02B21/36 ,  G01T1/02 ,  G06T7/00 ,  G06K9/00 ,  G01N11/00 ,  G02B9/02 ,  G03H1/00 ,  G03H1/04 ,  G01B9/02 ,  G01N15/00 ,  C12M1/34

Abstract: Among other things, a method comprises imaging a sample displaced between a sensor surface and a surface of a microscopy sample chamber to produce an image of at least a part of the sample. The image is produced using lensless optical microscopy, and the sample contains at least blood from a subject. The method also comprises automatically differentiating cells of different types in the image, generating a count of one or more cell types based on the automatic differentiation, and deriving a radiation dose the subject has absorbed based on the count.

公开(公告)号：US10459213B2

公开(公告)日：2019-10-29

申请号：US15995598

申请日：2018-06-01

Applicant: Alentic Microscience Inc.

Inventor： Alan Marc Fine ,  Hershel Macaulay ,  Noah Hymes-Vandermeulen

IPC: G02B21/34 ,  G01N1/28 ,  G01N1/40 ,  G01N15/06 ,  G01N15/14 ,  G01N33/49 ,  G01N21/59 ,  G01N35/00 ,  G01N15/00 ,  G01N15/10

Abstract: Among other things, a first surface is configured to receive a sample and is to be used in a microscopy device. There is a second surface to be moved into a predefined position relative to the first surface to form a sample space that is between the first surface and the second surface and contains at least part of the sample. There is a mechanism configured to move the second surface from an initial position into the predefined position to form the sample space. When the sample is in place on the first surface, the motion of the second surface includes a trajectory that is not solely a linear motion of the second surface towards the first surface.

公开(公告)号：US20190162648A1

公开(公告)日：2019-05-30

申请号：US16197265

申请日：2018-11-20

Applicant: Alentic Microscience Inc.

Inventor： Alan Marc Fine

IPC: G01N15/14 ,  G01N15/02 ,  G02B27/10 ,  G02B27/00 ,  G02B27/46 ,  G06E3/00

Abstract: Among other things, an imaging sensor includes a two-dimensional array of photosensitive elements and a surface to receive a sample within a near-field distance of the photosensitive elements. Electronics classify microbeads in the sample as belonging to different classes based on the effects of different absorption spectra of the different classes of microbeads on light received at the surface. In some examples, the number of different distinguishable classes of microbeads can be very large based on combinations of the effects on light received at the surface of the different absorption spectra together, spatial arrangements of colorants in the microbeads that impart the different absorption spectra, different sizes of microbeads, and different shapes of microbeads, among other things.

公开(公告)号：US20190094510A1

公开(公告)日：2019-03-28

申请号：US16157671

申请日：2018-10-11

Applicant: Alentic Microscience Inc.

Inventor： Alan Marc Fine

IPC: G02B21/00 ,  G06K9/00 ,  G01N33/80 ,  G02B21/36 ,  G01T1/02 ,  G01N15/14 ,  G03H1/00 ,  G01N11/00 ,  G03H1/04 ,  C12M1/34 ,  G01N15/10 ,  G01B9/02 ,  G01N15/00 ,  G06T7/00

Abstract: Among other things, a method comprises imaging a sample displaced between a sensor surface and a surface of a microscopy sample chamber to produce an image of at least a part of the sample. The image is produced using lensless optical microscopy, and the sample contains at least blood from a subject. The method also comprises automatically differentiating cells of different types in the image, generating a count of one or more cell types based on the automatic differentiation, and deriving a radiation dose the subject has absorbed based on the count.

公开(公告)号：US10114203B2

公开(公告)日：2018-10-30

申请号：US15642434

申请日：2017-07-06

Applicant: Alentic Microscience Inc.

Inventor： Alan Marc Fine ,  Peter Hodges Gregson

IPC: G02B21/00

Abstract: Among other things, an imaging device has a photosensitive array of pixels, and a surface associated with the array is configured to receive a specimen with at least a part of the specimen at a distance from the surface equivalent to less than about half of an average width of the pixels.

公开(公告)号：US20180284416A1

公开(公告)日：2018-10-04

申请号：US15995598

申请日：2018-06-01

Applicant: Alentic Microscience Inc.

Inventor： Alan Marc Fine ,  Hershel Macaulay ,  Noah Hymes-Vandermeulen

IPC: G02B21/34 ,  G01N21/59 ,  G01N1/40 ,  G01N15/06 ,  G01N15/14 ,  G01N1/28 ,  G01N33/49 ,  G01N35/00 ,  G01N15/00 ,  G01N15/10

Abstract: Among other things, a first surface is configured to receive a sample and is to be used in a microscopy device. There is a second surface to be moved into a predefined position relative to the first surface to form a sample space that is between the first surface and the second surface and contains at least part of the sample. There is a mechanism configured to move the second surface from an initial position into the predefined position to form the sample space. When the sample is in place on the first surface, the motion of the second surface includes a trajectory that is not solely a linear motion of the second surface towards the first surface.

公开(公告)号：US20170293133A1

公开(公告)日：2017-10-12

申请号：US15482215

申请日：2017-04-07

Applicant: Alentic Microscience Inc.

Inventor： Alan Marc Fine

IPC: G02B21/36 ,  G01N33/49 ,  G01N1/38 ,  G01N21/31 ,  G01N1/28

CPC classification number: G02B21/362 ,  B01L3/0293 ,  B01L3/502 ,  B01L2300/0663 ,  B01L2300/0838 ,  B01L2300/0858 ,  B01L2300/0877 ,  G01N1/2813 ,  G01N1/38 ,  G01N15/0612 ,  G01N21/31 ,  G01N33/492 ,  G01N2001/4083 ,  G01N2015/0073 ,  G01N2015/008 ,  G01N2015/0084 ,  G01N2015/1486 ,  G01N2035/1058 ,  G01N2201/068 ,  G01N2201/12 ,  G02B21/361

Abstract: In some instances, an apparatus can include a light sensitive imaging sensor having a surface to receive a fluid sample, a body to be moved relative to the light sensitive imaging sensor and having a surface to touch a portion of the fluid sample, and a carrier to move the body toward the surface of the light sensitive imaging sensor to cause the surface of the body to touch the portion of the fluid sample, so that as the surface of the body touches the portion of the fluid, the surface of the body (i) is parallel to the surface of the light sensitive imaging sensor, and (ii) settles on top of the fluid sample independently of motion of the carrier.

公开(公告)号：US09518920B2

公开(公告)日：2016-12-13

申请号：US14314743

申请日：2014-06-25

Applicant: Alentic Microscience Inc.

Inventor： Alan Marc Fine ,  Hershel Macaulay ,  Noah Hymes-Vandermeulen

IPC: G01N21/01 ,  G01N21/59 ,  G02B21/34

CPC classification number: G02B21/34 ,  G01N1/28 ,  G01N1/4077 ,  G01N15/0606 ,  G01N15/0612 ,  G01N15/1468 ,  G01N21/59 ,  G01N33/49 ,  G01N35/00029 ,  G01N2015/008 ,  G01N2015/1087 ,  G01N2015/1486

Abstract: Among other things, a first surface is configured to receive a sample and is to be used in a microscopy device. There is a second surface to be moved into a predefined position relative to the first surface to form a sample space that is between the first surface and the second surface and contains at least part of the sample. There is a mechanism configured to move the second surface from an initial position into the predefined position to form the sample space. When the sample is in place on the first surface, the motion of the second surface includes a trajectory that is not solely a linear motion of the second surface towards the first surface.

Abstract translation: 除其他之外，第一表面被配置为接收样品并且用于显微镜装置。 存在相对于第一表面移动到预定位置的第二表面以形成位于第一表面和第二表面之间并且包含至少部分样品的样品空间。 存在被配置为将第二表面从初始位置移动到预定位置以形成样本空间的机构。 当样品在第一表面上就位时，第二表面的运动包括不仅仅是第二表面朝向第一表面的线性运动的轨迹。