公开(公告)号：US20230303682A1

公开(公告)日：2023-09-28

申请号：US18004550

申请日：2021-07-16

Applicant: Genentech, Inc.

Inventor： Cecilia Pui Chi Chiu ,  Yan Wu ,  Adel Mahmoud ElSohly ,  Daniel George Lafkas ,  Jian Mehr-Dean Payandeh ,  Hoangdung Dang Ho ,  Siao-Ping Tsai

IPC: C07K16/28 ,  A61K45/06 ,  A61K39/395 ,  A61P11/00

CPC classification number: C07K16/28 ,  A61K39/3955 ,  A61K45/06 ,  A61P11/00 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/35 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: The invention provides anti-Notch2 antibodies and methods of using the same.

公开(公告)号：US20210087283A1

公开(公告)日：2021-03-25

申请号：US17073498

申请日：2020-10-19

Applicant: Genentech, Inc.

Inventor： Junichiro Sonoda ,  Yan Wu

IPC: C07K16/28 ,  A61K39/395 ,  A61K45/06 ,  C07K16/40

Abstract: The invention provides FGFR1 agonists, including agonistic anti-FGFR1 antibodies, and methods of using the same.

公开(公告)号：US10689455B2

公开(公告)日：2020-06-23

申请号：US16136478

申请日：2018-09-20

Applicant: Genentech, Inc.

Inventor： Christian W. Siebel ,  Yan Wu

IPC: A61K39/395 ,  C07K16/18 ,  C07K16/22 ,  C07K16/28 ,  C07K16/30 ,  A61K47/68 ,  C07K16/24 ,  C07K14/475 ,  C07K14/52 ,  A61K39/00

Abstract: The invention provides anti-Jagged antibodies and methods of using the same.

公开(公告)号：US10556951B2

公开(公告)日：2020-02-11

申请号：US15918842

申请日：2018-03-12

Applicant: GENENTECH, INC.

Inventor： Shang-Fan Yu ,  Wei-Ching Liang ,  Yan Wu ,  Steven Leong ,  Andrew Polson

IPC: A61K39/395 ,  C07K16/28 ,  G01N33/574 ,  A61K47/68 ,  A61K39/00

Abstract: The invention provides anti-CD33 antibodies and immunoconjugates and methods of using the same.

公开(公告)号：US10421822B2

公开(公告)日：2019-09-24

申请号：US16168503

申请日：2018-10-23

Applicant: Genentech, Inc.

Inventor： Robert F. Kelley ,  Daniel K. Kirchhofer ,  Joyce Lai ,  Chingwei V. Lee ,  Wei-Ching Liang ,  Michael T. Lipari ,  Kelly M. Loyet ,  Tao Sai ,  Menno Van Lookeren Campagne ,  Yan Wu ,  Germaine Fuh

IPC: C07K16/40 ,  A61K39/395 ,  A61K39/00

Abstract: The present invention provides anti-HtrA1 antibodies (including bispecific anti-HtrA1 anti-Factor D antibodies) and methods of making and using the same, for example, in methods of treating HtrA1-associated disorders, ocular disorders, and/or complement-associated disorders.

公开(公告)号：US10266597B2

公开(公告)日：2019-04-23

申请号：US15657472

申请日：2017-07-24

Applicant: Genentech, Inc.

Inventor： Bing Zheng ,  Andrew Polson ,  Cecilia Chiu ,  Wei-Ching Liang ,  Yan Wu

IPC: A61K39/395 ,  C07K16/28 ,  A61K31/5517 ,  A61K31/706 ,  A61K51/10 ,  C07K16/30 ,  G01N33/574 ,  A61K47/68

Abstract: The invention provides anti-CLL-1 antibodies and immunoconjugates and methods of using the same.

公开(公告)号：US10246518B2

公开(公告)日：2019-04-02

申请号：US15837801

申请日：2017-12-11

Applicant: Genentech, Inc.

Inventor： Yongmei Chen ,  James Ernst ,  Hok Seon Kim ,  Junichiro Sonoda ,  Christoph Spiess ,  Scott Stawicki ,  Yan Wu

IPC: C12N15/13 ,  C07K16/40 ,  C07K14/71 ,  C07K16/28 ,  A61K39/00

Abstract: The presently disclosed subject matter provides antibodies that bind KLB and FGFR1, and methods of using the same. In certain embodiments, an antibody of the present disclosure includes a bispecific antibody that binds to an epitope present on FGFR1 and binds to an epitope present on KLB.

公开(公告)号：US20190016826A1

公开(公告)日：2019-01-17

申请号：US16143098

申请日：2018-09-26

Applicant: Genentech, Inc.

Inventor： Yan Wu ,  Menno van Lookeren Campagne ,  Daniel Kirchhofer ,  Michael Terry Lipari ,  Kenneth J. Katschke, JR. ,  Paul M. Moran ,  Scott Stawicki ,  Wei-Ching Liang

IPC: C07K16/40

Abstract: The invention provides anti-HtrA1 antibodies and methods of using the same.

公开(公告)号：US10017572B2

公开(公告)日：2018-07-10

申请号：US15274603

申请日：2016-09-23

Applicant: Genentech, Inc.

Inventor： Jane L. Grogan ,  Robert J. Johnston ,  Yan Wu ,  Wei-Ching Liang ,  Patrick Lupardus ,  Mahesh Yadav ,  Dhaya Seshasayee ,  Meredith Hazen

IPC: A61K39/395 ,  C07K16/00 ,  C07K16/28 ,  C07K16/30 ,  A61K45/06 ,  A61K38/17 ,  A61K39/00

CPC classification number: C07K16/28 ,  A61K38/177 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/2818 ,  C07K16/2827 ,  C07K16/2878 ,  C07K16/3061 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/567 ,  C07K2317/70 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/90 ,  C07K2317/92 ,  C07K2317/94 ,  Y02A50/466

Abstract: The invention provides anti-TIGIT (T-cell immunoreceptor with Ig and ITIM domains) antibodies and methods of using the same.

公开(公告)号：US10005844B2

公开(公告)日：2018-06-26

申请号：US15722635

申请日：2017-10-02

Applicant: Genentech, Inc.

Inventor： Christian W. Siebel ,  Yan Wu

IPC: C07K16/28 ,  C12N5/00 ,  C12N5/10 ,  C12N5/12 ,  C12N15/09 ,  C12N15/63 ,  C12P21/08 ,  C07K16/30 ,  C07K14/705 ,  C07K14/71 ,  C07K14/715 ,  A61K39/00

CPC classification number: C07K16/30 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K14/705 ,  C07K14/71 ,  C07K16/18 ,  C07K16/28 ,  C07K16/2863 ,  C07K16/3015 ,  C07K2317/14 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C12N5/10 ,  C12N5/12 ,  C12N15/09 ,  C12N15/63 ,  C12N2330/50

Abstract: The invention provides anti-Notch1 NRR antibodies, and compositions comprising and methods of using these antibodies.